Vaccine News – VAXXED TV – DTaP vaccine gave my daughter epilepsy & Here’s Where the Aluminum from Vaccines Accumulates in the Body

Journal of Trace Elements in Medicine and Biology
Available online 26 November 2017

Study – Aluminium in brain tissue in autism
Matthew Mold – a, Dorcas Umar – b, Andrew King – c, Christopher Exley – a,

a The Birchall Centre, Lennard-Jones Laboratories, Keele University, Staffordshire, ST5 5BG, United Kingdom
b Life Sciences, Keele University, Staffordshire, ST5 5BG, United Kingdom
c Department of Clinical Neuropathology, Kings College Hospital, London, SE5 9RS, United Kingdom

Autism spectrum disorder is a neurodevelopmental disorder of unknown aetiology. It is suggested to involve both genetic susceptibility and environmental factors including in the latter environmental toxins. Human exposure to the environmental toxin aluminium has been linked, if tentatively, to autism spectrum disorder. Herein we have used transversely heated graphite furnace atomic absorption spectrometry to measure, for the first time, the aluminium content of brain tissue from donors with a diagnosis of autism. We have also used an aluminium-selective fluor to identify aluminium in brain tissue using fluorescence microscopy. The aluminium content of brain tissue in autism was consistently high. The mean (standard deviation) aluminium content across all 5 individuals for each lobe were 3.82(5.42), 2.30(2.00), 2.79(4.05) and 3.82(5.17) μg/g dry wt. for the occipital, frontal, temporal and parietal lobes respectively. These are some of the highest values for aluminium in human brain tissue yet recorded and one has to question why, for example, the aluminium content of the occipital lobe of a 15 year old boy would be 8.74 (11.59) μg/g dry wt.? Aluminium-selective fluorescence microscopy was used to identify aluminium in brain tissue in 10 donors. While aluminium was imaged associated with neurones it appeared to be present intracellularly in microglia-like cells and other inflammatory non-neuronal cells in the meninges, vasculature, grey and white matter. The pre-eminence of intracellular aluminium associated with non-neuronal cells was a standout observation in autism brain tissue and may offer clues as to both the origin of the brain aluminium as well as a putative role in autism spectrum disorder.

US National Library of Medicine
National Institutes of Health – Oct 2012

Study – Relative trends in hospitalizations and mortality among infants by the number of vaccine doses and age, based on the Vaccine Adverse Event Reporting System (VAERS), 1990-2010.

Goldman GS, Miller NZ.
Author information
Computer Scientist, Pearblossom, CA 93553, USA.

In this study, the Vaccine Adverse Event Reporting System (VAERS) database, 1990-2010, was investigated; cases that specified either hospitalization or death were identified among 38,801 reports of infants. Based on the types of vaccines reported, the actual number of vaccine doses administered, from 1 to 8, was summed for each case. Linear regression analysis of hospitalization rates as a function of (a) the number of reported vaccine doses and (b) patient age yielded a linear relationship with r(2) = 0.91 and r(2) = 0.95, respectively. The hospitalization rate increased linearly from 11.0% (107 of 969) for 2 doses to 23.5% (661 of 2817) for 8 doses and decreased linearly from 20.1% (154 of 765) for children aged <0.1 year to 10.7% (86 of 801) for children aged 0.9 year. The rate ratio (RR) of the mortality rate for 5-8 vaccine doses to 1-4 vaccine doses is 1.5 (95% confidence interval (CI), 1.4-1.7), indicating a statistically significant increase from 3.6% (95% CI, 3.2-3.9%) deaths associated with 1-4 vaccine doses to 5.5% (95% CI, 5.2-5.7%) associated with 5-8 vaccine doses. The male-to-female mortality RR was 1.4 (95% CI, 1.3-1.5). Our findings show a positive correlation between the number of vaccine doses administered and the percentage of hospitalizations and deaths. Since vaccines are given to millions of infants annually, it is imperative that health authorities have scientific data from synergistic toxicity studies on all combinations of vaccines that infants might receive. Finding ways to increase vaccine safety should be the highest priority.

Study – Aluminum in Vaccines Is Not Safe, According to Article in the Journal of American Physicians and Surgeons

The Association of American Physicians and Surgeons notes that, because of public concerns that mercury (as thimerosal) in childhood vaccines might be contributing to soaring rates of autism, this component was mostly phased out as a “precaution.” Autism rates continued to rise, prompting authorities to assert that autism is not linked to mercury in vaccines and that vaccination policies are safe and appropriate, writes Neil Z. Miller in the winter issue of the Journal of American Physicians and Surgeons.

Aluminum is a neurotoxin, yet infants and young children are repeatedly injected with aluminum adjuvants from multiple vaccines during critical periods of brain development. Numerous studies provide credible evidence that aluminum adversely affects important biological functions and may contribute to neurodegenerative and autoimmune disorders. It is impossible to predetermine which vaccinated babies will succumb to aluminum poisoning. Aluminum-free health options are needed.

Discovery of “Shockingly High” Levels of Aluminum in Brains of Individuals with Autism Suggests Link with Aluminum-Containing Vaccines
Children medical safety research institute

Study Shows Evidence of Inflammatory Cells Loaded with Aluminum Crossing the Blood-Brain Barrier and Meningeal Membranes
(November 27, 2017) Staffordshire, UK — A new study published in the Journal of Trace Elements in Medicine and Biology provides the strongest indication yet that aluminum is an etiological agent in autism spectrum disorder (ASD), according to researchers at Keele University in England.
The study used transversely heated graphite furnace atomic absorption spectrometry to measure, for the first time, the aluminum content of brain tissue from five donors who had died with diagnoses of ASD. The results showed the donors to have had some of the highest values of aluminum yet measured in human brain tissue.
The mean (standard deviation) aluminum content across all five individuals for each lobe were 3.82(5.42), 2.30(2.00), 2.79(4.05) and 3.82(5.17) mg/g dry wt. for the occipital, frontal, temporal and parietal lobes respectively. Previous measurements of 60 brains from humans not diagnosed with ASD showed an average content of 1 mg/g dry wt. of brain tissue.
“One has to wonder why aluminum in the occipital lobe of a 15-year-old boy with autism would be a value that is at least 10 times higher than what might be considered acceptable for an elderly adult?” said Christopher Exley PhD, Professor in Bioinorganic Chemistry and author of the study. Another ground-breaking study by Exley and his team, published earlier in the year, identified similarly high levels of aluminum in the brains of individuals who died of familial Alzheimer’s disease.

Here’s Where the Aluminum from Vaccines Accumulates in the Body

When it comes to the most widely used adjuvant ingredient found within vaccines, aluminum, many questions have yet to be answered, particularly when it comes to where the aluminum goes after injection, an issue known as biopersistence.
One reason this question arises is because a causative role has been established in what’s known as macrophagic myofasciitis (MMF) lesion in patients who have myalgic encephalomyelitis, or brain inflammation. Myalgia, arthralgia, chronic fatigue, cognitive dysfunction, dysautonomia, and autoimmunity have been temporally linked to aluminium adjuvant-containing vaccine administration (Gherardi and Authier, 2003; Authier et al., 2003; Exley et al., 2009; Rosenblum et al., 2011; Santiago et al., 2014; Brinth et al., 2015; Palmieri et al., 2016).
“Evidence that aluminum-coated particles phagocytozed in the injected muscle and its draining lymph nodes can disseminate within phagocytes throughout the body and slowly accumulate in the brain further suggested that alum safety should be evaluated in the long term.”

US National Library of Medicine
National Institutes of Health – Jun 2015

Study – Fluorescent nanodiamonds as a relevant tag for the assessment of alum adjuvant particle biodisposition.

Eidi H – 1,2, David MO – 3, Crépeaux G – 4, Henry L – 5, Joshi V – 6, Berger MH – 7, Sennour M – 8, Cadusseau J – 9,10, Gherardi RK – 11, Curmi PA – 12.
Author information
1 Institut National de la Santé et de la Recherche Médicale (INSERM) – UMR 1204, Université Evry-Val d’Essonne, Laboratoire Structure-Activité des Biomolécules Normales et Pathologiques, Evry, France.
2 Inserm – U955, Université Paris Est, Faculté de Médecine, Créteil, France.
3 Institut National de la Santé et de la Recherche Médicale (INSERM) – UMR 1204, Université Evry-Val d’Essonne, Laboratoire Structure-Activité des Biomolécules Normales et Pathologiques, Evry, France.
4 Inserm – U955, Université Paris Est, Faculté de Médecine, Créteil, France.
5 Institut National de la Santé et de la Recherche Médicale (INSERM) – UMR 1204, Université Evry-Val d’Essonne, Laboratoire Structure-Activité des Biomolécules Normales et Pathologiques, Evry, France.
6 Institut National de la Santé et de la Recherche Médicale (INSERM) – UMR 1204, Université Evry-Val d’Essonne, Laboratoire Structure-Activité des Biomolécules Normales et Pathologiques, Evry, France.
7 Laboratoire Pierre-Marie Fourt, Centre des Matériaux de l’Ecole des Mines de Paris and CNRS UMR 7633, Evry, France.
8 Laboratoire Pierre-Marie Fourt, Centre des Matériaux de l’Ecole des Mines de Paris and CNRS UMR 7633, Evry, France.
9 Inserm – U955, Université Paris Est, Faculté de Médecine, Créteil, France.
10 Faculté des Sciences et Technologie UPEC, Créteil, France.
11 Inserm – U955, Université Paris Est, Faculté de Médecine, Créteil, France.
12 Institut National de la Santé et de la Recherche Médicale (INSERM) – UMR 1204, Université Evry-Val d’Essonne, Laboratoire Structure-Activité des Biomolécules Normales et Pathologiques, Evry, France.


Aluminum oxyhydroxide (alum) is a crystalline compound widely used as an immunologic adjuvant of vaccines. Concerns linked to alum particles have emerged following recognition of their causative role in the so-called macrophagic myofasciitis (MMF) lesion in patients with myalgic encephalomyelitis, revealing an unexpectedly long-lasting biopersistence of alum within immune cells and a fundamental misconception of its biodisposition. Evidence that aluminum-coated particles phagocytozed in the injected muscle and its draining lymph nodes can disseminate within phagocytes throughout the body and slowly accumulate in the brain further suggested that alum safety should be evaluated in the long term. However, lack of specific staining makes difficult the assessment of low quantities of bona fide alum adjuvant particles in tissues.

We explored the feasibility of using fluorescent functionalized nanodiamonds (mfNDs) as a permanent label of alum (Alhydrogel(®)). mfNDs have a specific and perfectly photostable fluorescence based on the presence within the diamond lattice of nitrogen-vacancy centers (NV centers). As the NV center does not bleach, it allows the microspectrometric detection of mfNDs at very low levels and in the long-term. We thus developed fluorescent nanodiamonds functionalized by hyperbranched polyglycerol (mfNDs) allowing good coupling and stability of alum:mfNDs (AluDia) complexes. Specificities of AluDia complexes were comparable to the whole reference vaccine (anti-hepatitis B vaccine) in terms of particle size and zeta potential.

In vivo, AluDia injection was followed by prompt phagocytosis and AluDia particles remained easily detectable by the specific signal of the fND particles in the injected muscle, draining lymph nodes, spleen, liver and brain. In vitro, mfNDs had low toxicity on THP-1 cells and AluDia showed cell toxicity similar to alum alone. Expectedly, AluDia elicited autophagy, and allowed highly specific detection of small amounts of alum in autophagosomes.

The fluorescent nanodiamond technology is able to overcome the limitations of previously used organic fluorophores, thus appearing as a choice methodology for studying distribution, persistence and long-term neurotoxicity of alum adjuvants and beyond of other types of nanoparticles.

VAXXED TV – Vaccines gave my son autism

I am 22 and unvaccinated

Former researcher has unvaccinated children

Health professionals talk vaccinations

My only son is unvaccinated and healthy

My 3 children are unvaccinated and very healthy

Dr Ledbetter

3 months ago my baby died following vaccinations

My 2 children have autism from vaccines

DTaP vaccine gave my daughter epilepsy


ONE FOR ISRAEL Ministry – Jewish Johnathan Ben-David forgave his killer and you would not believe why!!!

How to accept Jesus Christ as your personal Saviour

Testimony by Phil Robertson from Duck Dynasty

1 Corinthians 15 Authorized (King James) Version (AKJV)
1 Moreover, brethren, I declare unto you the gospel which I preached unto you, which also ye have received, and wherein ye stand;
2 by which also ye are saved, if ye keep in memory what I preached unto you, unless ye have believed in vain.
3 For I delivered unto you first of all that which I also received, how that Christ died for our sins according to the scriptures;
4 and that he was buried, and that he rose again the third day according to the scriptures:

Hebrews 6 Authorized (King James) Version (AKJV)
1 Therefore leaving the principles of the doctrine of Christ, let us go on unto perfection; not laying again the foundation of repentance from dead works, and of faith toward God,
2 of the doctrine of baptisms, and of laying on of hands, and of resurrection of the dead, and of eternal judgment.
3 And this will we do, if God permit.
4 For it is impossible for those who were once enlightened, and have tasted of the heavenly gift, and were made partakers of the Holy Ghost,
5 and have tasted the good word of God, and the powers of the world to come,
6 if they shall fall away, to renew them again unto repentance; seeing they crucify to themselves the Son of God afresh, and put him to an open shame.
7 For the earth which drinketh in the rain that cometh oft upon it, and bringeth forth herbs meet for them by whom it is dressed, receiveth blessing from God:
8 but that which beareth thorns and briers is rejected, and is nigh unto cursing; whose end is to be burned.

Isaiah 53 – Old testament Prophecy about Jesus

1 Who hath believed our report? and to whom is the arm of the Lord revealed?
2 For he shall grow up before him as a tender plant,and as a root out of a dry ground:he hath no form nor comeliness;and when we shall see him,there is no beauty that we should desire him.
3 He is despised and rejected of men;a man of sorrows, and acquainted with grief:and we hid as it were our faces from him;he was despised, and we esteemed him not.
4 Surely he hath borne our griefs,and carried our sorrows:yet we did esteem him stricken,smitten of God, and afflicted.
5 But he was wounded for our transgressions,he was bruised for our iniquities:the chastisement of our peace was upon him;and with his stripes we are healed.
6 All we like sheep have gone astray;we have turned every one to his own way;and the Lord hath laid on him the iniquity of us all.
7 He was oppressed, and he was afflicted,yet he opened not his mouth:he is brought as a lamb to the slaughter,and as a sheep before her shearers is dumb,so he openeth not his mouth.
8 He was taken from prison and from judgment:and who shall declare his generation? for he was cut off out of the land of the living:for the transgression of my people was he stricken.
9 And he made his grave with the wicked,and with the rich in his death;because he had done no violence,neither was any deceit in his mouth.
10 Yet it pleased the Lord to bruise him;he hath put him to grief:when thou shalt make his soul an offering for sin,he shall see his seed, he shall prolong his days,and the pleasure of the Lord shall prosper in his hand.
11 He shall see of the travail of his soul, and shall be satisfied:by his knowledge shall my righteous servant justify many;for he shall bear their iniquities.
12 Therefore will I divide him a portion with the great,and he shall divide the spoil with the strong;because he hath poured out his soul unto death:and he was numbered with the transgressors;and he bare the sin of many,and made intercession for the transgressors.


Vaccine News – 10 Things I Want Parents Who Vaccinate Their Kids To Know

Footage from the phenomenal UPRISING in Poland! Where is the MEDIA? Poland, Italy, Sweden, Australia…the list goes on! All saying “NO!” to mandatory vaccinations!
Education is EMPOWERMENT – Playing now for free:
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100% Proof! Human DNA in Vaccines
Presentation recorded on February 16, 2017 in Sonora, California with Marcella Piper-Terry.
#Vaxxed #PrayBig #RecombinantDNA #InsertionalMutagenesis #FetalCellLine #ProLife #Abortion #ChooseLife #RespectLife #MarchForLife #MRC5 #WI38 #RA273 #WALVAX2
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A Mothers Worst Nightmare: Infant Son Dies After 13 Vaccines in One Day
As a parent, you do everything in your power to protect your children. What if that power is taken from you by the people you should trust the most? That’s exactly what happened to Alisa Neathery of Fort Worth, TX, when she took her six month-old unvaccinated baby to the doctor for the first time. During an interview with VacTruth about the ordeal, Alisa states:
“Prior to the shots being given, when the doctor was discussing the pros of getting vaccinated with me, he explained how he was from a village in Africa. That we were lucky in America to have the opportunity to receive vaccines because where he was from, the mothers had to have like 11 kids each, since most would die off from disease because they were not as fortunate to receive vaccines like we are here in America. He really pushed them on me hard. He spent a lot of time convincing me to give Bently the vaccines, but when it was done, we never saw the doctor again.”
Totally unbeknownst to his mother, Bently’s doctor settled on 13 vaccinations that day, including two triple doses of DTap, Hepatitis B, a polio shot, three oral rotavirus doses, and a pneumococcal pneumonia vaccine. It was combined into 3 shots and one taken orally. The doctor stated “Your boy is perfectly healthy and showed above average strength in his stomach and legs.” How would you feel having a pediatrician almost forcing you to vaccinate? I know that if I wasn’t aware about the dangers of vaccines, I would be inclined to believe them and trust their expertise.
When Alisa brought Bently home directly after receiving his combination of 13 vaccines, he was no longer making eye contact. He was extremely uncomfortable and was certainly not his usual joyful self.
Five days later, Bently passed away.
Bently took his last breath in his mothers arms 5 days after he received 13 vaccines in one day.

No You Don’t Need a Tetanus Shot: 4 Reasons Why
What Is Tetanus?
Tetanus, also known as lockjaw, occurs when the tetanus bacteria gets into the bloodstream and releases a nervous system toxin. The bacteria can be found extensively in cultivated soils. It also lives harmlessly in the gut of many animals. The infection caused by the bacteria is anaerobic (ie. it cant live in the presence of oxygen).
What’s The Real Cause of Tetanus?
It is not the bacteria itself which causes the development of tetanus, but the toxins it produces under certain conditions.
“Under normal conditions no disease will occur if spores are introduced into a wound.”(J. Ark Med Soc Vol 80, No 3 p134)
“It is the compromised host, or traumatised patient, either by surgery or accident, who is most apt to develop tetanus.” (J Foot Surgery Vol 23, No 3 p235).
So in other words, the tetanus bacteria may be a factor in tetanus, but not its main cause. If it was, the disease would be more common that it is, in light of the fact that it occurs frequently in many places.
4 Reasons Why You Don’t Need A Tetanus Shot

1. It’s Good Drainage That Prevents Tetanus
2. The Vaccine Doesn’t Prevent Tetanus
3. Your Chances Of Getting Tetanus Are Incredibly Low
4. The Harmful Ingredients In the Vaccine

What REALLY prevents Tetanus?
Keeping a wound clean is the best way to prevent it from getting infected, and if you do suspect tetanus, then there is the anti-toxin serum shot (which doesn’t have the harmful effects of the vaccine). Vitamin C has also been shown to be effective in treating tetanus.
No I won’t be getting a tetanus shot, or getting one for my child just because one child contracted it. I wont take the risk for something that is so incredibly rare that we’ve barely seen any cases in Australia in the last few decades. It’s time we all stopped judging other parents for the choices they make and start learning the facts.

Official Vaccine Injury Reward Report from the U.S. Court of Official Claims
Here’s the official Annual Report of Vaccine Claims, in a letter from the United States Court of Federal Claims, to Joseph, R. Biden, Jr. (then President of the United States Senate). 151 pages of vaccine injury cases bought to court in just ONE year. NOTE just two years later, the latest version of the document for 2015/1016 is 277 pages long, accounting for 126 more pages of vaccine injury claims. The dollar demand total for this most current year was just under 1 TRILLION – 995,275,774,000.00 to be exact.

2013/2014 Federal Report of Vaccine Injury
2014/2015 Federal Report of Vaccine Injury
2015/2016 Federal Report of Vaccine Injury

Taxpayers Pay for the Pharmaceutical Companies’ Negligences and Damages
Note, that due to a law passed in 1986 under President Reagan, this money, over 900 million dollars, comes from the taxpayers, and not from vaccine makers who caused the injury. According the the New York Times, “Mr. Reagan said he had approved the bill ”with mixed feelings” because he had ”serious reservations” about the vaccine compensation program.

10 Things I Want Parents Who Vaccinate Their Kids To Know
Like most parents who don’t vaccinate, I believe in freedom of choice for all parents. If we could all respect each others choice to choose what’s best for our children, we could leave behind judgement and ridicule, and parenting would be a lot more peaceful. That’s why it’s so upsetting to see ignorant comments that are plastered all over social media, from parents who don’t believe in freedom of choice. Here are a few things I want parents who do still vaccinate to know:

1.Most of the time the diseases we vaccinate for are very mild and unlike vaccine injury, they last only a short time.
2. Even if you choose to vaccinate, please please make yourselves aware of the adverse events that can occur.
3. If you are really are worried about viruses and bacteria, you dont want to see what the toxins in vaccine can do…
4. Your children will be shedding their live virus vaccines (this includes the measles and chickenpox vaccine) after their shots.
5. The latest study of vaccinated vs unvaccinated children, found significantly higher rates of autism, allergies, ear infections, learning disabilities and chronic diseases in those vaccinated to the schedule.
6. Vaccines are far from perfect…
7. If you are worried about where to get good and unbiased information from…
8. The people trying to convince you not to vaccinate have only one motivation, and that is to prevent more suffering, because they have either witnessed it first hand in their own family or know someone who has.
9. In the time you have spent reading this, more children have been damaged by vaccines, because they believed what Doctors and the government told them.
10. It’s not too late to change your mind.

A critical look at the current vaccine program in the United States suggests a possible Perfect Storm because there are a combination of factors surrounding the vaccine program which have the potential to lead to disastrous consequences. Below is a list of these potentially disastrous factors:
The “Disastrous Factors” List:

(1) Currently medical doctors receive large bonuses for giving vaccines, and the more vaccines they give, the larger their bonuses[1]
(2) Vaccines are hugely profitable, e.g., the worldwide pediatric vaccine market is projected to be valued at US$ 88.14 billion by the end of 2026[2]
(3) No vaccine manufacturer or doctor can be held accountable for any vaccine injury[3]
(4) The CDC, which is in charge of promoting vaccines, is reportedly corrupt according to CDC scientists[4], and receives millions of dollars each year from the pharmaceutical industry through the CDC Foundation[5]
(5) The vaccine schedule has never been tested in a publicly available long-term study[6]
(6) Vaccines contain ingredients which have not been adequately tested for safety, such as: mercury, aluminum, bovine cells, aborted human fetal cells, monkey lung tissue, etc[7]
(7) Many vaccines are made in China[8], a country known for toxic products, e.g., infant formulas made in China were recalled three times in the last decade for toxic contaminants
(8) Vaccines are found to contain contaminants, such as glyphosate (Round Up)[9], stainless steel[10], and glass[11]
(9) Doctors and scientists who speak out about vaccines are attacked and discredited[12]
(10) Vaccine advisory committees have conflicts of interest, e.g., four out of eight CDC advisory committee members who voted to approve guidelines for the rotavirus vaccine in 1998 had financial ties to pharmaceutical companies that were developing the vaccine[13]
(11) Mercury, a neurotoxicant, is still used in over half of the influenza-vaccine doses (>75 million], the meningococcal vaccine, and the tetanus-toxoid vaccine in the United States[14]
(12) ChildhoodVaccines are now mandatory in California and there is a push to make them mandatory in other States[15]

Former SEAL: 3000 Elite Pedophiles Arrested – Media Silent
April 30, 2017 Sean Adl-Tabatabai
Former Navy SEAL Craig Sawyer says that over 3,000 pedophiles belonging to an elite satanic pedophile ring have been arrested, amid a total blackout by the mainstream media.
Speaking with Infowars‘ Michael Zimmerman at the NRA’s annual convention, Sawyer says that intelligence insiders have confirmed that Trump’s vow to take down the elite pedophile ring in Washington DC is already being fulfilled.
According to Sawyer, his independent research has led him to discover that high-level government officials routinely torture and kill young children during satanic rituals. He says that despite a concerted effort by social media and the mainstream to suppress this information, they cannot escape the avalanche of truth being released by the independent media.

New evidence suggests Parkinson’s might start in the gut, not the brain

New evidence suggests Parkinson’s might start in the gut, not the brain
A new study adds to a growing body of research that suggests we might have been thinking about Parkinson’s disease wrong this whole time.
Instead of being isolated to the brain, new evidence in mice suggests that the condition might actually start in the gut. And it could explain some of the strange coincidences seen in the disease, such as why most Parkinson’s patients complain of constipation up to a decade before other symptoms arise.

Prediagnostic presentations of Parkinson’s disease in primary care: a case-control study
8166 individuals with and 46 755 individuals without Parkinson’s disease were included in the study. Apathy, REM sleep behaviour disorder, anosmia, hypersalivation, and cognitive decline were all reported in less than 1% of people per 1000 person-years and were excluded from further analyses. At 2 years before Parkinson’s disease diagnosis, the incidence of all studied prediagnostic features except neck pain or stiffness was higher in patients who went on to develop Parkinson’s disease (n=7232) than in controls (n=40 541). At 5 years before diagnosis, compared with controls (n=25 544), patients who went on to develop Parkinson’s disease (n=4769) had a higher incidence of tremor (RR 13·70, 95% CI 7·82–24·31), balance impairments (2·19, 1·09–4·16), constipation (2·24, 2·04–2·46), hypotension (3·23, 1·85–5·52), erectile dysfunction (1·30, 1·11–1·51), urinary dysfunction (1·96, 1·34–2·80), dizziness (1·99, 1·67–2·37), fatigue (1·56, 1·27–1·91), depression (1·76, 1·41–2·17), and anxiety (1·41, 1·09–1·79). At 10 years before diagnosis of Parkinson’s disease, the incidence of tremor (RR 7·59, 95% CI 1·11–44·83) and constipation (2·01, 1·62–2·49) was higher in those who went on to develop Parkinson’s disease (n=1680) than in controls (n=8305).
A range of prediagnostic features can be detected several years before diagnosis of Parkinson’s disease in primary care. These data can be incorporated into ongoing efforts to identify individuals at the earliest stages of the disease for inclusion in future trials and to help understand progression in the earliest phase of Parkinson’s disease.

The Guardian: Agricultural fungicides are ‘bad news for neurons’, study suggests

Agricultural fungicides are ‘bad news for neurons’, study suggests
Fungicides caused mouse cells to show changes similar to those seen in autism and Alzheimer’s, although a definite link to the disorders has not been proven
Modern fungicides that are sprayed on fruit and vegetables have come under fresh scrutiny after scientists found they caused similar genetic changes in mouse neurons to those seen in autism and Alzheimer’s disease.
Researchers exposed dishes of the brain cells to more than 300 different pesticides and fungicides and found that one class of fungicides, the strobilurins, produced patterns of genetic changes often seen in the human conditions.
Scientists at the University of North Carolina in Chapel Hill hoped the experiment might shed light on the kinds of substances in the environment that contribute to cases of autism. To their surprise, they found compounds that produced some genetic hallmarks of autism and neurodegenerative diseases at the same time.
The strobilurins have only been approved for use in the past 20 years, more than half a century after the first individual diagnosed with autism was announced in the medical literature. Since the fungicides arrived on the market, they have been sprayed in increasing quantities to protect crops such as cabbages, spinach, lettuce, kale, tomatoes, apples, pears and grapes.
While the fungicides produced autism-like and Alzheimer’s-like signatures in the way genes are expressed in mouse neurons, the relevance of the changes is unclear: the scientists have no evidence that the chemicals contribute to either condition.
“The study was designed to try and identify chemicals that could cause autism, but we in no way say these things do cause autism,” said lead scientist, Mark Zylka, whose study appears in Nature Communications.
“What this work provides is evidence that these chemicals are bad for neurons. They turn the same genes on or off that you see not only in autism brains, but also in neurodegeneration,” he added.

TORONTO – A strange vaccine-related phenomenon spotted at the start of the 2009 flu pandemic may well have been real, a new study suggests.

Canadian researchers noticed in the early weeks of the pandemic that people who got a flu shot for the 2008-2009 winter seemed to be more likely to get infected with the pandemic virus than people who hadn’t received a flu shot.
Five studies done in several provinces showed the same puzzling and unsettling results. But initially research outside of Canada did not, and the effect was dismissed as “the Canadian problem.”
News of the unexpected findings broke at a time when countries in North America and parts of Europe were getting ready to start vaccinating their populations against the pandemic virus.