Vaccine News – Study – Abnormal measles-mumps-rubella antibodies and CNS autoimmunity in children with autism & VAXXED TV – Vaccines gave my son autism

Study published in the Annals of Clinical Psychiatry suggests that Autism is likely triggered by a virus, and that measles virus (MV and/or MMR vaccine) might be a very good candidate. It supports the hypothesis that a virus-dincued autoimmune response may play a causal role in autism.

US National Library of Medicine
National Institutes of Health – 2002

Study – Abnormal measles-mumps-rubella antibodies and CNS autoimmunity in children with autism.

Singh VK, Lin SX, Newell E, Nelson C.
Author information
Department of Biology and Biotechnology Center, Utah State University, Logan, Utah 84322, USA. singhvk@cc.usu.edu

Abstract
Autoimmunity to the central nervous system (CNS), especially to myelin basic protein (MBP), may play a causal role in autism, a neurodevelopmental disorder. Because many autistic children harbor elevated levels of measles antibodies, we conducted a serological study of measles-mumps-rubella (MMR) and MBP autoantibodies. Using serum samples of 125 autistic children and 92 control children, antibodies were assayed by ELISA or immunoblotting methods. ELISA analysis showed a significant increase in the level of MMR antibodies in autistic children. Immunoblotting analysis revealed the presence of an unusual MMR antibody in 75 of 125 (60%) autistic sera but not in control sera. This antibody specifically detected a protein of 73-75 kD of MMR. This protein band, as analyzed with monoclonal antibodies, was immunopositive for measles hemagglutinin (HA) protein but not for measles nucleoprotein and rubella or mumps viral proteins. Thus the MMR antibody in autistic sera detected measles HA protein, which is unique to the measles subunit of the vaccine. Furthermore, over 90% of MMR antibody-positive autistic sera were also positive for MBP autoantibodies, suggesting a strong association between MMR and CNS autoimmunity in autism. Stemming from this evidence, we suggest that an inappropriate antibody response to MMR, specifically the measles component thereof, might be related to pathogenesis of autism.

A study published in the American Journal of Clinical Nutrition determined that an increased vulnerability to oxidative stress and decreased capacity for methylation may contribute to the development and clinical manifestation of autism. It’s well known that viral infections cause increased oxidative stress. Research suggests that metals, including those found in many vaccines are directly involved in increasing oxidative stress.

American Society for Clinical Nutrition – 2004

Study – Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism

S Jill James, Paul Cutler, Stepan Melnyk, Stefanie Jernigan, Laurette Janak, David W Gaylor, and James A Neubrander
Author Affiliations
From the Department of Pediatrics, University of Arkansas for Medical Sciences, and the Arkansas Children’s Hospital Research Institute, Little Rock, AR (SJJ, SM, and SJ); Niagara Falls, NY (PC); Colden, NY (LJ); Gaylor and Associates, LLC, Eureka Springs, AR (DWG); and Edison, NJ (JAN)

Abstract

Background: Autism is a complex neurodevelopmental disorder that usually presents in early childhood and that is thought to be influenced by genetic and environmental factors. Although abnormal metabolism of methionine and homocysteine has been associated with other neurologic diseases, these pathways have not been evaluated in persons with autism.

Objective: The purpose of this study was to evaluate plasma concentrations of metabolites in the methionine transmethylation and transsulfuration pathways in children diagnosed with autism.

Design: Plasma concentrations of methionine, S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), adenosine, homocysteine, cystathionine, cysteine, and oxidized and reduced glutathione were measured in 20 children with autism and in 33 control children. On the basis of the abnormal metabolic profile, a targeted nutritional intervention trial with folinic acid, betaine, and methylcobalamin was initiated in a subset of the autistic children.

Results: Relative to the control children, the children with autism had significantly lower baseline plasma concentrations of methionine, SAM, homocysteine, cystathionine, cysteine, and total glutathione and significantly higher concentrations of SAH, adenosine, and oxidized glutathione. This metabolic profile is consistent with impaired capacity for methylation (significantly lower ratio of SAM to SAH) and increased oxidative stress (significantly lower redox ratio of reduced glutathione to oxidized glutathione) in children with autism. The intervention trial was effective in normalizing the metabolic imbalance in the autistic children.

Conclusions: An increased vulnerability to oxidative stress and a decreased capacity for methylation may contribute to the development and clinical manifestation of autism.

A study published by the Department of Pharmaceutical Sciences at Northeastern University, Boston determined that a novel growth factor signalling pathway that regulates methionine synthase(MS) activity and thereby modulates methylation reactions. The potent inhibition of this pathway by ethanol, lead, mercury, aluminum and thimerosal suggests that it may be an important target of neurodevelopmental toxins. You can read more about this here, and here. You can read more about the MS/autism link here

US National Library of Medicine
National Institutes of Health – Apr 2004

Study – Activation of methionine synthase by insulin-like growth factor-1 and dopamine: a target for neurodevelopmental toxins and thimerosal

Waly M, Olteanu H, Banerjee R, Choi SW, Mason JB, Parker BS, Sukumar S, Shim S, Sharma A, Benzecry JM, Power-Charnitsky VA, Deth RC.
Author information
Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA.

Abstract
Methylation events play a critical role in the ability of growth factors to promote normal development. Neurodevelopmental toxins, such as ethanol and heavy metals, interrupt growth factor signaling, raising the possibility that they might exert adverse effects on methylation. We found that insulin-like growth factor-1 (IGF-1)- and dopamine-stimulated methionine synthase (MS) activity and folate-dependent methylation of phospholipids in SH-SY5Y human neuroblastoma cells, via a PI3-kinase- and MAP-kinase-dependent mechanism. The stimulation of this pathway increased DNA methylation, while its inhibition increased methylation-sensitive gene expression. Ethanol potently interfered with IGF-1 activation of MS and blocked its effect on DNA methylation, whereas it did not inhibit the effects of dopamine. Metal ions potently affected IGF-1 and dopamine-stimulated MS activity, as well as folate-dependent phospholipid methylation: Cu(2+) promoted enzyme activity and methylation, while Cu(+), Pb(2+), Hg(2+) and Al(3+) were inhibitory. The ethylmercury-containing preservative thimerosal inhibited both IGF-1- and dopamine-stimulated methylation with an IC(50) of 1 nM and eliminated MS activity. Our findings outline a novel growth factor signaling pathway that regulates MS activity and thereby modulates methylation reactions, including DNA methylation. The potent inhibition of this pathway by ethanol, lead, mercury, aluminum and thimerosal suggests that it may be an important target of neurodevelopmental toxins.

VAXXED TV – Vaccines gave my son autism

Vaccines while pregnant injured my daughter

Dr. Suzanne Humphries discusses smallpox from 1797 – 2005

MERCK’S DIRTY LITTLE SECRET – BY DR. SUZANNE HUMPHRIES

I Didn’t Realize we had a Choice

I am unvaccinated and want to be a nurse

More Vaxxed versus unvaccinated #vaxxed

I’m done vaccinating my family

No more vaccines #vaxxed #praybig

MMR gave my son autism

 

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How to accept Jesus Christ as your personal Saviour

Testimony by Phil Robertson from Duck Dynasty

1 Corinthians 15 Authorized (King James) Version (AKJV)
1 Moreover, brethren, I declare unto you the gospel which I preached unto you, which also ye have received, and wherein ye stand;
2 by which also ye are saved, if ye keep in memory what I preached unto you, unless ye have believed in vain.
3 For I delivered unto you first of all that which I also received, how that Christ died for our sins according to the scriptures;
4 and that he was buried, and that he rose again the third day according to the scriptures:

Hebrews 6 Authorized (King James) Version (AKJV)
1 Therefore leaving the principles of the doctrine of Christ, let us go on unto perfection; not laying again the foundation of repentance from dead works, and of faith toward God,
2 of the doctrine of baptisms, and of laying on of hands, and of resurrection of the dead, and of eternal judgment.
3 And this will we do, if God permit.
4 For it is impossible for those who were once enlightened, and have tasted of the heavenly gift, and were made partakers of the Holy Ghost,
5 and have tasted the good word of God, and the powers of the world to come,
6 if they shall fall away, to renew them again unto repentance; seeing they crucify to themselves the Son of God afresh, and put him to an open shame.
7 For the earth which drinketh in the rain that cometh oft upon it, and bringeth forth herbs meet for them by whom it is dressed, receiveth blessing from God:
8 but that which beareth thorns and briers is rejected, and is nigh unto cursing; whose end is to be burned.

 

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Vaccine News – Autism vs. Childhood Diseases: Breaking Down The Walls Of Pro-Vaccine Ignorance

Désirée Röver – Vaccines, Part 1
By OLE DAMMEGARD June 10, 2017
Ole Dammegård interviews Medical Research Journalist Désirée Röver from the Netherlands, about vaccines and the dangers involved. What started her painful journey of discovery into this dark world was the death of her 2 year old son, due to a vaccination.

 

 

Brittney Kara encourages parents to do their research before allowing toxic vaccines to be injected into their children. Start your research by watching Vaccines Revealed featuring 24 vaccine experts by clicking here http://bit.ly/2o0b5Cp and go to http://www.stopmandatoryvaccination.com/personal-choice/ to read Brittney’s vaccine free overview.

“I met with a pediatrician today and she said she watched Vaccines Revealed and she was shocked. She said she looked up the research and it was all there. She said she doesn’t know how to continue her practice as is. She said, should she read the parents the vaccine inserts and let them choose or just cold turkey quit. I hugged her neck and thanked God for opening her eyes.” The free replay is right here . . . tinyurl.com/9Episodes
#RevolutionForChoice #InformedConsent #EducateBeforeYouVaccinate #VAXXED

Medical Doctor who Escaped Vietnam as a Child in the 1970s Explains Why He no Longer Vaccinates
The VAXXED film crew recently interviewed Dr. Anthony Phan in California. Dr. Phan escaped from Vietnam in the 1970s when he was 8 years old. He was separated from his parents and escaped on a fishing boat along with his 2 year old brother.
Making it to the U.S. as a child refugee, Dr. Phan testifies that God led him through college and medical school, and he went on to become a medical doctor at Johns Hopkins.
Dr. Phan talks about how his mentor at Johns Hopkins taught him about the importance of the Hippocratic Oath to “do no harm.”
Do no harm means your oath is to the patient. Not to the CDC, not to the government, not to the FDA, your oath is to the patient.
His mentor also reportedly stated to him:
One day Tony, in your career (this was in 1993), when you see these threesome (CDC, FDA, and the government) in bed together, be very careful. When you see pharmaceutical companies being in bed with the government, and being controlled by the health industry, you need to make a decision about where you want to take your medical career.
Either #1 you retire and get out, because it is back to being controlled again, back to where I escaped (from Vietnam) in 1975.
Dr. Phan explains that his experience with vaccines began in 2000 when he did his fellowship in Integrated Medicine. He was taught to question the practices of “conventional” medicine that are wrong.

 

THOUSANDS protest in numerous cities across Italy in what is now an INTERNATIONAL️ uprising and Revolution for Choice!
What haven’t you been told? Find out now for free: tiny.cc/FreeVaccinationEducation
Networking, exemption information and doctor resources: tinyurl.com/RevolutionForVaccineChoice
Follow us: facebook.com/RevolutionForChoice
#RevolutionForChoice #InformedConsent #EducateBeforeYouVaccinate #VAXXED #Italy #VaccineInjury #NonCompliance #RiseUP

Learn OUR NAMES!!! Our international battle for medical choice and parental choice is only getting started! Join our movement of people who have done their research! . . . Click here to obtain the information you need to make the most informed choices for your yourself and your family >>> tinyurl.com/9Episodes
✴️ Translation courtesy of Teresa Iodice ️
✴️ Networking, exemption information and doctor resources: tinyurl.com/RevolutionForVaccineChoice
✴️ Follow us: facebook.com/RevolutionForChoice
✴️ Read all vaccine inserts: tinyurl.com/ReadTheVaccineInsert
#RevolutionForChoice #InformedConsent #EducateBeforeYouVaccinate #VAXXED #SB277 #RiseUp #Italy #Rome #Naples

Dirty Vaccines: New Study Reveals Prevalence of Contaminants
Posted by Celeste McGovern on Jan 30, 2017 5:31:20 PM
Every Human Vaccine Tested Was Contaminated by Unsafe Levels of Metals and Debris Linked to Cancer and Autoimmune Disease, New Study Reports
Researchers examining 44 samples of 30 different vaccines found dangerous contaminants, including red blood cells in one vaccine and metal toxicants in every single sample tested – except in one animal vaccine.
Using extremely sensitive new technologies not used in vaccine manufacturing, Italian scientists reported they were “baffled” by their discoveries which included single particles and aggregates of organic debris including red cells of human or possibly animal origin and metals including lead, tungsten, gold, and chromium, that have been linked to autoimmune disease and leukemia.
In the study, published this week in the International Journal of Vaccines and Vaccination, the researchers led by Antonietta Gatti, of the National Council of Research of Italy and the Scientific Director of Nanodiagnostics, say their results “show the presence of micro- and nano-sized particulate matter composed of inorganic elements in vaccine samples” not declared in the products’ ingredients lists.
Lead particles were found in the cervical cancer vaccines, Gardasil and Cervarix, for example, and in the seasonal flu vaccine Aggripal manufactured by Novartis as well as in the Meningetec vaccine meant to protect against meningitis C.
Samples of an infant vaccine called Infarix Hexa (against diphtheria, tetanus, pertussis, hepatitis B, poliomyelitis and haemophilus influenzae type B) manufactured by GlaxoSmithKline was found to contain stainless steel, tungsten and a gold-zinc aggregate.
Other metal contaminants included platinum, silver, bismuth, iron, and chromium. Chromium (alone or in alloy with iron and nickel) was identified in 25 of the human vaccines from Italy and France that were tested.
GSK’s Fluarix vaccine for children three years and older contained 11 metals and aggregates of metals. Similar aggregates to those identified in the vaccines have been shown to be prevalent in cases of leukemia, the researchers noted.

If a parent is vaccinating their child, these are just some facts they need to understand.
Greg Wyatt·Tuesday, June 20, 2017
“If a parent is vaccinating their child, these are just some facts they need to understand.

1. I understand that the pharmaceutical company who made this vaccine has NO liability if it injures or kills my child.
2. If my child is killed or hurt by a vaccine, the public will pay through increased taxes for any damage the vaccine does and in Canada it’s very little payment for a dead or injured child.
3. I understand that these vaccines contains neurotoxins such as aluminum and mercury that far exceed “safe levels” deemed by the EPA.
4. I understand that these vaccines contain carcinogenic ingredients PROVEN to cause CANCER.
5. I understand that some vaccines are made from aborted fetal cell lines, of both humans and animals and their DNA is INJECTED into you and your child along with everything else (including an adjuvant that tells your immune system to attack EVERYTHING in the vaccine, INCLUDING HUMAN CELLS.)
6. I understand that getting this vaccine does not ensure that I will be protected from the disease. Many OUTBREAKS include a Population of 100% vaccinated individuals.

Patients with an Allergy to Eggs Are at Risk of Anaphylaxis from MMR Vaccine
Posted on: Wednesday, February 1st 2017 at 10:30 am
Written By: Christina England, BA Hons
According to the National Institute of Allergy and Infectious Diseases Patients with an Allergy to Eggs Are at Risk of Anaphylaxis if Vaccinated with the MMR!
It is estimated that up to 15 million US citizens are currently suffering from food allergies. In 2013, a paper published on the CDC website stated that between 1997 and 2011, the prevalence of food and skin allergies increased in children under age of 18. This is extremely worrying, as according to the Food Allergy Research & Education website, a food allergy sends someone to the emergency department every three minutes, which, according to them, amounts to approximately 200,000 visits to the ER every year.
The NIAID Recommend the MMR to Children with Egg Allergies
In 2010, the National Institute of Allergy and Infectious Diseases (NIAID) published a paper titled Guidelines for the Diagnosis and Management of Food Allergy in the United States. The paper described how the NIAID had joined forces with 30 professional organizations, federal agencies and patient advocacy groups to set guidelines for the management and safety of patients suffering from food allergies.
One of the sections highlighted was a section titled Vaccinations in Patients with Egg Allergies.’ The authors wrote:
“In Summary: Patients who have generated IgE antibodies to an allergen are at risk for anaphylaxis with systemic exposure to that allergen. Thus, patients who have IgE-mediated egg allergy are at risk for anaphylaxis if injected with vaccines containing egg 17 protein.” (own emphasis)
They continued:
“More detailed information about specific egg-containing vaccines (measles, mumps, and rubella [MMR], MMR with varicella [MMRV], influenza, yellow fever, and rabies) is provided in … the Guidelines.
The EP recognizes that changes in these recommendations may occur in the future as there is an increased understanding of the risk factors for allergic reactions and as vaccine manufacturing processes improve and decrease the final egg protein content of vaccines. For the most current recommendations, health care professionals should refer to the Web sites of the American Academy of Pediatrics (AAP) and Advisory Committee for Immunization Practices (ACIP):
http://aapredbook.aappublications.org/
http://www.cdc.gov/vaccines/recs/acip/
However, despite stating that patients who have an allergy to eggs are at risk of anaphylaxis if they receive a vaccine containing the egg 17 protein, it appears that they are recommending the vaccine anyway.
I say this, because in section 5.1.11.1 they stated:
“Measles, Mumps, Rubella, and Varicella Vaccine
Guideline 31: The EP recognizes the varying consensus recommendations of the different organizations on this particular vaccine and recommends that children with egg allergy, even those with a history of severe reactions, receive vaccines for MMR and MMRV. The safety of this practice has been recognized by ACIP and AAP and is noted in the approved product prescribing information for these vaccines.” (own emphasis)
What I found interesting was the fact that the NIAID did not apply the same guidelines to any of the other vaccinations listed.
In fact, their recommendations for the flu vaccine clearly stated:
“In Summary: The EP concludes that insufficient evidence exists to recommend administering influenza vaccine, either inactivated or live-attenuated, to patients with a history of severe reactions to egg proteins. Severe reactions include a history of hives, angioedema, allergic asthma, or systemic anaphylaxis to egg proteins (or chicken proteins). Less severe or local manifestations of allergy to egg or feathers are not contraindications. However, the EP notes that egg allergy is relatively common among the very patients who would highly benefit from influenza vaccination. Such patients include children and young adults (from 6 months to 18 years old for seasonal influenza, and from 6 months to 24 years old for H1N1 influenza) and all patients with asthma. It should be noted that live-attenuated vaccine is not licensed for use in patients with asthma.” (own emphasis)
They continued:
“Although ACIP and AAP, and also the vaccine manufacturers, do not recommend influenza vaccination in patients who are allergic to egg, several publications have described different approaches to giving the influenza vaccine to patients with severe allergic reactions to egg. These approaches, which depend on the ovalbumin content and the results of SPTs or intradermal tests with the vaccine, include a single dose of vaccine, two doses of vaccine, or multiple doses. However, the evidence supporting these approaches is limited by the small numbers of patients included in each study. Moreover, data indicate that, although the vaccines are relatively safe, there remains some, albeit low, risk of systemic reactions. Also, negative SPT results do not accurately predict safety of vaccination, in that 5 percent of patients with negative SPTs had systemic reactions to vaccination.” (own emphasis)
With these recommendations in mind, we need to ask ourselves how many of our doctors are fully aware of any of these guidelines? If they are aware of this information, why are so many doctors not adhering to them?

13 Year-Old Boy Permanently Disabled from Chicken Pox Vaccine Wins His Case in Vaccine Court
A young man was recently awarded compensation in the United States Court of Federal Claims Vaccine Court, for injuries he sustained after being administered the hepatitis A and varicella vaccinations in 2009. After five long years of litigation, Health and Human Services (HHS), the Respondent in all vaccine injury cases, conceded that the varicella vaccination did in fact cause RD’s vaccine injury, transverse myelitis, which has left him a tetraplegic.
In November 2014, HHS conceded that the vaccination caused RD’s injuries. Even with this concession, his case continued for another year in the damages phase, during which time the parties continued to negotiate the amount of damages that RD would receive for his injuries. Although he was compensated for his suffering and injuries, the monetary award will never compensate for the lifelong effects this young man is suffering from his vaccine injury.
Five Long Years
RD was only 13 when his life changed forever. At a routine well-child visit in 2009, the doctor informed RD’s parents that he was due to receive the hepatitis A and varicella vaccinations. His parents complied with the doctor’s order and RD received the vaccinations.
RD’s mother explained that, at that time in RD’s state, only one dose of varicella vaccine was required and RD had already received one dose of that vaccine. This second dose that was administered to RD at this well visit was determined to be the cause of RD’s horrific injuries, and it was not even required for him, which his family didn’t realize until it was too late.
About 14 days later, RD began to experience excruciating pain shooting through his body along with tingling, numbness and paralysis of his limbs. After extensive testing and many invasive procedures, RD was diagnosed with transverse myelitis.
RD’s parents filed a case in Vaccine Court, which took over five years to settle. RD and his family faced arduous heartbreak along the way. In the ruling, a representative from the United States Department of Justice agreed that “a preponderance of the evidence establishes that petitioner’s transverse myelitis was caused-in-fact by the administration of his August 12, 2009 varicella vaccine.” [1]
RD’s lawyer, Patricia Finn, stated that:
“The injuries that RD suffered from this vaccine are severe and lifelong. Even though he has received a significant award as far as the awards in the Vaccine Court go, no amount of money will ever compensate him for what he has lost.
But RD is an amazing young man who has not let this injury stop him in any way. He has graduated high school with his class, attends a Tier 1 college, and has great aspirations that I know he will achieve despite the challenges he faces because of his injuries.”
RD’s Immune System Attacked His Spine

Autism vs. Childhood Diseases: Breaking Down The Walls Of Pro-Vaccine Ignorance
By Tami Canal On June 19, 2017
I can’t tell you how absolutely fed up I am with tragically misinformed people who proclaim that they would prefer to have an autistic child versus one with a case of the measles, mumps, chicken pox, etc.
A comment like that demonstrates immense ignorance in regards to the LIFETIME of issues that autism presents–things like social dysfunction, the inability to speak, aggression, self-destructive behavior, and a staggeringly diminished life expectancy. If you are one of the people who have ever believed measles or other infectious diseases to be worse than autism, this is for you.
Let’s take a look and examine these so-called “deadly” childhood diseases.

1. Chicken Pox (Varicella) = itchy rash with small fluid-filled blisters; 5-7 days of feeling tired and sluggish; mild fever; decreased appetite. Resolves itself.
2. Diptheria = low fever, sore throat, croup-like cough; many infections are asymptomatic or mild. Treat with antitoxin and antibiotics. Garlic juice and table salt are natural remedies to successfully treat diphtheria, as well.
3. Haemophilus influenzae Type B (Hib) = flu symptoms, stiff neck, lethargy. Treat with antibiotics for 10 days.
4. Hepatitis A = transmitted by eating food or drinking water contaminated with feces; children usually have no symptoms; when symptoms occur, they include flu-like symptoms, nausea, jaundice. Resolves itself.
5. Hepatitis B = transmitted through blood, semen, vaginal fluids; flu-like symptoms, dark urine, vomiting, jaundice; most people do not show symptoms. Acute Hep B resolves itself.
6. Human Papilloma Virus (HPV) = transmitted sexually; usually resolves itself with no symptoms; takes years to develop into cancer; regular pap screens prevent cancer; vaccine discontinued in Japan due to adverse reactions.
7. Influenza (flu) = high fever, cold symptoms, vomiting; lasts 7-10 days; Resolves itself. (Flu vaccine contains mercury [thimerosal]).
8. Measles = fever, cold symptoms, rash; 7-10 days; Resolves itself. Infection can be avoided with proper nutrition, primarily adequate levels of Vitamin A and C.
9. Meningitis = flu symptoms, stiff neck; usually caused by bacteria or virus; viral usually causes no symptoms and resolves itself; bacterial is spread through saliva (kissing, coughing); Most people who ‘carry’ the bacteria never become sick; bacterial meningitis is treated with antibiotics.
10. Mumps = fever, swelling of salivary glands; many people show no symptoms; Resolves itself within a few weeks. (There are many effective natural home remedies for mumps which are safe and provide relief from pain without any harmful side effects.)
11. Pertussis (whooping cough) = dry cough, watery eyes, slight fever, lethargy; treated with high doses of vitamin C; garlic, almond oil, honey, and onion are also effective, natural remedies to treat pertussis.
12. Pneumococcal Pneumonia = flu-like symptoms, fatigue, chills, stiff neck; Treated with antibiotics.
13. Poliomyelitis = 72% of infections cause no symptoms; 25% flu-like symptoms that last 2-5 days; 0.5% leads to more severe symptoms such as paralytic polio; only people with the paralytic infection are considered to have the disease. It is noteworthy to mention that a congressional hearing in the 1950s shed light that polio was actually the result of DDT poisoning and that the federal government and the chemical industry fabricated polio to conceal the true cause of paralysis-inducing epidemic sweeping the country. (Read more about polio here.)
14. Rotavirus = infection in the intestinal tract that causes vomiting, diarrhea, and dehydration; Children, even those that are vaccinated for rotavirus, may develop the disease more than once. A diet high in potassium, such as BRAT, will help bind the bowels and can greatly alleviate the symptoms of Rotavirus. Other natural remedies can be found here.
15. Rubella (German measles) = flu-like symptoms, swollen lymph nodes, joint pain, fatigue, rash; 1-3 days; 25 to 50% of people infected with rubella will not experience any symptoms. Resolves itself. Turmeric, licorice, and citrus are highly effective home remedies.
16. Tetanus = sudden, painful contractions of muscle groups; caused by Clostridium tetani transmitted through broken skin; Prevention is to allow wound to bleed freely. Tetanus bacteria is anaerobic – meaning oxygen will kill it.

Dr. Andrew Moulden: Every Vaccine Produces Microvascular Damage
by John P. Thomas
Health Impact News
Dr. Andrew Moulden recognized that every dose of vaccine given to a person produced microvascular damage whether or not the person was aware of the damage or had debilitating symptoms at the time the vaccines were given. He courageously stepped out of the conventional box of medical diagnosis and treatment, and gave us a new way to look at modern neurodevelopmental illnesses and syndromes.
This series of articles is intended to preserve the work of Dr. Moulden, who unexpectedly died in November of 2013. I want to acknowledge the contribution of this forward-thinking pioneer who worked to explain the truth about vaccine damage. This is article two in a series of four articles about Dr. Moulden’s life work.
As a physician and PhD researcher, he raised strong public objection to vaccine use, because he could literally see evidence of vaccine damage in the expressions of the human face. Each dose of a vaccine causes tiny strokes in the brain and in other organs of the body, which bring about a wide range of unexpected health conditions.
Dr. Moulden saw that the rapid rise in modern neurodevelopmental diseases such as autism, Alzheimer’s, and numerous other syndromes were actually caused by the same process. He saw the current epidemic of these modern diseases as having a single origin. The notion of single diseases with single causes had to be put aside, because that model could not adequately explain what we are facing in the world today.
How Vaccines and Toxins Producing a Syndrome of Closely Related Illnesses
Dr. Moulden understood that vaccines and toxins (in the air, in our water, in our homes, and in our food) were producing a syndrome of closely related illnesses. He said that it was time to begin thinking in terms of multiple causes for a syndrome that had multiple sets of symptoms.
Multiple factors can work together to trigger a single type of reaction in the body, which can then produce various sets of symptoms. Even though there were different sets of symptoms and different disease names given to each one, they were actually all part of a spectrum of diseases that he called Moulden Anoxia Spectrum Syndromes.
Learning disabilities, autism, Alzheimer’s, irritable bowel disease, Crohn’s disease, colitis, food allergies, shaken baby syndrome, sudden infant death, idiopathic seizure disorders, Gulf War syndrome, Gardasil adverse reactions, schizophrenia, Tourette’s syndrome, chronic fatigue syndrome, fibromyalgia, expressive aphasia, impaired speech skills, attention deficit disorders, silent ischemic strokes, blood clots, idiopathic thrombocytopenia purpura, Parkinson’s disease, and other modern neurodevelopmental disorders are closely related in many ways, and are part of a larger syndrome.

Slate.com tries to school Trump on vaccines. Fails.
You should watch this hilarious takedown of a Slate.com article on Trump and his Slow-Vaxxin’ ways.
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Study – Oxidative Stress and NAD+ in Ischemic Brain Injury: Current Advances and Future Perspectives
Abstract
Numerous studies have indicated oxidative stress as a key pathological factor in ischemic brain injury. One of the key links between oxidative stress and cell death is excessive activation of poly(ADP-ribose) polymerase-1 (PARP-1), which plays an important role in the ischemic brain damage in male animals. Multiple studies have also suggested that NAD+ depletion mediates PARP-1 cytotoxicity, and NAD+ administration can decrease ischemic brain injury.
A number of recent studies have provided novel information regarding the mechanisms underlying the roles of oxidative stress and NAD+-dependent enzymes in ischemic brain injury. Of particular interest, there have been exciting progresses regarding the mechanisms underlying the roles of NADPH oxidase and PARP-1 in cerebral ischemia. For examples, it has been suggested that androgen signaling and binding of PARP-1 onto estrogen receptors could account for the intriguing findings that PARP-1 plays remarkably differential roles in the ischemic brain damage of male and female animals; and some studies have suggested casein kinase 2, copper-zinc superoxide dismutase, and estrogen signaling can modulate the expression and activity of NADPH oxidase.
This review summarizes these important current advances, and proposes future perspectives for the studies on the roles of oxidative stress and NAD+ in cerebral ischemia. It is increasingly likely that future studies on NAD- and NADP-dependent enzymes, such as NADPH oxidase, PARP-1, and sirtuins, would expose novel mechanisms underlying the roles of oxidative stress in cerebral ischemia, and suggest new therapeutic strategies for treating the debilitating disease.

Natural News – Gardasil, considered the most dangerous vaccine on the market, may soon be pushed for infants
Wednesday, November 23, 2016 by: Vicki Batts
(NaturalNews) Gardasil has been the subject of controversy for many years now. In fact, it has even been regarded as one of the most dangerous vaccines on the market today. Perhaps what is most alarming about this treacherous vaccine, however, is the fact that its manufacturer, Merck & Co, now wants to begin marketing their product to infants – and trials on babies have already begun. Merck recently launched a Gardasil vaccine trial on children at least one year old, and it’s set to conclude in early 2017.
You read that right. A pharmaceutical giant is testing a vaccine for an STD on babies. It doesn’t really get more corrupt and outrageous than that, now does it?
Gardasil was developed for the STD known as HPV, and was approved by the FDA in 2006. The disease did not become of concern until the 1980s, when research first suggested that there may be a link between HPV and cervical cancer. However, whether this link actually exists has been a major point of contention. There are several hypotheses that explain why HPV may not actually cause cancer, but one particularly interesting theory was expressed by McCormack et al in their paper published by the journal Molecular Cytogenetics in 2015. The research team also raised several significant questions about the prevailing theory on the connection between HPV and cervical cancer. For example, HPV is present in 70 to 80 percent of the American adult population, so why does cervical cancer only effect one out of ever 10,000 women?
According to their paper, neither HPV nor genetic predisposition is required for the onset of cervical cancer. In fact, all of the cervical cancer cells analyzed during the course of their study contained new abnormal karyotypes. The genetic makeup of these new abnormal karyotypes suggested that the cervical cancers originated within the karyotypes, and not from a virus. A karyotype is the size, number and shape of chromosomes within an organism. Their theory, called the Karyotypic Speciation Theory, essentially suggests that “carcinomas are generated de novo from cellular chromosomes, genes and proteins, which are not immunogenic in the host of origin (just like all other cancers).” As SaneVax.org explains, in this theory, hypothetical cancer cells that are generated by viral proteins (such as HPV) would be eliminated by antiviral immunity.

Dr Tenpenny on Vit K
TinyURL.com/TenpennyVitK
#VaXism NEWS

VACCINURILE ȘI AUTOIMUNITATEA – un tratat de imunologie aplicată echilibrat; rezultatul zecilor de ani de experiență în vaccinologie și autoimunitate și a studierii unei cazuistici și literaturi de specialitate extrem de vaste, are 37 de capitole și exprimă un adevăr dramatic: o parte dintre oamenii sănătoși (despre care nu știm dacă s-ar fi îmbolnăvit vreodată) fac boli autoimune după și prin administrarea unui vaccin: lupus, vasculite, artrită reumatoidă, boli de țesut conjunctiv nediferențiate, purpură trombocitopenică, boală celiacă ETC.
« Autorii cărții sunt medici specializați în imunologie fundamentală și clinică. Este vorba de o lucrare curajoasă în condițiile vremurilor noastre deoarece trezește un spirit de prudență – altfel destul de amorțit sau bine manipulat – spirit prevazător imperios necesar de vreme ce unele guverne vor să decreteze obligativitatea vaccinării, adică să-și agreseze poporul lor cu o lege totalitară. », Dr. Pavel Chirilă, Prefață la ediția 2016.

Vaccine News – Study – INFANTS RECEIVING MERCURY-CONTAINING VACCINES DEVELOPED SPEECH DISORDERS, SLEEP DISORDERS, AND AUTISM, ACCORDING TO CDC SCIENTISTS

Dr. Andrew Moulden: Every Vaccine Produces Harm
by John P. Thomas
Health Impact News
Canadian physician Dr. Andrew Moulden provided clear scientific evidence to prove that every dose of vaccine given to a child or an adult produces harm. The truth that he uncovered was rejected by the conventional medical system and the pharmaceutical industry. Nevertheless, his warning and his message to America remains as a solid legacy of the man who stood up against big pharma and their program to vaccinate every person on the Earth.
Dr Moulden died unexpectedly in November of 2013 at age 49.
Because of the strong opposition from big pharma concerning Dr. Moulden’s research, I became concerned that the name of this brilliant researcher and his life’s work had nearly been deleted from the internet. His reputation was being disparaged, and his message of warning and hope was being distorted and buried without a tombstone.
I prepared a series of articles as a tribute to a great physician and as a memorial to a courageous individual who was not afraid to speak the truth about medical corruption and a flawed healthcare system that does more to harm health than it does to cure disease.
This is the first in a series of four articles about Dr. Moulden — the man, the physician, and the powerful advocate for ending all vaccine use. In future articles, I will summarize his detailed scientific evidence, which shows how vaccine damage occurs. I will explain the common mechanisms behind vaccine damage and how vaccines harm the health of everyone who receives them regardless of whether or not they notice any adverse reactions at the time they take the shots.
Dr. Moulden stated:
What we have done to each other [with vaccines] has produced the most profound damage to humankind by humankind in the history of humanity. And the reason why we got here is partly because of:
Our arrogance in thinking that we know everything. In physiology and medicine we do not know everything!
[Our greed] to advance our own self-interest to make money, to sell products and to advance corporate alliances. Commercialization has overtaken the fundamental human value of “do unto others as you would have others do unto you.” When society turns toward this human value, then we would all be working together for the greater good of each other. [However, other values have become more important] I don’t care whose feet I step on or how I get there as long as my American dream is realized. I don’t care who has to pay for it on the way of getting there. [1]
Dr. Moulden’s Credibility
Was Dr. Moulden a crackpot as some sources claim, or was he a brilliant physician and researcher? This series of articles will set the record straight, and summarize the contribution that his work has made to medical knowledge.
When I evaluate the credibility of people who are unknown to me, I begin by seeking answers to a few basic questions. For example: Is this person offering opinion, or can he or she back up the claims with valid science? Does he have educational credentials? Are there other physicians and scientists who support his or her beliefs and recommendations? Is this person controlled by the pharmaceutical industry, allopathic medical associations, or the US FDA (US Food and Drug Administration)? And finally, what do Quackwatch and their friends have to say about the person?
Dr. Moulden had a PhD in Clinical Psychology and Neuropsychology. He had a master’s degree in child development, and was also a medical doctor. [2] His work was respected by other researchers who don’t march to the drumbeat of the pharmaceutical companies. Dr. Moulden was a threat to the pharmaceutical industry, and their Quackwatch family of 21 related websites treated him as an enemy. [3, 4]

Vaccine Contraindications: Six People Who Should Not Be Vaccinated
The debate surrounding vaccinations is a fierce one, and personally, I don’t like to argue about it. I’m happy to make the right choices for my family while you make the right ones for yours. (I personally have suffered adverse reactions to vaccinations.) It’s ok to have different opinions, really it is. But there are a lot of folks out there who think everyone should be vaccinated, period, and those who choose not to vaccinate should be penalized or worse.
Listen. I get that people are scared and there’s a lot of fear-mongering in the media. But let’s be realistic here: vaccinations are a medical procedure. There are risks. Vaccinations are not right for everyone. There are at least six types of people in particular who should avoid vaccinations, and below, I’ll spell it out.
Vaccine Contraindications
Just like a particular surgery or prescription medication won’t work well for everyone, vaccinations are not a good choice for everyone.
Some people, in particular, are much more likely to have adverse reactions to vaccinations, including:

– Those with an autoimmune disease
– Children born to a mother with an autoimmune disease
– Anyone who is sick
– Pregnant women
– Those who have previously had a reaction to a vaccination

One size does not fit all
Clearly, vaccinations are not the right choice for everyone, and each family should decide what is right for them and their children. When parents are aware of vaccine contraindications, they can make informed and safer choices for their children.
Please share this post so that other parents can learn about vaccine contraindications and decide if vaccination is right for their children.

USA: Highest Vaccination Rate in the World Has the Worst Health
by PAUL FASSA
That “worst health” label includes a ranking of 34th in the world with infant mortality. In other words, the USA has the 34th worst infant survival with its highest rate of vaccinations. Some are directly from multiple vaccinations administered.
But the USA leads the world in infant vaccinations, those administered during the first year after their births – 26 vaccinations during that time.
The only vaccination I recall receiving during early childhood, circa 1948, was the smallpox vaccine, the one that left a circle of shallow pockmarks on the upper arm, a non-ink tattoo that proved you had received that vaccine. Months later there was the booster shot which gave me a vacation of several days away from my first grade teacher while sitting out the chicken pox.
During Naval training the mass vaccination high pressure hand held gun that replaced syringes and needles was tried on us with the polio shot. I wound up with a vacation in the base infirmary with an extended period of the flu. Between those two, there may have been a tetanus shot or two.
From the Healthy Home Economist:

-In1950, there were 3 childhood vaccines typically given when a child entered school.
-In 1983, there were 10 recommended vaccines by the age of 6 years old (24 doses, 7 injections, 4 oral doses for polio).
-In 2010, the CDC vax schedule totaled 68 doses with more than half given by the time a child was only a year and a half old.
-In 2016, the schedule has increased to 74 doses by age 17 with 53 injections and 3 oral doses of rotavirus.

The number of vaccines included in the current childhood vaccine schedule has quadrupled over the past 60 years, with several demanding multiple injections and boosters. During this exponential rise of CDC “recommended” schedules, the health of American children has plummeted.
Autoimmune diseases, learning disabilities, food allergies, chronic ailments, and childhood obesity have all risen. The overall health of this nation ranks very low compared to all other industrialized nations, dead last in most areas.
Vaccine false dogma is so heavy hardly anyone with authority, even in mainstream media, makes the connection between poor health with high vaccination rates. Instead, more, three added for 2016, are getting enforced by mandate or coerced by pediatricians who have the right to refuse medical care on kids who aren’t vaccinated.
Destroying Health with Vaccines is Good Business

50 Studies the AAP Avoided to Mention
There is a robust, worldwide body of published science from highly esteemed scientists questioning the safety of many different aspects of vaccines-how come we never hear from them? The majority of the most compelling science has been published since 2010. Below find 50 such studies to consider, sorted chronologically, and note that these studies only represent a portion of the published work implicating vaccinations in a wide variety of negative health outcomes.
The American Academy of Pediatrics made representations to President Trump in a letter dated 2/7/2017 that are utterly indefensible and inaccurate, as any rational review of the studies below quickly demonstrates. For example, the AAP wrote:
“Claims that vaccines are unsafe when administered according to expert recommendations have been disproven by a robust body of medical literature…we write to express our unequivocal support for the safety of vaccines.”
We contend that the AAP’s statements to the President are baseless, reckless, and easily refuted. The AAP’s letter alone supports the President’s desire to field a Vaccine Safety Commission and do all we can to make vaccines as safe as possible. Please click here for a list of all 50 studies detailed below.

2017
Temporal Association of Certain Neuropsychiatric Disorders Following Vaccination of Children and Adolescents A Pilot Case–Control Study
New Quality-Control Investigations on Vaccines Micro-and Nanocontamination
2016
Behavioral abnormalities in female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil
Autoimmune/Inflammatory Syndrome Induced by Adjuvants and Sjogren’s Syndrome
Combining Childhood Vaccines at One Visit Is Not Safe
Aluminum in Childhood Vaccines Is Unsafe
Aluminium in brain tissue in familial Alzheimer’s disease
2015
Evidence that Food Proteins in Vaccines Cause the Development of Food Allergies and Its Implications for Vaccine Policy
2014
Transcriptomic Analyses of Neurotoxic Effects in Mouse Brain After Intermittent Neonatal Administration of Thimerosal
A Dose-Response Relationship between Organic Mercury Exposure from Thimerosal-Containing Vaccines and Neurodevelopmental Disorders
A comparison of temporal trends in United States autism prevalence to trends in suspected environmental factors
2013
A Population-Based Cohort Study of Undervaccination in 8 Managed Care Organizations Across the United States
Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) 2013: Unveiling the pathogenic, clinical and diagnostic aspects
Aluminum in the central nervous system (CNS): toxicity in humans and animals, vaccine adjuvants, and autoimmunity
Autoimmune/inflammatory syndrome induced by adjuvants (Shoenfeld’s syndrome): clinical and immunological spectrum
A two-phase study evaluating the relationship between Thimerosal-containing vaccine administration and the risk for an autism spectrum disorder diagnosis in the United States
Human exposure to aluminium
Human Papilloma Virus Vaccine and Primary Ovarian Failure: Another Facet of the Autoimmune/Inflammatory Syndrome Induced by Adjuvants
2012
Risk of Febrile Seizures and Epilepsy After Vaccination With Diphtheria, Tetanus, Acellular Pertussis, Inactivated Poliovirus, and Haemophilus Influenzae Type b
Mechanisms of aluminum adjuvant toxicity and autoimmunity in pediatric populations
Neurologic adverse events following vaccination
The spectrum of ASIA: ‘Autoimmune (Auto-inflammatory) Syndrome induced by Adjuvants’
Relative trends in hospitalizations and mortality among infants by the number of vaccine doses and age, based on the Vaccine Adverse Event Reporting System (VAERS), 1990-2010
2011
Do aluminum vaccine adjuvants contribute to the rising prevalence of autism?
Maternal Thimerosal Exposure Results in Aberrant Cerebellar Oxidative Stress, Thyroid Hormone Metabolism, and Motor Behavior in Rat Pups; Sex- and Strain-Dependent Effects
2010
Interindividual variations in the efficacy and toxicity of vaccines
Sorting out the spinning of autism: heavy metals and the question of incidence
Influence of pediatric vaccines on amygdala growth and opioid ligand binding in rhesus macaque infants: A pilot study
The immunobiology of aluminium adjuvants: how do they really work?
Hepatitis B Vaccination of Male Neonates and Autism Diagnosis, NHIS 1997-2002
2009
Allergic Disease and Atopic Sensitization in Children in Relation to Measles Vaccination and Measles Infection
Long-term persistence of vaccine-derived aluminum hydroxide is associated with chronic cognitive dysfunction
Delayed acquisition of neonatal reflexes in newborn primates receiving a thimerosal-containing Hepatitis B vaccine: Influence of gestational age and birth weight
Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration
2008
Post-vaccination encephalomyelitis: Literature review and illustrative case
Thimerosal exposure in infants and neurodevelopmental disorders: An assessment of computerized medical records in the Vaccine Safety Datalink
Delay in diphtheria, pertussis, tetanus vaccination is associated with a reduced risk of childhood asthma?
Hepatitis B triple series vaccine and developmental disability in US children aged 1-9 years
2005
THE MERCURY USED AS A VACCINE PRESERVATIVE IS FAR MORE NEUROTOXIC THAN THE MERCURY FOUND IN FISH
Comparison of Blood and Brain Mercury Levels in Infant Monkeys Exposed to Methylmercury or Vaccines Containing Thimerosal
Thimerosal Neurotoxicity is Associated with Glutathione Depletion: Protection with Glutathione Precursors
2004
Activation of methionine synthase by insulin-like growth factor-1 and dopamine: a target for neurodevelopmental toxins and thimerosal
2002
UTAH STATE SCIENTISTS FIND AUTOIMMUNE REACTION TO MMR IN CHILDREN WITH AUTISM, INCLUDING AUTOIMMUNITY TO MYELIN BASIC PROTEIN, A BRAIN BUILDING-BLOCK
Abnormal Measles-Mumps-Rubella Antibodies and CNS Autoimmunity in Children with Autism
2001
Macrophagic myofasciitis lesions assess long-term persistence of vaccine derived aluminum hydroxide in muscle
2000
JAPANESE SCIENTISTS FIND VACCINE-STRAIN OF MEASLES IN THE GUTS OF CHILDREN WITH AUTISM
Detection and Sequencing of Measles Virus from Peripheral Mononuclear Cells from Patients with Inflammatory Bowel Disease and Autism
CDC SCIENTISTS ADMIT THAT 90% OF INFECTIOUS DISEASE MORTALITY DECREASE IN THE UNITED STATES HAPPENED BEFORE VACCINES WERE AVAILABLE
Annual Summary of Vital Statistics: Trends in the Health of Americans During the 20th Century
Iatrogenic exposure to mercury after hepatitis B vaccination in preterm infants
Effects of Diphtheria-Tetanus-Pertussis or Tetanus Vaccination on Allergies and Allergy-Related Respiratory Symptoms Among Children and Adolescents in the United States
1999
INFANTS RECEIVING MERCURY-CONTAINING VACCINES DEVELOPED SPEECH DISORDERS, SLEEP DISORDERS, AND AUTISM, ACCORDING TO CDC SCIENTISTS
Increased risk of developmental neurologic impairment after high exposure to thimerosal-containing vaccine in first month of life
INFECTIOUS DISEASE RATES DECLINED PRECIPITOUSLY IN THE UNITED STATES IN THE 20TH CENTURY BEFORE THE IMPLEMENTATION OF A NATIONAL VACCINE PROGRAM
Trends in Infectious Disease Mortality in the United States During the 20th Century
CDC SCIENTISTS FIND CHILDREN GIVEN THE MMR VACCINE SHED THE MEASLES VIRUS FOR AT LEAST 2 WEEKS AFTER GETTING THE VACCINE, MAKING THEM VECTORS TO SPREAD MEASLES
Detection of Measles Virus RNA in Urine Specimens from Vaccine Recipients

Autism related studies

Autism related studies
Fever plus mitochondrial disease could be risk factors for autistic regression.

Abstract
Autistic spectrum disorders encompass etiologically heterogeneous persons, with many genetic causes. A subgroup of these individuals has mitochondrial disease. Because a variety of metabolic disorders, including mitochondrial disease show regression with fever, a retrospective chart review was performed and identified 28 patients who met diagnostic criteria for autistic spectrum disorders and mitochondrial disease. Autistic regression occurred in 60.7% (17 of 28), a statistically significant increase over the general autistic spectrum disorder population (P < .0001). Of the 17 individuals with autistic regression, 70.6% (12 of 17) regressed with fever and 29.4% (5 of 17) regressed without identifiable linkage to fever or vaccinations. None showed regression with vaccination unless a febrile response was present. Although the study is small, a subgroup of patients with mitochondrial disease may be at risk of autistic regression with fever. Although recommended vaccinations schedules are appropriate in mitochondrial disease, fever management appears important for decreasing regression risk.

Is fever a predictive factor in the autism spectrum disorders?

If it is confirmed that autistic children with high fevers are of higher functionality, it is possible for preventive intervention programs to be developed where children are exposed to the least possible chemical drugs intervention (antipyretics, antibiotics, etc.) or even selective vaccination. Further experimental, epidemiological and clinical studies are necessary to investigate the above.

Prevalence of autism spectrum disorders–Autism and Developmental Disabilities Monitoring Network, 14 sites, United States, 2008.

RESULTS:
For 2008, the overall estimated prevalence of ASDs among the 14 ADDM sites was 11.3 per 1,000 (one in 88) children aged 8 years who were living in these communities during 2008. Overall ASD prevalence estimates varied widely across all sites (range: 4.8-21.2 per 1,000 children aged 8 years). ASD prevalence estimates also varied widely by sex and by racial/ethnic group. Approximately one in 54 boys and one in 252 girls living in the ADDM Network communities were identified as having ASDs. Comparison of 2008 findings with those for earlier surveillance years indicated an increase in estimated ASD prevalence of 23% when the 2008 data were compared with the data for 2006 (from 9.0 per 1,000 children aged 8 years in 2006 to 11.0 in 2008 for the 11 sites that provided data for both surveillance years) and an estimated increase of 78% when the 2008 data were compared with the data for 2002 (from 6.4 per 1,000 children aged 8 years in 2002 to 11.4 in 2008 for the 13 sites that provided data for both surveillance years). Because the ADDM Network sites do not make up a nationally representative sample, these combined prevalence estimates should not be generalized to the United States as a whole.

Bactericidal Antibiotics Induce Mitochondrial Dysfunction and Oxidative Damage in Mammalian Cells

Abstract
Prolonged antibiotic treatment can lead to detrimental side effects in patients, including ototoxicity, nephrotoxicity, and tendinopathy, yet the mechanisms underlying the effects of antibiotics in mammalian systems remain unclear. It has been suggested that bactericidal antibiotics induce the formation of toxic reactive oxygen species (ROS) in bacteria. We show that clinically relevant doses of bactericidal antibiotics—quinolones, aminoglycosides, and β-lactams—cause mitochondrial dysfunction and ROS overproduction in mammalian cells. We demonstrate that these bactericidal antibiotic–induced effects lead to oxidative damage to DNA, proteins, and membrane lipids. Mice treated with bactericidal antibiotics exhibited elevated oxidative stress markers in the blood, oxidative tissue damage, and up-regulated expression of key genes involved in antioxidant defense mechanisms, which points to the potential physiological relevance of these antibiotic effects. The deleterious effects of bactericidal antibiotics were alleviated in cell culture and in mice by the administration of the antioxidant N-acetyl-L-cysteine or prevented by preferential use of bacteriostatic antibiotics. This work highlights the role of antibiotics in the production of oxidative tissue damage in mammalian cells and presents strategies to mitigate or prevent the resulting damage, with the goal of improving the safety of antibiotic treatment in people.