Study – Human papilloma virus vaccine and primary ovarian failure: another facet of the autoimmune/inflammatory syndrome induced by adjuvants.
US National Library of Medicine
National Institutes of Health – Oct 2013
Colafrancesco S – 1, Perricone C, Tomljenovic L, Shoenfeld Y.
1 Zabludowicz Center for Autoimmune Diseases Sheba Medical Center, Tel-Hashomer, Israel; Rheumatology Unit, Department of Internal Medicine and Medical Specialities, Sapienza University of Rome, Rome, Italy.
Post-vaccination autoimmune phenomena are a major facet of the autoimmune/inflammatory syndrome induced by adjuvants (ASIA) and different vaccines, including HPV, have been identified as possible causes.
METHOD OF STUDY:
The medical history of three young women who presented with secondary amenorrhea following HPV vaccination was collected. Data regarding type of vaccine, number of vaccination, personal, clinical and serological features, as well as response to treatments were analyzed.
All three patients developed secondary amenorrhea following HPV vaccinations, which did not resolve upon treatment with hormone replacement therapies. In all three cases sexual development was normal and genetic screen revealed no pertinent abnormalities (i.e., Turner’s syndrome, Fragile X test were all negative). Serological evaluations showed low levels of estradiol and increased FSH and LH and in two cases, specific auto-antibodies were detected (antiovarian and anti thyroid), suggesting that the HPV vaccine triggered an autoimmune response. Pelvic ultrasound did not reveal any abnormalities in any of the three cases. All three patients experienced a range of common non-specific post-vaccine symptoms including nausea, headache, sleep disturbances, arthralgia and a range of cognitive and psychiatric disturbances. According to these clinical features, a diagnosis of primary ovarian failure (POF) was determined which also fulfilled the required criteria for the ASIA syndrome.
We documented here the evidence of the potential of the HPV vaccine to trigger a life-disabling autoimmune condition. The increasing number of similar reports of post HPV vaccine-linked autoimmunity and the uncertainty of long-term clinical benefits of HPV vaccination are a matter of public health that warrants further rigorous inquiry.
Study – Association of spontaneous abortion with receipt of inactivated influenza vaccine containing H1N1pdm09 in 2010-11 and 2011-12.
US National Library of Medicine
National Institutes of Health – Sep 2017
Donahue JG – 1, Kieke BA – 2, King JP – 3, DeStefano F – 4, Mascola MA – 5, Irving SA – 6, Cheetham TC – 7, Glanz JM – 8, Jackson LA – 9, Klein NP – 10, Naleway AL – 11, Weintraub E – 12, Belongia EA – 13.
1 Marshfield Clinic Research Institute, 1000 N. Oak Ave, Marshfield, WI 54449, United States. Electronic address: firstname.lastname@example.org.
2 Marshfield Clinic Research Institute, 1000 N. Oak Ave, Marshfield, WI 54449, United States. Electronic address: email@example.com.
3 Marshfield Clinic Research Institute, 1000 N. Oak Ave, Marshfield, WI 54449, United States. Electronic address: firstname.lastname@example.org.
4 Centers for Disease Control and Prevention, Immunization Safety Office, 1600 Clifton Road NE, MS-D26 Atlanta, GA 30333, United States. Electronic address: email@example.com.
5 Marshfield Clinic, Department of Obstetrics and Gynecology, 1000 N. Oak Ave, Marshfield, WI 54449, United States. Electronic address: firstname.lastname@example.org.
6 Kaiser Permanente Northwest, 3800 N. Interstate Ave, Portland, OR 97227, United States. Electronic address: email@example.com.
7 Kaiser Permanente Southern California, 100 S. Los Robles Ave., 2nd Floor, Pasadena, CA 91101, United States. Electronic address: firstname.lastname@example.org.
8 Kaiser Permanente Colorado, 10065 E. Harvard, Suite 300, Denver, CO 80231, United States. Electronic address: email@example.com.
9 Group Health Research Institute, 1730 Minor Avenue, Suite 1600, Seattle, WA 98101, United States. Electronic address: firstname.lastname@example.org.
10 Kaiser Permanente Northern California, 1 Kaiser Plaza, 16th Floor, Oakland, CA 94612, United States. Electronic address: Nicola.Klein@kp.org.
11 Kaiser Permanente Northwest, 3800 N. Interstate Ave, Portland, OR 97227, United States. Electronic address: Allison.Naleway@kpchr.org.
12 Centers for Disease Control and Prevention, Immunization Safety Office, 1600 Clifton Road NE, MS-D26 Atlanta, GA 30333, United States. Electronic address: email@example.com.
13 Marshfield Clinic Research Institute, 1000 N. Oak Ave, Marshfield, WI 54449, United States. Electronic address: firstname.lastname@example.org.
Inactivated influenza vaccine is recommended in any stage of pregnancy, but evidence of safety in early pregnancy is limited, including for vaccines containing A/H1N1pdm2009 (pH1N1) antigen. We sought to determine if receipt of vaccine containing pH1N1 was associated with spontaneous abortion (SAB).
We conducted a case-control study over two influenza seasons (2010-11, 2011-12) in the Vaccine Safety Datalink. Cases had SAB and controls had live births or stillbirths and were matched on site, date of last menstrual period, and age. Of 919 potential cases identified using diagnosis codes, 485 were eligible and confirmed by medical record review. Exposure was defined as vaccination with inactivated influenza vaccine before the SAB date; the primary exposure window was the 1-28days before the SAB.
The overall adjusted odds ratio (aOR) was 2.0 (95% CI, 1.1-3.6) for vaccine receipt in the 28-day exposure window; there was no association in other exposure windows. In season-specific analyses, the aOR in the 1-28days was 3.7 (95% CI 1.4-9.4) in 2010-11 and 1.4 (95% CI 0.6-3.3) in 2011-12. The association was modified by influenza vaccination in the prior season (post hoc analysis). Among women who received pH1N1-containing vaccine in the previous influenza season, the aOR in the 1-28days was 7.7 (95% CI 2.2-27.3); the aOR was 1.3 (95% CI 0.7-2.7) among women not vaccinated in the previous season. This effect modification was observed in each season.
SAB was associated with influenza vaccination in the preceding 28days. The association was significant only among women vaccinated in the previous influenza season with pH1N1-containing vaccine. This study does not and cannot establish a causal relationship between repeated influenza vaccination and SAB, but further research is warranted.
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How to accept Jesus Christ as your personal Saviour
1 Corinthians 15 Authorized (King James) Version (AKJV)
1 Moreover, brethren, I declare unto you the gospel which I preached unto you, which also ye have received, and wherein ye stand;
2 by which also ye are saved, if ye keep in memory what I preached unto you, unless ye have believed in vain.
3 For I delivered unto you first of all that which I also received, how that Christ died for our sins according to the scriptures;
4 and that he was buried, and that he rose again the third day according to the scriptures:
Hebrews 6 Authorized (King James) Version (AKJV)
1 Therefore leaving the principles of the doctrine of Christ, let us go on unto perfection; not laying again the foundation of repentance from dead works, and of faith toward God,
2 of the doctrine of baptisms, and of laying on of hands, and of resurrection of the dead, and of eternal judgment.
3 And this will we do, if God permit.
4 For it is impossible for those who were once enlightened, and have tasted of the heavenly gift, and were made partakers of the Holy Ghost,
5 and have tasted the good word of God, and the powers of the world to come,
6 if they shall fall away, to renew them again unto repentance; seeing they crucify to themselves the Son of God afresh, and put him to an open shame.
7 For the earth which drinketh in the rain that cometh oft upon it, and bringeth forth herbs meet for them by whom it is dressed, receiveth blessing from God:
8 but that which beareth thorns and briers is rejected, and is nigh unto cursing; whose end is to be burned.