JAMA – Spontaneous Abortions and Policies on COVID-19 mRNA Vaccine Use During Pregnancy

Source: https://jamanetwork.com/journals/jama/fullarticle/2784193

Abstract The use of mRNA vaccines in pregnancy is now generally considered safe for protection against COVID-19 in countries such as New Zealand, USA, and Australia. However, the influential CDC sponsored article by Shimabukuro et al. (2021) used to support this idea, on closer inspection, provides little assurance, particularly for those exposed in early pregnancy. The study presents falsely reassuring statistics related to the risk of spontaneous abortion in early pregnancy, since the majority of women in the calculation were exposed to the mRNA product after the outcome period was defined (20 weeks’ gestation). In this article, we draw attention to these errors and recalculate the risk of this outcome based on the cohort that was exposed to the vaccine before 20 weeks’ gestation. Our re-analysis indicates a cumulative incidence of spontaneous abortion 7 to 8 times higher than the original authors’ results (p < 0.001) and the typical average for pregnancy loss during this time period. In light of these findings, key policy decisions have been made using unreliable and questionable data. We conclude that the claims made using these data on the safety of exposure of women in early pregnancy to mRNA-based vaccines to prevent COVID-19 are unwarranted and recommend that those policy decisions be revisited.

Copyright © The Authors — Published Under the Creative Commons License Share/Alike (see https://creative commons.org/licenses/) Correspondence: s.thornley@auckland.ac.nz

Keywords COVID-19; Pregnancy; Adverse Events; Spontaneous Abortion

PDF: https://media-exp1.licdn.com/dms/document/C561FAQEWWDK5jejYtg/feedshare-document-pdf-analyzed/0/1635901285867?e=1636027200&v=beta&t=VGPp29Xuur8eWas5tyrZAESXkhFMIQSJf3Pw9ada_jk

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

This site uses Akismet to reduce spam. Learn how your comment data is processed.