French scientists sound the alarm about aluminum in vaccines — crickets from media and health authorities
PARIS, France — Roman K. Gherardi and his colleagues from the Université Paris Est Créteil (“UPEC”)in France issued a worldwide warning in late 2016 about the aluminum adjuvant used in childhood vaccines. Their paper, published in the highly-respected journal Toxicology, is deeply distrubing for any parent contemplating vaccinating their child according to the present schedule recommended by the American Centers for Disease Control (“CDC”). And, it’s highly likely that this is the first time you’ve ever heard about it.It’s safe to say that this study’s conclusions have revolutionized our understanding of aluminum adjuvant, the kind used in most children’s vaccines.The French study authors were very concerned about the widespread use of aluminum adjuvant: “Concerns about its [aluminum adjuvant’s] safety emerged following recognition of its unexpectedly long-lasting biopersistence within immune cells in some individuals, and reports of chronic fatigue syndrome, cognitive dysfunction, myalgia, dysautonomia and autoimmune/inflammatory features temporally linked to multiple Al-containing vaccine administrations.”
Journal of Toxicology – 28 November 2016
Study – Non-linear dose-response of aluminium hydroxide adjuvant particles: Selective low dose neurotoxicity
Guillemette Crépeaux a , b , * , 2 , Housam Eidi a , c , Marie-Odile David c , Yasmine Baba-Amer a , Eleni Tzavara d , Bruno Giros d , François-Jérôme Authier a , Christopher Exley e , Christopher A. Shaw f , Josette Cadusseau a , g , 1 ,Romain K. Gherardi a,1
a Inserm U955 E10, Université Paris Est Créteil (UPEC), Créteil, France
b Ecole Nationale Vétérinaire d’Alfort,Maisons-Alfort,France
c Inserm U1204, Université Evry Val d’ Essonne (UEVE),Evry,France
d Inserm U1130, CNRS UMR 8246, UPMC UM CR18,Paris, France
e Birchall Centre, Keele University,Staffordshire,UK
f Department of Ophthalmology, University of British Columbia,Vancouver,BC,Canada
g Faculté des Sciences&TechnologiesUPEC,Créteil,France
Aluminium (Al) oxyhydroxide (Alhydrogel 1), the main adjuvant licensed for human and animal vaccines, consists of primary nanoparticles that spontaneously agglomerate. Concerns about its safety emerged following recognition of its unexpectedly long-lasting biopersistence within immune cells in some individuals, and reports of chronic fatigue syndrome, cognitive dysfunction, myalgia, dysautonomia and autoimmune/inflammatory features temporally linked to multiple Al-containing vaccine administrations. Mouse experiments have documented its capture and slow transportation by monocyte-lineage cells from the injected muscle to lymphoid organs and eventually the brain. The present study aimed at evaluating mouse brain function and Al concentration 180 days after injection of various doses of Alhydrogel 1 (200, 400 and 800 mg Al/kg of body weight) in the tibialis anterior muscle in adult female CD1 mice. Cognitive and motor performances were assessed by 8 validated tests, microglial activation by Iba-1 immunohistochemistry, and Al level by graphite furnace atomic absorption spectroscopy. An unusual neuro-toxicological pattern limited to a low dose of Alhydrogel 1 was observed. Neurobehavioural changes, including decreased activity levels and altered anxiety-like behaviour, were observed compared to controls in animals exposed to 200 mg Al/kg but not at 400 and 800 mg Al/kg. Consistently, microglial number appeared increased in the ventral forebrain of the 200 mg Al/kg group. Cerebral Al levels were selectively increased in animals exposed to the lowest dose, while muscle granulomas had almost completely disappeared at 6 months in these animals. We conclude that Alhydrogel 1 injected at low dose in mouse muscle may selectively induce long-term Al cerebral accumulation and neurotoxic effects. To explain this unexpected result, an avenue that could be explored in the future relates to the adjuvant size since the injected suspensions corresponding to the lowest dose, but not to the highest doses, exclusively contained small agglomerates in the bacteria-size range known to favour capture and, presumably, transportation by monocyte-lineage cells. In any event, the view that Alhydrogel 1 neurotoxicity obeys “ the dose makes the poison ” rule of classical chemical toxicity appears overly simplistic.
Study – Spontaneous Integration of Human DNA Fragments into Host GenomeK. Koyama, T. A. DeisherSound Choice Pharmaceutical Institute, Seattle, WA
Introduction A trio of recent publications in the journal NEURON reports the presence of hundreds of diverse de novo gene mutations indicating that autism spectrum disorder (ASD) may be a disease of genomic instability, with a significant environmental component. Altered double strand break formation and repair pathways (DSB) may be a commonality among the diverse genetic mutations that have been documented in ASD. US birth year change points in AD are apparent in 1980, 1988 and 1996, coinciding with the switch to or introduction of childhood vaccines contaminated with human endogenous retrovirus K (HERVK) and human fetal DNA fragments (6). We hypothesize that the HERVK and human fetal DNA contaminants could contribute to the genomic instability of ASD as demonstrated by de novo mutations. Cell free DNA can be taken up by healthy cells via receptor mediated uptake or may spontaneously penetrate cell membranes that have altered permeability, for instance, during inflammatory reactions. Nuclear uptake of cell free DNA fragments is thought to provide a source for maintenance of DNA integrity during rescue of collapsed replication forks or base lesion repair. Spontaneous extracellular DNA uptake has also been exploited for gene therapy as well as for cellular gene correction (2,4,5,7,8, and 9). While free DNA uptake has been used advantageously, the process has also been associated with generation of mutations and chromosomal aberrations (3). Vaccines manufactured using human fetal cells contain residual DNA fragments (50-500 bp) (Table I). It is possible that these contaminating fragments could be incorporated into a child’s genome and disrupt normal gene function, leading to autistic phenotypes. In this study we demonstrate foreign DNA uptake in human cells and genomic integration by incubating the cells with Cy3-labeled human Cot1 (placental) DNA fragments which represents contaminating residual human fetal DNA in vaccines
Not only damaged human cells, but also healthy human cells can take up foreign DNA spontaneously. Foreign human DNA taken up by human cells will be transported into nuclei and be integrated into host genome, which will cause phenotype change. Hence, residual human fetal DNA fragments in vaccine can be one of causes of autism spectrum disorder in children through vaccination. Vaccine must be safe without any human DNA contaminations or reactivated viruses, and must be produced in ethically approved manufacturing processes
Study – Abortive and subclinical poliomyelitis in a family during the 1992 epidemic in The Netherlands
AuthorsKroon FP1, Weiland HT, van Loon AM, van Furth R.
Author informationDepartment of Infectious Diseases, University Hospital Leiden, The Netherlands.
AbstractWe describe a case of abortive poliomyelitis due to poliovirus type 3 (PV3) in an unvaccinated woman and a subclinical poliovirus infection in her family during an epidemic in the Netherlands. The woman excreted the epidemic strain (PV3) for 7 weeks. Her two children received oral attenuated poliovirus vaccine and were subsequently found to excrete PV1 and PV2 vaccine strains in addition to the epidemic PV3 strain. Her husband, who had neutralizing antibodies to all three poliovirus types because of previous vaccination, initially excreted no virus; subsequently, however, the vaccine strain PV1 and the epidemic strain PV3 could be cultured from his feces. These observations demonstrate the ease with which poliovirus circulates among family members, including those with neutralizing antibodies.
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1 Corinthians 15 Authorized (King James) Version (AKJV)
1 Moreover, brethren, I declare unto you the gospel which I preached unto you, which also ye have received, and wherein ye stand;
2 by which also ye are saved, if ye keep in memory what I preached unto you, unless ye have believed in vain.
3 For I delivered unto you first of all that which I also received, how that Christ died for our sins according to the scriptures;
4 and that he was buried, and that he rose again the third day according to the scriptures:
Hebrews 6 Authorized (King James) Version (AKJV)
1 Therefore leaving the principles of the doctrine of Christ, let us go on unto perfection; not laying again the foundation of repentance from dead works, and of faith toward God,
2 of the doctrine of baptisms, and of laying on of hands, and of resurrection of the dead, and of eternal judgment.
3 And this will we do, if God permit.
4 For it is impossible for those who were once enlightened, and have tasted of the heavenly gift, and were made partakers of the Holy Ghost,
5 and have tasted the good word of God, and the powers of the world to come,
6 if they shall fall away, to renew them again unto repentance; seeing they crucify to themselves the Son of God afresh, and put him to an open shame.
7 For the earth which drinketh in the rain that cometh oft upon it, and bringeth forth herbs meet for them by whom it is dressed, receiveth blessing from God:
8 but that which beareth thorns and briers is rejected, and is nigh unto cursing; whose end is to be burned.
Isaiah 53 – Old testament Prophecy about Jesus
1 Who hath believed our report? and to whom is the arm of the Lord revealed?
2 For he shall grow up before him as a tender plant,and as a root out of a dry ground:he hath no form nor comeliness;and when we shall see him,there is no beauty that we should desire him.
3 He is despised and rejected of men;a man of sorrows, and acquainted with grief:and we hid as it were our faces from him;he was despised, and we esteemed him not.
4 Surely he hath borne our griefs,and carried our sorrows:yet we did esteem him stricken,smitten of God, and afflicted.
5 But he was wounded for our transgressions,he was bruised for our iniquities:the chastisement of our peace was upon him;and with his stripes we are healed.
6 All we like sheep have gone astray;we have turned every one to his own way;and the Lord hath laid on him the iniquity of us all.
7 He was oppressed, and he was afflicted,yet he opened not his mouth:he is brought as a lamb to the slaughter,and as a sheep before her shearers is dumb,so he openeth not his mouth.
8 He was taken from prison and from judgment:and who shall declare his generation? for he was cut off out of the land of the living:for the transgression of my people was he stricken.
9 And he made his grave with the wicked,and with the rich in his death;because he had done no violence,neither was any deceit in his mouth.
10 Yet it pleased the Lord to bruise him;he hath put him to grief:when thou shalt make his soul an offering for sin,he shall see his seed, he shall prolong his days,and the pleasure of the Lord shall prosper in his hand.
11 He shall see of the travail of his soul, and shall be satisfied:by his knowledge shall my righteous servant justify many;for he shall bear their iniquities.
12 Therefore will I divide him a portion with the great,and he shall divide the spoil with the strong;because he hath poured out his soul unto death:and he was numbered with the transgressors;and he bare the sin of many,and made intercession for the transgressors.
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