The Guardian: Agricultural fungicides are ‘bad news for neurons’, study suggests

Agricultural fungicides are ‘bad news for neurons’, study suggests
Fungicides caused mouse cells to show changes similar to those seen in autism and Alzheimer’s, although a definite link to the disorders has not been proven
Modern fungicides that are sprayed on fruit and vegetables have come under fresh scrutiny after scientists found they caused similar genetic changes in mouse neurons to those seen in autism and Alzheimer’s disease.
Researchers exposed dishes of the brain cells to more than 300 different pesticides and fungicides and found that one class of fungicides, the strobilurins, produced patterns of genetic changes often seen in the human conditions.
Scientists at the University of North Carolina in Chapel Hill hoped the experiment might shed light on the kinds of substances in the environment that contribute to cases of autism. To their surprise, they found compounds that produced some genetic hallmarks of autism and neurodegenerative diseases at the same time.
The strobilurins have only been approved for use in the past 20 years, more than half a century after the first individual diagnosed with autism was announced in the medical literature. Since the fungicides arrived on the market, they have been sprayed in increasing quantities to protect crops such as cabbages, spinach, lettuce, kale, tomatoes, apples, pears and grapes.
While the fungicides produced autism-like and Alzheimer’s-like signatures in the way genes are expressed in mouse neurons, the relevance of the changes is unclear: the scientists have no evidence that the chemicals contribute to either condition.
“The study was designed to try and identify chemicals that could cause autism, but we in no way say these things do cause autism,” said lead scientist, Mark Zylka, whose study appears in Nature Communications.
“What this work provides is evidence that these chemicals are bad for neurons. They turn the same genes on or off that you see not only in autism brains, but also in neurodegeneration,” he added.

Adverse Associations of both Prenatal and Postnatal Exposure to Organophosphorous Pesticides with Infant Neurodevelopment in an Agricultural Area of Jiangsu Province China

Results: Based on the Gesell Developmental Schedules, the proportions of children with

developmental delays were less than 6%. Adverse associations between head circumference at

birth and prenatal OP exposure were demonstrated. Both prenatal and postnatal OP exposure was

significantly associated with increased risk of being developmentally delayed. Specifically, odds

ratio (OR) value for prenatal DEs was 9.75 [95% confidence interval (CI): 1.28~73.98]

(p=0.028) in the adaptive area, while in the social area, OR values for postnatal DEs and DAPs

were 9.56 (95% CI: 1.59~57.57) (p=0.014) and 12.00 (95% CI: 1.23~117.37) (p=0.033),

respectively. Adverse associations were observed only in boys but not in girls.

Conclusions: Both prenatal and postnatal OP exposure may adversely affect the

neurodevelopment of infants living in the agricultural area. The present study added to the

accumulating evidence on associations of prenatal and postnatal OP exposure with infant


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