SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro

Source: https://www.mdpi.com/1999-4915/13/10/2056/htm

PDF: https://www.naturalnews.com/files/viruses-13-02056-v2.pdf

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS–CoV–2) has led to the coronavirus disease 2019 (COVID–19) pandemic, severely affecting public health and the global economy. Adaptive immunity plays a crucial role in fighting against SARS–CoV–2 infection and directly influences the clinical outcomes of patients. Clinical studies have indicated that patients with severe COVID–19 exhibit delayed and weak adaptive immune responses; however, the mechanism by which SARS–CoV–2 impedes adaptive immunity remains unclear. Here, by using an in vitro cell line, we report that the SARS–CoV–2 spike protein significantly inhibits DNA damage repair, which is required for effective V(D)J recombination in adaptive immunity. Mechanistically, we found that the spike protein localizes in the nucleus and inhibits DNA damage repair by impeding key DNA repair protein BRCA1 and 53BP1 recruitment to the damage site. Our findings reveal a potential molecular mechanism by which the spike protein might impede adaptive immunity and underscore the potential side effects of full-length spike-based vaccines.

More on the subject here: https://www.naturalnews.com/2021-11-02-science-horror-vaccine-spike-protein-enters-cell-nuclei-suppresses-dna-repair-engine-of-the-human-body-cancer-aging.html#

Vaccine spike protein enters cell nuclei, suppresses DNA repair engine of the human body, will unleash explosion of cancer, immunodeficiency, autoimmune disorders and accelerated aging

(Natural News) This finding can only be described as a true “horror” in its implications. Stunning new research published in Viruses, part of the SARS-CoV-2 Host Cell Interactions edition of MDPI (Open Access Journals) reveals that vaccine spike proteins enter cell nuclei and wreak havoc on cells’ DNA repair mechanism, suppressing DNA repair by as much as 90%.

The research paper is entitled, “SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro” and is authored by Hui Jiang and Ya-Fang Mei, at the Department of Molecular Biosciences, The Wenner–Gren Institute, Stockholm University, SE-10691 Stockholm, Sweden, and the Department of Clinical Microbiology, Virology, Umeå University, SE-90185 Umeå, Sweden, respectively.

In the conclusion of the paper, authors write, “We found that the spike protein markedly inhibited both BRCA1 and 53BP1 foci formation (Figure 3D–G). Together, these data show that the SARS–CoV–2 full–length spike protein inhibits DNA damage repair by hindering DNA repair protein recruitment.”

The DNA repair mechanism, known as NHEJ (Non-Homologous End Joining) is a kind of intracellular “emergency response” system that repairs double-stranded DNA breaks. Without the NHEJ mechanism, all advanced multi-cellular life would cease to exist. No human being, animal or plant can survive with the integrity of its genetic code being protected and constantly repaired through multiple mechanisms.

DNA damage can be caused by exposure to radiation, chemicals found in foods and personal care products, or even exposure to mammography equipment. Excessive sunlight exposure can also cause DNA breaks, and minor DNA mutations occur spontaneously in all living organisms. Airline pilots, for example, are routinely exposed to ionizing radiation due to flying at altitude.

Journeyman Pictures – Yemen’s Famine Enters Its Second Year

 

Journeyman Pictures – Yemen’s Famine Enters Its Second Year
Yemen’s Food Crisis: Since 2014, Houthi rebels and the opposing Saudi coalition have used food as a weapon of war. In Yemen, subsequent control over resources has lead to one of the worst humanitarian crises in the world. Subscribe to Journeyman here: http://www.youtube.com/subscription_c… Doctor Aida Al Sadeeq sees “30-40 malnourished children per month, severely acutely malnourished”. Historically, Yemenis have relied on imports for 90% of their food. Today, the coalition monitors resources entering Yemen, diverting some ships to the already tightly packed port of Aden. “Some of the ships, they are waiting for 20 days”, says Marwan Al Bakshi, who watches over the ships that are waiting for permission from the coalition to dock. Some boats are carrying crucial supplies from the World Food Program, which could save lives. Reporter Marcia Briggs identifies that severe acute malnutrition is “a concept so commonplace in Yemen that it’s known by its acronym. SAM.” For more information, visit https://www.journeyman.tv/film/7347 Like us on Facebook: https://www.facebook.com/journeymanpi… Follow us on Twitter: https://twitter.com/JourneymanNews https://twitter.com/JourneymanVOD Follow us on Instagram: https://instagram.com/journeymanpictures Visit our subreddit: https://www.reddit.com/r/JourneymanPi… Say hi on tumblr: https://journeymanpictures.tumblr.com/ PBS Newshour Weekend – Ref. 7347

Just News – Zerohedge – Female Kurdish Fighter Blows Herself Up As Turkish Tank Enters Syrian Village

Zerohedge – Female Kurdish Fighter Blows Herself Up As Turkish Tank Enters Syrian Village
A female fighter within the Kurdish People’s Protection Units paramilitary group has blown herself up amid an ongoing offensive by Turkey-led forces in Syria’s Afrin regional sources report. Sources following developments on the ground in Afrin are reporting that a Kurdish female fighter by the name of Avesta Khabur committed the suicide attack to in an attempt to turn back an armored assault by the Turkish Army.
Meanwhile, Turkish-backed Free Syrian Army (FSA) ground forces continue to advance on villages on the edges of Afrin Canton. Though Turkey claims it is “bringing peace” to the area, several FSA media accounts have released videos showing its Islamist fighters declaring their intent to conduct ethnic cleansing against the “atheist Kurds”.
Though a number of such videos with threats of genocide by invading Turkish and FSA forces have made the rounds over the last week, and though President Erdoğan himself in public speeches of late has used similar language, mainstream media in the West has continued to be mild or completely silent in its criticism of Erdoğan or the Turkish military invasion of Syria.
Indeed Erdoğan has recently vowed “to give Afrin back to its real owners” while claiming that “55% of Afrin is composed of Arabs with 35% of Kurds coming there later on”. Such language of militarily forced “demographic shift” inside another nation’s sovereign territory by Turkish leadership has gone relatively unreported in major international press.

Vaccine News – Daily Mail – Thousands of children in Irish care homes at centre of ‘baby graves scandal’ were used in secret vaccine trials in the 1930s

Thousands of children in Irish care homes at centre of ‘baby graves scandal’ were used in secret vaccine trials in the 1930s
Scientists secretly gave 2,051 children and babies diphtheria vaccine
They were used as guinea pigs for drugs giant Burroughs Wellcome in 1930s
Academic Michael Dwyer uncovered shock truth in old medical records
He found no evidence of consent, nor of how many died or were affected
Comes as Irish PM intervenes from U.S. over scandal of mass baby grave
Hundreds of babies are believed to have been buried at former baby home
Enda Kenny says he’s ordered his officials to examine ‘if there are others’
By Harriet Arkell and Neil Michael Published: 09:17 GMT, 6 June 2014

Hillary Clinton’s Foundation Arranged for Chinese Vaccine Makers to Avoid U.S. Scrutiny, World Health Organization Report Reveals
by Yelena Sukhoterina | October 19, 2016
If it wasn’t bad enough that vaccines are still made with toxic controversial ingredients such as thimerosal, many are about to be manufactured in China with no oversight from other countries.
Because of a recent classification change, Chinese manufactured vaccines have been given the greenlight to be shipped in bulk to as many as 152 low and middle-income countries and can now bypass any inspection from any other country, including the U.S. — all because of the work of the Clinton Foundation.
The World Health Organization (WHO) has reported that vaccines will be pre-qualified, meaning they are so “confident in the quality, safety and effectiveness of vaccines that are made in China” that other countries will no longer test them for safety.
The Clinton Foundation, which is heavily involved in vaccine programs across the world, has reportedly been working with the Chinese vaccine manufacturers to give them pre-qualification, which was achieved in 2014 with little mention by the mainstream media.
A report by WHO states: “The Clinton Health Access Initiative (CHAI) has been working with Chinese suppliers to support their applications for WHO prequalification for several vaccine candidates for the last two years, says Joshua Chu, CHAI’s Director, Vaccines Markets.”
Can we trust China to manufacture vaccines? That may be hard for many people to do after the recent Chinese vaccine scandal.
This Year’s China Vaccine Scandal
Just recently Chinese vaccine manufacturers, wholesale sellers, and buyers came under fire over improperly transported and expired vaccines. The vaccinations were not refrigerated, and sold near their expiration dates, which made them virtually useless.

China enters the global vaccine market
China is gearing up to supply the world with affordable vaccines that fulfil all efficacy, safety and quality requirements. Jane Parry reports.
PDF version: http://www.who.int/bulletin/volumes/92/9/14-020914.pdf
The global vaccine industry has long been dominated by a few multinational companies. But now that companies in China, India and other emerging economies are becoming major vaccine manufacturers and have started selling these vaccines on the international market, competition is set to increase and prices to come down.
For Jiankang Zhang, representative for PATH’s China Programmes, the growth of China’s vaccine industry is “a very positive development for global health, as governments and international procurement agencies will be able to afford more life-saving vaccines and thus protect more lives”.
Since 1987, vaccine quality for international procurement has been assured through the prequalification system that is managed by the World Health Organization (WHO). The “prequalified” stamp of approval means that these vaccines are consistently safe, effective and of high quality, and thus recommended for bulk purchase by the United Nations Children’s Fund (UNICEF) in 152 low and middle-income countries, the GAVI Alliance – which funds vaccines in 73 of these countries – and other agencies.
When WHO pre-qualified a Chinese-made vaccine for the first time last October, the move showed what Chinese vaccine manufacturers could potentially achieve and – in a sense – paved the way for others to follow suit.
“The prequalification of the Japanese encephalitis vaccine in China is a big step forward, and now several other Chinese producers are interested in obtaining prequalification for their vaccines,” says Melissa Malhame, whose team at the GAVI Secretariat in Geneva works with vaccine manufacturers around the world to ensure sufficient supply of high quality vaccines at affordable prices.
This and other Chinese vaccines are licensed by the China Food and Drug Administration (CFDA) that is part of China’s National Regulatory Authority (CNRA), which received WHO’s seal of approval in March 2011, after finding that it met WHO standards for vaccine regulatory oversight.
In July, this status was renewed, after a successful WHO reassessment of the vaccine regulatory part of the CNRA. WHO Director-General Dr Margaret Chan welcomed the news saying: “As a result of this evaluation, WHO is confident in the quality, safety and effectiveness of vaccines that are made in China.”

Tetanus vaccines found spiked with sterilization chemical to carry out race-based genocide against Africans
Saturday, November 08, 2014 by Mike Adams, the Health Ranger
(NaturalNews) Tetanus vaccines given to millions of young women in Kenya have been confirmed by laboratories to contain a sterilization chemical that causes miscarriages, reports the Kenya Catholic Doctors Association, a pro-vaccine organization.
A whopping 2.3 million young girls and women are in the process of being given the vaccine, pushed by UNICEF and the World Health Organization.
“We sent six samples from around Kenya to laboratories in South Africa. They tested positive for the HCG antigen,” Dr. Muhame Ngare of the Mercy Medical Centre in Nairobi told LifeSiteNews. “They were all laced with HCG.”
Chemical causes a woman’s body to destroy its own fetus with vaccine-induced antibodies
HCG is a chemical developed by the World Health Organization for sterilization purposes. When injected into the body of a young woman, it causes a pregnancy to be destroyed by the body’s own antibody response to the HCG, resulting in a spontaneous abortion. Its effectiveness lasts for years, causing abortions in women up to three years after the injections.
Dr. Ngare explained “…this WHO campaign is not about eradicating neonatal tetanus but a well-coordinated forceful population control mass sterilization exercise using a proven fertility regulating vaccine.”

‘A mass sterilization exercise’: Kenyan doctors find anti-fertility agent in UN tetanus vaccine
Thu Nov 6, 2014 – 2:29 pm EST
UPDATE (Nov. 12): Kenya’s government has launched an investigation into the Catholic Church’s allegations. See follow up article here: https://www.lifesitenews.com/news/kenyan-gvmt-launches-probe-into-claim-un-is-using-vaccines-for-mass-sterili
Kenya’s Catholic bishops are charging two United Nations organizations with sterilizing millions of girls and women under cover of an anti-tetanus inoculation program sponsored by the Kenyan government.
According to a statement released Tuesday by the Kenya Catholic Doctors Association, the organization has found an antigen that causes miscarriages in a vaccine being administered to 2.3 million girls and women by the World Health Organization and UNICEF. Priests throughout Kenya reportedly are advising their congregations to refuse the vaccine.
“We sent six samples from around Kenya to laboratories in South Africa. They tested positive for the HCG antigen,” Dr. Muhame Ngare of the Mercy Medical Centre in Nairobi told LifeSiteNews. “They were all laced with HCG.”
Dr. Ngare, spokesman for the Kenya Catholic Doctors Association, stated in a bulletin released November 4, “This proved right our worst fears; that this WHO campaign is not about eradicating neonatal tetanus but a well-coordinated forceful population control mass sterilization exercise using a proven fertility regulating vaccine. This evidence was presented to the Ministry of Health before the third round of immunization but was ignored.”
But the government says the vaccine is safe. Health Minister James Macharia even told the BBC, “I would recommend my own daughter and wife to take it because I entirely 100% agree with it and have confidence it has no adverse health effects.”
And Dr. Collins Tabu, head of the Health Ministry’s immunization branch, told the Kenyan Nation, that “there is no other additive in the vaccine other than the tetanus antigen.”
Tabu said the same vaccine has been used for 30 years in Kenya. Moreover, “there are women who were vaccinated in October 2013 and March this year who are expectant. Therefore we deny that the vaccines are laced with contraceptives.”
Newspaper stories also report women getting pregnant after being vaccinated.
Responds Dr. Ngare: “Either we are lying or the government is lying. But ask yourself, ‘What reason do the Catholic doctors have for lying?’” Dr. Ngare added: “The Catholic Church has been here in Kenya providing health care and vaccinating for 100 years for longer than Kenya has existed as a country.”
Dr. Ngare told LifeSiteNews that several things alerted doctors in the Church’s far-flung medical system of 54 hospitals, 83 health centres, and 17 medical and nursing schools to the possibility the anti-tetanus campaign was secretly an anti-fertility campaign.
Why, they ask does it involve an unprecedented five shots (or “jabs” as they are known, in Kenya) over more than two years and why is it applied only to women of child-bearing years, and why is it not being conducted without the usual fanfare of government publicity?