Vitamin D supplementation improves autism in children, according to new study
Furthermore, children who received vitamin D supplementation experienced increased cognitive awareness, social awareness and social cognition compared to those who only received the placebo. Vitamin D supplementation significantly decreased repetitive hand movements, random noises, jumping and restricted interests.
The researchers concluded,
“This study is the first double-blinded RCT proving the efficacy of vitamin D3 in ASD patients…Oral vitamin D supplementation may safely improve signs and symptoms of ASD and could be recommended for children with ASD.”
The study also mentioned that the supplementation regimen was well tolerated among the children. Only five children experienced minor side effects during the four-month study period, such as skin rashes, itching and diarrhea.
Study – Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder.
Supplementation of vitamin D was well tolerated by the ASD children. The daily doses used in the therapy group was 300 IU vitamin D3/kg/day, not to exceed 5,000 IU/day. The autism symptoms of the children improved significantly, following 4-month vitamin D3 supplementation, but not in the placebo group. This study demonstrates the efficacy and tolerability of high doses of vitamin D3 in children with ASD.
This study is the first double-blinded RCT proving the efficacy of vitamin D3 in ASD patients. Depending on the parameters measured in the study, oral vitamin D supplementation may safely improve signs and symptoms of ASD and could be recommended for children with ASD. At this stage, this study is a single RCT with a small number of patients, and a great deal of additional wide-scale studies are needed to critically validate the efficacy of vitamin D in ASD.
Study – Vitamin D and omega-3 fatty acid supplements in children with autism spectrum disorder: a study protocol for a factorial randomised, double-blind, placebo-controlled trial
Children with ASD living in New Zealand (n = 168 children) will be randomised to one of four treatments daily: vitamin D (2000 IU), n-3 LCPUFAs (722 mg DHA), vitamin D (2000 IU) + n-3 LCPUFAs (722 mg DHA) or placebo for 12 months. All researchers, participants and their caregivers will be blinded until the data analysis is completed, and randomisation of the active/placebo capsules and allocation will be fully concealed from all mentioned parties. The primary outcome measures are the change in social-communicative functioning, sensory processing issues and problem behaviours between baseline and 12 months. A secondary outcome measure is the effect on gastrointestinal symptoms. Baseline data will be used to assess and correct basic nutritional deficiencies prior to treatment allocation. For safety measures, serum 25-hydroxyvitamin D 25(OH)D and calcium will be monitored at baseline, 6 and 12 months, and weekly compliance and gastrointestinal symptom diaries will be completed by caregivers throughout the study period.
To our knowledge there are no randomised controlled trials assessing the effects of both vitamin D and DHA supplementation on core symptoms of ASD. If it is shown that either vitamin D, DHA or both are effective, the trial would reveal a non-invasive approach to managing ASD symptoms.
Study – Vitamin D status in autism spectrum disorders and the efficacy of vitamin D supplementation in autistic children
Fifty-seven percent of the patients in the present study had vitamin D deficiency, and 30% had vitamin D insufficiency. The mean 25-OHD levels in patients with severe autism were significantly lower than those in patients with mild/moderate autism. Serum 25-OHD levels had significant negative correlations with Childhood Autism Rating Scale (CARS) scores. Of the ASD group, 106 patients with low-serum 25-OHD levels (<30 ng/ml) participated in the open label trial. They received vitamin D3 (300 IU/kg/day not to exceed 5000 IU/day) for 3 months. Eighty-three subjects completed 3 months of daily vitamin D treatment. Collectively, 80.72% (67/83) of subjects who received vitamin D3 treatment had significantly improved outcome, which was mainly in the sections of the CARS and aberrant behavior checklist subscales that measure behavior, stereotypy, eye contact, and attention span.
Vitamin D is inexpensive, readily available and safe. It may have beneficial effects in ASD subjects, especially when the final serum level is more than 40 ng/ml.
Study – Clinical improvement following vitamin D3 supplementation in Autism Spectrum Disorder
Objective High prevalence of vitamin D deficiency was previously reported in children with Autism Spectrum Disorder (ASD), but little is known about the efficacy of vitamin D3 treatment in ASD, although data from pilot studies seem promising. We hypothesized that serum vitamin D levels are reduced in ASD and correlate with the severity of disease. Also, we hypothesized that vitamin D3 treatment may be beneficial for a considerable portion of children with ASD. Methods In total, 215 children with ASD and 285 healthy control children were recruited in our study. Thirty seven of 215 ASD children received vitamin D3 treatment. The Autism Behaviour Checklist (ABC) and the Childhood Autism Rating Scale (CARS) were used to assess autism symptoms. High-performance liquid chromatography was used to assess the serum 25-hydroxyvitamin D [25(OH) D] level. Evaluations of ABC, CARS, and serum 25(OH) D levels were performed before and after 3 months of treatment. Results Serum levels of 25(OH) D were significantly lower in ASD children than typically developing children. Levels of serum 25(OH) D were negatively correlated with ABC total scores and language subscale scores. After vitamin D3 supplementation, symptom scores were significantly reduced on the CARS and ABC. In addition, the data also suggest that treatment effects were more pronounced in younger children with ASD. Conclusion Vitamin D deficiency might contribute to the aetiology of ASD. Supplementation of vitamin D3, which is a safe and cost-effective form of treatment, may significantly improve the outcome of some children with ASD, especially younger children (identifier ChiCTR-CCC-13004498). Clinical Trial Registration The trial ‘Association of Polymorphisms of Vitamin D Metabolism-Related Genes With Autism and the Treatment of Autism with Vitamin D’ has been registered at www.chictr.org/cn/proj/show.aspx ? proj=6135 (identifier ChiCTR-CCC-13004498).
Scientists Anthony Samsel and Stephanie Seneff have just gotten the fifth peer reviewed paper on Glyphosate published. Its named “Glyphosate pathways to modern diseases V: Amino acid analogue of glycine in diverse proteins”.
The biggest piece of information yet to be published in a sixth paper by Anthony Samsel is really upsetting the pharma apple cart. Essentially it says that vaccines sometimes use animal byproducts, such as gelatin from the animal’s bones. If these animals are fed GMO’s, which almost all of them are, then glyphosate is likely to transfer into the vaccine. And well, we know where the vaccine ends up.
Glyphosate pathways to modern diseases V: Amino acid analogue of glycine in diverse proteins
Glyphosate, a synthetic amino acid and analogue of glycine, is the most widely used biocide on the planet. Its presence in food for human consumption and animal feed is ubiquitous. Epidemiological studies have revealed a strong correlation between the increasing incidence in the United States of a large number of chronic diseases and the increased use of glyphosate herbicide on corn, soy and wheat crops. Glyphosate, acting as a glycine analogue, may be mistakenly incorporated into peptides during protein synthesis. A deep search of the research literature has revealed a number of protein classes that depend on conserved glycine residues for proper function. Glycine, the smallest amino acid, has unique properties that support flexibility and the ability to anchor to the plasma membrane or the cytoskeleton. Glyphosate substitution for conserved glycines can easily explain a link with diabetes, obesity, asthma, chronic obstructive pulmonary disease (COPD), pulmonary edema, adrenal insufficiency, hypothyroidism, Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), Parkinson’s disease, prion diseases, lupus, mitochondrial disease, non- Hodgkin’s lymphoma, neural tube defects, infertility, hypertension, glaucoma, osteoporosis, fatty liver disease and kidney failure. The correlation data together with the direct biological evidence make a compelling case for glyphosate action as a glycine analogue to account for much of glyphosate’s toxicity. Glufosinate, an analogue of glutamate, likely exhibits an analogous toxicity mechanism. There is an urgent need to find an effective and economical way to grow crops without the use of glyphosate and glufosinate as herbicides.
In this small trial of children with non-syndromic ASD and language impairment, treatment with high-dose folinic acid for 12 weeks resulted in improvement in measures of verbal communication as compared with placebo. These findings should be considered preliminary until treatment is assessed in larger multicenter studies with longer duration.
The researchers note that their cross-reactivity findings in mice are consistent with work conducted by Kanduc in humans, who identified considerable amino acid sequence similarity between the Gardasil vaccine antigen and a number of human proteins. According to Kanduc, “the number of viral matches and their locations make the occurrence of side autoimmune cross-reactions in the human host following HPV16-based vaccination almost unavoidable.”
The mouse study findings also corroborate and amplify a prior case study report by Tomljenovic and Shaw describing immunohistochemical analysis of brain tissue specimens from two young women who died after receiving the Gardasil vaccine. Immunohistochemistry is a method for demonstrating the presence and location of antigens in tissue using antibodies that recognize the target antigen. In both cases, the standard autopsies had previously failed to ascertain an exact cause of death. Case 1 experienced progressively worsening neurological symptoms following her first Gardasil injection and died in her sleep six months after her third Gardasil booster. She showed no notable neuroinflammatory changes upon autopsy using an unspecified histological protocol. Case 2 developed a variety of symptoms after her first injection and died two weeks after the second booster. The autopsy report for Case 2 found cerebral changes consistent with encephalopathy and indicative of a “focally disrupted blood-brain barrier.”
The World Health Organization’s Global Advisory Committee on Vaccine Safety (GACVS) critiqued the Tomljenovic and Shaw case study but did so on the basis of several extremely careless and factually incorrect statements, as rebutted by leading scientist Sin Hang Lee of Milford Molecular Diagnostics. One of the objections of the GACVS was that there was “no evidence of inflammation on autopsy”—despite the fact that the autopsy for Case 2 found evidence of encephalopathy. In addition, Tomljenovic and Shaw point out that their fine-tuned analyses of brain tissue from the two deceased young women, unlike the autopsies, used microglia- and astroglia-specific markers that were able to identify “exceptionally intense micro- and astrogliosis in all brain tissue sections examined” from both cases. Microgliosis represents “an intense reaction… to pathogenic insults” and astrogliosis similarly occurs when the “astrocytic defense mechanisms [are] overwhelmed in pathological conditions.” This type of glial activation can produce “irreversible neurodestructive and pro-inflammatory processes in the brain,” according to Tomljenovic and Shaw.
With its triple findings from behavioral tests and serum and brain tissue analyses, the mouse study validates the case study report, which concludes that Gardasil (and Cervarix) are “inherently unsafe” for at least some individuals. Although it is clear that much more needs to be done to tease out the specific mechanisms whereby HPV (and other) vaccines and aluminum adjuvants can trigger autoimmune disease, the combined results of the carefully conducted mouse and human Gardasil studies cannot be easily dismissed. Together, the two studies’ results indicate that there is good reason to be cautious about aluminum-containing HPV vaccines—particularly now that the reformulated Gardasil-9 vaccine contains more than twice the amount of aluminum as its quadrivalent predecessor. The next time vaccine experts loudly proclaim that vaccine safety is unassailable, consider whether the researchers exhibited any genuine curiosity about adverse events to begin with. It’s not possible to find what you don’t look for.