Adverse Associations of both Prenatal and Postnatal Exposure to Organophosphorous Pesticides with Infant Neurodevelopment in an Agricultural Area of Jiangsu Province China

Results: Based on the Gesell Developmental Schedules, the proportions of children with

developmental delays were less than 6%. Adverse associations between head circumference at

birth and prenatal OP exposure were demonstrated. Both prenatal and postnatal OP exposure was

significantly associated with increased risk of being developmentally delayed. Specifically, odds

ratio (OR) value for prenatal DEs was 9.75 [95% confidence interval (CI): 1.28~73.98]

(p=0.028) in the adaptive area, while in the social area, OR values for postnatal DEs and DAPs

were 9.56 (95% CI: 1.59~57.57) (p=0.014) and 12.00 (95% CI: 1.23~117.37) (p=0.033),

respectively. Adverse associations were observed only in boys but not in girls.

Conclusions: Both prenatal and postnatal OP exposure may adversely affect the

neurodevelopment of infants living in the agricultural area. The present study added to the

accumulating evidence on associations of prenatal and postnatal OP exposure with infant


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