Oral Contraceptives and Autism

Oral Contraceptives and Autism
The mechanisms by which oral contraceptives instigate neurodevelopmental changes is slowly emerging. It appears that in addition to preventing pregnancy, synthetic hormones like ethinylestradiol, used in most birth control formulations, initiate epigenetic alterations in the oocytes (eggs) causing persistent changes in expression of the estrogen receptor beta gene (ERβ). When those eggs become fertilized and conception ensues, the changes in the estrogen receptor gene impact the expression of autism and other neurodevelopmental disorders.
Ethinylestradiol is an Endocrine Disruptor
Ethinylestradiol is a known endocrine disruptor. Anything that disrupts endogenous hormones can be considered an endocrine disruptor. Evidence is emerging that ethinylestradiol may trigger what is called DNA methylation of the estrogen receptor gene. This then causes decreased messenger RNA resulting in impaired brain estrogen signaling in offspring [2]. Let’s think more deeply about this.
Methylation means that, by way of a chemical process, a gene is turned on (hypomethylation) or turned off (methylation) by an enzyme or protein. Researchers believe that methylation is one of a number of mechanisms by which environmental interactions influence genetic activity. In this case, ethinylestradiol silences or turns off some important processes that are associated with estrogen signaling, namely receptor activity.
Methylation and other epigenetic reactions influence health and disease processes across generations. This is called transgenerational transmission. So, I suspect that the deleterious effects of ethinylestradiol on the estrogen receptor gene are transgenerational. This is possible because the estrogen receptor gene may be an imprinted gene. Imprinting is a dynamic epigenetic phenomenon by which certain genes are expressed in a parent-of-origin manner. If the allele, an alternative form of the same gene, inherited from the father is imprinted, it is thereby silenced, and only the allele from the mother is expressed. If the allele from the mother is imprinted, then only the allele from the father is expressed.

Study: The link between oral contraceptive use and prevalence in autism spectrum disorder
Autism spectrum disorder (ASD) is a group of developmental disabilities that include full syndrome
autism, Asperger’s syndrome, and other pervasive developmental disorders. The identified prevalence of ASD has increased in a short time period across multiple studies causing some to conclude that it has reached epidemic proportions in the U.S.
Many possible explanations for the rise in numbers of individuals diagnosed with ASD have been offered and yet, causes and contributing factors for ASD are inadequately understood. Current evidence suggests that both genetics and environment play a part in causing ASD.
One possible risk factor for the increase in prevalence has been profoundly overlooked in the existing biomedical and epidemiologic literature. As the prevalence of ASD has risen in the last sixty years, so has the prevalence of the usage of the oral contraceptives and other modern hormonal delivery methods. In 1960 about one million American women were using oral contraceptives, today close to 11 million women in the U.S. use oral contraceptives. Eighty-two percent of sexually active women in the U.S. have used oral contraceptives at some point during their reproductive years. Thus, the growth in use of progesterone/estrogen-based contraceptives in the United State has reached near-ubiquitous levels among women in the child-bearing age range.
The suppression of ovulation produced by estrogen–progesterone is an indisputable abnormality. It is logical to consider the outcome of the ovum that would have been normally released from the ovary during ovulation. To date there is no comprehensive research into the potential neurodevelopmental effects of oral contraceptive use on progeny. The issue has been only sparsely considered in the biomedical literature. This article hypothesizes that the compounds, estrogen and progesterone, used in oral contraceptives modify the condition of the oocyte and give rise to a potent risk factor that helps explain the recent increase in the prevalence of ASD’s.
This hypothesis does not propose to delineate the cause of autism. Rather, it attempts to explain the recent dramatic increase in prevalence and point the way for further study that will lead to causal examination

Study: An epigenetic basis for autism spectrum disorder risk and oral contraceptive use
In the United States 1 in 68 children are diagnosed with autism spectrum disorder (ASD). Although the etiology is unknown, many scientists believe ASD is caused by a combination of genetic and environmental factors and/or epigenetic factors. The widespread use of oral contraceptives is one environmental risk factor that has been greatly overlooked in the biomedical literature. Oral contraceptives, synthetic hormones created to imitate natural human hormones and disrupt endogenous endocrine function to inhibit pregnancy, may be causing the harmful neurodevelopmental effects that result in the increased prevalence of ASD.
It is conceivable that the synthetic hormones repeatedly assault the oocyte causing persistent changes in expression of the estrogen receptor beta gene. Ethinylestradiol, a known endocrine
disruptor, may trigger DNA methylation of the estrogen receptor beta gene causing decreased mRNA resulting in impaired brain estrogen signaling in progeny. In addition, it is possible the deleterious effects are transgenerational as the estrogen receptor gene and many of its targets may be imprinted and the methylation marks protected from global demethylation and preserved through fertilization and beyond to progeny generations. This article will delineate the hypothesis that ethinylestradiol activates DNA methylation of the estrogen receptor beta gene causing decreased mRNA resulting in diminished brain estrogen signaling in offspring of mothers exposed to oral contraceptives. Considering the detrimental epigenetic and transgenerational effects proposed, it calls for further study.

Potential Link between Oral Contraceptives and Autism
Oral Contraceptives are Endocrine Disruptors
One of the compounds found in oral contraceptives is the synthetic estrogen called Ethinylestradiol (EE2). EE2 is a known endocrine disrupting compound (EDC) capable of causing harm to the endocrine system and to progeny. Studies show that EDCs have the potential to do harm by adversely affecting the sensitive hormonal pathways that regulate reproductive function in a variety of species including humans. The National Institute for Environmental Health Sciences (NIEHS) reports that EDCs may disturb the endocrine system and produce adverse developmental, reproductive, neurological, and immune effects in humans and wildlife. The NIEHS indicates that research also shows that the highest risk of endocrine disruption occurs during prenatal and early postnatal development. Humans might be exposed to EDCs through foods, beverages, pesticides, and cosmetics, but the case with EE2 is particularly striking because EE2 exposure in female humans occurs at a pharmacologically effective dose, administered every day, for extended periods of time.
Hormones and their signaling pathways are essential to normal functioning of all tissues and organs in invertebrate and vertebrate species. Normal communication of the endocrine system can be disrupted by exogenous substances like EDCs, which have the same attributes as endogenous hormones. EDCs possess the ability to be active at low concentrations and like endogenous hormones, they are able to bind to receptors at very low concentrations. Therefore, endocrine disruption can occur from low-dose exogenous hormone exposure or from hormonally active substances that interfere with receptors for other hormonally assisted processes. In addition, some EDCs are able to interact with multiple hormone receptors concurrently. They can work simultaneously to create additive or synergistic effects not observed with the individual compounds. EDCs can act on a number of physiological processes in a tissue specific manner. And, as with endogenous hormones, it is often not feasible to extrapolate low-dose effects from the high-dose effects of EDCs. Thus the mimicry of estradiol (E2) and the information that such compounds can cause harmful effects on reproduction and the endocrine system provide mechanistic evidence that EE2 found in oral contraceptives may adversely affect the oocyte or developing embryo.

Update: Oral Contraceptive Use and Autism
In the realm of environmental risk factors, the oral contraceptive hypothesis I first proposed is compelling. As a group of agents, there are explicit documented mechanisms through which oral contraceptives can impact the oocyte and/or the developing embryo. Additional reasons for considering the role of oral contraceptives and autism include:

The exposure concentration is directly administered and pharmacologically effective.
The exposure to the endocrine disruptor may be of larger magnitude than other environmental exposures that mostly occur through passive secondary means.
A temporal correlation exists between the increased prevalence of oral contraceptive use and the increased prevalence of autism spectrum disorders over the last fifty years.
The possibility exists that the effects of EE2 could intensify over generations due to transgenerational transmission of altered epigenetic programming.
Continued exposure across generations could possibly impart sensitivity to developing autism spectrum disorders.

Do We Really Understand Oral Contraceptives?
While researching my hypothesis linking oral contraceptive use to the development of autism in children, I wondered about why so many women are still using a drug that has dangerous side-effect and could cause neurodevelopmental disorders in offspring. The simple answer seems to be lack of accurate medical information. Not only do individual women lack critical information about the pill, but the support systems women depend on for advice and help with decision-making also seem to lack information about the pill.
All health choices are complex and influenced by multiple variables that all interact. There are multiple levels, underlying determinants of health behaviors, which are relevant for understanding why oral contraceptives are still the primary method of choice in the United States. The following influencing factors are not exhaustive, but do shed light on why pill use is so prevalent in the U.S. Simply put, we don’t know better.

NaturalNews: CDC scientist confirms Donald Trump is right about vaccines and autism

CDC scientist confirms Donald Trump is right about vaccines and autism
The statement pertained to a 2004 study published in the journal Pediatrics. The doctor revealed that he and his colleagues intentionally destroyed data in the study which showed that African American MMR-vaccinated boys under the age of three had a 340 percent increased risk for autism. According to the whistleblower, the CDC held a meeting of scientists to discuss whether they should destroy the evidence. The authors decided to scrap their findings. Fortunately, Dr. Thompson saved computer files and hard copies of the omitted data for legal reasons.(3)

MMR vaccines cause 340% increased risk of autism in African American infants
Vaccines do cause autism, and the U.S. Centers for Disease Control and Prevention (CDC) has been lying about this fact for years, according to newly uncovered information. As it turns out, the CDC fudged some numbers in a 2003 study it conducted on the MMR vaccine that, if honestly reported, would have revealed a 340 percent increased risk of autism among male African American infants.
But the CDC instead shrunk down the sample size of this study to conceal any possible correlation between MMR and autism, in the end publishing what amounts to fraudulent data that has repeatedly be used as “evidence” that vaccines do not cause autism. To the contrary, there are major effects of the MMR vaccine that at least three CDC officials who supported the bogus study are now culpable for withholding from the public, possibly resulting in untold thousands of cases of autism.

The Polio Vaccine Cancer Cover-up & Cancer risk associated with simian virus 40 contaminated polio vaccine

Cancer risk associated with simian virus 40 contaminated polio vaccine.
RESULTS:
Our analysis indicates increased rates of ependymomas (37%), osteogenic sarcomas (26%), other bone tumors (34%) and mesothelioma (90%) among those in the exposed as compared to the unexposed birth cohort.
CONCLUSIONS:
These data suggest that there may be an increased incidence of certain cancers among the 98 million persons exposed to contaminated polio vaccine in the U.S.; further investigations are clearly justified.

The Polio Vaccine Cancer Cover-up
The polio vaccines developed in the 1950s by Jonas Salk and Albert Sabin allegedly eradicated one of the most feared diseases of the 20th century. The media hailed the success of these vaccines as a modern day miracle. However, the polio story has a much darker side that has mostly been kept a secret.
Both Sabin’s live virus vaccine given orally and Salk’s inactivated virus vaccine given by injection were far from perfect. In fact, in 1955 the vaccine used in Berkley, California infected some 200 children, leaving several dead and many paralyzed. Yet this incident proved minor compared to what was later discovered.
In order to grow large quantities of the poliovirus, scientists needed to use Rhesus monkey kidney cells, which carried many different viruses. As a result, their polio vaccine became contaminated with a cancer-causing virus carried by these monkeys. This vaccine was given to almost 100 million people.
The virus found in this particular polio vaccine was SV40, or simian virus. It is present in human tumors, and research has established it to be a contributing factor in the rise of many types of cancer, including mesothelioma, bone, and brain cancer.
When the government became aware of this, it was downplayed for fear the public would stop accepting vaccination.

Study: Increased Risk of Noninfluenza Respiratory Virus Infections Associated With Receipt of Inactivated Influenza Vaccine

Increased Risk of Noninfluenza Respiratory Virus Infections Associated With Receipt of Inactivated Influenza Vaccine
We randomized 115 children to trivalent inactivated influenza vaccine (TIV) or placebo. Over the following 9 months, TIV recipients had an increased risk of virologically-confirmed non-influenza infections (relative risk: 4.40; 95% confidence interval: 1.31-14.8). Being protected against influenza, TIV recipients may lack temporary non-specific immunity that protected against other respiratory viruses.
Influenza vaccination is effective in preventing influenza virus infection and associated morbidity among school-aged children [1, 2]. The potential for temporary nonspecific immunity between respiratory viruses after an infection and consequent interference at the population level between epidemics of these viruses has been hypothesized, with limited empirical evidence to date, mainly from ecological studies [3–15]. We investigated the incidence of acute upper respiratory tract infections (URTIs) associated with virologically confirmed respiratory virus infections in a randomized controlled trial of influenza vaccination.

EIGHT EDUCATED PARENTS share the many reasons why they no longer vaccinate, or never vaccinated

 

EIGHT EDUCATED PARENTS share the many reasons why they no longer vaccinate, or never vaccinated. Reasons include: near death, uncontrollable screaming, horrible adverse reactions, getting the disease for which vaccinated against, high fever, vomiting, seizures, skin reactions, vaccines are poison, natural immunity is superior, high risk, cancer, aborted fetal cells, population control, vaccines cannot be made safe, and more

This campaign challenges you to LEARN THE RISK of vaccination. Do the RESEARCH. Know the ingredients. Build up your natural immunity — the ONLY type that truly works

This campaign challenges you to LEARN THE RISK of vaccination. Do the RESEARCH. Know the ingredients. Build up your natural immunity — the ONLY type that truly works.
The vaccine schedule has tripled since the 1980s and a generation of children are suffering. Why? Because the vaccine market is VERY profitable — annually worth tens of billions in the US alone with exponential growth opportunities. There are 271 new vaccines under development. The government is trying to make ALL vaccines mandatory (53 on the childhood schedule alone, over 130 on the adult schedule) — first for kids, then adults (google)
Why don’t you hear about this in the media? Because pharma accounts for at least 40% of advertising dollars — media censorship at it’s best. Pharma also spends billions on marketing their drugs to medical schools, doctors, universities and legislators. Pharma is the second biggest lobby group in Washington DC.
Because vaccines are not classified as standard pharmaceutical drugs, they undergo far LESS safety testing and 90% of the studies are funded by pharma, which profits off the vaccine.

The received documents from the CDC show that in 2003 a 340% risk of autism in African American boys related to the MMR vaccine was discovered and then hidden due to pressure from senior officials

The received documents from the CDC show that in 2003 a 340% risk of autism in African American boys related to the MMR vaccine was discovered and then hidden due to pressure from senior officials. The CDC researchers then recalculated their results by removing a population to get the results that were desired. Even with the recalculated data from the original report a significant risk of autism due to the MMR is found and can be seen in the IOM presentation of the original study, highlighted on page 29 and 31.

Dr. Harper explained in her presentation that the cervical cancer risk in the U.S. is already extremely low, and that vaccinations are unlikely to have any effect upon the rate of cervical cancer in the United States

Dr. Harper explained in her presentation that the cervical cancer risk in the U.S. is already extremely low, and that vaccinations are unlikely to have any effect upon the rate of cervical cancer in the United States.  In fact, 70% of all HPV infections resolve themselves without treatment in a year, and the number rises to well over 90% in two years.  Harper also mentioned the safety angle.  All trials of the vaccines were done on children aged 15 and above, despite them currently being marketed for 9-year-olds.  So far, 15,037 girls have reported adverseside effects from Gardasil™ alone to the Vaccine Adverse Event Reporting System (VAERS), and this number only reflects parents who underwent the hurdles required for reporting adverse reactions.  At the time of writing, 44 girls are officially known to have died from these vaccines.  The reported side effects include Guillian Barré Syndrome (paralysis lasting for years, or permanently — sometimes eventually causing suffocation), lupus, seizures, blood clots, and brain inflammation.  Parents are usually not made aware of these risks.  Dr. Harper, the vaccine developer, claimed that she was speaking out, so that she might finally be able to sleep at night.  ’About eight in every ten women who have been sexually active will have HPV at some stage of their life,’ Harper says.  ’Normally there are nosymptoms, and in 98 per cent of cases it clears itself.  But in those cases where it doesn’t, and isn’t treated, it can lead to pre-cancerous cells which may develop into cervical cancer.’

Vaccines cause cancer in cats at their injection site and, according to the Journal of Veterinary Medicine,August 2003, vaccines cause cancer in dogs at their injection sites

Vaccines cause cancer in cats at their injection site and, according to the Journal of Veterinary Medicine,August 2003, vaccines cause cancer in dogs at their injection sites.  Vaccines cause autoimmune haemolytic anaemia (JVM, Vol 10, No. 5, September/ October 1996; Merck Veterinary Manual), andarthritis (BVJ, May 1995 and Am Coll Vet Intern Med, 2000; 14:381).  Epilepsy is a symptom of encephalitis, which, as we already know, can be caused by vaccines.
According to Dr Larry Glickman and his team at Purdue University, serum and foreign proteins in vaccines can cause autoimmunity (i.e. cancer, leukaemia, organ failure, etc.).  This research also indicates that genetic damage is possible, since vaccinated dogs developed autoantibodies to attack their own DNA.  Research from the University of Geneva echoes this finding.
http://www.wethepeoplereport.com/corruption/big-pharma-intentionally-harming-pets/
According to Dr Jean W Dodds, an eminent vet and researcher, both allergic and autoimmune diseases have been rising since the introduction of modified live virus vaccines.  Autoimmune diseases are where the body attacks self; they include cancer, leukaemia, thyroid disease, Addisons, Grave’s disease, autoimmune haemolytic anaemia, rheumatoid arthritis, diabetes, lupus, thrombocytopenia, organ failure, skin inflammations, and more.

Vaccinations have saved many pets’ lives over the years, but they aren’t without risk. Now, with new research showing that immunity may last longer than once thought, veterinary experts say it’s safer to decrease the frequency of most shots that typically have been given every year.
Veterinarians have suspected for years that annual vaccinations for cats and dogs aren’t necessary, but large, well-controlled studies just didn’t exist to prove it one way or the other. With the exception of rabies vaccine, the U.S. Department of Agriculture doesn’t require data beyond one year for any vaccine.
Three-year interval recommended
“Current vaccine protocol is to properly immunize puppies and kittens with two or three doses, starting later than we used to, maybe at eight weeks and not earlier than six weeks,” Dodds says. “Then you can give a booster at one year and either repeat it every three years, stagger it by giving one vaccine per year instead of combination vaccines, or do titers instead.” Titers are tests that measure the level of antibodies in the blood, which would indicate that immunity still exists.
That recommended three-year interval was a compromise decision. “Annual boosters for the core vaccinations are excessive for most dogs and cats,” says veterinarian Link Welborn of North Bay Animal and Bird Hospital in Tampa, Fla., and a member of the most recent panel of veterinarians that revised vaccination guidelines for dogs and cats. “Limited studies suggest that booster vaccinations for many of the core vaccinations last for at least seven years. However, given the limited number of animals involved in these studies, three years seemed like a reasonable compromise.”
There’s also an advantage to giving single rather than combination vaccines. “Giving more vaccinations increases the likelihood of side effects,” Welborn says. “Separating vaccinations allows the veterinarian to determine which vaccine caused a side effect if one occurs.”
If you’re concerned that your dog or cat will develop a vaccine-related health problem, but you want to make sure they’re protected against disease, annual titers are an economical alternative.

You’ve undoubtedly seen them in your mailbox. Cute little reminder cards from your vet that it’s time for Beauregard’s annual vaccinations. But after looking a bit closer at the risks and benefits of these vaccines, you might want to paws before making that appointment.
Could these vaccines not only be unnecessary, but actually harmful to your pet’s health?
Absolutely.
A study of more than 2,000 cats and dogs in the United Kingdom by Canine Health Concern showed a 1 in 10 risk of adverse reactions from vaccines. This contradicts what the vaccine manufacturers report for rates of adverse reactions, which is “less than 15 adverse reactions in 100,000 animals vaccinated” (0.015 percent).
Additionally, adverse reactions of small breeds are 10 times higher than large breeds, suggesting standard vaccine doses are too high for smaller animals.

Study

Results—4,678 adverse events (38.2/10,000 dogs vaccinated) were associated with administration of 3,439,576 doses of vaccine to 1,226,159 dogs. The VAAE rate decreased significantly as body weight increased. Risk was 27% to 38% greater for neutered versus sexually intact dogs and 35% to 64% greater for dogs approximately 1 to 3 years old versus 2 to 9 months old. The risk of a VAAE significantly increased as the number of vaccine doses administered per office visit increased; each additional vaccine significantly increased risk of an adverse event by 27% in dogs ≤ 10 kg (22 lb) and 12% in dogs > 10 kg.
Conclusions and Clinical Relevance—Young adult small-breed neutered dogs that received multiple vaccines per office visit were at greatest risk of a VAAE within 72 hours after vaccination. These factors should be considered in risk assessment and risk communication with clients regarding vaccination. (J Am Vet Med Assoc 2005;227:1102–1108)

Supreme Court Ruling: Vaccines are Unavoidably Unsafe

Supreme Court Ruling: Vaccines are Unavoidably Unsafe

CRASH COURSE: Vaccine Injury Act of 1986 in SB277 California
Limited online access to 40 participants! We encourage users to gather in small groups and review the outline and links below prior to meeting so we can teach each other and discover ways to fix this very BROKEN law in a state that is forcing vaccines on our children in order to get childcare and an education!  We know adult mandates are coming.

Stories about vaccine injury:

Vaccine Injury Stories

General Recommendations on Immunization & Timing and Spacing of Vaccines

Adverse Effects of Vaccines: Evidence and Causality.

Predicting post-vaccination autoimmunity: Who might be at risk?

Vaccinations have been used as an essential toolin the fight against infectious diseases, and succeeded in improving public health.
However, adverse effects, including autoimmune conditions may occur following vaccinations (autoimmune/inflammatory syndrome induced
by adjuvants–ASIA syndrome). It has been postulated that autoimmunity could be triggered or enhanced by the vaccine immunogen contents,
as well as by adjuvants, which are used to increase the immune reaction to the immunogen. Fortunately, vaccination-related ASIA is uncommon.
Yet, by defining individuals at risk we may further limit the number of individuals developing post-vaccination ASIA.
In this perspective we defined four groups of individuals who might be susceptible to develop vaccination-induced ASIA: patients with prior
post-vaccination autoimmune phenomena, patients with a medical history of autoimmunity, patients with a history of allergic reactions,
and individuals who are prone to develop autoimmunity (having a family history of autoimmune diseases; presence of autoantibodies; carrying
certain genetic profiles, etc.).© 2014 Elsevier Ltd. All rights reserved.

Autoimmune disease

Epidemiologic Tenets of Causality
Epidemiology is the study of the causes of disease. Continually advancing for hundreds of years, it is the scientific discipline which focuses on the identification of cause and effect. Traditionally, it has been associated with the identification of the cause of disease (e.g. the identification of polluted water sources as the cause of gastrointestinal illness in London).  It is also associated with the identification of an effective treatment for a disease (e.g. the role of citrus fruit ingestion in the prevention of scurvy).
Over the course of study, epidemiologists have postulated a series of tenets or conditions that must be in place in order for the causative relationship to be identified. These tenets are
Through the use of research timing and research directionality, scientists work to demonstrate these seven tenets, and thereby build a strong causative argument.

Safety of Vaccines Used for Routine Immunization in the United States.

Vaccine Safety Scientific  Agenda