SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro

Source: https://www.mdpi.com/1999-4915/13/10/2056/htm

PDF: https://www.naturalnews.com/files/viruses-13-02056-v2.pdf

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS–CoV–2) has led to the coronavirus disease 2019 (COVID–19) pandemic, severely affecting public health and the global economy. Adaptive immunity plays a crucial role in fighting against SARS–CoV–2 infection and directly influences the clinical outcomes of patients. Clinical studies have indicated that patients with severe COVID–19 exhibit delayed and weak adaptive immune responses; however, the mechanism by which SARS–CoV–2 impedes adaptive immunity remains unclear. Here, by using an in vitro cell line, we report that the SARS–CoV–2 spike protein significantly inhibits DNA damage repair, which is required for effective V(D)J recombination in adaptive immunity. Mechanistically, we found that the spike protein localizes in the nucleus and inhibits DNA damage repair by impeding key DNA repair protein BRCA1 and 53BP1 recruitment to the damage site. Our findings reveal a potential molecular mechanism by which the spike protein might impede adaptive immunity and underscore the potential side effects of full-length spike-based vaccines.

More on the subject here: https://www.naturalnews.com/2021-11-02-science-horror-vaccine-spike-protein-enters-cell-nuclei-suppresses-dna-repair-engine-of-the-human-body-cancer-aging.html#

Vaccine spike protein enters cell nuclei, suppresses DNA repair engine of the human body, will unleash explosion of cancer, immunodeficiency, autoimmune disorders and accelerated aging

(Natural News) This finding can only be described as a true “horror” in its implications. Stunning new research published in Viruses, part of the SARS-CoV-2 Host Cell Interactions edition of MDPI (Open Access Journals) reveals that vaccine spike proteins enter cell nuclei and wreak havoc on cells’ DNA repair mechanism, suppressing DNA repair by as much as 90%.

The research paper is entitled, “SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro” and is authored by Hui Jiang and Ya-Fang Mei, at the Department of Molecular Biosciences, The Wenner–Gren Institute, Stockholm University, SE-10691 Stockholm, Sweden, and the Department of Clinical Microbiology, Virology, Umeå University, SE-90185 Umeå, Sweden, respectively.

In the conclusion of the paper, authors write, “We found that the spike protein markedly inhibited both BRCA1 and 53BP1 foci formation (Figure 3D–G). Together, these data show that the SARS–CoV–2 full–length spike protein inhibits DNA damage repair by hindering DNA repair protein recruitment.”

The DNA repair mechanism, known as NHEJ (Non-Homologous End Joining) is a kind of intracellular “emergency response” system that repairs double-stranded DNA breaks. Without the NHEJ mechanism, all advanced multi-cellular life would cease to exist. No human being, animal or plant can survive with the integrity of its genetic code being protected and constantly repaired through multiple mechanisms.

DNA damage can be caused by exposure to radiation, chemicals found in foods and personal care products, or even exposure to mammography equipment. Excessive sunlight exposure can also cause DNA breaks, and minor DNA mutations occur spontaneously in all living organisms. Airline pilots, for example, are routinely exposed to ionizing radiation due to flying at altitude.

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Spiritual News – FaceLikeTheSun – Will the Mark of the Beast Change Your DNA? (Lecture)

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This lecture by Douglas Hamp was given on February 21, 2014 at the Prophecy Forum Conference in Southern California.

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Just News – RichiefromBoston II – There were Giants in those Days LA Marzulli

RichiefromBoston II – There were Giants in those Days LA Marzulli

Me and LA are going to talk about Giants, and the D N A evidence he is getting ready to finally reveal on the extensive work hes done with BRIAN FOERSTER in Peru. This is going to be EPIC. RFB press conference on FEB 2nd http://www.lamarzulli.net/about_lynn_… https://www.youtube.com/channel/UCySe… https://vimeo.com/user73954749 RFB on vimeo https://www.youtube.com/watch?v=qE_zF… RFB II BACKUP CHANNEL paypal.me/RichieFromBoston https://www.patreon.com/RichieFromBoston Help me help others as well as Make much needed upgrades to my equipment and channel https://twitter.com/NULOOKREFINISH TWITTER RFB Special thanks to ODD Reailty And NICHOLSON1968 for the intros and outros Disclaimer: All works by RichieFromBoston are criticism, comment, news reporting, teaching and research. -All footage taken falls under ”fair use” of the Digital Millennium Copyright Act (1998). Therefore, no breach of privacy or copyright has been committed. -FAIR USE STATEMENT This video may contain copyrighted material the use of which has not been specifically authorized by the copyright owner. This material is being made available within this transformative or derivative work for the purpose of education, commentary and criticism, is being distributed without profit, and is believed to be “fair use” in accordance with Title 17 U.S.C. Section 107

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