Steve Kirsch – The case for fluvoxamine for treating COVID-19


Today, if we follow the CDC advice, nearly 100,000 people a month will die from COVID. This advice is now outdated.

On January 22, 2021, thirty key opinion leaders (KOL) from NIH, CDC, and leading academic institutions met to review the evidence for using fluvoxamine for treating COVID. Even though they spent only 45 minutes and just reviewed the 2 clinical studies and some plausible mechanisms of action (and ignored anecdotal evidence and multiple retrospective trials, all of which were supportive), after the meeting they voted overwhelmingly (11 to 5 with 4 being neutral) in favor of having doctors talk to their patients about using fluvoxamine if they have COVID using a “shared decision making” process. I believe they made the right decision and we should be rushing to follow their advice. Here’s why.

Fluvoxamine is a very safe drug… on market for 37 years, tens of millions of people have taken it, no record in scientific literature of anyone dying on overdose, and according to doctors that know the drug the best, about as dangerous as taking a Tylenol. At the dosing for COVID (50mg BID x 14 days), there is a 1% chance of mild-nausea and because the dose is so low and the time it is taken is so short, and there are no psychotropic effects (which require more than 3 weeks of use; the psychotropic effects non-existent if you don’t have depression or an anxiety disorder in the first place). Drug interactions should be checked for. Patients should be advised to limit/avoid the use of caffeine while on the drug since fluvoxamine extends the half life of caffeine (making you super wired).

In two trials (both published studies in peer reviewed journals with Editor’s Choice in both cases), the drug had a 100% effect size in protecting against hospitalization from the respiratory symptoms from COVID. The combined p value of the two studies is <.0001. 95% confidence effect size is 75% or more.

In every case we are aware of, the drug was successful in reversing COVID symptoms, generally in 3 days or less. In severe cases, it takes longer. I have never heard of a case it didn’t work.

I am not aware of a single case where taking the made things worse, e.g., person was doing fine BEFORE the drug and symptoms worsened after taking the drug.

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