Vaccine News – Study – Subcutaneous injections of aluminum at vaccine adjuvant levels activate innate immune genes in mouse brain that are homologous with biomarkers of autism & My daughter has autism from vaccines – VAXXED TV

VAXXED TV – My sister is vaccine injured #vaxxed #DidYouKnow #Praybig

My daughter has autism from vaccines #vaxxed #DidYouKnow #praybig

Legally blind from the MMR vaccine #vaxxed #DidYouKnow #praybig

3 Hours Later I Lost My Hearing
Robert tells about his vaccine injury that has resulted in loss of hearing in one ear along with other side affects.

I stopped vaccines for my children #vaxxed #DidYouKnow #praybig

Vaccines injured us #vaxxed #DidYouKnow #praybig

Gardasil vaccine injured me #vaxxed #DidYouKnow #praybig

My only daughter is injured by vaccines #vaxxed #DidYouKnow #praybig

Vaccines injured my son #vaxxed #DidYouKnow #praybig

My sons first vaccine at 13 months gave him a stroke #vaxxed #DidYouKnow

Study – Subcutaneous injections of aluminum at vaccine adjuvant levels activate innate immune genes in mouse brain that are homologous with biomarkers of autism

Journal of Inorganic Biochemistry – 2017

Highlights
• Mechanisms underlying aluminum adjuvant neurotoxicity have been investigated.
• Key proinflammatory factors were found elevated in the brains of aluminum-injected mice.
• Male mice were more susceptible to aluminum’s neuroinflammatory effects than females.
• Frontal cortex was the most affected area in males.
• Frontal cortex is involved in emotional and social functions which are impaired in autism.

Abstract
Autism is a neurobehavioral disorder characterized by immune dysfunction. It is manifested in early childhood, during a window of early developmental vulnerability where the normal developmental trajectory is most susceptible to xenobiotic insults. Aluminum (Al) vaccine adjuvants are xenobiotics with immunostimulating and neurotoxic properties to which infants worldwide are routinely exposed. To investigate Al′s immune and neurotoxic impact in vivo, we tested the expression of 17 genes which are implicated in both autism and innate immune response in brain samples of Al-injected mice in comparison to control mice. Several key players of innate immunity, such as cytokines CCL2, IFNG and TNFA, were significantly upregulated, while the nuclear factor-kappa beta (NF-κB) inhibitor NFKBIB, and the enzyme controlling the degradation of the neurotransmitter acetylcholine (ACHE), were downregulated in Al-injected male mice. Further, the decrease of the NF-κB inhibitor and the consequent increase in inflammatory signals, led to the activation of the NF-κB signaling pathway resulting in the release of chemokine MIP-1A and cytokines IL-4 and IL-6. It thus appears that Al triggered innate immune system activation and altered cholinergic activity in male mice, observations which are consistent with those in autism. Female mice were less susceptible to Al exposure as only the expression levels of NF-κB inhibitor and TNFA were altered. Regional patterns of gene expression alterations also exhibited gender differences, as frontal cortex was the most affected area in males and cerebellum in females. Thus, Al adjuvant promotes brain inflammation and males appear to be more susceptible to Al′s toxic effects.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

This site uses Akismet to reduce spam. Learn how your comment data is processed.