Vaccine News – Study – INFANTS RECEIVING MERCURY-CONTAINING VACCINES DEVELOPED SPEECH DISORDERS, SLEEP DISORDERS, AND AUTISM, ACCORDING TO CDC SCIENTISTS

Dr. Andrew Moulden: Every Vaccine Produces Harm
by John P. Thomas
Health Impact News
Canadian physician Dr. Andrew Moulden provided clear scientific evidence to prove that every dose of vaccine given to a child or an adult produces harm. The truth that he uncovered was rejected by the conventional medical system and the pharmaceutical industry. Nevertheless, his warning and his message to America remains as a solid legacy of the man who stood up against big pharma and their program to vaccinate every person on the Earth.
Dr Moulden died unexpectedly in November of 2013 at age 49.
Because of the strong opposition from big pharma concerning Dr. Moulden’s research, I became concerned that the name of this brilliant researcher and his life’s work had nearly been deleted from the internet. His reputation was being disparaged, and his message of warning and hope was being distorted and buried without a tombstone.
I prepared a series of articles as a tribute to a great physician and as a memorial to a courageous individual who was not afraid to speak the truth about medical corruption and a flawed healthcare system that does more to harm health than it does to cure disease.
This is the first in a series of four articles about Dr. Moulden — the man, the physician, and the powerful advocate for ending all vaccine use. In future articles, I will summarize his detailed scientific evidence, which shows how vaccine damage occurs. I will explain the common mechanisms behind vaccine damage and how vaccines harm the health of everyone who receives them regardless of whether or not they notice any adverse reactions at the time they take the shots.
Dr. Moulden stated:
What we have done to each other [with vaccines] has produced the most profound damage to humankind by humankind in the history of humanity. And the reason why we got here is partly because of:
Our arrogance in thinking that we know everything. In physiology and medicine we do not know everything!
[Our greed] to advance our own self-interest to make money, to sell products and to advance corporate alliances. Commercialization has overtaken the fundamental human value of “do unto others as you would have others do unto you.” When society turns toward this human value, then we would all be working together for the greater good of each other. [However, other values have become more important] I don’t care whose feet I step on or how I get there as long as my American dream is realized. I don’t care who has to pay for it on the way of getting there. [1]
Dr. Moulden’s Credibility
Was Dr. Moulden a crackpot as some sources claim, or was he a brilliant physician and researcher? This series of articles will set the record straight, and summarize the contribution that his work has made to medical knowledge.
When I evaluate the credibility of people who are unknown to me, I begin by seeking answers to a few basic questions. For example: Is this person offering opinion, or can he or she back up the claims with valid science? Does he have educational credentials? Are there other physicians and scientists who support his or her beliefs and recommendations? Is this person controlled by the pharmaceutical industry, allopathic medical associations, or the US FDA (US Food and Drug Administration)? And finally, what do Quackwatch and their friends have to say about the person?
Dr. Moulden had a PhD in Clinical Psychology and Neuropsychology. He had a master’s degree in child development, and was also a medical doctor. [2] His work was respected by other researchers who don’t march to the drumbeat of the pharmaceutical companies. Dr. Moulden was a threat to the pharmaceutical industry, and their Quackwatch family of 21 related websites treated him as an enemy. [3, 4]

Vaccine Contraindications: Six People Who Should Not Be Vaccinated
The debate surrounding vaccinations is a fierce one, and personally, I don’t like to argue about it. I’m happy to make the right choices for my family while you make the right ones for yours. (I personally have suffered adverse reactions to vaccinations.) It’s ok to have different opinions, really it is. But there are a lot of folks out there who think everyone should be vaccinated, period, and those who choose not to vaccinate should be penalized or worse.
Listen. I get that people are scared and there’s a lot of fear-mongering in the media. But let’s be realistic here: vaccinations are a medical procedure. There are risks. Vaccinations are not right for everyone. There are at least six types of people in particular who should avoid vaccinations, and below, I’ll spell it out.
Vaccine Contraindications
Just like a particular surgery or prescription medication won’t work well for everyone, vaccinations are not a good choice for everyone.
Some people, in particular, are much more likely to have adverse reactions to vaccinations, including:

– Those with an autoimmune disease
– Children born to a mother with an autoimmune disease
– Anyone who is sick
– Pregnant women
– Those who have previously had a reaction to a vaccination

One size does not fit all
Clearly, vaccinations are not the right choice for everyone, and each family should decide what is right for them and their children. When parents are aware of vaccine contraindications, they can make informed and safer choices for their children.
Please share this post so that other parents can learn about vaccine contraindications and decide if vaccination is right for their children.

USA: Highest Vaccination Rate in the World Has the Worst Health
by PAUL FASSA
That “worst health” label includes a ranking of 34th in the world with infant mortality. In other words, the USA has the 34th worst infant survival with its highest rate of vaccinations. Some are directly from multiple vaccinations administered.
But the USA leads the world in infant vaccinations, those administered during the first year after their births – 26 vaccinations during that time.
The only vaccination I recall receiving during early childhood, circa 1948, was the smallpox vaccine, the one that left a circle of shallow pockmarks on the upper arm, a non-ink tattoo that proved you had received that vaccine. Months later there was the booster shot which gave me a vacation of several days away from my first grade teacher while sitting out the chicken pox.
During Naval training the mass vaccination high pressure hand held gun that replaced syringes and needles was tried on us with the polio shot. I wound up with a vacation in the base infirmary with an extended period of the flu. Between those two, there may have been a tetanus shot or two.
From the Healthy Home Economist:

-In1950, there were 3 childhood vaccines typically given when a child entered school.
-In 1983, there were 10 recommended vaccines by the age of 6 years old (24 doses, 7 injections, 4 oral doses for polio).
-In 2010, the CDC vax schedule totaled 68 doses with more than half given by the time a child was only a year and a half old.
-In 2016, the schedule has increased to 74 doses by age 17 with 53 injections and 3 oral doses of rotavirus.

The number of vaccines included in the current childhood vaccine schedule has quadrupled over the past 60 years, with several demanding multiple injections and boosters. During this exponential rise of CDC “recommended” schedules, the health of American children has plummeted.
Autoimmune diseases, learning disabilities, food allergies, chronic ailments, and childhood obesity have all risen. The overall health of this nation ranks very low compared to all other industrialized nations, dead last in most areas.
Vaccine false dogma is so heavy hardly anyone with authority, even in mainstream media, makes the connection between poor health with high vaccination rates. Instead, more, three added for 2016, are getting enforced by mandate or coerced by pediatricians who have the right to refuse medical care on kids who aren’t vaccinated.
Destroying Health with Vaccines is Good Business

50 Studies the AAP Avoided to Mention
There is a robust, worldwide body of published science from highly esteemed scientists questioning the safety of many different aspects of vaccines-how come we never hear from them? The majority of the most compelling science has been published since 2010. Below find 50 such studies to consider, sorted chronologically, and note that these studies only represent a portion of the published work implicating vaccinations in a wide variety of negative health outcomes.
The American Academy of Pediatrics made representations to President Trump in a letter dated 2/7/2017 that are utterly indefensible and inaccurate, as any rational review of the studies below quickly demonstrates. For example, the AAP wrote:
“Claims that vaccines are unsafe when administered according to expert recommendations have been disproven by a robust body of medical literature…we write to express our unequivocal support for the safety of vaccines.”
We contend that the AAP’s statements to the President are baseless, reckless, and easily refuted. The AAP’s letter alone supports the President’s desire to field a Vaccine Safety Commission and do all we can to make vaccines as safe as possible. Please click here for a list of all 50 studies detailed below.

2017
Temporal Association of Certain Neuropsychiatric Disorders Following Vaccination of Children and Adolescents A Pilot Case–Control Study
New Quality-Control Investigations on Vaccines Micro-and Nanocontamination
2016
Behavioral abnormalities in female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil
Autoimmune/Inflammatory Syndrome Induced by Adjuvants and Sjogren’s Syndrome
Combining Childhood Vaccines at One Visit Is Not Safe
Aluminum in Childhood Vaccines Is Unsafe
Aluminium in brain tissue in familial Alzheimer’s disease
2015
Evidence that Food Proteins in Vaccines Cause the Development of Food Allergies and Its Implications for Vaccine Policy
2014
Transcriptomic Analyses of Neurotoxic Effects in Mouse Brain After Intermittent Neonatal Administration of Thimerosal
A Dose-Response Relationship between Organic Mercury Exposure from Thimerosal-Containing Vaccines and Neurodevelopmental Disorders
A comparison of temporal trends in United States autism prevalence to trends in suspected environmental factors
2013
A Population-Based Cohort Study of Undervaccination in 8 Managed Care Organizations Across the United States
Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) 2013: Unveiling the pathogenic, clinical and diagnostic aspects
Aluminum in the central nervous system (CNS): toxicity in humans and animals, vaccine adjuvants, and autoimmunity
Autoimmune/inflammatory syndrome induced by adjuvants (Shoenfeld’s syndrome): clinical and immunological spectrum
A two-phase study evaluating the relationship between Thimerosal-containing vaccine administration and the risk for an autism spectrum disorder diagnosis in the United States
Human exposure to aluminium
Human Papilloma Virus Vaccine and Primary Ovarian Failure: Another Facet of the Autoimmune/Inflammatory Syndrome Induced by Adjuvants
2012
Risk of Febrile Seizures and Epilepsy After Vaccination With Diphtheria, Tetanus, Acellular Pertussis, Inactivated Poliovirus, and Haemophilus Influenzae Type b
Mechanisms of aluminum adjuvant toxicity and autoimmunity in pediatric populations
Neurologic adverse events following vaccination
The spectrum of ASIA: ‘Autoimmune (Auto-inflammatory) Syndrome induced by Adjuvants’
Relative trends in hospitalizations and mortality among infants by the number of vaccine doses and age, based on the Vaccine Adverse Event Reporting System (VAERS), 1990-2010
2011
Do aluminum vaccine adjuvants contribute to the rising prevalence of autism?
Maternal Thimerosal Exposure Results in Aberrant Cerebellar Oxidative Stress, Thyroid Hormone Metabolism, and Motor Behavior in Rat Pups; Sex- and Strain-Dependent Effects
2010
Interindividual variations in the efficacy and toxicity of vaccines
Sorting out the spinning of autism: heavy metals and the question of incidence
Influence of pediatric vaccines on amygdala growth and opioid ligand binding in rhesus macaque infants: A pilot study
The immunobiology of aluminium adjuvants: how do they really work?
Hepatitis B Vaccination of Male Neonates and Autism Diagnosis, NHIS 1997-2002
2009
Allergic Disease and Atopic Sensitization in Children in Relation to Measles Vaccination and Measles Infection
Long-term persistence of vaccine-derived aluminum hydroxide is associated with chronic cognitive dysfunction
Delayed acquisition of neonatal reflexes in newborn primates receiving a thimerosal-containing Hepatitis B vaccine: Influence of gestational age and birth weight
Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration
2008
Post-vaccination encephalomyelitis: Literature review and illustrative case
Thimerosal exposure in infants and neurodevelopmental disorders: An assessment of computerized medical records in the Vaccine Safety Datalink
Delay in diphtheria, pertussis, tetanus vaccination is associated with a reduced risk of childhood asthma?
Hepatitis B triple series vaccine and developmental disability in US children aged 1-9 years
2005
THE MERCURY USED AS A VACCINE PRESERVATIVE IS FAR MORE NEUROTOXIC THAN THE MERCURY FOUND IN FISH
Comparison of Blood and Brain Mercury Levels in Infant Monkeys Exposed to Methylmercury or Vaccines Containing Thimerosal
Thimerosal Neurotoxicity is Associated with Glutathione Depletion: Protection with Glutathione Precursors
2004
Activation of methionine synthase by insulin-like growth factor-1 and dopamine: a target for neurodevelopmental toxins and thimerosal
2002
UTAH STATE SCIENTISTS FIND AUTOIMMUNE REACTION TO MMR IN CHILDREN WITH AUTISM, INCLUDING AUTOIMMUNITY TO MYELIN BASIC PROTEIN, A BRAIN BUILDING-BLOCK
Abnormal Measles-Mumps-Rubella Antibodies and CNS Autoimmunity in Children with Autism
2001
Macrophagic myofasciitis lesions assess long-term persistence of vaccine derived aluminum hydroxide in muscle
2000
JAPANESE SCIENTISTS FIND VACCINE-STRAIN OF MEASLES IN THE GUTS OF CHILDREN WITH AUTISM
Detection and Sequencing of Measles Virus from Peripheral Mononuclear Cells from Patients with Inflammatory Bowel Disease and Autism
CDC SCIENTISTS ADMIT THAT 90% OF INFECTIOUS DISEASE MORTALITY DECREASE IN THE UNITED STATES HAPPENED BEFORE VACCINES WERE AVAILABLE
Annual Summary of Vital Statistics: Trends in the Health of Americans During the 20th Century
Iatrogenic exposure to mercury after hepatitis B vaccination in preterm infants
Effects of Diphtheria-Tetanus-Pertussis or Tetanus Vaccination on Allergies and Allergy-Related Respiratory Symptoms Among Children and Adolescents in the United States
1999
INFANTS RECEIVING MERCURY-CONTAINING VACCINES DEVELOPED SPEECH DISORDERS, SLEEP DISORDERS, AND AUTISM, ACCORDING TO CDC SCIENTISTS
Increased risk of developmental neurologic impairment after high exposure to thimerosal-containing vaccine in first month of life
INFECTIOUS DISEASE RATES DECLINED PRECIPITOUSLY IN THE UNITED STATES IN THE 20TH CENTURY BEFORE THE IMPLEMENTATION OF A NATIONAL VACCINE PROGRAM
Trends in Infectious Disease Mortality in the United States During the 20th Century
CDC SCIENTISTS FIND CHILDREN GIVEN THE MMR VACCINE SHED THE MEASLES VIRUS FOR AT LEAST 2 WEEKS AFTER GETTING THE VACCINE, MAKING THEM VECTORS TO SPREAD MEASLES
Detection of Measles Virus RNA in Urine Specimens from Vaccine Recipients

Whooping cough resurgence due to vaccinated people not knowing they’re infectious?

Whooping cough resurgence due to vaccinated people not knowing they’re infectious?
Date:
June 24, 2015
Source:
Santa Fe Institute
Summary:
The dramatic resurgence of whooping cough is due, in large part, to vaccinated people who are infectious but who do not display the symptoms, suggests a new study.
…vaccinated people who are infectious but who do not display the symptoms of whooping cough, suggesting that the number of people transmitting without symptoms may be many times greater than those transmitting with symptoms.
The problem is, the newer vaccines might not block transmission. A January 2014 study in PNAS by another research team demonstrated that giving baboons acellular pertussis vaccines prevented them from developing symptoms of whooping cough but failed to stop transmission.
Building on that result, Althouse and Scarpino used whopping cough case counts from the CDC, genomic data on the pertussis bacteria, and a detailed epidemiological model of whooping cough transmission to conclude that acellular vaccines may well have contributed to — even exacerbated — the recent pertussis outbreak by allowing infected individuals without symptoms to unknowingly spread pertussis multiple times in their lifetimes.

Public Health Officials Know: Recently Vaccinated Individuals Spread Disease

Washington, D.C., March 3, 2015 (GLOBE NEWSWIRE) — Physicians and public health officials know that recently vaccinated individuals can spread disease and that contact with the immunocompromised can be especially dangerous. For example, the Johns Hopkins Patient Guide warns the immunocompromised to “Avoid contact with children who are recently vaccinated,” and to “Tell friends and family who are sick, or have recently had a live vaccine (such as chicken pox, measles, rubella, intranasal influenza, polio or smallpox) not to visit.”1
A statement on the website of St. Jude’s Hospital warns parents not to allow people to visit children undergoing cancer treatment if they have received oral polio or smallpox vaccines within four weeks, have received the nasal flu vaccine within one week, or have rashes after receiving the chickenpox vaccine or MMR (measles, mumps, rubella) vaccine.2
“The public health community is blaming unvaccinated children for the outbreak of measles at Disneyland, but the illnesses could just as easily have occurred due to contact with a recently vaccinated individual,” says Sally Fallon Morell, president of the Weston A. Price Foundation. The Foundation promotes a healthy diet, non-toxic lifestyle and freedom of medical choice for parents and their children. “Evidence indicates that recently vaccinated individuals should be quarantined in order to protect the public.”
Scientific evidence demonstrates that individuals vaccinated with live virus vaccines such as MMR (measles, mumps and rubella), rotavirus, chicken pox, shingles and influenza can shed the virus for many weeks or months afterwards and infect the vaccinated and unvaccinated alike.

Officials at the U.S. Centers for Disease Control and Prevention (CDC) say the best way to prevent pertussis is to get vaccinated. But data from the Vermont Department of Health (DOH) suggest that going through the pertussis vaccination regimen is not a sure-fire way to ward off the highly contagious disease.

In 2014, an outbreak of whooping cough (pertussis) broke out in the San Diego area. Of the 621 individuals who were infected, nearly all of them were completely up to date on all preventive vaccinations. If vaccines are given to protect from disease, how could this happen?
San Diego public health official Dr. Wilma Wooten argued that the cause was related to a decrease in the protection offered by vaccines after the first year. This answer is most revealing, in that it speaks to the actual efficacy of vaccines. It also shows that the concept of herd immunity is largely myth—and completely misunderstood.
The theory of herd immunity states that when a critical mass of the population (usually stipulated at 95%) is vaccinated against a disease, the possibility of outbreaks is eliminated. This is the main argument that is used to shame parents who wish to refuse certain vaccinations for their children: by not vaccinating, they put the health of the “herd” at risk.
However, if vaccines start losing effectiveness after the first year, as Dr. Wooten says, then constant revaccination would be required, since the immunity offered is only temporary for most vaccines. Achieving the required rate of protection is virtually impossible under this paradigm.
Of course, if we look back over the decades and note the lack of rampant epidemics in our nation, while remembering that vaccine protection is in perpetual decline, the myth of herd immunity quickly unravels. Our society has never achieved this level of herd immunity, yet not a single major outbreak of disease has occurred.
The argument for herd immunity was actually developed out of observations of natural immunity, not vaccination. Statisticians observed that populations were protected when sufficient members contracted the wild form of a disease, and subsequently acquired lifelong immunity. With vaccines, however, evidence shows that unvaccinated children may catch infectious diseases from vaccinated children. What is true of natural immunity is not true of vaccination.

Adverse Effects of Pertussis and Rubella Vaccines (1991)
Description
Parents have come to depend on vaccines to protect their children from a variety of diseases. Some evidence suggests, however, that vaccination against pertussis (whooping cough) and rubella (German measles) is, in a small number of cases, associated with increased risk of serious illness.
This book examines the controversy over the evidence and offers a comprehensively documented assessment of the risk of illness following immunization with vaccines against pertussis and rubella. Based on extensive review of the evidence from epidemiologic studies, case histories, studies in animals, and other sources of information, the book examines:
The relation of pertussis vaccines to a number of serious adverse events, including encephalopathy and other central nervous system disorders, sudden infant death syndrome, autism, Guillain-Barre syndrome, learning disabilities, and Reye syndrome.
The relation of rubella vaccines to arthritis, various neuropathies, and thrombocytopenic purpura.
The volume, which includes a description of the committee’s methods for evaluating evidence and directions for future research, will be important reading for public health officials, pediatricians, researchers, and concerned parents.

Whooping cough increase related to current vaccine
The move to an artificially created vaccine for whooping cough is behind an increase in cases of the deadly disease in the US, a new study suggests.
The findings highlight the need to do similar research in Australia where whooping cough cases have spiralled upward in the past decade, co-author Associate Professor Manoj Gambhir, from the University of Monash, says.
In 2012 the US saw the highest number of pertussis (whooping cough) cases since 1955.
At the same time there has been a shift in the age group reporting the largest number of cases from adolescents to 7 to 11 year olds.
In the paper, published today in PLOS Computational Biology, Gambhir and colleagues use mathematical modelling of 60 years of pertussis disease data to determine what best explains this increase.

A Change in Vaccine Efficacy and Duration of Protection Explains Recent Rises in Pertussis Incidence in the United States
Published: April 23, 2015
PDF version
Abstract
Over the past ten years the incidence of pertussis in the United States (U.S.) has risen steadily, with 2012 seeing the highest case number since 1955. There has also been a shift over the same time period in the age group reporting the largest number of cases (aside from infants), from adolescents to 7–11 year olds. We use epidemiological modelling and a large case incidence dataset to explain the upsurge. We investigate several hypotheses for the upsurge in pertussis cases by fitting a suite of dynamic epidemiological models to incidence data from the National Notifiable Disease Surveillance System (NNDSS) between 1990–2009, as well as incidence data from a variety of sources from 1950–1989. We find that: the best-fitting model is one in which vaccine efficacy and duration of protection of the acellular pertussis (aP) vaccine is lower than that of the whole-cell (wP) vaccine, (efficacy of the first three doses 80% [95% CI: 78%, 82%] versus 90% [95% CI: 87%, 94%]), increasing the rate at which disease is reported to NNDSS is not sufficient to explain the upsurge and 3) 2010–2012 disease incidence is predicted well. In this study, we use all available U.S. surveillance data to: 1) fit a set of mathematical models and determine which best explains these data and 2) determine the epidemiological and vaccine-related parameter values of this model. We find evidence of a difference in efficacy and duration of protection between the two vaccine types, wP and aP (aP efficacy and duration lower than wP). Future refinement of the model presented here will allow for an exploration of alternative vaccination strategies such as different age-spacings, further booster doses, and cocooning.

FDA NEWS RELEASE – FDA study helps provide an understanding of rising rates of whooping cough and response to vaccination
For Immediate Release: Nov. 27, 2013
A new study is helping to provide a better understanding of vaccines for whooping cough, the common name for the disease pertussis. Based on an animal model, the study conducted by the U.S. Food and Drug Administration (FDA) and published November 25, 2013, in The Proceedings of the National Academy of Sciences, shows that acellular pertussis vaccines licensed by the FDA are effective in preventing the disease among those vaccinated, but suggests that they may not prevent infection from the bacteria that causes whooping cough in those vaccinated or its spread to other people, including those who may not be vaccinated.
While the reasons for the increase in cases of whooping cough are not fully understood, multiple factors are likely involved, including diminished immunity from childhood pertussis vaccines, improved diagnostic testing, and increased reporting. With its own funds plus support from the National Institutes of Health (NIH), the FDA conducted the study to explore the possibility that acellular pertussis vaccines, while protecting against disease, might not prevent infection.

Study- Acellular pertussis vaccines protect against disease but fail to prevent infection and transmission in a nonhuman primate model
Although pertussis resurgence is not completely understood, we hypothesize that current acellular pertussis (aP) vaccines fail to prevent colonization and transmission.
To test our hypothesis, infant baboons were vaccinated at 2, 4, and 6 mo of age with aP or whole-cell pertussis (wP) vaccines and challenged with
pertussis at 7 mo. Infection was followed by quantifying colonization in nasopharyngeal washes and monitoring leukocytosis and symptoms. Baboons vaccinated with aP were
protected from severe pertussis-associated symptoms but not from colonization, did not clear the infection faster than naïve animals, and readily transmitted
pertussis to unvaccinated contacts. Vaccination with wP induced a more rapid clearance compared with naïve and aP-vaccinated animals. By comparison, previously infected
animals were not colonized upon secondary infection. Although all vaccinated and previously infected animals had robust serum antibody responses, we found key differences in T-cell immunity.
Previously infected animals and wP-vaccinated animals possess strong pertussis-specific T helper 17 (Th17) memory and Th1 memory,whereas aP vaccination induced a Th1/Th2 response instead. The
observation that aP, which induces an immune response mismatched to that induced by natural infection, fails to prevent colonization or transmission provides a plausible explanation for the
resurgence of pertussis and suggests that optimal control of pertussis will require the development of improved vaccine

Whooping cough increase related to current vaccine

Whooping cough increase related to current vaccine
The move to an artificially created vaccine for whooping cough is behind an increase in cases of the deadly disease in the US, a new study suggests.
The findings highlight the need to do similar research in Australia where whooping cough cases have spiralled upward in the past decade, co-author Associate Professor Manoj Gambhir, from the University of Monash, says.
In 2012 the US saw the highest number of pertussis (whooping cough) cases since 1955.
At the same time there has been a shift in the age group reporting the largest number of cases from adolescents to 7 to 11 year olds.
In the paper, published today in PLOS Computational Biology, Gambhir and colleagues use mathematical modelling of 60 years of pertussis disease data to determine what best explains this increase.

A Change in Vaccine Efficacy and Duration of Protection Explains Recent Rises in Pertussis Incidence in the United States
Published: April 23, 2015
PDF – Study
Abstract
Over the past ten years the incidence of pertussis in the United States (U.S.) has risen steadily, with 2012 seeing the highest case number since 1955. There has also been a shift over the same time period in the age group reporting the largest number of cases (aside from infants), from adolescents to 7–11 year olds. We use epidemiological modelling and a large case incidence dataset to explain the upsurge. We investigate several hypotheses for the upsurge in pertussis cases by fitting a suite of dynamic epidemiological models to incidence data from the National Notifiable Disease Surveillance System (NNDSS) between 1990–2009, as well as incidence data from a variety of sources from 1950–1989. We find that: the best-fitting model is one in which vaccine efficacy and duration of protection of the acellular pertussis (aP) vaccine is lower than that of the whole-cell (wP) vaccine, (efficacy of the first three doses 80% [95% CI: 78%, 82%] versus 90% [95% CI: 87%, 94%]), increasing the rate at which disease is reported to NNDSS is not sufficient to explain the upsurge and 3) 2010–2012 disease incidence is predicted well. In this study, we use all available U.S. surveillance data to: 1) fit a set of mathematical models and determine which best explains these data and 2) determine the epidemiological and vaccine-related parameter values of this model. We find evidence of a difference in efficacy and duration of protection between the two vaccine types, wP and aP (aP efficacy and duration lower than wP). Future refinement of the model presented here will allow for an exploration of alternative vaccination strategies such as different age-spacings, further booster doses, and cocooning.

FDA NEWS RELEASE – FDA study helps provide an understanding of rising rates of whooping cough and response to vaccination
For Immediate Release: Nov. 27, 2013
A new study is helping to provide a better understanding of vaccines for whooping cough, the common name for the disease pertussis. Based on an animal model, the study conducted by the U.S. Food and Drug Administration (FDA) and published November 25, 2013, in The Proceedings of the National Academy of Sciences, shows that acellular pertussis vaccines licensed by the FDA are effective in preventing the disease among those vaccinated, but suggests that they may not prevent infection from the bacteria that causes whooping cough in those vaccinated or its spread to other people, including those who may not be vaccinated.
While the reasons for the increase in cases of whooping cough are not fully understood, multiple factors are likely involved, including diminished immunity from childhood pertussis vaccines, improved diagnostic testing, and increased reporting. With its own funds plus support from the National Institutes of Health (NIH), the FDA conducted the study to explore the possibility that acellular pertussis vaccines, while protecting against disease, might not prevent infection.

Study- Acellular pertussis vaccines protect against disease but fail to prevent infection and transmission in a nonhuman primate model
Although pertussis resurgence is not completely understood, we hypothesize that current acellular pertussis (aP) vaccines fail to prevent colonization and transmission.
To test our hypothesis, infant baboons were vaccinated at 2, 4, and 6 mo of age with aP or whole-cell pertussis (wP) vaccines and challenged with
pertussis at 7 mo. Infection was followed by quantifying colonization in nasopharyngeal washes and monitoring leukocytosis and symptoms. Baboons vaccinated with aP were
protected from severe pertussis-associated symptoms but not from colonization, did not clear the infection faster than naïve animals, and readily transmitted
pertussis to unvaccinated contacts. Vaccination with wP induced a more rapid clearance compared with naïve and aP-vaccinated animals. By comparison, previously infected
animals were not colonized upon secondary infection. Although all vaccinated and previously infected animals had robust serum antibody responses, we found key differences in T-cell immunity.
Previously infected animals and wP-vaccinated animals possess strong pertussis-specific T helper 17 (Th17) memory and Th1 memory,whereas aP vaccination induced a Th1/Th2 response instead. The
observation that aP, which induces an immune response mismatched to that induced by natural infection, fails to prevent colonization or transmission provides a plausible explanation for the
resurgence of pertussis and suggests that optimal control of pertussis will require the development of improved vaccine

The TDap vaccine started to be given to pregnant women in 2011 and this is when fetal deaths started to outnumber infant deaths for the first time

The TDap vaccine started to be given to pregnant women in 2011 and this is when fetal deaths started to outnumber infant deaths for the first time. There has been a study showing that TDaP vaccine increases rate of miscarriage by 16.7% in the third trimester. And since it’s the third trimester it’s considered a fetal death.
Study: Adverse event reports after tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccines in pregnant women.
RESULTS
The most frequent pregnancy-specific AE was spontaneous abortion in 22 (16.7%) reports. Injection site reactions were the most frequent non-pregnancy-specific AE found in 6 (4.5%) reports. One report with a major congenital anomaly (gastroschisis) was identified.

Study: Live virus vaccination near a pregnancy: flawed policies, tragic results.
Vaccination of women with live virus vaccines around conception has always been contraindicated by the Center for Disease Control and Prevention (CDC) and the vaccine manufacturer because of potential risks to the fetus. Nevertheless this dangerous practice occurs and is associated with maternal health problems and a very high incidence of early-onset autism in the children. Postpartum vaccination with live virus vaccines has been recommended by the CDC, and described as ‘convenient’ by the vaccine manufacturer. This ‘routine practice’ may lead to health and is also associated with many health and obstetrical problems in the recipient, and is frequently associated with autism in both current and future children. Re-vaccination often fails to produce immunity, the very reason for which it was recommended.

Medscape Medical News
Fetal Deaths Outnumber Infant Deaths for First Time in US
Fetal deaths after 20 weeks’ gestation have not declined in recent years, and starting in 2011, there were more fetal deaths than infant deaths in the United States, according to data from 2011 to 2013 published by the Centers for Disease Control and Prevention in a National Vital Statistics Report.
“Much of the public concern surrounding reproductive loss has focused on infant mortality, due in part to a lesser knowledge of the incidence, etiology, and prevention strategies for fetal mortality,” the authors write, calling for more research on the occurrence and causes of fetal death.

Fetal and Perinatal Mortality: United States, 2013
by Marian F. MacDorman, Ph.D., and Elizabeth C.W. Gregory, M.P.H., Division of Vital Statistics
Results—
A total of 23,595 fetal deaths at 20 weeks of gestation or  more  were  reported  in  the  United  States  in  2013.  The  U.S.  fetal  mortality rate was 5.96 fetal deaths at 20 weeks of gestation or more
per 1,000 live births and fetal deaths, not significantly different from the  rate  of  6.05  in  2012.  The  lack  of  decline  in  fetal  mortality  in  recent  years,  coupled  with  declines  in  infant  mortality,  meant  that
more fetal deaths than infant deaths occurred in the United States for 2011–2013 (although the rates were essentially the same). In 2013, the  fetal  mortality  rate  for  non-Hispanic  black  women  (10.53)  was
more than twice the rate for non-Hispanic white (4.88) and Asian or Pacific Islander (4.68) women. The rate for American Indian or Alaska Native  women  (6.22)  was  27%  higher,  and  the  rate  for  Hispanic
women (5.22) was 7% higher, than the rate for non-Hispanic white women.  Fetal  mortality  rates  were  highest  for  teenagers,  women  aged  35  and  over,  unmarried  women,  and  women  with  multiple  pregnancies.

U.S. has highest first-day infant mortality out of industrialized world, group reports
About 11,300 newborns die within 24 hours of their birth in the U.S. each year, 50 percent more first-day deaths than all other industrialized countries combined, the report’s authors stated.
The 14th annual State of the World’s Mothers report, put together by non-profit organization Save the Children, ranked 168 countries according to where the best places to be a mother would be. Criteria included child mortality, maternal mortality, the economic status of women, educational achievement and political representation of women.
Worldwide, the report found that 800 women die each day during pregnancy or childbirth, and 8,000 newborns die during the first month of life. Newborn deaths make up 43 percent of all deaths for children under five. Sixty percent of infant deaths occur during the first month of life.
The top five countries to be a mom were Finland, Sweden, Norway, Iceland and the Netherlands. The bottom five were Niger, Mali, Sierra Leone, Somalia and the Democratic Republic of the Congo.
Because of their high infant mortality rates, the U.S. only ranked number 30 this year on the report, down five spots from the 2012 report. Save the Children CEO Carolyn Miles told CBSNews.com she was shocked to find that out that the U.S. did so poorly.
“We do not do as well on many of those as the Scandinavian countries,” Miles admitted.

Results of a CDC-funded study entitled “A Clinical Analysis of Gelatin Allergy and Determination of its Causal Relationship to the Previous Administration of Gelatin-Containing Acellular Pertussis Vaccine Combined with Diphtheria and Tetanus Toxoids” concludes

Results of a CDC-funded study entitled “A Clinical Analysis of Gelatin Allergy and Determination of its Causal Relationship to the Previous Administration of Gelatin-Containing Acellular Pertussis Vaccine Combined with Diphtheria and Tetanus Toxoids” concludes:
“Most anaphylactic reactions and some urticarial reactions to gelatin-containing measles, mumps and rubella monovalent vaccines are associated with IgE-mediated gelatin allergy. DTaP immunization histories suggest that the gelatin-containing DTaP vaccine may have a causal relationship to the development of this gelatin allergy.”
Study: https://www.ncbi.nlm.nih.gov/pubmed/9949325
A clinical analysis of gelatin allergy and determination of its causal relationship to the previous administration of gelatin-containing acellular pertussis vaccine combined with diphtheria and tetanus toxoids.
RESULTS:
The 366 reported patients were categorized as follows: 34 with anaphylaxis, 76 with urticaria, 215 with nonurticarial generalized eruption, and 41 with local reactions only. In 206 patients from whom serum was available, IgE antibodies to gelatin were detected in 25 of 27 (93%) with anaphylaxis, 27 of 48 (56%) with urticaria, and 8 of 90 (9%) with a generalized eruption. None of a group of 41 patients with only local reactions at the injected site and none of a control group of 29 subjects with no adverse reaction had such antibodies. Among 202 patients for whom prior vaccine information was available, all had received DTaP vaccines. Among those for whom the prior DTaP vaccine could be determined to contain gelatin or be free of gelatin, 155 of 158 (98%) subjects had received gelatin-containing DTaP vaccines. This rate is higher than would be expected on the basis of the market share of gelatin-containing (vs gelatin-free) DTaP vaccines (75%). Furthermore, before 1993, when a trivalent measles, mumps, and rubella vaccine (with the same 0.2% gelatin content as the monovalent vaccines) was used and administered before DTaP vaccination, no reports of anaphylaxis to the measles, mumps, and rubella vaccine were received.
CONCLUSION:
Most anaphylactic reactions and some urticarial reactions to gelatin-containing measles, mumps, and rubella monovalent vaccines are associated with IgE-mediated gelatin allergy. DTaP immunization histories suggest that the gelatin-containing DTaP vaccine may have a causal relationship to the development of this gelatin allergy.

Diphtheria and Tetanus DTaP Toxoids and Acellular Pertussis Vaccine Adsorbed

Adverse events reported during post-approval use of Tripedia vaccine include idiopathic thrombocytopenic purpura, SIDS, anaphylactic reaction, cellulitis, autism, convulsion/grand mal convulsion, encephalopathy, hypotonia, neuropathy, somnolence and apnea. Events were included in this list because of the seriousness or frequency of reporting. Because these events are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequencies or to establish a causal relationship to components of Tripedia vaccine

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