Vaccine News – “It took me 7 years to teach him how to chew”

Big Pharma is the biggest, baddest, most dangerous drug dealer in the world.

Study – Clinical clues for autoimmunity and neuroinflammation in patients with autistic regression.
RESULTS:
The charts of 206 children with ASD and 33 diagnosed with autistic regression variant were reviewed. The incidence of febrile illness in the 6 months prior to initial parental concern was significantly higher in the children with autistic regression compared with those with ASD (30% vs 0%; p<0.001). The overall prevalence of familial autoimmunity was also higher in children with autistic regression compared with those with ASD (33% vs 12%; p<0.001). Type 1 diabetes and autoimmune thyroiditis were both more common in families with children with autistic regression. Other non-immune risk factors did not differ between the two groups.
INTERPRETATION:
Our findings suggest that predisposition to autoimmunity, and immune/inflammatory activation, may be associated with autistic regression.

The Vaccine Science Contradiction
The modern human race has been thriving and evolving for at least the last 200,000 years according to Anthropologists. Vaccines have only been around for less than 200 years. So how did humans survive for the 199,800 years before that. The answer is that you are born with a fully functioning immune system, capable of self-immunization. Vaccines are not required for immunization. Your body does it automatically. Just like 10,000 generations of your ancestors who also survived without vaccines. If your immune system didn’t work automatically to keep you alive then you would have never been born.

The Amazing Dr. Franz from Orlando.
#gooddoctor #pediatrician #vaxxed #praybig

Episode 7 of The Truth About Vaccines is NOW PLAYING. Tonight’s episode is all about Vaccine alternatives and Freedom of Choice. Super important for you to see.

Aluminium Adjuvants Have Never Been Approved For Use In Vaccination
In a press release, describing Professor Exley’s latest paper, the founder of the Dwoskin Family Foundation, Mrs. Claire Dwoskin wrote:
“Research at Keele University led by Professor Christopher Exley aims to understand the toxicity of aluminum adjuvants in vaccinations and their latest findings are now published in Nature’s ‘Scientific Reports.
In a project funded by the Medical Research Council (MRC) and the Dwoskin Foundation the group at Keele investigated the relationship between the physicochemical properties of aluminum adjuvants and the immune response. Specifically, they show that the reaction of the aluminum adjuvant at the injection site will determine its subsequent fate and therefore its activity both at the injection site and away from the injection site.
One form of aluminum adjuvant which is most commonly used in vaccines is an aluminum hydroxyphosphate salt and is more toxic at the injection site than the second form of aluminum adjuvant, also commonly used in vaccines, aluminum oxyhydroxide salt. However, the latter is more easily loaded into immune reactive cells with the possibility to be transported throughout the body. It is suggested by the Keele research that this loading of aluminum into viable cells offers a mechanism whereby significant amounts of aluminum, a known neurotoxin, might be translocated throughout the body and even across the blood brain barrier and into the central nervous system.” [2, 3, 4]
Countless Childhood Vaccinations Contain Aluminum

Shingles Vaccine Zostavax Is Causing What It’s Designed To Prevent
April 19, 2017
By now I think most people have seen the commercials on television telling us that if we’ve ever had the chicken pox at any point in our lives, then the shingles virus is already inside of us. As it stands right now, there is a vaccine for shingles called Zostavax, but what we’re finding out now about this vaccine makes it seem like it might be pretty dangerous or at least cause some side effects that are actually the same as what we’d see from shingles. Ring of Fire’s Farron Cousins talks with Attorney Troy Bouk about the dangers associated with Zostavax

Dying 13 Year Old Diagnoses Her Own HPV Vaccine Injury that Stumped Doctors
April 20, 2017
Health Impact News Editor Comments
One of the true tragedies in modern medicine is the refusal to consider vaccine injuries when diagnosing or treating disease. The U.S. government acknowledges that people die and are injured by vaccines, as is evidenced from the Department of Justice’s quarterly reports on settlements in vaccine court: http://vaccineimpact.com/vaccine-injuries-and-deaths-compensated-through-vaccine-court/
However, medical students are given no training in recognizing or treating vaccine injuries, and no studies are ever conducted to find out why some children suffer from vaccines while others do not.
In this story out of the U.K., a 13 year old girl accomplishes something her doctors could not do, and that was diagnose her own life-threatening disease by researching all of the possibilities, without excluding vaccine injuries, something that apparently handicapped her doctors. She discovered that she suffered from an autoimmune disease after receiving the HPV vaccine.

Professor Hamamoto talks about the persecution he faces at UC Davis after speaking the truth to his students. #Vaxxed #DarrylHamamoto #SenatorPan #SB277 #OperationPaperClip
Camera, editing and sound by Joshua Coleman.
YOUTUBE:

It took me 7 years to teach him how to chew
Nancy Kirkman’s son was severely injured by vaccines at 3 months of age. The family has been subjected to immense heartache and cruelty.
Interview recorded on February 2, 2017 in San Diego, California.
YOUTUBE LINK:

#VaxxedNation #VaxxedNationTour #RFKcommission #Truth #Science #Vaxxed #Tears #VaxxedTears

Baby’s Health Rapidly Declines After Receiving 13 Vaccines at One Time – Mom Accused of Abuse for Disagreeing with Doctors
April 20, 2017
Durenda and her son KJ on his 1st birthday, before he had 8 shots in one day.
by Health Impact News/MedicalKidnap.com Staff
A young Georgia mother had no idea that a routine trip to the pediatrician’s office for her son’s 1 year check-up would change her son’s life forever, and leave her fighting the state for custody of her own son. When the nurse-practitioner told her that her son was a little behind on his shots and they would need to catch up, Durenda Whitehead didn’t question the need for the vaccines. She did, however, question the safety of giving 13 vaccines at once.
Durenda’s pediatrician assured her that it was fine:
I can give up to 20 at one time.
Durenda was unaware of a research study published in the summer 2016 edition of the Journal of American Physicians and Surgeons by Neil Z. Miller entitled, “Combining Childhood Vaccines at One Visit Is Not Safe.” In a press release, Miller wrote:
Our study showed that infants who receive several vaccines concurrently…are significantly more likely to be hospitalized or die when compared with infants who receive fewer vaccines simultaneously.
Baby’s Health Declines After 13 Vaccines in One Day
During his first year of life, little KJ had a few bouts with respiratory illness, but on January 16, 2017, he was healthy, happy, and active.

Study – Combining Childhood Vaccines at One Visit Is Not Safe
Neil Z. Miller

#VaXism NEWS
#Texas Well done Texans For Vaccine Choice!!
Thank you freedom Reps!
Zedler let TIP have it!!
#HB2249

Skip that Newborn Vitamin K Shot
How much synthetic vitamin K is in the shot? Shockingly, the national standard mandated by most states for US hospitals to administer is over 100 times the infant’s RDA of this nutrient. Since studies have linked large doses of vitamin K with childhood cancers and leukemia, this large dose of synthetic K administered within minutes of birth seems questionable at best.
The fact is that medical science still does not know that much about the metabolic fate of vitamin K. Little to no unmetabolized vitamin K shows up in urine or bile. This is disturbing given the fact that vitamin K is a fat soluble vitamin and therefore has the potential to accumulate in body tissues. More disturbing is that the liver of a newborn does not begin to function until 3 or 4 days after birth. As a result, this little being has very limited to no ability to detoxify the large dose of synthetic vitamin K and all other the dangerous ingredients in the injection cocktail including:

– Phenol (carbolic acid – a poisonous substance derived from coal tar)
– Benzyl alcohol (preservative)
– Propylene glycol (better known as “edible” antifreeze)
– Acetic acid (astringent, antimicrobial agent)
– Hydrochloric acid
– Lecithin
– Castor oil

The manufacturer’s insert included with the shot includes the following warning:
Severe reactions, including fatalities, have occurred during and immediately after intravenous injection of phytonadione [synthetic Vitamin K] even when precautions have been taken to dilute the vitamin and avoid rapid infusion ….
The manufacturer’s insert is no exaggeration of the risks. On October 17, 2013, a case of anaphylactic shock in a newborn from the synthetic vitamin K shot was reported making the possibility of death from this shot a a very real side effect
Source:
Anaphylactic shock due to vitamin K in a newborn and review of literature
Abstract
Newborn infants are born with an immature innate immunity. They are less likely to develop anaphylaxis since their immune system is weaker than older infants and children. There are only a few reports of side effects after vitamin K injection in neonates although prophylaxis against hemorrhagic disease of the newborn with this drug has been in routine practice in all over the world for many years. We herein report a case of anaphylactic shock developing after the intramuscular administration of vitamin K1 in a newborn. To our knowledge, this patient is the first case of neonatal anaphylactic shock developing due to intramuscular administration of vitamin K1. We suggest the clinicians should be aware of this possibility of potentially fatal adverse effect occurring with intramuscular administration of vitamin K1.
Does this make any sense to you? It makes absolutely no sense to me. How could anyone say that this shot is safe and effective for newborns?

Is There Vaccine Cause-And-Correlation Regarding The Dramatic Rise In Children’s Chronic Diseases?
Posted on April 18, 2017
Since the introduction of CDC’s hyper-vaccine schedule, which saw children’s vaccines schedules increase from 10 to 69 vaccines after the 1986  National Childhood Vaccine Injury Act was passed into law, very young children are contracting chronic “old age type” diseases early in life—an anomaly heretofore not experienced demographically.
First off, obesity rates (2013-2014) for U.S. children between the ages of 6 and 11 years was 17.4% [1]  Three leading causes of death in children between 1 and 4 years of age were congenital malformations, deformations and chromosomal abnormalities. [1]   Mandatory pregnancy vaccines have impact upon growing fetuses.  For children 5 to 14 years of age, it’s cancer! [1]   However, according to Contemporary Pediatrics [2] 2014 published data, cancer was the second leading cause of death for children between 1 and 9 years of age (11.8% of deaths).  For infants, the third leading cause of death was sudden infant death syndrome (SIDS, 8.4%)—something that seemingly appeared in pediatric medicine context concomitantly with the increase in mandated vaccines, specifically with multi-valent vaccines, i.e., numerous vaccines given at one time.  However, the CDC’s information about SIDS claims vaccines do not cause SIDS.  Try telling that to many parents.
According to Focus for Health, 27% of U.S. children live with chronic diseases! [3]   That website asks the question, “Why are today’s children sicker than ever before?”  The answer: “While genes may play a role in obesity, asthma and ADHD, environmental and social changes are behind the surge, researchers said.”5 [Children Sicker Now Than in Past, Harvard Report Says] [4]   That Harvard Report found a fourfold increase in childhood obesity; twice the asthma rate since the 1980s; and regarding diabetes: White children’s rate was 26.1 per 100,000; black children, 25.4 per 100,000; American Indian youth, 25 per 100,000 including the highest rate of type-2 diabetes. [4] According to the CDC, one in six children in the USA has a developmental disability, which represents a 17% rise between 1997 and 2008. [7]
Furthermore, are you aware the cost of fully vaccinating a child has increased by 2,700% during the last decade?  Vaccines are extremely profitable for manufacturers, but very costly in terms of adverse health effects, medical bills for parents, and social issues (day care, school, jobs, welfare benefits, etc.) for infants, toddlers, teens and adults.

The Dangers Of Vaccines and Vaccination
Vaccines Are Unavoidably Unsafe
According to the US Food and Drug Administration, safety assessments for vaccines have not often included toxicity studies because vaccines have not been viewed as inherently toxic. Yet vaccines are legally defined as unavoidably unsafe.
It is not just childhood vaccines that come with substantial risk. Influenza vaccines, vaccines for sexually transmitted diseases, and others contain similar risks for adverse events. Also troubling is that vaccination is recommended now for pregnant women, even though vaccine package inserts clearly state they have not been tested on pregnant women, so the effects on the fetus can’t be known.
In the 1960s only a handful of childhood vaccines were given. The current CDC recommended vaccine schedule for children now has over 30 vaccines by the time a child turns 6 and an additional potential for up to 30 more by the time they reach 18. Could this increase be linked to our declining health? For example, currently:

    One in six children in the US has a learning disability
Over 50% suffer from some type of chronic illness.
Cancer is the leading cause of death in our children
Autism rates have soared from 1 in 10,000 in 1990 to 1 in 68 today

Since genetic mutations change slowly over generations, we must look to environmental causes for these changes. While other environmental toxins certainly are at play in these statistics, disregarding the potential role to the amounts of toxin injected into children through vaccines is not only bad public policy, it is bad science. By disregarding the role of vaccines in our statistics for infant mortality and chronic diseases, we could be doing more harm than good in mandating, or even advising, them.
Vaccine Adverse Effects: Known Risks
The list of adverse side effects for vaccines is long and troubling. A quick scan of the Vaccine Injury Table kept by the Health Resource Center for the U.S. Department of Health and Human Services reveals that compensation for injury is possible from a variety of the most common vaccines given to children.
Adverse events are the reason the Vaccine Injury Compensation Program has paid out over 3 billion dollars from 1988 – 2016 despite the fact that only 1 in 5 claims receives any compensation at all. Studies reveal that a small fraction of those injured by vaccines ever file any claim at all since most doctors reject the notion that a problem was caused by a vaccine despite the reality that such problems are listed on the manufacturers product insert. You can learn more by reading this fficial document: National Vaccine Injury Compensation Program.
Vaccines: Adverse Effects List
Various vaccines are linked to the following serious adverse reactions:

    Anaphylactic shock
Aseptic meningitis, meningitis
Bell’s palsy, facial palsy, isolated cranial nerve palsy
Blood disorders such as thrombocytopenic purpura (a disease that destroys platelets need for clotting)
Brachial neuritis
Cerebrovascular accident (stroke)
Chronic rheumatoid arthritis
Convulsions, seizures, febrile seizure
Death
Encephalopathy and encephalitis (brain swelling)
Hearing loss
Guillain-Barré syndrome
Immune system disorders
Lymphatic system disorders
Multiple sclerosis
Myocarditis
Nervous system disorders
Neurological syndromes including autism
Paralysis and myelitis including transverse myelitis
Peripheral neuropathy
Pneumonia and lower respiratory infections
Skin and tissue disorders including eczema
Sudden infant death syndrome (SIDS)
Tinnitus (ringing in the ears)
Vaccine-strain versions of chicken pox, measles, mumps, polio, influenza, meningitis, yellow fever, and pertussis
Vasculitis (inflammation of blood vessels)

 

 

Birth Control Shots For Men Prevent Pregnancy, But Cause Mood Swings, Depression

Birth Control Shots For Men Prevent Pregnancy, But Cause Mood Swings, Depression
GENEVA, Switzerland (CBS) — Birth control shots for men are an effective form of contraception but the side effects are a problem.
An international study just found they’re almost as effective as the pill for women. It was published in the Journal of Clinical Endocrinology & Metabolism.
The injections work by using hormones to drastically lower sperm count.
Of the 266 married men who participated in the study, only 4 became fathers.
Sounds promising but the gender gap in contraceptive use may not close anytime soon.
For one thing the pharmaceutical companies aren’t throwing a whole lot of money at the idea.
“Their concern may be there’s a lack of profitability, maybe there is a question of gender bias,” says CBS medical contributor Dr. Tara Narula. “There’s a concern of regulatory hurdles. In addition, it’s not as easy to stop 1,500 sperm that are produced per second as opposed to one egg per month.”
Another concern are the side effects. Researchers actually stopped the study early due to mood changes and depression in some of the participants.
Researchers say other side effects were acne, injection site pain, and increased libido.

Study: Efficacy and Safety of an Injectable Combination Hormonal Contraceptive for Men
Results:
Of the 320 participants, 95.9 of 100 continuing users (95% confidence interval [CI], 92.8–97.9) suppressed to a sperm concentration less than or equal to 1 million/mL within 24 weeks (Kaplan-Meier method). During the efficacy phase of up to 56 weeks, 4 pregnancies occurred among the partners of the 266 male participants, with the rate of 1.57 per 100 continuing users (95% CI, 0.59–4.14). The cumulative reversibility of suppression of spermatogenesis after 52 weeks of recovery was 94.8 per 100 continuing users (95% CI, 91.5–97.1). The most common adverse events were acne, injection site pain, increased libido, and mood disorders. Following the recommendation of an external safety review committee the recruitment and hormone injections were terminated early.
Conclusions:
The study regimen led to near-complete and reversible suppression of spermatogenesis. The contraceptive efficacy was relatively good compared with other reversible methods available for men. The frequencies of mild to moderate mood disorders were relatively high.

Whooping cough resurgence due to vaccinated people not knowing they’re infectious?

Whooping cough resurgence due to vaccinated people not knowing they’re infectious?
Date:
June 24, 2015
Source:
Santa Fe Institute
Summary:
The dramatic resurgence of whooping cough is due, in large part, to vaccinated people who are infectious but who do not display the symptoms, suggests a new study.
…vaccinated people who are infectious but who do not display the symptoms of whooping cough, suggesting that the number of people transmitting without symptoms may be many times greater than those transmitting with symptoms.
The problem is, the newer vaccines might not block transmission. A January 2014 study in PNAS by another research team demonstrated that giving baboons acellular pertussis vaccines prevented them from developing symptoms of whooping cough but failed to stop transmission.
Building on that result, Althouse and Scarpino used whopping cough case counts from the CDC, genomic data on the pertussis bacteria, and a detailed epidemiological model of whooping cough transmission to conclude that acellular vaccines may well have contributed to — even exacerbated — the recent pertussis outbreak by allowing infected individuals without symptoms to unknowingly spread pertussis multiple times in their lifetimes.

Public Health Officials Know: Recently Vaccinated Individuals Spread Disease

Washington, D.C., March 3, 2015 (GLOBE NEWSWIRE) — Physicians and public health officials know that recently vaccinated individuals can spread disease and that contact with the immunocompromised can be especially dangerous. For example, the Johns Hopkins Patient Guide warns the immunocompromised to “Avoid contact with children who are recently vaccinated,” and to “Tell friends and family who are sick, or have recently had a live vaccine (such as chicken pox, measles, rubella, intranasal influenza, polio or smallpox) not to visit.”1
A statement on the website of St. Jude’s Hospital warns parents not to allow people to visit children undergoing cancer treatment if they have received oral polio or smallpox vaccines within four weeks, have received the nasal flu vaccine within one week, or have rashes after receiving the chickenpox vaccine or MMR (measles, mumps, rubella) vaccine.2
“The public health community is blaming unvaccinated children for the outbreak of measles at Disneyland, but the illnesses could just as easily have occurred due to contact with a recently vaccinated individual,” says Sally Fallon Morell, president of the Weston A. Price Foundation. The Foundation promotes a healthy diet, non-toxic lifestyle and freedom of medical choice for parents and their children. “Evidence indicates that recently vaccinated individuals should be quarantined in order to protect the public.”
Scientific evidence demonstrates that individuals vaccinated with live virus vaccines such as MMR (measles, mumps and rubella), rotavirus, chicken pox, shingles and influenza can shed the virus for many weeks or months afterwards and infect the vaccinated and unvaccinated alike.

Officials at the U.S. Centers for Disease Control and Prevention (CDC) say the best way to prevent pertussis is to get vaccinated. But data from the Vermont Department of Health (DOH) suggest that going through the pertussis vaccination regimen is not a sure-fire way to ward off the highly contagious disease.

In 2014, an outbreak of whooping cough (pertussis) broke out in the San Diego area. Of the 621 individuals who were infected, nearly all of them were completely up to date on all preventive vaccinations. If vaccines are given to protect from disease, how could this happen?
San Diego public health official Dr. Wilma Wooten argued that the cause was related to a decrease in the protection offered by vaccines after the first year. This answer is most revealing, in that it speaks to the actual efficacy of vaccines. It also shows that the concept of herd immunity is largely myth—and completely misunderstood.
The theory of herd immunity states that when a critical mass of the population (usually stipulated at 95%) is vaccinated against a disease, the possibility of outbreaks is eliminated. This is the main argument that is used to shame parents who wish to refuse certain vaccinations for their children: by not vaccinating, they put the health of the “herd” at risk.
However, if vaccines start losing effectiveness after the first year, as Dr. Wooten says, then constant revaccination would be required, since the immunity offered is only temporary for most vaccines. Achieving the required rate of protection is virtually impossible under this paradigm.
Of course, if we look back over the decades and note the lack of rampant epidemics in our nation, while remembering that vaccine protection is in perpetual decline, the myth of herd immunity quickly unravels. Our society has never achieved this level of herd immunity, yet not a single major outbreak of disease has occurred.
The argument for herd immunity was actually developed out of observations of natural immunity, not vaccination. Statisticians observed that populations were protected when sufficient members contracted the wild form of a disease, and subsequently acquired lifelong immunity. With vaccines, however, evidence shows that unvaccinated children may catch infectious diseases from vaccinated children. What is true of natural immunity is not true of vaccination.

Adverse Effects of Pertussis and Rubella Vaccines (1991)
Description
Parents have come to depend on vaccines to protect their children from a variety of diseases. Some evidence suggests, however, that vaccination against pertussis (whooping cough) and rubella (German measles) is, in a small number of cases, associated with increased risk of serious illness.
This book examines the controversy over the evidence and offers a comprehensively documented assessment of the risk of illness following immunization with vaccines against pertussis and rubella. Based on extensive review of the evidence from epidemiologic studies, case histories, studies in animals, and other sources of information, the book examines:
The relation of pertussis vaccines to a number of serious adverse events, including encephalopathy and other central nervous system disorders, sudden infant death syndrome, autism, Guillain-Barre syndrome, learning disabilities, and Reye syndrome.
The relation of rubella vaccines to arthritis, various neuropathies, and thrombocytopenic purpura.
The volume, which includes a description of the committee’s methods for evaluating evidence and directions for future research, will be important reading for public health officials, pediatricians, researchers, and concerned parents.

Whooping cough increase related to current vaccine
The move to an artificially created vaccine for whooping cough is behind an increase in cases of the deadly disease in the US, a new study suggests.
The findings highlight the need to do similar research in Australia where whooping cough cases have spiralled upward in the past decade, co-author Associate Professor Manoj Gambhir, from the University of Monash, says.
In 2012 the US saw the highest number of pertussis (whooping cough) cases since 1955.
At the same time there has been a shift in the age group reporting the largest number of cases from adolescents to 7 to 11 year olds.
In the paper, published today in PLOS Computational Biology, Gambhir and colleagues use mathematical modelling of 60 years of pertussis disease data to determine what best explains this increase.

A Change in Vaccine Efficacy and Duration of Protection Explains Recent Rises in Pertussis Incidence in the United States
Published: April 23, 2015
PDF version
Abstract
Over the past ten years the incidence of pertussis in the United States (U.S.) has risen steadily, with 2012 seeing the highest case number since 1955. There has also been a shift over the same time period in the age group reporting the largest number of cases (aside from infants), from adolescents to 7–11 year olds. We use epidemiological modelling and a large case incidence dataset to explain the upsurge. We investigate several hypotheses for the upsurge in pertussis cases by fitting a suite of dynamic epidemiological models to incidence data from the National Notifiable Disease Surveillance System (NNDSS) between 1990–2009, as well as incidence data from a variety of sources from 1950–1989. We find that: the best-fitting model is one in which vaccine efficacy and duration of protection of the acellular pertussis (aP) vaccine is lower than that of the whole-cell (wP) vaccine, (efficacy of the first three doses 80% [95% CI: 78%, 82%] versus 90% [95% CI: 87%, 94%]), increasing the rate at which disease is reported to NNDSS is not sufficient to explain the upsurge and 3) 2010–2012 disease incidence is predicted well. In this study, we use all available U.S. surveillance data to: 1) fit a set of mathematical models and determine which best explains these data and 2) determine the epidemiological and vaccine-related parameter values of this model. We find evidence of a difference in efficacy and duration of protection between the two vaccine types, wP and aP (aP efficacy and duration lower than wP). Future refinement of the model presented here will allow for an exploration of alternative vaccination strategies such as different age-spacings, further booster doses, and cocooning.

FDA NEWS RELEASE – FDA study helps provide an understanding of rising rates of whooping cough and response to vaccination
For Immediate Release: Nov. 27, 2013
A new study is helping to provide a better understanding of vaccines for whooping cough, the common name for the disease pertussis. Based on an animal model, the study conducted by the U.S. Food and Drug Administration (FDA) and published November 25, 2013, in The Proceedings of the National Academy of Sciences, shows that acellular pertussis vaccines licensed by the FDA are effective in preventing the disease among those vaccinated, but suggests that they may not prevent infection from the bacteria that causes whooping cough in those vaccinated or its spread to other people, including those who may not be vaccinated.
While the reasons for the increase in cases of whooping cough are not fully understood, multiple factors are likely involved, including diminished immunity from childhood pertussis vaccines, improved diagnostic testing, and increased reporting. With its own funds plus support from the National Institutes of Health (NIH), the FDA conducted the study to explore the possibility that acellular pertussis vaccines, while protecting against disease, might not prevent infection.

Study- Acellular pertussis vaccines protect against disease but fail to prevent infection and transmission in a nonhuman primate model
Although pertussis resurgence is not completely understood, we hypothesize that current acellular pertussis (aP) vaccines fail to prevent colonization and transmission.
To test our hypothesis, infant baboons were vaccinated at 2, 4, and 6 mo of age with aP or whole-cell pertussis (wP) vaccines and challenged with
pertussis at 7 mo. Infection was followed by quantifying colonization in nasopharyngeal washes and monitoring leukocytosis and symptoms. Baboons vaccinated with aP were
protected from severe pertussis-associated symptoms but not from colonization, did not clear the infection faster than naïve animals, and readily transmitted
pertussis to unvaccinated contacts. Vaccination with wP induced a more rapid clearance compared with naïve and aP-vaccinated animals. By comparison, previously infected
animals were not colonized upon secondary infection. Although all vaccinated and previously infected animals had robust serum antibody responses, we found key differences in T-cell immunity.
Previously infected animals and wP-vaccinated animals possess strong pertussis-specific T helper 17 (Th17) memory and Th1 memory,whereas aP vaccination induced a Th1/Th2 response instead. The
observation that aP, which induces an immune response mismatched to that induced by natural infection, fails to prevent colonization or transmission provides a plausible explanation for the
resurgence of pertussis and suggests that optimal control of pertussis will require the development of improved vaccine

Whooping cough increase related to current vaccine

Whooping cough increase related to current vaccine
The move to an artificially created vaccine for whooping cough is behind an increase in cases of the deadly disease in the US, a new study suggests.
The findings highlight the need to do similar research in Australia where whooping cough cases have spiralled upward in the past decade, co-author Associate Professor Manoj Gambhir, from the University of Monash, says.
In 2012 the US saw the highest number of pertussis (whooping cough) cases since 1955.
At the same time there has been a shift in the age group reporting the largest number of cases from adolescents to 7 to 11 year olds.
In the paper, published today in PLOS Computational Biology, Gambhir and colleagues use mathematical modelling of 60 years of pertussis disease data to determine what best explains this increase.

A Change in Vaccine Efficacy and Duration of Protection Explains Recent Rises in Pertussis Incidence in the United States
Published: April 23, 2015
PDF – Study
Abstract
Over the past ten years the incidence of pertussis in the United States (U.S.) has risen steadily, with 2012 seeing the highest case number since 1955. There has also been a shift over the same time period in the age group reporting the largest number of cases (aside from infants), from adolescents to 7–11 year olds. We use epidemiological modelling and a large case incidence dataset to explain the upsurge. We investigate several hypotheses for the upsurge in pertussis cases by fitting a suite of dynamic epidemiological models to incidence data from the National Notifiable Disease Surveillance System (NNDSS) between 1990–2009, as well as incidence data from a variety of sources from 1950–1989. We find that: the best-fitting model is one in which vaccine efficacy and duration of protection of the acellular pertussis (aP) vaccine is lower than that of the whole-cell (wP) vaccine, (efficacy of the first three doses 80% [95% CI: 78%, 82%] versus 90% [95% CI: 87%, 94%]), increasing the rate at which disease is reported to NNDSS is not sufficient to explain the upsurge and 3) 2010–2012 disease incidence is predicted well. In this study, we use all available U.S. surveillance data to: 1) fit a set of mathematical models and determine which best explains these data and 2) determine the epidemiological and vaccine-related parameter values of this model. We find evidence of a difference in efficacy and duration of protection between the two vaccine types, wP and aP (aP efficacy and duration lower than wP). Future refinement of the model presented here will allow for an exploration of alternative vaccination strategies such as different age-spacings, further booster doses, and cocooning.

FDA NEWS RELEASE – FDA study helps provide an understanding of rising rates of whooping cough and response to vaccination
For Immediate Release: Nov. 27, 2013
A new study is helping to provide a better understanding of vaccines for whooping cough, the common name for the disease pertussis. Based on an animal model, the study conducted by the U.S. Food and Drug Administration (FDA) and published November 25, 2013, in The Proceedings of the National Academy of Sciences, shows that acellular pertussis vaccines licensed by the FDA are effective in preventing the disease among those vaccinated, but suggests that they may not prevent infection from the bacteria that causes whooping cough in those vaccinated or its spread to other people, including those who may not be vaccinated.
While the reasons for the increase in cases of whooping cough are not fully understood, multiple factors are likely involved, including diminished immunity from childhood pertussis vaccines, improved diagnostic testing, and increased reporting. With its own funds plus support from the National Institutes of Health (NIH), the FDA conducted the study to explore the possibility that acellular pertussis vaccines, while protecting against disease, might not prevent infection.

Study- Acellular pertussis vaccines protect against disease but fail to prevent infection and transmission in a nonhuman primate model
Although pertussis resurgence is not completely understood, we hypothesize that current acellular pertussis (aP) vaccines fail to prevent colonization and transmission.
To test our hypothesis, infant baboons were vaccinated at 2, 4, and 6 mo of age with aP or whole-cell pertussis (wP) vaccines and challenged with
pertussis at 7 mo. Infection was followed by quantifying colonization in nasopharyngeal washes and monitoring leukocytosis and symptoms. Baboons vaccinated with aP were
protected from severe pertussis-associated symptoms but not from colonization, did not clear the infection faster than naïve animals, and readily transmitted
pertussis to unvaccinated contacts. Vaccination with wP induced a more rapid clearance compared with naïve and aP-vaccinated animals. By comparison, previously infected
animals were not colonized upon secondary infection. Although all vaccinated and previously infected animals had robust serum antibody responses, we found key differences in T-cell immunity.
Previously infected animals and wP-vaccinated animals possess strong pertussis-specific T helper 17 (Th17) memory and Th1 memory,whereas aP vaccination induced a Th1/Th2 response instead. The
observation that aP, which induces an immune response mismatched to that induced by natural infection, fails to prevent colonization or transmission provides a plausible explanation for the
resurgence of pertussis and suggests that optimal control of pertussis will require the development of improved vaccine