aging

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS–CoV–2) has led to the coronavirus disease 2019 (COVID–19) pandemic, severely affecting public health and the global economy. Adaptive immunity plays a crucial role in fighting against SARS–CoV–2 infection and directly influences the clinical outcomes of patients. Clinical studies have indicated that patients with severe COVID–19 exhibit delayed and weak adaptive immune responses; however, the mechanism by which SARS–CoV–2 impedes adaptive immunity remains unclear. Here, by using an in vitro cell line, we report that the SARS–CoV–2 spike protein significantly inhibits DNA damage repair, which is required for effective V(D)J recombination in adaptive immunity. Mechanistically, we found that the spike protein localizes in the nucleus and inhibits DNA damage repair by impeding key DNA repair protein BRCA1 and 53BP1 recruitment to the damage site. Our findings reveal a potential molecular mechanism by which the spike protein might impede adaptive immunity and underscore the potential side effects of full-length spike-based vaccines.

More on the subject here: https://www.naturalnews.com/2021-11-02-science-horror-vaccine-spike-protein-enters-cell-nuclei-suppresses-dna-repair-engine-of-the-human-body-cancer-aging.html#

Vaccine spike protein enters cell nuclei, suppresses DNA repair engine of the human body, will unleash explosion of cancer, immunodeficiency, autoimmune disorders and accelerated aging

(Natural News) This finding can only be described as a true “horror” in its implications. Stunning new research published in Viruses, part of the SARS-CoV-2 Host Cell Interactions edition of MDPI (Open Access Journals) reveals that vaccine spike proteins enter cell nuclei and wreak havoc on cells’ DNA repair mechanism, suppressing DNA repair by as much as 90%.

The research paper is entitled, “SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro” and is authored by Hui Jiang and Ya-Fang Mei, at the Department of Molecular Biosciences, The Wenner–Gren Institute, Stockholm University, SE-10691 Stockholm, Sweden, and the Department of Clinical Microbiology, Virology, Umeå University, SE-90185 Umeå, Sweden, respectively.

In the conclusion of the paper, authors write, “We found that the spike protein markedly inhibited both BRCA1 and 53BP1 foci formation (Figure 3D–G). Together, these data show that the SARS–CoV–2 full–length spike protein inhibits DNA damage repair by hindering DNA repair protein recruitment.”

The DNA repair mechanism, known as NHEJ (Non-Homologous End Joining) is a kind of intracellular “emergency response” system that repairs double-stranded DNA breaks. Without the NHEJ mechanism, all advanced multi-cellular life would cease to exist. No human being, animal or plant can survive with the integrity of its genetic code being protected and constantly repaired through multiple mechanisms.

DNA damage can be caused by exposure to radiation, chemicals found in foods and personal care products, or even exposure to mammography equipment. Excessive sunlight exposure can also cause DNA breaks, and minor DNA mutations occur spontaneously in all living organisms. Airline pilots, for example, are routinely exposed to ionizing radiation due to flying at altitude.

Just News – Israeli News Live – Did Isaiah Prophesy of World Leaders Contacting Aliens?

The Alex Jones Channel – Trumps Orb Is Nothing More Than A TV Remote For Giant Threat Fusion Center

Donald Trump touches glowing orb to open anti-terrorism centre – video
The US president, Donald Trump, and a number of Saudi Arabian regional leaders visit the new Global Centre for Combating Extremist Ideology in Riyadh on Sunday. The heart of the centre is a giant wall filled with screens displaying real-time online extremist activity. Trump, the Saudi king, Salman bin Abdulaziz al-Saud, the Egyptian president, Abdel Fattah al-Sisi, and Melania Trump placed their hands on a miniature globe, officially activating the centre and launching a futuristic welcome video

PALANTIR – PRODUCTS BUILT FOR A PURPOSE
Ten years ago, we set out to create products that would transform the way organizations use their data. Today, our products are deployed at the most critical government, commercial, and non-profit institutions in the world to solve problems we hadn’t even dreamed of back then.

Israeli News Live – Did Isaiah Prophesy of World Leaders Contacting Aliens?
www.IsraeliNewsLive.org
This is beyond provocative it seems the demons as many believe to be Aliens will try one last effort to find mercy from the Creator, Our eternal father. This may be what causes the showing of the Antichrist, the man of sin to be revealed. But Isaiah goes much deeper, he even speaks about how these demons have tried to alter humans to prevent us from having our own relationship with Yeshua. As Isaiah says their rivers have spolied the land. Jeremiah ask why have we forsaken the fountains of living water. Now the Demons will come up on Mount Zion with a gift hoping God will receive them

Medvedev talks about aliens on Earth! (English Subs)

Men In Black Russian Documentary With English Subtitles
Men In Black is the Documentary advised by Medvedev during an interview regarding how much the russian presidents and institutions knows about aliens living on Earth, it doesn’t say all what there is to say and some things are wrong, but it’s a good start. Remeber to belive only what you are ready to belive into

Israeli News Live – Norwegian Special Forces Enter Syria
Norwegian troops have entered Syria via Iraq’s western border with Syria. The special forces will be joining US and British forces already supporting the Free Syrian Army fighting against the Syrian forces. Germany eyes a Jordanian military base to move forces to claiming Turkey obstructing access to the Incirlik airbase. No doubt a good excuse while NATO prepares to take down Damascus.

The Official Hagmann & Hagmann Report – Revisionist Investigation: Liz Crokin, Diamond & Silk, Steve Quayle and Dr Michael Lake
Steve is the former editor and publisher of Survival Quest and Security and Survival Chronicles – monthly newsletters which dealt with perilous events and how to prepare for them.
For the past seven years, Quayle has articulated the need for Americans to be aware of bioterrorism and weapons of mass destruction. Upon publication of Breathe No Evil, Quayle upstaged mainstream media by years spelling out detailed effects of bioterrorism. Prior to publication of Breathe No Evil, Quayle went on record predicting a major chemical or biological attack in a large world city. Three weeks later, the Aum Shinrikyo cult released nerve gas in the Tokyo subway.
Steve continues to shout from the rooftops, his concern for the massive loss of life due to lack of civil defense and preparation in the public and private sectors. Breathe No Evil was written as an antidote for fear informing people of the necessary steps to take prior to biological and chemical terrorism.
Grab a cup, a pen and a notepad as we hit the skinny pedal on the right with Hagmann and Hagmann Report favorite, Mr Steve Quayle of stevequayle.com.
Steve agreed to check in for and we are all awaiting updates on the Antarctica Deception, as mapped out in his wildly popular, Empire Beneath the Ice.
Dr. Michael K. Lake. Dr Lake holds doctorates in theology and religious education, and he is the chancellor and founder of Biblical Life College and Seminary. In 1995, Dr. Lake and his family found themselves in the crosshairs of an all-out attack from the occult community.

Schumann resonances
From Wikipedia, the free encyclopedia
The Schumann resonances (SR) are a set of spectrum peaks in the extremely low frequency (ELF) portion of the Earth’s electromagnetic field spectrum. Schumann resonances are global electromagnetic resonances, generated and excited by lightning discharges in the cavity formed by the Earth’s surface and the ionosphere.

Whirling Wi-Fi: Vibrant images reveal how wireless networks sweep and surround us
A student from Newcastle University has made images that ‘show’ Wi-Fi
Luis Hernan made a programme that can measure Wi-Fi strength
He then took long-exposure photography to expose wireless networks
The results are stunning arrays of colour in fantastic shapes
He has also released an app so can take other similar images themselves

Cannabis is one of the safest therapeutic substances on the planet. Dr. Gupta explains why this is valuable for both patients and the medical community alike.
Source: #CNN

Catch Up: Australia’s shocking secret trade in Muslim child brides, some as young as ten. Megan Miller reports.
www.todaytonightadelaide.com.au
#TTAdelaide

Scientists Discover That Fasting Triggers Stem Cell Regeneration & Fights Cancer
A study published in Cell Stem Cell shows that cycles of prolonged fasting not only protect against immune system damage — a major side effect of chemotherapy — but also induce immune system regeneration, shifting stem cells from a dormant state to a state of self-renewal.
In both mice and a Phase 1 human clinical trial involving patients receiving chemotherapy, long periods of not eating significantly lowered white blood cell counts. In mice, fasting cycles then “flipped a regenerative switch,” changing the signaling pathways for hematopoietic stem cells, which are responsible for the generation of blood and immune systems, the research showed.
“We could not predict that prolonged fasting would have such a remarkable effect in promoting stem cell-based regeneration of the hematopoietic system.”
The study has major implications for healthier aging, in which immune system decline contributes to increased susceptibility to disease as people age. By outlining how prolonged fasting cycles — periods of no food for two to four days at a time over the course of six months — kill older and damaged immune cells and generate new ones, the research also has implications for chemotherapy tolerance and for those with a wide range of immune system deficiencies, including autoimmunity disorders.
Study – Saying No to Drugs: Fasting Protects Hematopoietic Stem Cells from Chemotherapy and Aging

Low B12 Seen in Aging, Autism and Schizophrenia

The brains of the elderly and younger people with autism and schizophrenia may share a common link: Both have low levels of vitamin B12, researchers say.

The facts that blood levels of B12 do not always mirror brain levels of the vitamin, and that brain levels decrease more over the years than blood levels, may imply that various types of neurological diseases — such as old-age dementia and the disorders of autism and schizophrenia — could be related to poor uptake of vitamin B12 from the blood into the brain, the scientists said.

The findings, reported last month in the journal PLOS ONE, support an emerging theory that the human brain uses vitamin B12 in a tightly regulated manner to control gene expression and to spur neurological development at key points during life, from the brain’s high-growth periods during fetal development and early childhood, through the refining of neural networks in adolescence, and then into middle and old age.

Vitamin B12, also called cobalamin, plays a crucial role in blood formation and the normal functioning of the nervous system. The vitamin is found in foods derived from animal sources, although some plant-based foods can be fortified with B12. [6 Foods That Are Good For Your Brain]

In the new study, scientists led by Richard Deth, a professor of pharmacology at Nova Southeastern University in Fort Lauderdale, Florida, examined the brains of more than 60 deceased individuals, ranging in age from a fetus in a late stage of gestation to 80 years. The study included 12 people who had autism and nine with schizophrenia.

This is the first study to compare the levels of vitamin B12 in the brain across the human lifetime, Deth told Live Science. The vitamin B12 levels in the brain were 10 times lower in the oldest people compared with the youngest, reflecting a gradual, natural, and consistent decline over the years.

For the elderly, this decline might not be a bad thing. Lower levels at advanced ages may offer some degree of brain protection by slowing cellular reactions and the production of DNA-damaging chemicals called free radicals, Deth said. In previous work with his colleague Yiting Zhang of Northeastern University in Boston, Deth found that the body’s creation of biologically active forms of vitamin B12 produces free radicals as a waste product.

Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration

Environmental factors, including pesticides, have been linked to autism and neurodegeneration risk using retrospective epidemiological studies. Here we sought to prospectively identify chemicals that share transcriptomic signatures with neurological disorders, by exposing mouse cortical neuron-enriched cultures to hundreds of chemicals commonly found in the environment and on food. We find that rotenone, a pesticide associated with Parkinson’s disease risk, and certain fungicides, including pyraclostrobin, trifloxystrobin, famoxadone and fenamidone, produce transcriptional changes in vitro that are similar to those seen in brain samples from humans with autism, advanced age and neurodegeneration (Alzheimer’s disease and Huntington’s disease). These chemicals stimulate free radical production and disrupt microtubules in neurons, effects that can be reduced by pretreating with a microtubule stabilizer, an antioxidant, or with sulforaphane. Our study provides an approach to prospectively identify environmental chemicals that transcriptionally mimic autism and other brain disorders

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