Vaccine News – Study – The Blood-Brain Barrier Bottleneck in Brain Drug Development

Study – Systematic review and meta-analysis links autism and toxic metals and highlights the impact of country development status: Higher blood and erythrocyte levels for mercury and lead, and higher hair antimony, cadmium, lead, and mercury.

US National Library of Medicine
National Institutes of Health – 3 Oct 2017

Saghazadeh A – 1, Rezaei N – 2.
Author information
1 Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran; MetaCognition Interest Group (MCIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
2 Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Systematic Review and Meta-analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Boston, MA, USA. Electronic address: Rezaei_nima@tums.ac.ir.

Abstract
BACKGROUND:
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder that affects cognitive and higher cognitive functions. Increasing prevalence of ASD and high rates of related comorbidities has caused serious health loss and placed an onerous burden on the supporting families, caregivers, and health care services. Heavy metals are among environmental factors that may contribute to ASD. However, due to inconsistencies across studies, it is still hard to explain the association between ASD and toxic metals. Therefore the objective of this study was to investigate the difference in heavy metal measures between patients with ASD and control subjects.
METHODS:
We included observational studies that measured levels of toxic metals (antimony, arsenic, cadmium, lead, manganese, mercury, nickel, silver, and thallium) in different specimens (whole blood, plasma, serum, red cells, hair and urine) for patients with ASD and for controls. The main electronic medical database (PubMed and Scopus) were searched from inception through October 2016.
RESULTS:
52 studies were eligible to be included in the present systematic review, of which 48 studies were included in the meta-analyses. The hair concentrations of antimony (standardized mean difference (SMD)=0.24; 95% confidence interval (CI): 0.03 to 0.45) and lead (SMD=0.60; 95% confidence interval (CI): 0.17 to 1.03) in ASD patients were significantly higher than those of control subjects. ASD patients had higher erythrocyte levels of lead (SMD=1.55, CI: 0.2 to 2.89) and mercury (SMD=1.56, CI: 0.42 to 2.70). There were significantly higher blood lead levels in ASD patients (SMD=0.43, CI: 0.02 to 0.85). Sensitivity analyses showed that ASD patients in developed but not in developing countries have lower hair concentrations of cadmium (SMD=-0.29, CI: -0.46 to -0.12). Also, such analyses indicated that ASD patients in developing but not in developed lands have higher hair concentrations of lead (SMD=1.58, CI: 0.80 to 2.36) and mercury (SMD=0.77, CI: 0.31 to 1.23). These findings were confirmed by meta-regression analyses indicating that development status of countries significantly influences the overall effect size of mean difference for hair arsenic, cadmium, lead, and mercury between patients with ASD and controls.
CONCLUSION:
The findings help highlighting the role of toxic metals as environmental factors in the etiology of ASD, especially in developing lands. While there are environmental factors other than toxic metals that greatly contribute to the etiology of ASD in developed lands. It would be, thus, expected that classification of ASD includes etiological entities of ASD on the basis of implication of industrial pollutants (developed vs. developing ASD).

Study – Autism: A form of lead and mercury toxicity

Environmental Toxicology and Pharmacology
Volume 38, Issue 3, November 2014, Pages 1016–1024

Highlights
•Autism is a developmental disability characterized by severe, pervasive deficits in social interaction and communications.
•Lead and mercury two of the most common heavy metals in the environment.
•Lead and mercury can lead to autistic disorders.
•Many risk factors contribute to the high level of heavy metals in autistic children.
•Defect in the metabolism of the heavy metals in autistic children also contribute to the high level of these heavy metals in their body.
•Chelating agents can be used in the treatment of the autistic disorders.

Abstract
Aim
Autism is a developmental disability characterized by severe deficits in social interaction and communication. The definite cause of autism is still unknown. The aim of this study is to find out the relation between exposure to Lead and/or mercury as heavy metals and autistic symptoms, dealing with the heavy metals with chelating agents can improve the autististic symptoms.

Method
Blood and hair samples were obtained from 45 children from Upper Egypt with autism between the ages of 2 and 10 years and 45 children served as controls in the same age range, after taken an informed consent and fill a questionnaire to assess the risk factors. The samples were analyzed blindly for lead and mercury by using atomic absorption and ICP-MS. Data from the two groups were compared, then follow up of the autistic children after treatment with chelating agents were done.

Results
The results obtained showed significant difference among the two groups, there was high level of mercury and lead among those kids with autism. Significant decline in the blood level of lead and mercury with the use of DMSA as a chelating agent. In addition, there was decline in the autistic symptoms with the decrease in the lead and mercury level in blood.

Conclusion
Lead and mercury considered as one of the main causes of autism. Environmental exposure as well as defect in heavy metal metabolism is responsible for the high level of heavy metals. Detoxification by chelating agents had great role in improvement of those kids.

Study – The Blood-Brain Barrier: Bottleneck in Brain Drug Development

US National Library of Medicine
National Institutes of Health – Jan 2005

William M. Pardridge
Department of Medicine, UCLA, Los Angeles, California 90024
Address correspondence and reprint requests to William M. Pardridge, M.D., UCLA Warren Hall, 13-164, 900 Veteran Avenue, Los Angeles,

ABSTRACT
Summary: The blood-brain barrier (BBB) is formed by the brain capillary endothelium and excludes from the brain ∼100% of large-molecule neurotherapeutics and more than 98% of all small-molecule drugs. Despite the importance of the BBB to the neurotherapeutics mission, the BBB receives insufficient attention in either academic neuroscience or industry programs. The combination of so little effort in developing solutions to the BBB problem, and the minimal BBB transport of the majority of all potential CNS drugs, leads predictably to the present situation in neurotherapeutics, which is that there are few effective treatments for the majority of CNS disorders. This situation can be reversed by an accelerated effort to develop a knowledge base in the fundamental transport properties of the BBB, and the molecular and cellular biology of the brain capillary endothelium. This provides the platform for CNS drug delivery programs, which should be developed in parallel with traditional CNS drug discovery efforts in the molecular neurosciences.

VAXXED TV – Nick Johansen #vaxxed #PrayBig

Dr. Judy Mikovits, PhD Research Scientist at #TxMFA #TxMFA2017
Dr. Judy Mikovits, PhD research scientist, dives deep into the crude science of vaccination

Austin Bennett #vaxxed #PrayBig

Dawn Richardson

David Oldham

Barbara Loe Fisher #vaxxed #truth #science #praybig

Q&A vaccine syndrome

Global Vaccine Initiative Houston Protest #TxMFA #TxMFA2017
Jonathan Tommey and The Vaxxed Team hit the ground running at the Texas Medical Freedom Alliance world symposium in Housant, Texas.
They discusses vaccine safety concerns with our #TexasPeeps protesting on the ground and also interview medical doctor, Jim Meehan, M.D. with regard to his passion for exposing the deception endemic to the present vaccine paradigm.

Glaxo’s Vaccine Trials survivor speaks out
David tells his story and presents documentation of his history going through the Glaxo’s trials. His mother was told he had passed as an infant here they kept him as an orphan until 4 years old.
Interview recorded on May 5th, 2017 in The United Kingdom

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How to accept Jesus Christ as your personal Saviour

Testimony by Phil Robertson from Duck Dynasty

1 Corinthians 15 Authorized (King James) Version (AKJV)
1 Moreover, brethren, I declare unto you the gospel which I preached unto you, which also ye have received, and wherein ye stand;
2 by which also ye are saved, if ye keep in memory what I preached unto you, unless ye have believed in vain.
3 For I delivered unto you first of all that which I also received, how that Christ died for our sins according to the scriptures;
4 and that he was buried, and that he rose again the third day according to the scriptures:

Hebrews 6 Authorized (King James) Version (AKJV)
1 Therefore leaving the principles of the doctrine of Christ, let us go on unto perfection; not laying again the foundation of repentance from dead works, and of faith toward God,
2 of the doctrine of baptisms, and of laying on of hands, and of resurrection of the dead, and of eternal judgment.
3 And this will we do, if God permit.
4 For it is impossible for those who were once enlightened, and have tasted of the heavenly gift, and were made partakers of the Holy Ghost,
5 and have tasted the good word of God, and the powers of the world to come,
6 if they shall fall away, to renew them again unto repentance; seeing they crucify to themselves the Son of God afresh, and put him to an open shame.
7 For the earth which drinketh in the rain that cometh oft upon it, and bringeth forth herbs meet for them by whom it is dressed, receiveth blessing from God:
8 but that which beareth thorns and briers is rejected, and is nigh unto cursing; whose end is to be burned.

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Vaccine News – A mother shares her story about her children’s reactions to the vaccines – VAXXED TV

VAXXED TV – Barbara Loe Fisher #vaxxed #truth #science #praybig

Q&A vaccine syndrome

Global Vaccine Initiative Houston Protest #TxMFA #TxMFA2017
Jonathan Tommey and The Vaxxed Team hit the ground running at the Texas Medical Freedom Alliance world symposium in Housant, Texas.
They discusses vaccine safety concerns with our #TexasPeeps protesting on the ground and also interview medical doctor, Jim Meehan, M.D. with regard to his passion for exposing the deception endemic to the present vaccine paradigm.

Banned From Australia! #VaxxedAustralia #VaxxedWorld

Glaxo’s Vaccine Trials survivor speaks out
David tells his story and presents documentation of his history going through the Glaxo’s trials. His mother was told he had passed as an infant here they kept him as an orphan until 4 years old.
Interview recorded on May 5th, 2017 in The United Kingdom

I can’t believe they are doing this!
Patricia Gua tells of her injuries from receiving the HEP-B vaccination.

What If I Harmed My Children
Kelly Johnson, author of “What If?: I Harmed My Children” gives detailed accounts of her experiences with her kids which inspired her to write the book

I had every reaction documented – Liola shares about the details of her children’s reactions to vaccinations and the challenges they faced.
Interview recorded on May 5th, 2017 in The United Kingdom

It’s sad we have to learn the hard way
A mother shares her story about her children’s reactions to the vaccines.

Know Your Body

 

How to accept Jesus Christ as your personal Saviour

1 Corinthians 15 Authorized (King James) Version (AKJV)
1 Moreover, brethren, I declare unto you the gospel which I preached unto you, which also ye have received, and wherein ye stand;
2 by which also ye are saved, if ye keep in memory what I preached unto you, unless ye have believed in vain.
3 For I delivered unto you first of all that which I also received, how that Christ died for our sins according to the scriptures;
4 and that he was buried, and that he rose again the third day according to the scriptures:

Hebrews 6 Authorized (King James) Version (AKJV)
1 Therefore leaving the principles of the doctrine of Christ, let us go on unto perfection; not laying again the foundation of repentance from dead works, and of faith toward God,
2 of the doctrine of baptisms, and of laying on of hands, and of resurrection of the dead, and of eternal judgment.
3 And this will we do, if God permit.
4 For it is impossible for those who were once enlightened, and have tasted of the heavenly gift, and were made partakers of the Holy Ghost,
5 and have tasted the good word of God, and the powers of the world to come,
6 if they shall fall away, to renew them again unto repentance; seeing they crucify to themselves the Son of God afresh, and put him to an open shame.
7 For the earth which drinketh in the rain that cometh oft upon it, and bringeth forth herbs meet for them by whom it is dressed, receiveth blessing from God:
8 but that which beareth thorns and briers is rejected, and is nigh unto cursing; whose end is to be burned.

 

Vaccine News – Please keep these things in mind when choosing to vaccinate your pet

Natural News – Merck in hot water over dangerous shingles vaccine that caused numerous injuries, deaths
Tuesday, April 04, 2017 by: Ethan Huff
Commercials for the jab showing happy people free of shingles are a common feature of television advertising. But Merck & Co’s “Zosatavax” vaccine to prevent varicella, the adult version of chickenpox, is causing the international drug giant some serious headaches after numerous people who got the shot suffered injuries and/or death.
Multiple lawsuits are making their way through the court system alleging that Merck’s blockbuster vaccine for shingles isn’t safe, and could cause serious adverse effects. Plaintiffs in the state of Pennsylvania, and elsewhere, allege that Zostavax isn’t safe, and are taking to both the state and federal court system to seek justice.
According to Marc Bern of Marc J. Bern & Partners, there have been “thousands of complaints” about Zostavax in Pennsylvania alone. Patient injuries from the vaccine, he says, range from shingles itself, which the vaccine is supposed to prevent, to serious personal injuries such as blindness and paralysis. Other reports of adverse effects from Zostavax include brain damage and death.
“I think Merck has failed terribly … to warn about the very serious side effects and the failure of the vaccine to do what they claim it does,” Bern told FiercePharma.

Dangers of the DTP vaccine
#VaXism NEWS
#Pertussis
Barbara Loe Fisher 1986

DO YOU KNOW HOW TO RECOGNIZE A HARMFUL VACCINE REACTION?
Some babies handle vaccines without any apparent problems, and some have severe reactions that exempt them from future vaccines. But what about those who suffer a moderate side effect that could cause ongoing harm if vaccination is continued? Do you, as a parent, know how to recognize signs of potential harm? And will your doctor be honest with you when your baby experiences that type of moderate reaction?
Watch this video, and others, on our website: http://immunityeducationgroup.org/videos/

 Just a few short years ago DPaT was Not for pregnant women but they suddenly changed that as fetuses die from it.


130 Research papers supporting Vaccine/Autism CausationGinger Taylor, MS
Mainstream research has found that vaccines and their ingredients can cause the underlying medical conditions that committed physicians and researchers are commonly finding in children who have been given an autism diagnosis. These conditions include gastrointestinal damage, immune system impairment, chronic infections, mitochondrial disorders, autoimmune conditions, neurological regression, glial cell activation, brain inflammation, damage to the blood–brain barrier, seizures, synaptic dysfunction, dendritic cell dysfunction, mercury poisoning, aluminum toxicity, gene activation and alteration, glutathione depletion, impaired methylation, oxidative stress, impaired thioredoxin regulation, mineral deficiencies, impairment of the opioid system, endocrine dysfunction, cellular apoptosis, and other disorders.
Book – Vaccination Roulettehttps://www.scribd.com/document/230208917/Vaccination-Roulette-Experiences-Risks-and-Alternatives

Evidence Concerning Pertussis Vaccines and Central Nervous System Disorders, Including Infantile Spasms, Hypsarrhythmia, Aseptic Meningitis, and Encephalopathy
History of Suspected Association with Pertussis Vaccines
Among the earliest case reports suggesting a possible link between infantile spasms and pertussis immunization are those of Baird and Borofsky (1957). They described 24 children who had hypsarrhythmia and infantile myoclonic seizures and whose development prior to the onset of spasms was apparently normal. Nine cases of infantile spasms were reported to have occurred between 1 and 5 days after DPT vaccination. Three of these nine children also had a history of perinatal complications that the authors thought might have been related to a risk of infantile spasms. The authors also stated, on the basis of a review of published EEG tracings, that hypsarrhythmia was present in two of the affected children described by Byers and Moll (1948). Since these early case reports, additional cases of infantile spasms in association with pertussis immunization have been described in the literature (Fukuyama et al., 1977; Millichap, 1987; Portoian-Shuhaiber and Al Rashied, 1986). The time intervals reported between vaccination and the onset of infantile spasms have been from minutes to weeks (Melchior, 1971).
Evidence from Studies in Humans
Case Reports and Case Series
One of the largest case series of infantile spasms following pertussis immunization was published by Millichap (1987). Six children ranging in age from 2 to 9 months were included. The time interval from immunization to the onset of spasms was from 6.5 hours to 5 days, and first seizures were reported to have occurred in conjunction with the first, second, or third doses of pertussis vaccine. Except for one case who had experienced myoclonic seizures since birth, no mention was made of the children having seizures prior to immunization. In reviewing the etiology and treatment of infantile spasms, Millichap (1987) listed the postulated mechanisms for pertussis-related seizures as (1) a direct neurotoxic effect, (2) an immediate immune reaction, (3) delayed cellular hypersensitivity reaction, and (4) vaccine-induced activation of a latent neurotropic virus infection.
In addition to the variability in age at the time of onset of spasms, associated vaccine dose, and time from immunization to the onset of spasms, there was no consistent pattern in the types of neurologic abnormalities reported in conjunction with infantile spasms. These included spastic diplegia, psychomotor retardation, hypotonic diplegia, and progressive neurologic deterioration. Not all children with infantile spasms have other neurologic or developmental problems, and when they do, diversity of expression of these associated neurologic conditions is typically reported (Lacy and Penry, 1976). This case series provides some of the better clinical descriptions available in the published literature of seizures occurring after immunization with DPT. Although typical of many cases of infantile spasms, information from this series also suggests that there is no consistent syndrome of neurologic manifestations among children whose spasms follow DPT immunization.
Fukuyama and colleagues (1977) studied 185 cases of infantile spasms seen in the Department of Pediatrics of the Tokyo Women’s Medical College from 1968 to 1972. Table 2 of their paper lists “DPT or DT” as one of the types of vaccines to which cases were exposed, whereas the text and all other tables and figures refer to “DPT or DP.” Thus, although there is some uncertainty about the precise vaccines to which these children were exposed, the committee considered DP to be the exposure the authors intended to describe. Complete information on immunization histories and health status prior to vaccination was available for 110 of the 185 infantile spasms cases. Of these 110 children, 22 (20 percent) had been immunized within 1 month of the onset of spasms, 10 with DPT or DP vaccine alone, 5 with DPT vaccine in combination with one or more other vaccines, 4 with smallpox vaccine alone, 2 with Japanese encephalitis vaccine alone, and 1 with polio vaccine alone. Of the 15 cases of infantile spasms with onset after immunization with either DPT or DP vaccine alone or DPT vaccine in combination with another vaccine, onset occurred after the first immunization in 3 cases, after the second in 10 cases, and after the third in 2 cases. The interval from immunization to the reported onset of spasms ranged from less than 48 hours to more than 7 days. The remaining cases had been vaccinated either more than 1 month before or more than 1 month after the onset of spasms (n = 44, 40 percent) or had never been immunized (n = 44, 40 percent). The authors gave no indication that any of the cases had had whooping cough, either before or after the onset of infantile spasms.
The authors considered vaccination as the etiology of infantile spasms if cases met the following three criteria: (1) no other identifiable cause, (2) normal development prior to the onset of spasms, and (3) the interval from immunization to the onset of spasms was within 48 hours for pertussis-containing vaccines and within 18 days for smallpox, polio, and Japanese encephalitis vaccines. Given these criteria, 5 of the 110 cases were considered by the authors to have infantile spasms caused by vaccination. It was not possible to determine from the data given in the paper how many of these five cases followed administration of DPT vaccine, since detailed information was given only for three of the five cases. At least one of the five cases occurred following smallpox vaccination alone, and at least two occurred following administration of DP vaccine.
It could not be determined from the information provided whether cases were representative of all those with infantile spasms from a defined geographic area or whether they were a selected group who were referred to these experts in pediatric neurology. The investigators acknowledged that because there is no biologic marker for vaccine-associated infantile spasms, the assignment of cause was made “solely from the clinical standpoint.” They stated that because of the diversity of the etiology of infantile spasms, “there is still free space for any agent to be suspected as an injurious factor causative of infantile spasms” (Fukuyama et al., 1977, p. 229).
Jeavons and colleagues (1970) reported on a follow-up of 98 cases of infantile spasms, 13 of which were attributed to immunization (type not specified). The follow-up ranged from 4 to 12 years. Outcomes were similar in the cryptogenic and immunization groups, among whom the survivorship, percent without neurologic abnormality at follow-up, and percent in regular school were higher than for those cases of infantile spasms attributed to perinatal or other causes (e.g., tuberous sclerosis).
Factors that should be considered in evaluating the study findings are that the patient groups were highly selected, the different lengths of follow-up were not considered in comparing outcomes among the groups, criteria for defining mental outcome were not given, and developmental status at follow-up was not ascertained uniformly for all cases. The first weakness affects the generality of the findings, and the last three problems given above make it difficult to compare outcomes between the groups studied.
Fifty-eight cases of infantile spasms (International Classification of Disease [ICD] 9 code 345.6 includes hypsarrhythmia and drop seizures) occurring within 28 days of DPT immunization were reported through the Centers for Disease Control’s (CDC’s) Monitoring System for Adverse Events Following Immunization (MSAEFI) system from 1978 to 1990, a period in which approximately 80.1 million doses of DPT vaccine were administered through public mechanisms in the United States (J. Mullen, Centers for Disease Control, personal communication, 1990). Of these 58 cases, 41 (71 percent) also received at least one other vaccine at the time of DPT immunization. No follow-up of the cases was made, and a physicians’s diagnosis was not required.

Ever wonder WHY we NEED a religious exemption from vaccines?
Are you aware that some vaccines are made from ABORTIONS?
Marcella Piper-Terry explains in detail how abortions are used in vaccine manufacturing and the implications of that.
Interview by Polly Tommey and camera by Joshua Coleman and Anu Vaidya with editing by Joshua Coleman.

#RFKCommission #Vaxxed

Please keep these things in mind when choosing to vaccinate your pet

Barbara Loe Fisher, President of the National Vaccine Information Center (NVIC), a non-profit charity she co-founded with parents of DPT vaccine injured children in 1982 speaks about powerful profile of pertussis vaccine injury in many families

Barbara Loe Fisher, President of the National Vaccine Information Center (NVIC), a non-profit charity she co-founded with parents of DPT vaccine injured children in 1982 speaks about powerful profile of pertussis vaccine injury in many families.

Janet Ciotoli, a Mother whose son died after the DPT vaccine, speaks with Regis and Kathie Lee back in 1986

Janet Ciotoli, a Mother whose son died after the DPT vaccine, speaks with Regis and Kathie Lee back in 1986. She is joined by Barbara Loe Fisher whose child was seriously injured by the DPT vaccine. As always, we must hear the reprehensible defense of the vaccine industry from a mainstream medical worker brought in to sit with grieving parents and perpetuate the false narrative that vaccines are safe and that injuries are rare.