Dr Mercola – Senolytic Fisetin May Help Treat Older SARS-CoV-2 Patients

Analysis by Dr. Joseph Mercola

Source: https://media.mercola.com/ImageServer/Public/2021/November/PDF/senolytic-fisetin-pdf.pdf

STORY AT-A-GLANCE

  • Fisetin has been shown to reduce the burden of COVID-19 in the lab and an animal model with significant results; researchers are now testing it in skilled nursing facility residents
  • Fisetin is a flavonoid with known senolytic properties, which help reduce the number of senescent cells in the body. These cells have lost the ability to proliferate and are resistant to apoptosis
  • The foods highest in fisetin are strawberries; yet you need to eat 37 strawberries each day to get the benefits. The compound also extended the health span of animals used in the study
  • Fisetin has been shown to have anti-inflammatory and antitumorigenic properties, to inhibit bone-damaging glycation, to maintain glutathione levels, and to protect brain function

Fisetin is a flavonoid molecule that’s found in fruits and vegetables. An animal study published in July 20211 demonstrated that it may help reduce the mortality rate in older adults with COVID-19. A human study2 is underway to analyze the effect it may have on elderly patients with COVID-19.

There are nearly 6,000 flavonoids3 found in fruits, vegetables, herbs and medicinal plants. Flavonoids are also antioxidants and have a number of subclasses, including flavanols, flavones and flavanones.4 During 2020, there was a growing focus on the value of antioxidants in the fight against infectious diseases.

As the science grows, researchers are becoming interested in individual flavonoids for the positive effect they can have on human health. Past research has suggested that fisetin may help extend a healthy life span by acting as a senolytic.5

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