REQUIRED

Vaccination Status Is Temporary, Boosters for Life Required

Analysis by Dr. Joseph Mercola

Source: https://media.mercola.com/ImageServer/Public/2021/November/PDF/vaccination-status-is-temporary-pdf.pdf

STORY AT-A-GLANCE

  • Major health organizations across the world have changed several definitions of medical terms, including the definitions for “vaccine,” “herd immunity” and “pandemic,” which in turn have a significant impact on everyday life. The U.S. Centers for Disease Control and Prevention is now considering changing the definition of “fully vaccinated”
  • Israel and Australia have already pushed back the goal post. Citizens must get a booster at six months after their second jab or lose all “passport freedoms.” Australian premier Daniel Andrews has actually stated that, going forward, life for the vaccinated will “be about the maintenance of your vaccination status”
  • Updating the definition of “fully vaccinated” will also have the side effect of skewing mortality statistics, giving government another round of ammunition for false claims. We’ve been repeatedly told that we’re now in a pandemic of the unvaccinated, and this lie will gain new traction once fully vaccinated people are dropped into the unvaccinated category, six months after their last dose
  • The National Basketball Association is urging players who got a single-dose Janssen shot as recently as two months ago to get a Pfizer or Moderna booster, or face game-day testing starting December 1, 2021. Players who completed a two-dose regimen are being told to get a booster at the six-month mark
  • The Occupational Safety and Health Administration (OSHA) is already talking about expanding its COVID-19 vaccine rule, so that small businesses with fewer than 100 employees may also be required to force the jab on their employees or face stiff fines. The public comment period closes December 6, 2021

Study – The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets

Source: https://pubmed.ncbi.nlm.nih.gov/33907312/

Abstract

SARS-CoV-2 entry requires sequential cleavage of the spike glycoprotein at the S1/S2 and the S2′ cleavage sites to mediate membrane fusion. SARS-CoV-2 has a polybasic insertion (PRRAR) at the S1/S2 cleavage site that can be cleaved by furin. Using lentiviral pseudotypes and a cell-culture-adapted SARS-CoV-2 virus with an S1/S2 deletion, we show that the polybasic insertion endows SARS-CoV-2 with a selective advantage in lung cells and primary human airway epithelial cells, but impairs replication in Vero E6, a cell line used for passaging SARS-CoV-2. Using engineered spike variants and live virus competition assays and by measuring growth kinetics, we find that the selective advantage in lung and primary human airway epithelial cells depends on the expression of the cell surface protease TMPRSS2, which enables endosome-independent virus entry by a route that avoids antiviral IFITM proteins. SARS-CoV-2 virus lacking the S1/S2 furin cleavage site was shed to lower titres from infected ferrets and was not transmitted to cohoused sentinel animals, unlike wild-type virus. Analysis of 100,000 SARS-CoV-2 sequences derived from patients and 24 human postmortem tissues showed low frequencies of naturally occurring mutants that harbour deletions at the polybasic site. Taken together, our findings reveal that the furin cleavage site is an important determinant of SARS-CoV-2 transmission.