Birth Control Shots For Men Prevent Pregnancy, But Cause Mood Swings, Depression

Birth Control Shots For Men Prevent Pregnancy, But Cause Mood Swings, Depression
GENEVA, Switzerland (CBS) — Birth control shots for men are an effective form of contraception but the side effects are a problem.
An international study just found they’re almost as effective as the pill for women. It was published in the Journal of Clinical Endocrinology & Metabolism.
The injections work by using hormones to drastically lower sperm count.
Of the 266 married men who participated in the study, only 4 became fathers.
Sounds promising but the gender gap in contraceptive use may not close anytime soon.
For one thing the pharmaceutical companies aren’t throwing a whole lot of money at the idea.
“Their concern may be there’s a lack of profitability, maybe there is a question of gender bias,” says CBS medical contributor Dr. Tara Narula. “There’s a concern of regulatory hurdles. In addition, it’s not as easy to stop 1,500 sperm that are produced per second as opposed to one egg per month.”
Another concern are the side effects. Researchers actually stopped the study early due to mood changes and depression in some of the participants.
Researchers say other side effects were acne, injection site pain, and increased libido.

Study: Efficacy and Safety of an Injectable Combination Hormonal Contraceptive for Men
Results:
Of the 320 participants, 95.9 of 100 continuing users (95% confidence interval [CI], 92.8–97.9) suppressed to a sperm concentration less than or equal to 1 million/mL within 24 weeks (Kaplan-Meier method). During the efficacy phase of up to 56 weeks, 4 pregnancies occurred among the partners of the 266 male participants, with the rate of 1.57 per 100 continuing users (95% CI, 0.59–4.14). The cumulative reversibility of suppression of spermatogenesis after 52 weeks of recovery was 94.8 per 100 continuing users (95% CI, 91.5–97.1). The most common adverse events were acne, injection site pain, increased libido, and mood disorders. Following the recommendation of an external safety review committee the recruitment and hormone injections were terminated early.
Conclusions:
The study regimen led to near-complete and reversible suppression of spermatogenesis. The contraceptive efficacy was relatively good compared with other reversible methods available for men. The frequencies of mild to moderate mood disorders were relatively high.

Zero Hedge: Remember Ray Dalio’s “Depression” Warning: This Is Where We Stand Now

Zero Hedge: Remember Ray Dalio’s “Depression” Warning: This Is Where We Stand Now
In recent weeks, Ray Dalio – a vocal proponent of QE4 and certainly against any form of monetary tightening – has been about as doom and gloomy as we have ever heard the head of the world’s biggest hedge fund. Just last week, we reported that the founder of Birdgewater, when speaking before the New York Fed, voiced his latest warning about the potential losses that would befall asset holders if interest rates rose by just 1%. Recall from his speech that “if interest rates rise just a little bit more than is discounted in the curve it will have a big negative effect on bonds and all asset prices, as they are all very sensitive to the discount rate used to calculate the present value of their future cash flows. That is because with interest rates having declined, the effective durations of all assets have lengthened, so they are more price-sensitive.”
And the punchline:
… it would only take a 100 basis point rise in Treasury bond yields to trigger the worst price decline in bonds since the 1981 bond market crash. And since those interest rates are embedded in the pricing of all investment assets, that would send them all much lower.
Using a Goldman calculation which we showed earlier in the year, we estimated that the impact of a 100bp shock to interest rates – the same one that Dalio envisions – and assuming a total US bond market size market size of $40trn, in line with estimates…