Vaccine News – Study – Gender-selective toxicity of thimerosal

PubMed.gov – Mar.2009
Abstract
A recent report shows a correlation of the historical use of thimerosal in therapeutic immunizations with the subsequent development of autism; however, this association remains controversial. Autism occurs approximately four times more frequently in males compared to females; thus, studies of thimerosal toxicity should take into consideration gender-selective effects. The present study was originally undertaken to determine the maximum tolerated dose (MTD) of thimersosal in male and female CD1 mice. However, during the limited MTD studies, it became apparent that thimerosal has a differential MTD that depends on whether the mouse is male or female. At doses of 38.4-76.8mg/kg using 10% DMSO as diluent, seven of seven male mice compared to zero of seven female mice tested succumbed to thimerosal. Although the thimerosal levels used were very high, as we were originally only trying to determine MTD, it was completely unexpected to observe a difference of the MTD between male and female mice. Thus, our studies, although not directly addressing the controversy surrounding thimerosal and autism, and still preliminary due to small numbers of mice examined, provide, nevertheless, the first report of gender-selective toxicity of thimerosal and indicate that any future studies of thimerosal toxicity should take into consideration gender-specific differences.
PubMed.gov – 15.Mar.2010
Abstract
Mercury (Hg) exposure from dental amalgam fillings and thimerosal in vaccines is not a major health hazard, but adverse health effects cannot be ruled out in a small and more susceptible part of the exposed population. Individual differences in toxicokinetics may explain susceptibility to mercury. Inbred, H-2-congenic A.SW and B10.S mice and their F1- and F2-hybrids were given HgCl2 with 2.0 mg Hg/L drinking water and traces of (203)Hg. Whole-body retention (WBR) was monitored until steady state after 5 weeks, when the organ Hg content was assessed. Despite similar Hg intake, A.SW males attained a 20-30% significantly higher WBR and 2- to 5-fold higher total renal Hg retention/concentration than A.SW females and B10.S mice. A selective renal Hg accumulation but of lower magnitude was seen also in B10.S males compared with females. Differences in WBR and organ Hg accumulation are therefore regulated by non-H-2 genes and gender. Lymph nodes lacked the strain- and gender-dependent Hg accumulation profile of kidney, liver and spleen. After 15 days without Hg A.SW mice showed a 4-fold higher WBR and liver Hg concentration, but 11-fold higher renal Hg concentration, showing the key role for the kidneys in explaining the slower Hg elimination in A.SW mice. The trait causing higher mercury accumulation was not dominantly inherited in the F1 hybrids. F2 mice showed a large inter-individual variation in Hg accumulation, showing that multiple genetic factors influence the Hg toxicokinetics in the mouse. The genetically heterogeneous human population may therefore show a large variation in mercury toxicokinetics.
US National Library of Medicine – National Institutes of Health – Feb.2015
Results
Developmental Domain: ASD Diagnostic Criteria
Social Communication/Social Interaction
Deficits in social communication and social interaction are core factors in the diagnostic criteria of ASD. Impairments in social communication may present as abnormalities in eye contact, poor integration of verbal and nonverbal behaviors, and difficulties understanding the nonverbal communication of others (American Psychiatric Association, 2013). In some cases, persons with ASD may not participate in conversation or struggle with pragmatic language (American Psychiatric Association, 2013). Impairments in social interaction include difficulties with social-emotional reciprocity, failure to develop peer relationships, and reduced empathetic understanding and/or response (American Psychiatric Association, 2013).
There were 21 articles reviewed on social communication and social interaction in persons with ASD published between 1993 and 2013: 13 case-control studies, 7 cross-sectional studies, and 1 surveillance study. Nine studies were conducted in the United States and 12 studies were conducted at outside of the US. Of these 21 articles, 14 address social communication or other language abilities. In samples of children with varying cognitive abilities, some studies showed no significant differences in communication, conversational deficits, and language levels between males and females with ASD (Andersson et al., 2013; Dawson et al., 2007; Nicholas et al., 2008; Pilowsky et al., 1998; Park et al., 2012a, 2012b; Mayes and Calhoun, 2011; Mandy et al., 2012; Sipes et al., 2011; Solomon et al., 2012; Amr et al., 2011). One study found that males with ASD had greater expressive and receptive language skills than females with ASD (Carter et al., 2007) and another study found that females with ASD had more impaired social communication skills than males with ASD (Hartley and Sikora, 2009). Conversely, Park et al. (2012b) found that females with ASD had stronger non-verbal communication abilities than males with ASD. The majority of the literature reviewed on social communication found no difference between males and females with ASD, but there is some inconsistency.
The literature on sex differences in social interaction among persons with ASD (13 of 21 articles reviewed) is also inconsistent but generally suggests no significant sex differences in social interaction skills (Andersson et al., 2013; Dawson et al., 2007; Nicholas et al., 2008; Pilowsky et al., 1998; Mayes and Calhoun, 2011; Park et al. 2012b; Mandy et al., 2012; Sipes et al., 2011; Solomon et al., 2012). In population-level surveillance of eight-year olds, 80 % of children with ASD had poor social-emotional reciprocity with no significant difference between males and females (Nicholas et al., 2008). Szatmari et al. (2012) also found no sex differences in social-emotional reciprocity for children with varying cognitive abilities in a study from the Autism Genome Project. Oppositely, in an age and IQ matched case–control study, female adults with ASD were found to have fewer socio-communication difficulties during interpersonal interaction than male adults with ASD (Lai et al., 2013). Lastly, no sex differences have been noted in emotional reactiveness or being withdrawn (Hartley and Sikora, 2009) and in empathetic understanding and responses (Auyeung et al., 2009).
Cognitive functioning is likely to play a role in these social processes. Lower intellectual abilities are often linked with greater social impairment regardless of sex (Dawson et al., 2007). Among children with high functioning autism (IQ≥70), social skills have been found to be more impaired in female children than male children (Holtmann et al., 2007) and more severe as children aged (McLennan et al., 1993). In contrast, other studies found adult females with high functioning autism to have less socio-communication issues compared to males (Lai et al., 2011) or there were no sex differences in socio-communication skills in older children and adolescents (Holtmann et al., 2007; Kopp and Gillberg, 2011).
Overall, the 21 articles reviewed suggest no difference in social interaction between males and females with ASD and inconsistent differences in social communication between males and females with ASD, although both social interaction and social communication may be influenced by intellectual ability and age.
Restricted, Repetitive Patterns of Behavior, Interests, or Activities
There were 18 articles reviewed on restricted and repetitive patterns of behaviors and interests (RRBI) published between 1993 and 2013: nine cross-sectional studies, seven case–control studies, one cohort study, and one surveillance study. Eleven studies were conducted in the United States and seven studies were conducted in other countries. Based on this review, the literature suggests that males with ASD have more RRBI than females with ASD (Hattier et al., 2011; Carter et al., 2007). When assessing individual facets of RRBI, restricted interests are seen more often in males with ASD than females with ASD independent of cognitive ability (Kohane et al., 2012; May et al., 2012; Mandy et al., 2012; Szatmari et al., 2012). Males with ASD are also more likely to have more routines, rituals, and fascination with parts of objects than females with ASD (Nicholas et al., 2008; Park, et al., 2012b; Beuker et al., 2013). The literature on repetitive motor movements is less consistent: adult males with high functioning autism or Asperger’s syndrome had more repetitive motor movements than adult females with high functioning autism or Asperger’s syndrome in one case-control study (May et al., 2012), but there were no sex differences in repetitive motor movements among persons with autism in two other case-control studies (McLennan et al., 1993; Worley and Matson, 2011), one cross-sectional study (Auyeung et al., 2009), and one population-based cross-sectional study (Nicholas et al., 2008).
Age may influence the presentation of RRBI in males and females with ASD. One study found no sex difference among RRBI in toddlers (Sipes et al., 2011), whereas a different study found significantly more RRBI among adult males with ASD compared to females with ASD (Hattier et al., 2011). In summation, most studies reviewed suggested that males with ASD are likely to have more RRBI than females with ASD across levels of cognitive ability, although RRBI may be influenced by age.
Sensory issues are prevalent among persons with ASD (Nicholas et al., 2008) and are included as a RRBI in the DSM 5 (American Psychiatric Association, 2013). Common issues are oversensitivity to touch, sound, smell, taste, and attraction to certain tactile stimuli (American Psychiatric Association, 2013; Baranek et al., 2006; Rogers et al., 2003). Abnormal sensory reactions have been reported to occur in up to 47 % of persons with ASD, which is a rate ten times higher than reported in the general population (Nicholas et al., 2008). Additionally, there is a significant correlation between sensory issues in each of the individual senses (Kern et al., 2007); therefore, impairment is compounded for persons with ASD and sensory abnormalities.
Cross-sectional studies found no observed differences between males and females in sensitivity to sound (Mandy et al., 2012) or sensory sensitivity in general (Louisa et al., 2012; Mayes and Calhoun, 2011; Baranek et al., 2006). Mandy et al. (2012) examined RRBI in children and adolescents 3 to 18 years of age and found that age did not influence the presentation of RRBI. However, Lai et al. (2011) found that adult females with high functioning autism had more lifetime sensory issues than males with ASD. Overall, the majority of articles reviewed that addressed sensory issues in ASD do not suggest a sex difference, although aging may be a factor and should be further explored.
Developmental Domain: other Developmental Endophenotypes
Attention Deficit Hyperactivity Disorder
Attention deficit hyperactivity disorder (ADHD) and corresponding symptoms are common in children with ASD (Bradley and Isaacs, 2006; Nicholas et al., 2008). Previous studies show that 50 % to 83 % of children and teenagers with ASD had hyperactivity and attention problems (Nicholas et al., 2008; Bradley and Isaacs, 2006). There were seven articles that met search criteria and addressed ADHD. These seven articles were published between 2008 and 2012 with five cross-sectional studies and two cohort studies. Two studies were conducted in the United States and five were conducted in other countries.
A study of 7 to 12 year-olds with varying cognitive abilities found that males with ASD had higher levels of hyperactivity and impulsivity than females with ASD and this difference was more pronounced at younger ages (May et al., 2012). Males with high functioning autism from middle childhood to adolescence had higher levels of hyper-activity and inattention in teacher reports as compared to female peers, but there was no difference in parental reports (Mandy et al., 2012). A study of children and young adults aged 5 to 20 with high functioning autism found females had more attention problems (Bryson et al., 2008). A majority of studies found no difference in ADHD co-occurrence between males and females with ASD (Simonoff et al., 2008; Sinzig et al., 2009; Mayes and Calhoun, 2011; Horovitz et al., 2011). In summary, the current literature leans toward no sex differences in the co-occurrence of ADHD and ASD, but there is still inconsistency in the literature and thus, the sex difference is largely inconclusive
Challenging Behavior (Aggressiveness/Temper Tantrums/Oppositional Tendencies)
Challenging behavior is a common associated feature of ASD and includes aggression expressed toward other people, temper tantrums, and oppositional and defiant tendencies. Aggression expressed toward other people and temper tantrums are found in 50 % and 54 % of children with ASD compared to only 28 % and 23 % of children without ASD (Nicholas et al., 2008). The 12 articles in this review that met search criteria and addressed challenging behaviors were published between 2005 and 2012 and included six cross-sectional studies, four case–control studies, one clinical trial, and one surveillance study. Six studies were conducted in the United States and six were conducted in other countries. In general, there were no differences in aggression, temper tantrums, or anger between child sexes, regardless of age or cognitive ability (Kozlowski et al., 2012; Worley and Matson, 2011; Carter et al., 2007; Murphy et al., 2009; Mandy et al., 2012; Quek et al., 2012; Mayes and Calhoun, 2011; Horovitz et al., 2011). One study found that females with ASD had more “challenging behaviors” than males with ASD, although challenging behaviors were not explicitly defined (Dworzynski et al., 2012). Delinquent behavior (Park et al., 2012b) and oppositional defiance (Gadow et al., 2005) were more prevalent in males than in females with ASD in two studies reviewed.
Cognitive Skills and Intellectual Disability
In a review from 1966 to 2001, Fombonne (2003) found that the median prevalence of intellectual impairment in persons with ASD was 70 % in the studies evaluated. More recent population-based studies have found lower rates of ID in persons with ASD, with a range from 18 % to 55 % (Charman et al., 2011). The National Health Interview Study found 0.71 % of all children aged 3 to 17 from 1998 to 2007 had an ID (Boyle et al., 2011). Our review found 12 articles that met the search criteria and addressed ID or specific cognitive skills. These 12 articles were published between 1983 and 2011, and included seven cross-sectional studies, four case–control studies, and one-surveillance study. Four studies were conducted in the United States and eight were conducted in other countries.
The 12 articles reviewed support a relationship between child sex and co-occurring ID in children with ASD. The sex ratio between males and females without ID is greater than the sex ratio for all levels of cognitive ability combined (Nicholas et al., 2008; Hartley and Sikora, 2009). Consequently, the male to female ratio is lower when there is co-occurring ID compared to when there is no co-occurring ID (Hartley and Sikora, 2009; Nicholas et al., 2008; Yeargin-Allsopp et al., 2003). The ratio of males to females with ASD and co-occurring ID has been seen to range from 1.3:1 (Tsai and Beisler, 1983) to 2.8:1 (Bryson et al., 2008) with a trend toward fewer sex differences as ID becomes more severe (Yeargin-Allsopp et al., 2003). This differential sex difference in ID results in females with ASD, on average, having lower intelligence test scores than males with ASD (Banach et al., 2009; Volkmar et al., 1993).
Specific cognitive skills posited to vary between males and females with ASD include cognitive flexibility, response inhibition, working memory, and attention to detail (Geurts et al., 2004). Female adolescents with high functioning autism were seen to have superior information processing, multiple conceptual tracking, divided attention, and cognitive flexibility compared to male adolescents with high functioning autism (Bolte et al., 2011). In contrast, studies show males with ASD have superior attention to detail, visuo-spatial skills (Auyeung et al., 2009), and inhibitory control (Lemon et al., 2011) compared to females with ASD. There were no sex differences between adults with ASD in the “eyes test” which measures ability to infer mental states through the eyes (Lai et al., 2011). In summary, the 12 journal articles reviewed in this section suggest that females with ASD generally have lower intelligence test scores than males with ASD and that specific cognitive skills may vary by sex.
Developmental Regression
Parents of some children with ASD report a period of typical development followed by a loss in language, social, motor, self-help, imaginative play, or other skills. This developmental regression is usually reported to occur between 15 and 24 months of age (Meilleur and Fombonne, 2009). Our review found six articles that met search criteria and addressed developmental regression. These six articles were published between 2007 and 2013 and comprised two cohort studies, three cross-sectional studies, and one surveillance study. In a population-based surveillance study of children with ASD, 17 % of children had documented developmental regression and that percentage rose if the child had a previous ASD diagnosis (Wiggins et al., 2009). Males had significantly more regression than females and were more likely to regress at a younger age (Wiggins et al., 2009). This higher risk of regression in males was also seen in smaller, non-population based studies (n=4, 8, and 17 female children) (Bernabei et al., 2007; Ekinci et al., 2012; Zhang et al., 2012). In contrast, a cross-sectional study found that females aged 18 months to 15 years had significantly higher occurrence of regression as compared to males (30 % vs. 19 %) (Ben-Itzchak et al., 2013). No difference in the presence of developmental regression between males and females with ASD was observed in a small clinical sample of 20 females (Meilleur and Fombonne, 2009). In sum, the review of sex differences of developmental regression is contradictory and thus inconclusive.
Excess/Absence of Fear
Excess or absence of fear is more common in children with ASD than other children (Evans et al. 2005; Nicholas et al., 2008). In a population-based surveillance of eight-year olds, Nicholas et al. (2008) found that 32 % of children with ASD had atypical fear noted in service records compared to 6 % of children with ASD symptoms but no ASD diagnosis. Three articles met search criteria and addressed excess or absence of fear. All three of these articles were published in the United States between 1990 and 2011 and were two cross-sectional studies and one case–control study. In these studies, females with ASD had more specific phobias than males with ASD (Gadow and DeVincent, 2012; Matson and Love, 1990) and more unusual fears (Mayes et al., 2013). One study conducted by Matson and Love (1990) found more fear in typically developing female children compared to male children and no significant difference in fear between typically developing female children and female children with ASD. Given the sparse amount of research on this topic, further exploration is warranted to understand sex differences in fear among persons with ASD.
Safety Issues (Self-Injury/Elopement)
About 50 % of children with ASD engage in self-injurious behavior (Richards et al., 2012; Baghdadli et al., 2003; Duerden et al., 2012). Four studies met search criteria and three pertained to self-injurious behavior. All three of these studies were cross-sectional designs with two being conducted in Europe and one in the United States. No difference in self-injurious behavior was found between males and females with ASD (Richards et al., 2012; Baghdadli et al., 2003; Duerden et al., 2012).
Elopement, also known as wandering off, is a rising concern among parents of children with ASD. One online survey addressing elopement met our search criteria. This survey was conducted in the United States in 2013 and found that 49 % of parents reported that their child with an ASD wandered off at least once after the age of four years (Anderson et al., 2012). Results also found that sex did not influence the prevalence of elopement, although children with more intellectual impairment were more likely to elope (Anderson et al., 2012). Few conclusions can be drawn since there is little research on elopement and other safety issues in children with ASD and associated sex differences.
Psychiatric Domain
Anxiety/Mood Disorders
Symptoms of anxiety and mood disorders are more prevalent in children with ASD than in typically developing children (Worley and Matson, 2011; Nicholas et al., 2008). Among children who met a surveillance definition for an ASD, 55 % had abnormal mood or affect compared to 26 % of children with at least one symptom of an ASD but no ASD diagnosis (Schendel et al., 2009). The Special Needs Autism Project in the UK found 44 cases of emotional disorder per 100 children with ASD (Simonoff et al., 2008). Moreover, among eight-year-old children who met a surveillance definition for an ASD, 3 % had anxiety, 2 % had emotional disorder, 2 % had mood disorder, and less than 2 % had obsessive-compulsive disorder (OCD), depression, bipolar, or oppositional defiant disorder (Levy et al., 2010). Nine studies were found that met search criteria and addressed anxiety or mood disorders. These nine studies were published between 2005 and 2012 and included five cross-sectional studies and four case–control studies. Four of the studies were conducted in the United States and five were conducted in other countries.
The literature on sex differences in co-occurring anxiety or mood disorders and ASD is mixed and dependent on cognitive abilities. In some studies, females with high functioning autism were at greater risk for internalizing psychopathology than both male children with ASD and typically developing female children (Solomon et al., 2012; Mandy et al., 2012). These studies are supported by a Finnish report that found female children with ASD had lower scores on a test associated with major depressive disorder compared to male children with ASD (Mattila et al., 2010). Other studies found no sex differences in the of co-occurrence of anxiety or depression in children with ASD and varying cognitive abilities (Quek et al., 2012; Gadow et al., 2005; Park et al., 2012b; Simonoff et al., 2008; Mayes and Calhoun, 2011; Lai et al., 2011). In the general population, females have more panic attacks, generalized anxiety disorders and males have more social anxiety (American Psychiatric Association, 2013). Based on this review, the current literature is inconclusive on whether a sex difference in children with ASD and co-occurring anxiety or mood disorders exists, although a few studies suggest more anxiety and mood disorders in females than males with ASD.
Schizophrenia
Schizophrenia is a mental disorder that involves delusions, disorganized behavior, disorganized speech, hallucinations, and restrictions in the range and intensity of emotions (American Psychiatric Association, 2013). Schizophrenia typically presents between 18 and 30 years of age with earlier onset associated with male sex. Lifetime prevalence of schizophrenia is near 0.2 % (American Psychiatric Association, 2013) The prevalence of schizophrenia in eight-year olds with ASD is less than 1 % (Levy et al., 2010). Two articles met search criteria and addressed schizophrenia. These two articles were published in 2005 and 2010 and were both case–control studies. Review of the two studies found conflicting results on sex differences and the co-occurrence of ASD and schizophrenia or schizophrenia spectrum traits. A parental survey of 6 to 12 year olds with ASD found schizophrenia spectrum traits to be twice as prevalent in females compared to males (57 %: 28 %) independent of ID (Gadow and DeVincent, 2012). Conversely, in a group of 6 to 12 year olds with ASD and ID, schizophrenia was more common in males than females (Tsakanikos et al., 2011). Again, the literature is relatively sparse due to the late onset of schizophrenia and the rarity of co-occurring schizophrenia: future research is warranted.
Medical Domain
Birth defects/Chromosomal Disorders /Genetic Disorders
Population-based surveillance data from the 2008 ADDM report found that among children with ASD, less than 1 % had a co-occurrence of fragile X syndrome, Down syndrome, chromosomal disorders, or other genetic and congenital diagnoses (Levy et al., 2010). It is likely that these rates are under-reported because investigation of ASD co-occurring conditions was not the focus of the ADDM surveillance effort. However, a cohort study of children in Georgia found a similar prevalence of chromosomal disorders and Down syndrome in persons with ASD (Schendel et al., 2009).
There were four studies reviewed that met search criteria and addressed ASD sex differences in birth defects, chromosomal disorders, and genetic disorders: two systematic reviews, one case–control study, and one surveillance study. Co-occurring birth defects, such as impairments to the central nervous system, cardiovascular system, genitourinary system, or musculoskeletal system, appear more often in males than females with ASD. Among children with ASD, the male to female ratio was 9:1 if a child had a co-occurring birth defect and 3.6:1 if the child did not have a co-occurring birth defect (Schendel et al., 2009).
A review conducted by Reilly (2009) found that males with ASD have more co-occurring Down syndrome than females with ASD and the male to female ratio among children with both ASD and Down syndrome may be near the overall ASD prevalence ratio of 4:1. A review conducted by Wiznitzer (2004) found no difference between males and females with ASD and the co-occurrence of tuberous sclerosis. Clifford et al. (2007) found that about 70 % of males aged 5 to 80 with fragile X syndrome had co-occurring ASD while 23 % of females in the same age range with fragile X had co-occurring ASD. The difference in co-occurrence of ASD between males and females may suggest a greater association between the two conditions in males as compared to females.
It is important to note that birth defects, chromosomal disorders, and genetic disorders are rare and seldom studied. Therefore, the results on sex differences for co-occurring ASD and chromosomal and genetic conditions are inconclusive.
Head Size / Encephalopathy
Head size, specifically an enlarged head circumference or macrocephaly, has been associated with ASD (Wallace and Treffert, 2004). Three articles were reviewed that examined differences in head size between males and females with ASD. Studies include two case–control studies and one cross-sectional study. Two studies were conducted in the US and one study was conducted in Italy. A cross-sectional study by Fombonne et al. (1999) found no difference in head size between males and females aged 2 to 16 with ASD. Sacco et al. (2007) also found no difference in head size between males and females aged 3 to 16 with ASD. In contrast, Aylward et al. (2002) found larger head sizes in male adults and children compared to female adults and children with ASD, but the female sample size was low (n=9).
Abnormal Eating and Gastrointestinal Issues
In a population-based study conducted by Nicholas et al. (2008), about 54 % of children with ASD had an abnormality in eating, drinking, or sleeping, which is nearly 40 % higher than that of children with at least one symptom of ASD but no diagnosis (Nicholas et al., 2008). Some studies have shown an increase in certain gastrointestinal symptoms among persons with ASD, including constipation (Ibrahim et al., 2009) and diarrhea (Wang et al., 2006), while other studies found no significant increase in overall gastrointestinal symptoms or symptoms such as esophageal reflux, vomiting, and abdominal discomfort (Ibrahim et al., 2009; Wang et al., 2006; Valicenti-McDermott et al., 2007). However, little research on gastrointestinal issues has been conducted at a population level and no studies were found that compared males to females on gastrointestinal response. More research is needed to determine if there is an association between gastrointestinal symptoms and ASD and whether the association differs between the sexes.
Four studies were found that compared the sexes and addressed food selectivity. These four studies were conducted in the United States between 2006 and 2010 and included one case–control and three cross-sectional designs. In general, review of these studies found food selectivity and feeding issues to be more frequent in children with ASD than children without ASD (Valicenti-McDermott et al., 2007; Ibrahim et al., 2009), although limited research is available in this area. There was no difference between child sexes in over or under-eating in a study of children with high functioning autism (Worley and Matson, 2011) and no differences between the sexes in eating abnormalities in two studies conducted in children with ASD and varying cognitive abilities (Mayes and Calhoun, 2011; Horovitz et al., 2011). Based on this limited review, it appears unlikely that there is a difference in eating habits between males and females with ASD.
Seizures/ Epilepsy
Epilepsy and other seizure disorders co-occur in 5 % to 40 % of children with ASD and there is differential prevalence based on ID (Baird et al., 2008; Nicholas et al., 2008). This review found three articles that met search criteria and addressed seizures or epilepsy. These three articles were published between 2008 and 2013 and consist of a cohort study, one cross-sectional study, and one meta-analysis. Females with ASD were found to have more epilepsy than males with ASD; the male to female ratio drops to near 2:1 in children with ASD and co-occurring epilepsy, but this may be partly due to differential ID (Amiet et al., 2008; Bolton et al., 2011; Ben-Itzchak et al., 2013). There may be an increased likeliness in females with ASD to have co-occurring epilepsy or seizure disorder; however, the literature is sparse so a conclusion cannot be drawn. Further research is needed to enhance current knowledge of sex differences in children with ASD and epilepsy or seizure disorder.
Sleep Disturbances
In a systematic review of parental sleep surveys, sleep problems were present in 50 % to 80 % of children with ASD compared to 9 % to 50 % in matched typically developing children (Kotagal and Broomall, 2012). There were six articles reviewed that met search criteria and addressed sleep disturbances. These six articles were published between 2004 and 2012 and included two case–control studies, two cohort studies, and two cross-sectional studies. Four were conducted in the United States and three were conducted in other countries. Based on this review, some studies found no sex differences in sleep problems among persons with ASD (Liu et al., 2006; Wiggs and Stores, 2004; Mayes and Calhoun, 2011; Horovitz et al., 2011), one study found that female children with ASD have less sleep problems than male children with ASD (Sivertsen et al., 2012), and one study found female children with ASD have more sleep problems than male children with ASD (Hartley and Sikora, 2009). The minimal amount of research in this area leads to inconsistent results and prevents definitive conclusions on whether a sex difference exists in sleep disturbance.
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Vaccine News – This is just a tiny snapshot of the pain and suffering occurring WORLDWIDE right after the Gardasil injection

This is just a tiny snapshot of the pain and suffering occurring WORLDWIDE right after the Gardasil injection. We do not need more “studies” and more mindless meetings to use our COMMON SENSE and see that this mass-poisoning of our children must be put to an end! Right now, there is a 9-part docu-series available to everyone who intends to protect their families from the heartless industry profiting from these tragedies >>> tinyurl.com/9Episodes
✴️ Networking, exemption information and doctor resources: tinyurl.com/RevolutionForVaccineChoice
✴️ Follow us: facebook.com/RevolutionForChoice
✴️ Read all vaccine inserts: tinyurl.com/ReadTheVaccineInsert
#RevolutionForChoice #InformedConsent #EducateBeforeYouVaccinate #VAXXED #Gardasil #Cervarix #Seizures

100% Proof! Human DNA in Vaccines
Presentation recorded on February 16, 2017 in Sonora, California with Marcella Piper-Terry.
#Vaxxed #PrayBig #RecombinantDNA #InsertionalMutagenesis #FetalCellLine #ProLife #Abortion #ChooseLife #RespectLife #MarchForLife #MRC5 #WI38 #RA273 #WALVAX2
Youtube Link:
https://youtu.be/dlqFQLLOTEU
Editor: Robin Aris

Finding Hope after a Gardasil Disaster
September 19, 2013
By Tracie Toler Moorman, Overland Park, Kansas
Gardasil: An uphill battle for Maddie
Gardasil: Please research before you decide!
It is difficult to know where to begin when charting the 19-month journey my daughter and family have traveled since she was injured by the Gardasil vaccine in 2012. Maddie, my girl, as I like to call her, was a 15-year old happy, healthy, straight-A, honors/AP high school student. It was easy being her mother; it was a joy to be with her. She lit up the room when she entered. She was a beautiful writer and an amazing guitar player. That was my girl.
In December of 2011, she developed a hormone imbalance. It was rather bothersome but her pediatrician did not seem too concerned. In retrospect, I wonder if this hormone imbalance may have pre-selected her for injury from the vaccine. Perhaps it was genetics. I may never know. Her pediatrician suggested birth control pills to regulate the hormones and I took her to my gynecologist for a second opinion. My doctor concurred. Birth control pills were prescribed and while we were in the office, the gynecologist recommended the vaccine. Her pediatrician had also been recommending it. I trusted both doctors and believed them when they said that Gardasil was safe and the threat of cervical cancer was real.
As her mother, I wanted to protect her from any form of harm so I thought it made sense to begin the three-part vaccine. Maddie had always been tough when receiving vaccines but this one was very different. She described it as similar to being hit in the arm with a baseball bat swung by a professional ball player. It was excruciating pain.
Looking back, Maddie got sick after the first dose of the vaccine, but it was masked by symptoms we attributed to the birth control pills. After five days of headaches and nausea, I called the gynecologist and reported that she was not well. The doctor switched her from one birth control pill to another. The nausea subsided a bit but the headache lingered. She was still able to go about her normal routine most days.

UFC Veteran Speaks Out Against Vaccines After Tragic Death of Son
Posted on July 1, 2017
By Brandon Turbeville
“This is unacceptable, I will fight for my son, this happened to the wrong family.” – Nick Catone
Former UFC fighter, Nick Catone, is making waves on social media. But while many fighters are drawing attention to themselves for attacking their opponents, Catone is gathering attention for another reason: his vocal criticism of vaccination.
For him, the issue is very personal since on May 12, his otherwise healthy 20-month-old son passed away in the middle of the night. While the family was initially perplexed as to how a healthy little boy could just simply die without warning, consultations with numerous doctors and even an autopsy yielded no results. Instead, the cause of Nicholas’ death was listed as “natural.”
Shortly after, however, Catone began hearing stories from other parents regarding their child’s adverse reactions to vaccines, ranging from seizures to autism and death. Catone began doing his own research and is now convinced that it was the vaccine that killed his son.

Italian Government To Remove Unvaccinated Children From Parents
June 17, 2017 Baxter Dmitry
Major demonstrations have rocked Italy this past week as the government attempts to pass a new law that will triple the number of mandatory vaccinations for Italian children and threatens to remove unvaccinated children from their parents.
“Lorenzin cancel your law, we are not your herd,” tens of thousands of Italians chanted at a protest in Rome, holding banners decrying government overreach into their homes and the health of their children.
Under the draconian new law, Italian children who have not received the full schedule of 12 mandatory vaccinations will lose their right to attend school, the parents will be fined up to 7,500 euros ($8396), and in case the Italian government had not already made it clear they are completely in the pockets of Big Pharma, they also announced that unvaccinated children will be taken away by local child protective services.
But Italians of all stripes are rising up in defiance of the new law. Politicians, associations, doctors, lawyers, and parents came together for the first time on the streets of Rome to make their voices heard.
One protestor shared a heart-rending account of his difficulties raising a vaccine damaged child in Italy:
“I am here as a parent, as a parent of a child who, unfortunately, has been damaged by a hexavalent vaccine. I am a parent who has tried to follow the path of the law and I have found myself in front of shameful situations, when the state courts consider vaccine injured kids as, allow me to say, the town’s idiots, the losers.”

15,000 PEOPLE MARCH IN ROME AGAINST AN OPPRESSIVE NEW MANDATORY VACCINE LAW
from Francesca Alesse

Vaccines, Retroviruses, DNA, and the Discovery That Destroyed Judy Mikovits’ Career
December 1, 2015 by Allene Edwards
Last updated on: March 15, 2017
Judy Mikovits, PhD is a biochemist and molecular biologist with more than 33 years of experience. Internationally known, a veritable “rock star” of the scientific world, she served as the director of the lab of Antiviral Drug Mechanisms at the National Cancer Institute before directing the Cancer Biology program at EpiGenX Pharmaceuticals. She later developed the first neuroimmune institute. Her early work focused on cancer and HIV, her latest on Chronic Fatigue Syndrome and autism. She has published more than 50 peer-reviewed articles.
In 2011, she made the discovery that destroyed her career. She found that at least 30% of our vaccines are contaminated with gammaretroviruses. Not only is this contamination associated with autism and chronic fatigue syndrome, it is also associated with Parkinson’s, Lou Gehrig’s disease, and Alzheimer’s.
When she released this shocking information, she was warned by Dr. Andrew Wakefield that she would become a target, just as he had been. But she assured him that all of her work had been properly reviewed and, of course, she was safe.
She was wrong. She was threatened and told to destroy her data; she refused. She was fired, then arrested for supposedly stealing her data from her worksite. She had been facing charges and was bound by a gag order from the court for the last four years. Recently, charges were dropped and the gag order was lifted. Dr. Mikovits is now free to talk, and boy is she talking.
The retroviruses contaminating vaccines originate from mice used for research. Dr. Mikovits asks, “How many new retroviruses have we created through all the mouse research, the vaccine research, gene therapy research? More importantly, how many new diseases have we created?”
“When they destroyed all of our work, and discredited everything I or Frank Ruscetti had ever published, and arranged for the publication of my mug shot in Science, the NIH very deliberately sent the message to researchers everywhere about what would happen to any honest scientist who dared ask those important questions.”
New technology now exists to clean up retroviruses in vaccines and blood. Dr. Mikovits believes we will win this war, that we will eventually clean up vaccines, stop vaccinating infants, and stop injecting our children with multiple vaccines. But she also believes the government will continue to cover up their culpability in the current epidemic of autism and other diseases.

Dr. Suzanne talks about mumps in Washington State and responds to criticism.
LINKS:
Document: http://www.vaxxed.com/wp-content/uploads/2017/06/A-Scientific-Reply-to-a-Simple-Minded-Criticism.pdf
Powerpoint: http://www.vaxxed.com/wp-content/uploads/2017/06/Reply-To-Kathy.pdf
#vaxxed #science #truth

Mercury and Aluminum in Vaccines: a Primer on NVIC’s Vaccine Ingredients Calculator
Posted on January 30, 2012 by Marcella
by Marcella Piper-Terry, M.S.
This article will tell you how to recognize the symptoms of aluminum toxicity. Aluminum toxicity is something I am very concerned about. In 2004, a large portion of the mercury that was previously used in childhood vaccines was removed from those sold and administered in the United States.
Many people, including many physicians, believe and will tell you “There is no mercury in vaccines anymore. They took that out years ago!” This is not true. For a list of vaccines that still contain mercury above EPA safety levels click here. Seven vaccines are reported to still contain thimerosal, which is 49.5% mercury.
The statement that there is no thimerosal in vaccines anymore is usually made by those attempting to make the claim that there is no link between autism and vaccines. These folks will frequently say things like, “They removed mercury from the shots and the autism rate has continued to go up! That proves vaccines don’t cause autism!”
Ummm….. No. and No.
At almost the exact same time they took a large percentage of mercury out of what was then the childhood schedule, the CDC and ACIP made a new recommendation. The vaccine-pushers recommended every pregnant woman receive a flu shot during the second trimester. In addition, the recommendation was made that every child receive annual flu vaccines, beginning at six months of age.
Flu vaccines often contain high levels of thimerosal, which is 50% mercury. Those pregnant mothers and infants who are most likely to get the flu vaccines with mercury are those who are the least likely to have adequate health care. Physicians in private practices are more likely to use single-dose vials. It’s the multi-dose vials that contain the highest level of Thimerosal: 50 mcg. for the adult dose and 25 mcg. for the pediatric dose. That means when a pregnant woman gets a flu shot from her local health department, Walmart, CVS, University Health Center, etc… her tiny fetus is being injected with levels of toxic mercury that are hundreds of times above the “safe limit” (as defined by the EPA).
If the fetus survives and if he/she is vaccinated again at six months, 18 months and every year after that, and if those vaccines are administered from multi-dose vials, he or she is getting a whopping dose of mercury every year.

Study – Hepatic response to aluminum toxicity: dyslipidemia and liver diseases.
Abstract
Aluminum (Al) is a metal toxin that has been implicated in the etiology of a number of diseases including Alzheimer’s, Parkinson’s, dialysis encephalopathy, and osteomalacia. Al has been shown to exert its effects by disrupting lipid membrane fluidity, perturbing iron (Fe), magnesium, and calcium homeostasis, and causing oxidative stress. However, the exact molecular targets of aluminum’s toxicity have remained elusive. In the present review, we describe how the use of a systems biology approach in cultured hepatoblastoma cells (HepG2) allowed the identification of the molecular targets of Al toxicity. Mitochondrial metabolism is the main site of the toxicological action of Al. Fe-dependent and redox sensitive enzymes in the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS) are dramatically decreased by Al exposure. In an effort to compensate for diminished mitochondrial function, Al-treated cells stabilize hypoxia inducible factor-1α (HIF-1α) to increase ATP production by glycolysis. Additionally, Al toxicity leads to an increase in intracellular lipid accumulation due to enhanced lipogenesis and a decrease in the β-oxidation of fatty acids. Central to these effects is the alteration of α-ketoglutarate (KG) homeostasis. In Al-exposed cells, KG is preferentially used to quench ROS leading to succinate accumulation and HIF-1α stabilization. Moreover, the channeling of KG to combat oxidative stress leads to a reduction of l-carnitine biosynthesis and a concomitant decrease in fatty acid oxidation. The fluidity and interaction of these metabolic modules and the implications of these findings in liver-related disorders are discussed herein.

Study – Mechanisms of aluminum adjuvant toxicity and autoimmunity in pediatric populations
L Tomljenovic, CA Shaw
First Published January 10, 2012
Abstract
Immune challenges during early development, including those vaccine-induced, can lead to permanent detrimental alterations of the brain and immune function. Experimental evidence also shows that simultaneous administration of as little as two to three immune adjuvants can overcome genetic resistance to autoimmunity. In some developed countries, by the time children are 4 to 6 years old, they will have received a total of 126 antigenic compounds along with high amounts of aluminum (Al) adjuvants through routine vaccinations. According to the US Food and Drug Administration, safety assessments for vaccines have often not included appropriate toxicity studies because vaccines have not been viewed as inherently toxic. Taken together, these observations raise plausible concerns about the overall safety of current childhood vaccination programs. When assessing adjuvant toxicity in children, several key points ought to be considered: (i) infants and children should not be viewed as “small adults” with regard to toxicological risk as their unique physiology makes them much more vulnerable to toxic insults; (ii) in adult humans Al vaccine adjuvants have been linked to a variety of serious autoimmune and inflammatory conditions (i.e., “ASIA”), yet children are regularly exposed to much higher amounts of Al from vaccines than adults; (iii) it is often assumed that peripheral immune responses do not affect brain function. However, it is now clearly established that there is a bidirectional neuro-immune cross-talk that plays crucial roles in immunoregulation as well as brain function. In turn, perturbations of the neuro-immune axis have been demonstrated in many autoimmune diseases encompassed in “ASIA” and are thought to be driven by a hyperactive immune response; and (iv) the same components of the neuro-immune axis that play key roles in brain development and immune function are heavily targeted by Al adjuvants. In summary, research evidence shows that increasing concerns about current vaccination practices may indeed be warranted. Because children may be most at risk of vaccine-induced complications, a rigorous evaluation of the vaccine-related adverse health impacts in the pediatric population is urgently needed.

Study – Aluminum Adjuvant in Vaccines Causes Risk to Children According to New Journal Report
Share Article
A new Canadian study of the mechanisms of aluminum adjuvant toxicity in pediatric patients confirms that immune challenges during early development, including those vaccine-induced, can lead to permanent detrimental alterations of the brain and immune system function. Lucija Tomljenovic, PhD and Christopher A. Shaw, PhD of the University of British Columbia’s evidence-based study was recently published in Lupus, the only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research.
Summary
Immune challenges during early development, including those vaccine-induced, can lead to permanent detrimental alterations of the brain and immune system function. Experimental evidence also shows that simultaneous administration of as little as two to three immune adjuvants can overcome genetic resistance to autoimmunity. In some developed countries, by the time children are 4 to 6 years old, they will have received a total of 126 antigenic compounds along with high amounts of aluminum (Al) adjuvants through routine vaccinations. According to the US Food and Drug Administration, safety assessments for vaccines have often not included appropriate toxicity studies because vaccines have not been viewed as inherently toxic. Taken together, these observations raise plausible concerns about the overall safety of current childhood vaccination programs.
When assessing adjuvant toxicity in children, several key points ought to be considered:
1) During prenatal and early postnatal development the brain is extremely vulnerable to neurotoxic insults;
2) Aluminum is a neurotoxin and a strong immune stimulant. Hence, aluminum has all the necessary biochemical properties to induce neuro-immune diseases. Autism is one such disease. Namely, autism is characterized by dysfunctional immunity and abnormalities in brain function;
3) In adult humans aluminum vaccine adjuvants have been linked to a variety of serious autoimmune and inflammatory conditions, yet children are regularly exposed to much higher amounts of aluminium from vaccines than adults;
4) It is often incorrectly assumed that peripheral immune challenges (analogous to vaccinations) do not affect brain function. However, it is now clearly established that there is a cross-talk between the nervous and the immune system. It is also demonstrated that this cross-talk plays a crucial role in both immunoregulation as well as brain function. In turn, perturbations of the neuro-immune regulatory system have been demonstrated in many autoimmune diseases and are thought to be driven by a hyperactive immune response;
5) The same components of the neuro-immune regulatory system that have key roles in both brain development and immune function are heavily affected by aluminum adjuvants;
In summary, research evidence shows that increasing concerns about current vaccination practices may indeed be warranted. Because children may be most at risk of vaccine-induced complications, a rigorous evaluation of the vaccine-related adverse health impacts in the pediatric population is urgently needed.

Quantities of Vaccine Excipients – updated September 2016

Tetanus Vaccine Causes a New Disease Known as Antiphospholipid Syndrome
July 3, 2017
by Heidi Stevenson
Gaia-Health.com
The vaccine junta is not only unconcerned with vaccine-induced diseases, it’s massively gearing up this vaccine arms race against the human race. It’s known that tetanus vaccine causes a new disease, antiphospholipid syndrome. New adjuvants are composed of phospholipids, a potential disaster.
The tetanus vaccine causes a new disease known both as Hughes syndrome and antiphospholipid syndrome (APS). It’s an autoimmune condition that can attack any part of the body, though is best noted for heart attacks and killing fetuses. It’s likely that APS will become more common with the new generation of vaccine adjuvants now being produced.
The sufferers of (APS) are mostly women, and its diagnosis is often made as a result of multiple pregnancy losses. As is typical of new diseases, research is focused on finding a genetic cause, in spite of the fact that the connection with vaccines is well known and documented.
As the name implies, APS is a condition in which phospholipids, natural and necessary substances required by every part of the body, is seen as an infectious agent by the immune system. So, this substance that exists in every cell becomes subject to attack. Symptoms include:

Blindness
Cardiovascular:
Deep vein thrombosis (clots in veins)
Phlebitis
Thrombocytopenia (deficiency of blood platelets, causing bleeding & bruising)
Atherosclerosis
Pulmonary embolus (clots in the lungs)
Heart valve abnormatilies
Stroke
Headaches & migraines
Miscarriages
Neurological disorders:
Epilepsy
Chorea (sudden uncontrollable jittery movements)
Transverse myelitis (inflammation of the spinal cord)
Multiple sclerosis
Cognitive dysfunction
Skin disorders, including mottling, ulcers, and necrosis
APS can also be diagnosed—more accurately, misdiagnosed—as lupus erythematosus, which is another vaccine-induced condition.

APS and Vaccines
One study calls Hughes syndrome the “classical antiphospholipid syndrome”[1]. That study refers to similarities between plasma protein beta-2-glycoprotein-I (β2GPI), which is attacked in APS, and the tetanus vaccine. That is, the tetanus antigen has parts that are virtually identical to β2GPI, which is found virtually everywhere in the body.
Another study documents how APS can be induced in laboratory animals with tetanus vaccination[2]. Many large number of other studies document and investigate the connection between vaccines and antiphospholipid syndrome[3,4,5,6,7,8].
These studies leave little doubt that APS is caused by vaccines. That should come as little surprise, since it was first identified as a disease during the 1980s. If this disease existed prior to vaccines, it was so rare that it was unknown. Now, it can take its place among a growing list of vaccine-induced conditions, including rheumatoid arthritis, macrophagic myofasciitis, multiple sclerosis, autism, and siliconosis. The list keeps growing and many believe that all these conditions should be included under a single name, autoimmune/inflammatory syndrome induced by adjuvants, or ASIA.

Dara Berger, author of “How to Prevent Autism: Expert Advice from Medical Professionals,” DEMOLISHES pro-vax propaganda. You too can be JUST as informed and confident in your decisions ~ Learn everything you need to know, for FREE while this ground-breaking docu-series is still available! ➤➤➤ tinyurl.com/9Episodes
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The vitamin with a black box warning
Interview recorded on February 5, 2017 in Riverside, California.
Editing: Robin Aris

“Just a Vitamin” – Child with MTHFR Poisoned by Vitamin K Shot at Birth
Nicole was firm in her decision to delay all vaccines, but she was under the common misconception that the Vitamin K shot was, “just a vitamin”. She believes that her now 13 year-old son, Wyatt, was poisoned by the “Vitamin” K shot at birth. The shot now carries a black box warning.
Interview recorded on February 2, 2017 in San Diego, California
#Vaxxed #VaxxedNation
Editor: Robin Aris

I said please give him everything
Interview recorded on February 5, 2017 in Riverside, California.
Editing: Robin Aris

VaxXed Stories: Lily in Florida
Lily was born with Moebius Syndrome, believed to have been caused by her mothers flu vaccine while pregnant. Lily suffered subsequent damage from her childhood vaccines as well.

Expert believes the lower teen birth rate may be due to infertility from Gardasil
By Erin Elizabeth – June 23, 2017
Based on birth certificate data, teen birthrates are dropping. In 2015, the teen birthrate hit a record low, dropping 8%. In 2014, the birthrate per 1000 teen girls (aged 15 to 19) fell to 22.3 births. Since 1991 there’s been a 64% decrease.
The CDC is touting (as you can imagine) the success of birth control. After all, they’ve spent decades as “pharma’s marketing voice.”1 But, what if something else more sinister is responsible for the lower birthrate?
According to Norma Erickson from SaneVax, the Gardasil vaccine being given to teens to “prevent” HPV might actually be causing infertility (among other things):
“I would suspect that quite a bit of it may be related to Gardasil, particularly since there have been campaigns targeting black, Hispanic and ‘at risk’ young women (those incarcerated) – coincidentally also those with the highest teen birth rates.
I have personally spoken with a 17 year old California boy who after the second injection is impotent. He said one of his friends has the same problem, but is too embarrassed to speak of it (even to his parents).
We are barely seeing the tip of the iceberg.” 2

Gardasil: Don’t let your child become “one less”
By Erin Elizabeth – March 7, 2015
Today we have an article written by Shannon Powers
SaneVax.org
I share our story hoping our experience will save another from becoming “one less” healthy child.
Our fifteen year old daughter, Leah is vaccine injured. It all began March 30th 2011. Leah was 11 years old, soon to be 12. We had been referred to an Adolescent doctor so Leah could be placed on oral contraceptives to help prevent cysts from forming on her ovaries.
A month prior, February 20, 2011 Leah had an Oophorectomy losing her left ovary. We were told since we had just gone through this scary ordeal, in order to keep her healthy we needed to vaccinate with the Gardasil vaccine.
Trusting in doctors and believing what they recommend is best, I never questioned their belief that this was a “must” for Leah’s health. After all, Leah had received all her recommended vaccines prior to Gardasil. What could we possibly have to worry about?
First, I have to tell you Leah has a very high tolerance for pain. The only way I knew I needed to take her to the hospital in February was because she was clammy and dry heaving. The surgeon who performed the Oophorectomy came and told us after, that she should have been in excruciating pain.
She laughed when telling Leah, “I tells my kids to quit complaining all the time, but YOU need to complain and let us know when something is wrong in your body. You know your body best and when something is off let mom and dad know!”
Recovery went smooth and we then were released and referred to the adolescent doctor for all of Leah’s follow-up care.

Holistic MD Exposes Gardasil Coverup: Deceptive Emails by Health Officials
By Erin Elizabeth – January 29, 2016
Holistic MD Exposes Gardasil Coverup
By: Brian Shilhavy
“I predict that Gardasil will become the greatest medical scandal of all times because at some point in time, the evidence will add up to prove that this vaccine, technical and scientific feat that it may be, has absolutely no effect on cervical cancer and that all the very many adverse effects which destroy lives and even kill, serve no other purpose than to generate profit for the manufacturers.”
This past week, Dr. Sin Hang Lee, M.D., F.R.C.P. (C), FCAP, director of the Milford Molecular Diagnostics Laboratory in Connecticut, proved Dr. Dalbergue’s prediction correct, when he published a letter sent to the U.S. CDC, the World Health Organization, the Ministry of Health in Japan, and others, documenting “scientific misconduct” among the world’s leading health organizations tasked with providing vaccine safety, by deliberately misleading Japanese health authorities on the safety of the HPV vaccine.
Japanese health authorities had halted their recommendation of the HPV vaccines in 2013 due to safety concerns. Japanese officials began a full investigation into the HPV vaccines at that time.
Dr. Sin Hang Lee has allegedly discovered that at a public hearing on HPV vaccine safety which was held in Tokyo, Japan on February 26, 2014, members of the Global Advisory Committee on Vaccine Safety (GACVS), the World Health Organization, the CDC and other scientific/health professionals:
deliberately set out to mislead Japanese authorities regarding the safety of the human papillomavirus (HPV) vaccines, Gardasil® and Cervarix®, which were being promoted at that time.
Dr. Lee discovered the alleged deception by obtaining a series of emails via a Freedom of Information request submitted in New Zealand.
According to Dr. Lee, these emails reveal:
that Dr. Robert Pless, the chairperson of the Global Advisory Committee on Vaccine Safety (GACVS), Dr. Nabae Koji of the Ministry of Health of Japan, Dr. Melinda Wharton of the CDC, Dr. Helen Petousis-Harris of Auckland University, New Zealand, and others (including WHO officials) may have been actively involved in a scheme to deliberately mislead the Japanese Expert Inquiry on human papillomavirus (HPV) vaccine safety before, during and after the February 26, 2014 public hearing in Tokyo. (Source.)

Allegations of Scientific Misconduct by GACVS/WHO/CDC Representatives et al
An open-letter of complaint to the Director-General of the World Health Organization, Dr.Margaret Chan chanm@who.int

Healthy Boy Dies After Gardasil Injection
By Erin Elizabeth – July 7, 2016
Joel Gomez was just 14 years old. Medical records show he was a healthy boy who made all his check-ups at his pediatrician’s office.
He had no pre-existing health issues.
He had no cardiac abnormalities, psychological disorders, substance abuse, or any other issues.
But, he had a vaccine the day before he died.
From the article:
“An expert hired by the family of a boy who died after his second Gardasil injection has testified that Gardasil likely caused the boy’s death. The case – Gomez versus USDOH: Petition No. 15-0160V1 – was filed by a California law firm for petitioners Adan Gomez and Raquel Ayon, on behalf of their deceased son Joel Gomez. The petition states, in part:
“Joel Gomez received a Merck Gardasil vaccine on June 19, 2013 and again on August 19, 2013, and died in his sleep the following day on August 20, 2013. The death was caused in fact by receiving the Gardasil Vaccine.
Gardasil did cause or contributed to a myocardial infarction in the decedent, and that the second dose of Gardasil finally caused a fatal hypotension in this case on the day of vaccination. There was no other plausible cause for the death of Joel Gomez. . .”
Sadly, Joel was another casualty of the Gardasil vaccine.

Natural News – Top 9 vaccines you NEVER need and exactly why the CDC has to scare everybody into getting them
Monday, June 13, 2016 by: S. D. Wells
What the medical industrial complex doesn’t want anyone to know
The real reason many children and babies have weaker immune systems than adults is because they receive over 50 toxic vaccines before age 7, as recommended by the CDC and the state department – and enforced at gunpoint in certain states, like California.
Chicken pox is a common childhood disease caused by a virus that lasts two to four days, and then most children are immune to it for life. Measles is like a cold that can include a cough, fever and a blotchy rash that fades after a few days and peels. Mumps is an acute viral infection usually accompanied by a mild fever lasting a couple of days, with a sore throat and swollen glands. What the medical industrial complex doesn’t want anyone to know is that the normal human body that’s not beaten down and infected by vaccine toxins and food toxins beats these infections easily. Same goes for the Zika virus, which does not cause deformations in babies; that’s all a huge lie and scare tactic. The swine flu was a hoax, as was the vaccine, and those vaccine manufacturers have paid out millions in damages due directly to that toxic jab. Then there’s the MMR vaccine that causes autism, as confessed by the head CDC scientist, Dr. William Thompson.
The anthrax vaccine is highly experimental and dangerous, and the polio vaccine, given by injection or through oral or nasal application, actually spreads the disease, with those children themselves becoming carriers, infecting other children and family members. It’s criminal and the vaccine industry knows it, but the profits from selling the vaccine to all the paranoid parents and brainwashed, uneducated folks through fear-mongering far outweigh the damages paid out in settlements for health detriment. It’s a simple formula for evil capitalistic success: sell millions of toxic vaccines and create a slush fund from about 1 percent of those profits to shut parents up who try to sue the industry when their kids and babies become crippled and maimed.
The only thing parents should be scared of is the vaccine industry. Take measures to build immunity with organic food and holistic medicine, and don’t fall for all the propaganda and fear-mongering spread by the CDC in America. End of story.

 

Vaccine News – Vaccine Mechanisms in Autism

 

Truth from “a real doctor” about vaccines, both medically and the business of running a medical clinic without accepting the bribes for vaccinating children.

Six doctors who have administered vaccines in their practice are all asked the same question. When you were in medical school, how much education regarding vaccines was provided before you were permitted to administer them?
Interviews, camera and editing by Joshua Coleman.

Our 8 Unvaccinated children are super healthy #vaxxed #prayBig #PeoplesStudy #truth #science

Newborn baby dies after receiving eight vaccinations on schedule; pathologists confirm vaccines responsible for death
A mother from Michigan has gone through an emotional journey in finding exactly what caused her son to mysteriously die.
What she uncovered is another case added to the excessive vaccination-induced early death.
Elijah Daniel French was born on May 4, 2007, and had mysteriously died a couple days after receiving 8 routine vaccinations, as recommended by the Centers for Disease Control and Prevention (CDC) for childhood vaccination. This was determined by child death investigator and many pathologists to have been a result from vaccination.
According to VacTruth.com: Baby Elijah was happy, healthy, and smiling until he underwent routine vaccinations. His health began to worsen, and ended up developing a high fever and breathing problems.
In the family account, it was noted that Danny had been vaccinated for seven other conditions at 5 1/2 months old, including hepatitis B, DTaP, Hib, pneumococcal and polio vaccines. To make things worse, a few months later he was brought over to the doctor’s office where he was administered a second round of the same vaccines. This caused him to develop asthma and exacerbated his problems even more.
Daniel’s mother didn’t know what else to do, other than see a doctor for her Childs condition. So, she brought Daniel back to the doctor’s office where ehe was given a third round of vaccines at 14 months old. He was administered 8 vaccines in 4 injections: Varicella, Hib, DTaP and MMR (measles, mumps, and rubella). This is when Daniel’s started to dramatically worsen.
“That night, Danny was still eating and drinking but was cranky and slept more than usual,” his mother reported.
“By the next day, he was extremely fatigued, irritable and had a loss of appetite. He did not have a fever at this time. He was red and warm where they injected him. These symptoms only worsened.”
“By the third day, Danny was unable to stay awake for longer than thirty minutes, he had zero food intake, his fluid intake diminished and he cried excessively. Seventy-one hours after his doctor visit, Danny developed a fever from the vaccines and was given Children’s Tylenol. His doctor was called but there was no answer from him because it was the July 4th holiday, the office was closed.”
Three independent pathologists confirm that young Danny’s death was caused by vaccines

Infant Accidentally Vaccinated with Gardasil – Mother Blamed for Vaccine Injuries and Baby Medically Kidnapped
June 29, 2017
by Health Impact News/MedicalKidnap.com Staff
Doctors call it a “medication administration error.” During a routine check-up at her pediatrician’s office, 4-month old Aniya was accidentally given the Gardasil 9 vaccine, and she hasn’t been the same since.
Anita Vasquez of Victoria, Texas, herself a nurse, says that “doctors are in denial” that any of the medical issues that began after her daughter received the shot are related to the vaccine.
Aniya was a happy and healthy breastfed baby before her 4-month doctor visit. Her only illness was an ear infection which had been cleared up with antibiotics shortly before that fateful day of December 29, 2016. Since then, she has suffered numerous health issues and several hospitalizations.
Rather than acknowledge the possibility that the Gardasil 9 vaccine contributed to the decline in Aniya’s health, doctors and Child Protective Services have reportedly blamed the mother. Her desperate search for answers has led instead to her being accused of Munchausen by Proxy, or “medical child abuse,” and her baby has been seized by the Texas Department of Family and Protective Services (DFPS).
Anita told Health Impact News that her concerns about the vaccine have been dismissed and ignored by virtually everyone involved in her daughter’s care. DFPS refers to her “unfounded concerns” about the Gardasil 9 vaccine. She believes that they are trying to cover up the dangers of the vaccine.
This is any mother’s worst nightmare, and no one deserves this.
Distracted Doctor Administers Wrong Vaccine – Infant Received 8 Vaccines at Same Visit
The Vasquez family nightmare began when Anita took her 13 year old son and her 4 month old baby girl to a routine check-up.
Anita is a registered nurse by trade, and she didn’t question the recommended vaccinations. Her son was to receive the Gardasil 9 vaccine, and her daughter was to receive 2 shots and an oral vaccine. The nurse drew up and labeled the vaccines and placed the syringes in a single envelope.
Anita says that Dr. Veronica Guel-Valdivia came into the room talking on her cell phone. When the doctor finished her phone conversation, she asked Anita to put baby Aniya on the table.

Polio Paralyzes 17 Children in Syria, W.H.O. Says
Unlike Syria’s first polio outbreak in 2013, caused by a wild strain that paralyzed 36 children before it was brought under control, the new outbreak derived from the polio vaccine itself, Mr. Jasarevic said.
The vaccine, a weakened form of the polio virus that triggers the immune system’s response, is secreted in the waste of vaccinated children, and over time can mutate into an infectious strain that may afflict the unvaccinated. The risks are especially high in areas where not all children have received the vaccine and where the mutated virus can spread from contaminated sewage or water.
“These vaccine-derived outbreaks really are a marker of poor vaccination and poor sanitation in the community,” said Dr. Homer Venters, director of programs at Physicians for Human Rights, an international aid group based in New York that supports humanitarian work in war zones, including Syria and Yemen.

After receiving a flu shot, this beautiful young girl suffered vaccine-induced paralysis, also known as Transverse Myeltis, one of many labels given to our modern-day “Polio”, which was never eradicated by vaccines and in fact, is many times directly caused by them.
What else aren’t you being told? Find out here, while this groundbreaking, 9-part docu-series is still free>>> tinyurl.com/9Episodes
Guillain-Barré Syndrome is another label given to this paralysis, very often caused by vaccines.
More info here: vactruth.com/2012/04/25/change-names-of-diseases
✴️ Networking, exemption information and doctor resources: tinyurl.com/RevolutionForVaccineChoice
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Flu Vaccine Efficacy Slips From Prior Estimate, CDC Says
Robert Lowes
June 23, 2017
The influenza vaccine for the 2016-2017 season was 42% effective in preventing an infection from any A or B virus in people of all ages, down from a preliminary estimate of 48% in February, the Centers for Disease Control and Prevention (CDC) announced earlier this week.
The CDC frames the effectiveness rating in terms of reducing a vaccinated person’s risk of getting sick and having to visit a clinician on an outpatient basis because of the flu.
The vaccine worked the best among children aged 6 months to 8 years, at 61%, and the least among individuals aged 18 to 49 years, at 19%. For people aged 65 years or older — a demographic group that’s especially vulnerable to the flu — effectiveness stood at 25%.
The CDC reported the efficacy rates at a meeting of its Advisory Committee on Immunization Practices (ACIP) in Atlanta, Georgia, on June 21 and 22.
Vaccine effectiveness varied considerably by influenza virus type. It was at its lowest in all age groups — 34% — for the A/H3N2 virus that dominated this season. Performance picked up for the A/H1N1 pandemic virus (54%), the B/Yamagata virus (55%), and the B/Victoria virus (60%), according to epidemiologist Jill Ferdinands, PhD, in the CDC’s Influenza Division.
The CDC adjusts its efficacy estimates for such factors as age, sex, and underlying medical conditions.
The 42% overall effectiveness of the latest influenza vaccine is somewhat lower than the 47% for the 2015-2016 vaccine, but a big improvement over the 23% for the 2014-2015 edition. Vaccine performance suffers when the viruses they’re designed to thwart undergo genetic drift after the vaccine is formulated. However, the CDC reported that most of the flu viruses in circulation in 2016-2017 were similar to those in the latest vaccine, which came in trivalent and quadrivalent formulas.

The prenatal flu vaccine and ASD: Good research, bad conclusions.
Brian S. Hooker, Ph.D.
June 23, 2017
Very early this year, a research group from the insurance giant Kaiser Permanente published a paper concluding no evidence of harm in administering prenatal influenza vaccines. The study authors asserted that there was no relationship between those who received the flu shot during pregnancy and later autism spectrum disorder (ASD) diagnosis in the child. However, that proclamation was not consistent with the study’s results. Specifically, women who received the vaccine during their first trimester of pregnancy showed a 20% greater risk of having the child later develop ASD. This was based on a sampling of 13,477 women who received the maternal flu shot in the first trimester, resulting in 260 ASD cases, versus 151,698 “control” women who received no flu shot during pregnancy, resulting in 2,338 ASD cases. This result was statistically significant with a p value of 0.01, which in this case means that the possibility that this is a “chance” finding and not a “true” association was just 1%. In other words, the chances of this being a “true” association are 99%.
In statistics, the gold standard “cut-off” to determine statistical significance is actually a higher p value of 0.05, meaning that the possibility of a chance association is less than 5%. Thus, the first trimester flu shot – ASD relationship should have been deemed statistically significant, with p=0.01, and accordingly a policy change should have been made to suspend use of that vaccine, at least in the first trimester of pregnancy.
However, the study authors instead reached into their statistical “bag of tricks” and trotted out what is termed the “Bonferroni” adjustment. This adjustment is applied in statistics only under very specific instances, when multiple, unrelated statistical evaluations are made using a single data sampling. In this adjustment, simply, the p value is adjusted by multiplying its original value with the number of “independent” evaluations completed in the study of that single data set (Bland et al. 1995 BMJ 310:170). In the case of Zerbo et al. 2017, there were 8 evaluations completed (4 evaluations regarding the flu shot and 4 evaluations regarding women who actually contracted the flu during pregnancy) and thus the original p value of 0.01 was adjusted to 0.08, above the “cut off” value used for deeming “statistical significance.” The Zerbo et al. authors rounded the result up to p=0.1, further moving the result away from the “magic” 0.05 cut-off level, causing the significant result to disappear.
There’s a huge problem here, however, which I pointed out in my letter to the editor of the journal (Hooker 2017 JAMA Pediatrics 171:600) published in their June 2, 2017 edition. The Bonferroni adjustment, among other corrections for multiple, independent comparisons, should not be applied to statistics when there is any interdependence within the different evaluations completed within the data sample. In this case, 4 of the evaluations completed dealt specifically with the timing of the maternal flu shot (first, second and third trimesters, as well as overall risk at any point in pregnancy) and subsequent ASD incidence. So, not only were these four trials all focused on an ASD outcome, but they all dealt with different phases of pregnancy, which were then summed to develop an “overall” risk at any phase of pregnancy. By definition, these trials were anything but statistically independent. An example of an independent evalution would be polling different groups of college students for their tastes in music, food, art, and perhaps health care practices, where none of the preferences could be empirically tied to the next.

Study – Association Between Influenza Infection and Vaccination During Pregnancy and Risk of Autism Spectrum Disorder
January 2, 2017

 

Spokane WA parents report on their vaccinated and Unvaccinated children #vaxxed #peoplesStudy #praybig #truth #science

Don’t Vaccinate to Protect My Cancer Kid
Posted on February 10, 2015
I read with great interest the recent ‘measles epidemic’ articles that addressed the vaccine debate from the point of view of a cancer parent. My interest is the result of being a cancer parent myself – my little girl has been battling leukemia on and off for the past 10 years. I read these articles, and I became angry. Very, very angry. Once again, the government and drug companies are exploiting the plight of children stricken by cancer to achieve a profit-driven end without actually helping them. In fact, this profitable end could cause great harm, even increasing the rates of pediatric leukemia, if their obvious goal of a federally mandated vaccination protocol is achieved. I am a seasoned Momcologist, a term the research-driven cancer parents call themselves. We are the cancer equivalent of Thinking Moms, critical thinkers. I have done extensive reading on the etiology of leukemia, its connection to autoimmune disease, and how vaccines and natural disease may influence these sorts of childhood illnesses. Come connect the dots with me.
Clearly, I empathize with the raw fear the parents in these articles have that their immunocompromised children may contract an illness that could be devastating. I have walked for years in their shoes. I get it. However, the parents in these articles are either grossly misinformed, or their comments have been edited with bias. Let’s get some facts straight about cancer treatment and infection. One of the first things we were warned about after my daughter’s diagnosis was live-virus vaccination. No one in the family was to receive a live-virus vaccine while my daughter was on treatment because these viruses can and do shed (1, 2, 3, 4), some for as much as four weeks (5), potentially infecting the immunocompromised patient with disastrous results. That includes the measles vaccine (MMR II and ProQuad), the intranasal flu vaccine, and the chicken pox shot. In fact, my other children were able to get medical waivers not to receive vaccines because of my daughter’s illness. I know my child is much more likely to encounter a peer at school who has been recently vaccinated with a live-virus vaccine than she is to encounter natural disease from an unvaccinated child.

Mutant Strains Of Polio Vaccine Now Cause More Paralysis Than Wild Polio
June 28, 20173:22 PM ET
For the first time, the number of children paralyzed by mutant strains of the polio vaccine are greater than the number of children paralyzed by polio itself.
So far in 2017, there have been only six cases of “wild” polio reported anywhere in the world. By “wild,” public health officials mean the disease caused by polio virus found naturally in the environment.
By contrast, there have been 21 cases of vaccine-derived polio this year. These cases look remarkably similar to regular polio. But laboratory tests show they’re caused by remnants of the oral polio vaccine that have gotten loose in the environment, mutated and regained their ability to paralyze unvaccinated children
“It’s actually an interesting conundrum. The very tool you are using for [polio] eradication is causing the problem,” says Raul Andino, a professor of microbiology at the University of California at San Francisco.
The oral polio vaccine used throughout most of the developing world contains a form of the virus that has been weakened in the laboratory. But it’s still a live virus. (This is a different vaccine than the injectable one used in the U.S. and most developed countries. The injectable vaccine is far more expensive and does not contain live forms of the virus.)
Andino studies how viruses mutate. In a study published in March, he and his colleagues found that the laboratory-weakened virus used in the oral polio vaccine can very rapidly regain its strength if it starts spreading on its own. After a child is vaccinated with live polio virus, the virus replicates inside the child’s intestine and eventually is excreted. In places with poor sanitation, fecal matter can enter the drinking water supply and the virus is able to start spreading from person to person.
“We discovered there’s only a few [mutations] that have to happen and they happen rather quickly in the first month or two post-vaccination,” Andino says. “As the virus starts circulating in the community, it acquires further mutations that make it basically indistinguishable from the wild-type virus. It’s polio in terms of virulence and in terms of how the virus spreads.”

New Polio Virus Evolution Insights Could Lead to Improved Vaccine
Blocking ‘Gateway Mutations’ Could Prevent Vaccine from Re-Evolving Virulence
By Nicholas Weiler on March 27, 2017
A relentless vaccination campaign has succeeded in eradicating the polio virus from most of the world, reducing the burden of the disease by 99 percent since the year 2000 and preventing more than 13 million children from contracting the disease, according to World Health Organization estimates. However, in regions where vaccination has remained incomplete, on rare occasions the weakened virus used in the vaccine has evolved the ability to escape the vaccinated person and spread to other, unprotected individuals.
Now a new study led by researchers at UC San Francisco and Tel-Aviv University in Israel has revealed that in every vaccine-derived polio outbreak, the polio virus used the same three evolutionary steps to evolve from harmless vaccine into a regional menace. In the new study – published online March 23, 2017, in Cell – the researchers mapped out these key steps, identifying so-called “gatekeeper mutations” that must occur before the vaccine can evolve and regain full virulence. They have used this knowledge to develop a new polio vaccine that should be unable to escape and cause outbreaks, which they hope to put into clinical trials soon.
“If one could get everyone fully vaccinated, this would prevent the virus from being able to spread and evolve, but particularly in areas of the world that are riddled with conflict and poverty, it is very hard to get full coverage,” said Raul Andino, PhD, a professor of microbiology and immunology at UCSF and senior author of the new study. “Thus, it has been critical to understand how the virus manages to evolve virulence, and come up with strategies to stop it.”

Official Push to Hide Drug & Vaccine Side Effects; Reduce Informed Consent
Posted on: Monday, June 26th 2017 at 3:45 pm
Written By: Jefferey Jaxen
In a disturbing turn of events, Big Pharma pushes to hijack informed consent by removing side effects from direct-to-consumer pharmaceutical advertising.
Direct-to-consumer pharmaceutical advertising (DTCPA) has exploded during the past several decades and is now the most prominent type of health communication the public encounters. DTCPA has been legal in the US since 1985, but exponentially expanded in 1997 when the Food and Drug Administration (FDA) changed a rule that once forced drug companies to offer a detailed list of side-effects in their long format commercials. The impact was immediate. Spending by drug companies on TV ads hit $664 million within a year. By 2005, the industry was spending more than $3 billion annually on televised direct-to-consumer (DTC) ads. 2008 saw Big Pharma post just under $5 billion. Spending on DTCPA rose 9% to $5.6 billion in 2016 and expected to rise further in 2017. To date, the US and New Zealand are the only two countries that allow DTCPA.
In what appears to be a coordinated effort both the FDA and the UK’s Academy of Medical Sciences (AMS) have each announced their intentions to hide or eliminate side effects from DTCPA and patient information leaflets (PIL). Lending credence to larger picture unfolding, both the FDA and the AMS announced their intentions to toy with further concealing drug and vaccine side effects on the same day [June 19].
Hijacking Informed Consent
The FDA announced it will begin a study titled Experimental Study of Risk Information Amount and Location in Direct-to-Consumer Print Ads. To fulfill the regulatory requirements for fair balance and the brief summary (the part of the ad which lists side effects, contraindications and effectiveness) drug companies must included risk information about their product in DTC print ads both in the main part of the ad where the product claims appear, and in a separate brief summary page. The FDA’s rationale for its new study claims that listing the unfavorable risks and side effects of a drug may be ‘overwarning’ consumers in addition to potentially leading to habituation. The agency’s Office of Prescription Drug Promotion is planning to test what happens when the side effects are reduced or eliminated from DTC television ads.
The AMS is a self-proclaimed “independent body in the UK representing the diversity of medical science” who, according to their website, is funded by GlaxoSmithKline, Amgen, Merck Sharp and Dohme, and Roche. Their recent project was “…to examine how the generation, trustworthiness and communication of scientific evidence can be enhanced [key term] to strengthen its role in decisions by patients, carers, healthcare professionals and others about the benefits and harms of medicines.” In other words since the UK can’t market drugs and vaccines directly to the consumers the AMS has set out to see how eliminating informed consent by hiding product side effects from patients will boost pharmaceutical product uptake. Their report starts out with perhaps the most important statistic to date showing widespread rejection of Big Pharma and its influence on the medical community:
“Only about a third (37%) of the public trust evidence from medical research, compared to approximately two-thirds (65%) who trust the experiences of their friends and family, according to a report launched today.”
In a rational health world focused on true healing, such dismal percentages would be evidence to rework a broken medical system, remove Big Pharma conflicts of interest in research and medical practice and begin to listen to patients. Instead, the AMS report goes on to call for “improvements” to the PIL and “a bigger role” for UK’s National Health Service to be a “source of trusted information online”. The report calls for the European Commission and the European Medicines Agency (EMA) to work with pharmaceutical companies to “reform” PIL’s.
Currently the EMA has two open complaints against it by the Nordic Cochrane Centre over maladministration, conflict of interest, secrecy and unprofessionalism concerning the handling of HPV vaccine safety data, research and whistleblowers. What kind of improvements in the PIL are being suggested? The AMS is calling for a more “balanced view” because there is too much focus on the potential side effects of drugs and vaccines on the PIL’s and not enough on their benefits. The rationale for reworking the PIL is not rooted in reality. The broken peer-reviewed process and pharmaceutical industry influence on medical research has continually omitted both greater incidences and number side effects along with exaggeration of benefits.

The Toxicity of Aluminum Adjuvants There are NO clinically approved vaccine aluminium adjuvants
Professor Christopher Exley, world’s leading expert on aluminium.
“There are NO clinically approved vaccine aluminium adjuvants !!!”
The Toxicity of Aluminum Adjuvants

Documentary – The Age of Aluminium (Die Akte Aluminium)
The Age of Aluminium: Die Akte Aluminium. A film and documentary created by Bert Ehgartner (Full English version).

Top Doctors Reveal Vaccines Turn Our Immune System Against Us
Dec 1, 2016
The research is hard to ignore, vaccines can trigger autoimmunity with a laundry list of diseases to follow. With harmful and toxic metals as some vaccine ingredients, who is susceptible and which individuals are more at risk?
No one would accuse Yehuda Shoenfeld of being a quack. The Israeli clinician has spent more than three decades studying the human immune system and is at the pinnacle of his profession. You might say he is more foundation than fringe in his specialty; he wrote the textbooks. The Mosaic of Autoimmunity, Autoantibodies, Diagnostic Criteria in Autoimmune Diseases, Infection and Autoimmunity, Cancer and Autoimmunity – the list is 25 titles long and some of them are cornerstones of clinical practice. Hardly surprising that Shoenfeld has been called the “Godfather of Autoimmunology” – the study of the immune system turned on itself in a wide array of diseases from type 1 diabetes to ulcerative colitis and multiple sclerosis.
But something strange is happening in the world of immunology lately and a small evidence of it is that the Godfather of Autoimmunology is pointing to vaccines – specifically, some of their ingredients including the toxic metal aluminum – as a significant contributor to the growing global epidemic of autoimmune diseases. The bigger evidence is a huge body of research that’s poured in in the past 15 years, and particularly in the past five years. Take for example, a recent article published in the journal Pharmacological Research in which Shoenfeld and colleagues issue unprecedented guidelines naming four categories of people who are most at risk for vaccine-induced autoimmunity.
“On one hand,” vaccines prevent infections which can trigger autoimmunity, say the paper’s authors, Alessandra Soriano, of the Department of Clinical Medicine and Rheumatology at the Campus Bio-Medico University in Rome, Gideon Nesher, of the Hebrew University Medical School in Jerusalem and Shoenfeld, founder and head of the Zabludowicz Center of Autoimmune Diseases in the Sheba Medical Center at Tel Hashomer. He is also editor of three medical journals and author of more than 1,500 research papers across the spectrum of medical journalism and founder of the International Congress on Autoimmunology. “On the other hand, many reports that describe post-vaccination autoimmunity strongly suggest that vaccines can indeed trigger autoimmunity. Defined autoimmune diseases that may occur following vaccinations include arthritis, lupus (systemic lupus erythematosus, SLE) diabetes mellitus, thrombocytopenia, vasculitis, dermatomyosiositis, Guillain-Barre syndrome and demyelinating disorders. Almost all types of vaccines have been reported to be associated with the onset of ASIA.”
ASIA – or Autoimmune/inflammatory Syndrome Induced by Adjuvants (also known as Shoenfeld’s syndrome) — first appeared in the Journal of Autoimmunology four years ago. It is an umbrella term for a collection of similar symptoms, including Chronic Fatigue Syndrome, that result after
exposure to an adjuvant – an environmental agent including common vaccine ingredients that stimulate the immune system. Since then an enormous body of research, using ASIA as a paradigm, has begun to unravel the mystery of how environmental toxins, particularly the metal aluminum used in vaccines, can trigger an immune system chain reaction in susceptible individuals and may lead to overt autoimmune disease.

Study – ‘ASIA’ – autoimmune/inflammatory syndrome induced by adjuvants.
Abstract
The role of various environmental factors in the pathogenesis of immune mediated diseases is well established. Of which, factors entailing an immune adjuvant activity such as infectious agents, silicone, aluminium salts and others were associated with defined and non-defined immune mediated diseases both in animal models and in humans. In recent years, four conditions: siliconosis, the Gulf war syndrome (GWS), the macrophagic myofasciitis syndrome (MMF) and post-vaccination phenomena were linked with previous exposure to an adjuvant. Furthermore, these four diseases share a similar complex of signs and symptoms which further support a common denominator.Thus, we review herein the current data regarding the role of adjuvants in the pathogenesis of immune mediated diseases as well as the amassed data regarding each of these four conditions. Relating to the current knowledge we would like to suggest to include these comparable conditions under a common syndrome entitled ASIA, “Autoimmune (Auto-inflammatory) Syndrome Induced by Adjuvants”.

200 Evidence-Based Reasons NOT To Vaccinate – FREE Research PDF Download!
Posted on: Sunday, February 22nd 2015 at 1:45 pm
Written By: GreenMedInfo Research Group
This article is copyrighted by GreenMedInfo LLC, 2017
The media, your pediatrician, politicians and health authorities like the CDC and FDA claim that vaccines are safe and effective. So why do hundreds of peer-reviewed studies indicate the opposite is true? Read, download, and share this document widely to provide the necessary evidence-based counterbalance to the pro-vaccination propaganda that has globally infected popular consciousness and discussion like an intractable disease.
It is abundantly clear that if the present-day vaccine climate, namely, that everyone must comply with the CDC’s one-size-fits-all vaccination schedule or be labeled a health risk to society at large, is to succumb to open and balanced discussion, it is the peer-reviewed biomedical evidence itself that is going to pave the way towards making rational debate on the subject happen.
With this aim in mind, GreenMedInfo.com has painstakingly collected over 300 pages of study abstracts culled directly from the National Library of Medicine’s pubmed.gov bibliographic database on the wide-ranging adverse health effects linked to vaccines in the today’s schedule (over 200 distinct adverse effects, including death), as well as numerous studies related to vaccine contamination, and vaccine failure in highly vaccine compliant populations.
This is the literature that the media, politicians and governmental health organizations like the CDC, pretend with abject dishonesty does not exist – as if vaccine injury did not happen, despite the over 3 billion dollars our government has paid out to vaccine injured through the National Vaccine Injury Compensation Fund since it was inaugurated in 1986.
We have written extensively about this research previously, highlighting different studies, focusing on translating their implications to the lay persons (view our vaccine article section here), but we believe that collecting and condensing solely the primary literature itself makes a much more powerful statement.
This document is being made free to download to the world at large in order to encourage the lay public, health professionals, activists, and elected officials alike to read, acknowledge and share the voluminous literature with their family, friends, colleagues and related stakeholders. You will find this research undermines the national and global agenda to continue to expand the vaccine schedule (on behalf of a vaccine industry that is indemnified against lawsuit for defective or harmful products), with increasing legislative pressure to remove exemptions and mandate them against the evidence of harm and at best equivocal effectiveness as a preventive health measure.
If the vaccination arm of modern medicine today is to continue to promote itself as a science- and evidence-based practice, it must acknowledge and incorporate the implications of the research we are releasing here, or lose any pretense at credibility. Failing to do so will reveal that the widespread push to remove your choice in the matter is agenda and not evidence driven, and due to the fact that vaccines all carry the risk of irreversible harm and even death (any vaccine insert proves this), it clearly violates the Nuremberg code of medical ethics to promote them as a priori safe and effectiveness.
http://www.greenmedinfo.com/anti-therapeutic-action/vaccination-all
http://cdn.greenmedinfo.com/sites/default/files/gmipub_58635_anti_therapeutic_action_vaccination_all.pdf

Vaccine Mechanisms in Autism
Disclaimer: The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this Website. All research is referenced at the end of this article.
This article will explain how specific vaccine adjuvants, in combination with the herbicide glyphosate, keep the brain in a permanent inflammatory state leading to the symptoms as seen in autism. It will point out key adjuvants believed to be involved with the development of autism. Lastly, it will briefly touch upon the key part in the brain involved and touches upon novel therapeutic possibilities.

Vaccine News – Many Infectious Disease Outbreaks Are Occurring Among Vaccinated Population Revealing Vaccine Failure

Pet vaccinations side effects

Robert F Kennedy jr. drops a major truth bomb on the toxicity of vaccines: http://bit.ly/2jcOJ19

>> http://www.vaccinesrevealed.com/free/ <<<
Witness this young girl’s life after the Gardasil vaccine – How many more beautiful human beings will suffer this same fate before MERCK is shut down?
http://www.gofundme.com/mias-recovery-fund
This is my Daughter Mia who is just 12 years old, the first video is of her looking well happy & singing (her favourite thing to do) 10 days before the vaccination. Then the other videos are some of Mia’s diaries filmed throughout this terrible ordeal she’s been through over the past 5 months. They show just how unwell she has become since having the hpv vaccination on 21st September at school last year.
They show her having involuntary spasms and also show how she cannot use any of her limbs.
Her latest Video diary was taken just last week she’s wearing her splints on this one & it shows she can still only blink, speak & she still has involuntary spasms. She’s not moved a single limb for 11 weeks now and apart from a couple of nights at home between hospital admissions she has been in hospital all this time. Over the past the past 2 weeks shes deteriorated & she’s also been vomiting in the afternoon & evenings today she was sick 34 times in 40 mins.
She’s currently just rotting in a hospital bed & no one cares!
We hope by going public we will find someone to help us to help her recovery and also help the other girls that have been affected.
Her story is now on http://yournewswire.com/gardasil-destroying-daughters
Thank you everyone that’s donated to her Go Fund Me Page and also for sharing this post.
http://www.gofundme.com/mias-recovery-fund
It means a lot to us & it may help us find the right person that can help Mia. xx
#Gardasil #Cervarix #Merck #HPV
Looking for group support? tinyurl.com/RevolutionForVaccineChoice
Follow our page: facebook.com/RevolutionForChoice
#RevolutionForChoice #InformedConsent #EducateBeforeYouVaccinate #VAXXED #VAXwithMe

Natural News – Confirmed science shows that vaccinated children have 420% higher risk of ADHD compared to non-vaccinated kids
Monday, May 22, 2017 by: Tracey Watson
(Natural News) For the longest time, I’ve wondered why scientists have not done more straightforward, direct comparisons of the health outcomes of vaccinated children versus those whose parents have chosen not to vaccinate them. After all, that would provide the definitive answer, wouldn’t it? No more of this shilly-shallying back and forth; if you took a group of kids around the same age, half of whom were vaccinated while the other half were not, and checked which group had the better health outcomes, the vaccine debate would be over.
The Centers for Disease Control and Prevention (CDC) and other agencies have stubbornly refused to promote such uncomplicated, straight-forward scientific analyses – no points for figuring out why – but a group of scientists from the School of Public Health at Jackson State University has nonetheless risen to the challenge. For those who have been warning parents about the dangers of vaccines for years, like Mike Adams, the Health Ranger, and Robert F. Kennedy, Jr., the scientists’ findings are not the least bit surprising.
The study, which was published recently in the Journal of Translational Science, sought to do two things: Firstly, the scientists wanted to compare a broad range of health outcomes for vaccinated and unvaccinated children; and secondly, they wanted to determine whether there was an association between vaccination and neurodevelopmental disorders (NDD) which remained significant after adjusting for other factors.
Interestingly, the study abstract begins by singing the praises of vaccines and all they have accomplished in preventing diseases in the past. They then go on to point out, however, that in terms of the current recommended pediatric vaccine schedule, children receive 48 doses of vaccines to prevent 14 different diseases by the age of 6 – a number which has increased steadily over the past 60 years.
The researchers point out that individual vaccines are tested before being rolled out to the public, and that though they are known to carry risks, these risks are believed to be minimal.
But here’s the kicker: It’s the long-term effects of these vaccines, and particularly having so many vaccines in such a short space of time, that scientists have not assessed. “There are very few randomized trials on any existing vaccine recommended for children in terms of morbidity and mortality,” they note, “in part because of ethical concerns involving withholding vaccines from children assigned to a control group.”
Okay, so scientists haven’t wanted to withhold vaccines from children in order to study them, as that would raise ethical concerns, so they’ve rather just gone ahead with vaccinating millions of children with pretty much untested vaccine combinations? Okay … moving on.
Study PDF source
Study – Pilot comparative study on the health of vaccinated and unvaccinated 6- to 12-year-old U.S. children
Abstract
Vaccinations have prevented millions of infectious illnesses, hospitalizations and deaths among U.S. children, yet the long-term health outcomes of the vaccination
schedule remain uncertain. Studies have been recommended by the U.S. Institute of Medicine to address this question. This study aimed 1) to compare vaccinated and
unvaccinated children on a broad range of health outcomes, and 2) to determine whether an association found between vaccination and neurodevelopmental disorders
(NDD), if any, remained significant after adjustment for other measured factors. A cross-sectional study of mothers of children educated at home was carried out
in collaboration with homeschool organizations in four U.S. states: Florida, Louisiana, Mississippi and Oregon. Mothers were asked to complete an anonymous
online questionnaire on their 6- to 12-year-old biological children with respect to pregnancy-related factors, birth history, vaccinations, physician-diagnosed illnesses,
medications used, and health services. NDD, a derived diagnostic measure, was defined as having one or more of the following three closely-related diagnoses: a
learning disability, Attention Deficient Hyperactivity Disorder, and Autism Spectrum Disorder. A convenience sample of 666 children was obtained, of which 261
(39%) were unvaccinated. The vaccinated were less likely than the unvaccinated to have been diagnosed with chickenpox and pertussis, but more likely to have been
diagnosed with pneumonia, otitis media, allergies and NDD. After adjustment, vaccination, male gender, and preterm birth remained significantly associated with
NDD.  However,  in  a  final  adjusted  model  with  interaction,  vaccination  but  not  preterm  birth  remained  associated  with  NDD,  while  the  interaction  of  preterm
birth and vaccination was associated with a 6.6-fold increased odds of NDD (95% CI: 2.8, 15.5). In conclusion, vaccinated homeschool children were found to have
a higher rate of allergies and NDD than unvaccinated homeschool children. While vaccination remained significantly associated with NDD after controlling for
other factors, preterm birth coupled with vaccination was associated with an apparent synergistic increase in the odds of NDD. Further research involving larger,
independent  samples  and  stronger  research  designs  is  needed  to  verify  and  understand  these  unexpected  findings  in  order  to  optimize  the  impact  of  vaccines  on  children’s health

Superintendent: Third mumps case confirmed at Jacobs High School
updated: 5/25/2017 12:35 PM
By Katie Smith
Daily Herald correspondent
A third case of mumps has been confirmed at Jacobs High School in Algonquin, Superintendent Fred Heid announced Tuesday.
The district sent a notice to parents Tuesday confirming that test results for a student with a suspected case of mumps have come back positive.
“The student has been out of school since May 14th and, as a result, there is minimal chance that other students were exposed during the period of time that he may have been contagious,” Heid wrote in the letter posted on District 300’s website.
The Kane County Health Department had notified the school of a second confirmed case Thursday.
All three students were vaccinated, according to a letter to parents posted Thursday. Two of shared one class, school officials said. The third student does not share classes or activities with the other two.

Many Infectious Disease Outbreaks Are Occurring Among Vaccinated Population Revealing Vaccine Failure
May 26, 2017
Infectious Disease Outbreaks: Are the Vaccines to Blame?
by Marco Caceres
The Vaccine Reaction
It seems like whenever there is an outbreak of an infectious disease in the United States, the media, local public health officials and legislators immediately blame people, who weighed the benefits and risks of vaccination for themselves or their minor children and exercised their right to informed consent to medical risk taking, which includes the freedom to decline to take the risk. News reports abound about how the outbreak would not have happened had people just done what doctors told them to do and gotten their shots.
Of course, the irony is that, in many outbreaks of infectious disease of late in the U.S., a substantial minority or, in some cases, a majority of those infected had been vaccinated. So the obvious conclusion would be that there is a problem with the vaccine’s long term effectiveness. But that conclusion is often downplayed or ignored.
The preferred explanation of why infections occur in vaccinated people, especially in small communities where a lot of people are living in close proximity to each other, is that people are “particularly susceptible to the virus, even if they’ve been vaccinated.” [1] That was the most common explanation, for example, for the outbreak of mumps on college campuses throughout the country last year.
During the first half of 2016, more than 40 students at Harvard University came down with mumps. All of the students had been fully vaccinated with two doses of the MMR (measles, mumps, rubella) vaccine. [2, 3] There were a total of more than 4,000 cases of mumps in the U.S. last year, “fueled in part by its spread on college campuses.” [4]
According to Amesh Adalja, MD of the University of Pittsburgh Medical Center’s Center for Health Security:
The exposure that they have to mumps is so high in these situations that it overcomes the ability of the vaccine to protect them. It may be that, in these special situations, a much higher level of antibodies [against mumps] is needed to keep the virus at bay. [1]
(Short answer: We don’t really know.) An article in The Philadelphia Inquirer following the mumps outbreak at Pennsylvania State University last year reported:
As Pennsylvania State University copes with an ongoing outbreak of mumps, infectious-disease experts are investigating why vaccinated young people are getting sick and whether a booster shot would help. [5]
Dr. Amesh noted that, “Repeatedly being exposed to the disease essentially overcomes their protective immunity, and they can become sick.”
But isn’t that precisely the point of vaccination: to protect you from exposures to disease, even repeated exposures?

12 Year Old Girl Develops Guillain-Barré Syndrome After Gardasil Vaccine – Suffers Paralysis
May 26, 2017
The VAXXED film crew was recently in California interviewing people about their experiences with vaccines.
They interviewed Michelle Snyder and her daughter Ashley about the Gardasil vaccine.
The mother had reservations about the Gardasil vaccine, but doctors said it was fine. She has five daughters, and began to make plans to have them vaccinated with Gardasil.
After the first shot, her 12 year old daughter came in from playing and said her legs “weren’t working.” She had been a dancer since age 4.
The next morning, she could not even walk.
The mom called for help, and was told it sounded like “ascending paralysis” or Guillain-Barré Syndrome (GBS).
By the time they got her to a hospital, she could not even swallow, requiring them to insert a feeding tube into her.
Listen to the entire interview: https://www.facebook.com/RevolutionForChoice/videos/223320054742255/

When the CDC Pertussis VIS says, “Lowered Consciousness,” It Means Hypotonic-Hyporesponsive Episode
May 24, 2017
In late 2014, the Maine Coalition for Vaccine Choice wished to clarify the meaning of the language of the CDC’s Pertussis Vaccine Information Statement when it referred to, “lowered consciousness,” as a serious adverse outcome of the vaccine.
VACCINE INFORMATION STATEMENT – DTaP Vaccine
What You Need to Know

“Severe problems (very rare)
• Serious allergic reaction (less than 1 out of a million doses)
• Several other severe problems have been reported after DTaP vaccine.
These include:
– Long-term seizures, coma, or lowered consciousness
– Permanent brain damage.”

#NewZealand news clip

 

Vaccine News – A study from West Africa’s Guinea-Bissau discovered that all-cause infant mortality more than doubled after the introduction of the DTP vaccination

The Alex Jones Channel – Shocking! Elmo Lies To Children About Vaccine Safety / Laughs At Autistic Victim

The First 6 Years Of A Fully Vaccinated Child’s Life Looks Like This…
We want you to have a choice. We want you to always know the facts. No laws should govern your child’s medical decisions, only you should.
Here is a comprehensive list of what your child receives if you fully vaccinate them for the first six years of their life.
Source: “What The Pharmaceutical Companies Don’t Want You To Know About Vaccines” – By Dr. Todd M. Elsner. Todd’s book is available on Amazon here.
Dr. Tenpenny’s Book is currently available on Amazon

17,500 mcg 2-phenoxyethanol (antifreeze)
5,700 mcg aluminum (neurotoxin)
Unknown amounts of fetal bovin serum(aborted cow blood)
801.6 mcg formaldehyde (carcinogen, embalming agent)
23,250 mcg gelatin (ground up animal carcuses)
500 mcg human albumin (human blood)
760 mcg of monosodium L-glutamate (causes obesity & diabetis)
Unknown amounts of MRC-5 cells (aborted human babies)
Over 10 mcg neomycin (antibiotic)
Over 0.075 mcg polymyxin B (antibiotic)
Over 560 mcg polysorbate 80 (carcinogen)
116 mcg potassium chloride (used in lethal injection)
188 mcg potassium phosphate (liquid fertilizer agent)
260 mcg sodium bicarbonate (baking soda)
70 mcg sodium borate (Borax, used for cockroach control)
54,100 mcg of sodium chloride (table salt)
Unknown amounts of sodium citrate (food additive)
Unknown amounts of sodium hydroxide (Danger! Corrosive)
2,800 mcg sodium phosphate (toxic to any organism)
Unknown amounts of sodium phosphate monobasic monohydrate (toxic to any organism)
32,000 mcg sorbitol (Not to be injected)
0.6 mcg streptomycin (antibiotic)
Over 40,000 mcg sucrose (cane sugar)
35,000 mcg yeast protein (fungus)
5,000 mcg urea (metabolic waste from human urine)
Other chemical residuals

What The Pharmaceutical Companies Don’t Want You To Know About VACCINES… Paperback – 2009
This book is a must read for parents, soon to be parents and physicians who regularly administer vaccines. There are over 500 pages of information proving that vaccines are not responsible for the eradication of communicable disease; vaccines have done nothing but promote chronic disease and illness; and vaccines contain the most toxic chemicals known to man. Furthermore, there are close to 2,000 references that back up the information in this book. The references are from studies published in peer reviewed medical journals, the Centers for Disease Control and Prevention, the Food and Drug Administration, the prestigious Institute of Medicine, and from the United States Congressional Reform Committee. Lastly, this book contains all the U.S. licensed vaccines and the ingredients each vaccine contains. The ingredients of each vaccine come directly from the pharmaceutical companies’ vaccine package insert which are cross referenced with the National Library of Medicine for their human health effects-You will be SHOCKED at the side effects these vaccine ingredients have on the human body! FACT: If anyone from the medical community wants to argue with the information in this book, they will argue among themselves-it is their information!

Ever wonder WHY we NEED a religious exemption from vaccines?
Are you aware that some vaccines are made from ABORTIONS?
Marcella Piper-Terry explains in detail how abortions are used in vaccine manufacturing and the implications of that.
Interview by Polly Tommey and camera by Joshua Coleman and Anu Vaidya with editing by Joshua Coleman.

#RFKCommission #Vaxxed

Countless teenage girls suffer paralysis, blood clots, brain damage and chronic pain from force-vaccination of Gardasil’s HPV “shot in the dark”
Friday, March 17, 2017 by: S.D. Wells
(Natural News) A sexually transmitted disease called human papillomavirus (HPV) is the only form of cancer known to be contagious, but what the medical community won’t tell parents of teenagers and preteens is that HPV is easily defeated by a normal functioning immune system. Of the 120 or more different strains of HPV, only about 15 are carcinogenic, and the HPV vaccines, which have never been proven safe or effective in any clinical trials, literally take a shot in the dark at a couple of these strains, much like the haphazard flu shot administered every year to tens of millions of unsuspecting victims of neurological poisoning.
Still, the CDC and rogue hacks and shills from Big Pharma use scare tactics to all but force-vaccinate girls as young as 9-years-old with sodium chloride and two versions of the dormant HPV cancers hidden in protein and genetically modified organisms.
Scare tactics and medical propaganda con mothers into getting their young daughters jabbed with deadly neurotoxins
“You won’t be able to have children if you get cervical cancer.” “You can catch cancer from having sex and die.” “The shot will make you immune to cancer.” “The shot prevents cancer.” “You wanna have children later? You better get this shot.” The propaganda is mind-blowing, and it unfortunately works. It convinces parents to do the unthinkable: have their little girls (and boys) jabbed with some of the most dangerous carcinogens on earth to “prevent” a couple of strains of a rather benign, pre-cancerous STD. It doesn’t even make sense. What’s even worse is that the HPV vaccine’s protection effect wears off after a few years (as does the cancer itself under normal immune conditions), so what’s the use of taking the risk of getting jabbed with all these neurotoxins? Just how young are kids becoming promiscuous enough to worry about STDs anyhow?
More than 10,000 adverse events have been reported from victims of the HPV scam, including blood clots in the heart and lungs, anaphylactic shock, loss of muscle use and seizures. Most infections from HPV are benign and cleared rapidly by the human immune system and never progress to cervical cancer, or even precancerous lesions of the vagina, vulva or anus. No valid reason for administering the HPV vaccine has ever even been established.
Why are HPV vaccines, like Gardasil (made by Merck) and Cervarix (made by GSK) so dangerous? Answer: They’re made with “denatured” forms and fragmented strains of the virus, meaning the virus is weakened and can remain dormant for months, if not years, so if you do get the virus later, who’s to say you didn’t get it from the vaccine itself? No studies on this have ever been conducted, nor will they likely ever be. Plus, Gardasil contains aluminum, sodium chloride, polysorbate 80 and l-histidine, the latter of which interferes with the brain’s defenses against metal toxins. That means the aluminum has a heightened chance of crossing the blood/brain barrier. Got brain damage? No wonder. The following are just four examples of the hundreds (if not thousands) of girls permanently damaged by HPV vaccines.

Stronger More Toxic Gardasil Vaccine Approved by FDA: Will More Girls Suffer and Die?
March 23, 2017
Malfeasance is when a public official violates the public trust by performing an act that is wrongful, legally unjustified, or contrary to law. Nonfeasance is the failure to act where there is a duty to act. Misfeasance is conduct that is lawful but inappropriate. Perhaps, when it comes to the recent approval of Gardasil 9 all of these apply.
10 December 2014: The FDA approved the use of a reportedly “new and improved” version of Gardasil, which will be marketed as Gardasil 9. According to the FDA approval letter, this action was taken without consultation with VRBPAC (the Vaccines and Related Biological Products Advisory Committee) which is responsible for reviewing and evaluating data concerning the safety, effectiveness, and appropriate use of vaccines and related biological products.
The FDA approval letter, signed by Marion Gruber, Director of Office of Vaccines Research and Review CBER,  states the reason for bypassing the advice of VRBPAC writing:
”We did not refer your application to the Vaccines and Related Biological Products Advisory Committee because our review of information submitted in your BLA, including the clinical study design and trial results, did not raise concerns or controversial issues which would have benefited from an advisory committee discussion.”
So, the Office of Vaccines Research and Review, Center for Biologics Evaluation and Research (CBER) committee took it upon themselves to decide there were ”no concerns or controversial issues” regarding the approval of Gardasil 9?
This division of CBER decided there would be no benefit from ”an advisory committee discussion”?
According to their own mission statement, the FDA is ”responsible for protecting the public health by assuring the safety, efficacy and security of human and veterinary drugs, biological products, medical devices, our nation’s food supply, cosmetics, and products that emit radiation.”
The FDA, and all committees associated with the FDA, are public officials and therefore obliged to act in the public’s best interest particularly when it comes to health and safety issues.
Is bypassing advisory committee discussions regarding Gardasil 9’s potential safety and efficacy acting in the public’s best interest, or is it malfeasance, nonfeasance and/or misfeasance?
Gardasil 9 Facts: More than DOUBLE the amount of Toxic Aluminum!
CBER decided there was no need for VRBPAC to review or evaluate any data concerning the safety, effectiveness, and appropriate use of Merck’s proposed Gardasil 9 vaccine before making a decision to approve the nine-valent HPV vaccine. This move is particularly disturbing when one considers the worldwide controversy surrounding Gardasil’s safety, effectiveness and appropriate use.

Studies about the aluminium toxicity on humans
Gardasil 9 insert
Gardasil insert

Dr. Yehuda Shoenfeld says vaccines cause auto-immunity. It’s really not a question of “IF” there are adverse events from vaccines, it’s a question of “how often?”, “how severe?”, and whether it’s worth the trade-off? You can listen to the pre-eminent expert on vaccine-induced autoimmunity in the world, or you can go to your mainstream pediatrician who will tell you that vaccines have “no risk, lots of benefits.” It’s really up to you!
This is just a clip from his talk, entire talk in comments below, as well as Dr. Shoenfeld’s new TEXTBOOK, called “Vaccines and Autoimmunity”!
By the way, “autoimmunity” includes all the crazy epidemics in our kids that weren’t around in the 1980s or earlier: asthma, food allergies, skin rashes, etc. “Some of the main examples of autoimmune disorders include diabetes mellitus type 1 (IDDM), systemic lupus erythematosus (SLE), Hashimoto’s thyroiditis, Graves’ disease of the thyroid, Sjögren’s syndrome, Churg-Strauss Syndrome, Coeliac disease, rheumatoid arthritis (RA), and idiopathic thrombocytopenic purport.”
Listen to Dr. Shoenfeld: “Dr. Yehuda Shoenfeld is on the editorial board of 43 journals in the fields of rheumatology and autoimmunity and is the founder and editor of the Israel Medical Association Journal, the representative journal of science and medicine in the English language in Israel. He is also is the founder and editor of “Autoimmunity Reviews” and co-editor of “The Journal of Autoimmunity”. His clinical and scientific works focus on autoimmune and rheumatic diseases, and he has published more than 1700 papers in journals such as the New England Journal of Medicine, Nature, the Lancet, the Proceedings of the National Academy of Sciences of the United States of America, the Journal of Clinical Investigation, the Journal of Immunology, Blood, the Journal of the Federation of American Societies for Experimental Biology, the Journal of Experimental Medicine, Circulation, Cancer, and others, and his articles have had over 31,000 citations. He has written more than three hundred and fifty chapters in books, and has authored and edited 25 books.”

A study from West Africa’s Guinea-Bissau discovered that all-cause infant mortality more than doubled after the introduction of the DTP vaccination.
An observational study from the West African country Guinea-Bissau titled, “The Introduction of Diphtheria-Tetanus-Pertussis and Oral Polio Vaccine Among Young Infants in an Urban African Community: A Natural Experiment,” [i] examined the introduction of diphtheria-tetanus-pertussis (DTP) and oral polio vaccine (OPV) in an urban community in Guinea-Bissau in the early 1980s. The World Health Organization introduced the Expanded Program on Immunization (EPI) in low-income countries in the 1970s with the goal of universal immunization for all children. In the introduction, the study’s authors state, “Except for the measles vaccines, surprisingly few studies examined the introduction of vaccines and their impact on child survival.”
The purpose of the study was to examine what happens to child survival when DTP and OPV were introduced in low-income countries. A community study [ii] of the state of nutrition and family structure found that severe malnutrition was not evident in urban Guinea-Bissau although it was initially assumed to be the main cause of the under-five mortality rate.
The study findings emerged from a child population that had been followed with 3-monthly nutritional weighing sessions since 1978. From June 1981 DTP and OPV were offered from 3 months of age at these sessions. Due to the 3-monthly intervals between sessions, the children were allocated by birthday in a ‘natural experiment’ to receive vaccinations early or late between 3 and 5 months of age. The study included children who were greater than 6 months of age when vaccinations started and children born until the end of December 1983. The researchers compared mortality between 3 and 5 months of age of DTP-vaccinated and not-yet-DTP- vaccinated children in Cox proportional hazard models.
When mortality was compared, the mortality hazard ratio (HR) among 3-5-month-old children having received the DTP (±OPV) was 5.00 compared with not-yet-DTP-vaccinated children [i.e. a 400% increase]. According to the authors, differences in background factors did not explain the effect. All-cause infant mortality after 3 months of age increased after the introduction of these vaccines (2.12 (1.07–4.19)) [i.e. a 212% increase]. However, the study findings revealed the negative effect was particularly strong for children who had received DTP-only and no OPV (10.0 (2.61–38.6)).
The researchers concluded:
“DTP was associated with increased mortality; OPV may modify the effect of DTP.”

Study – The Introduction of Diphtheria-Tetanus-Pertussis and Oral Polio Vaccine Among Young Infants in an Urban African Community: A Natural Experiment
Abstract
Background
We examined the introduction of diphtheria-tetanus-pertussis (DTP) and oral polio vaccine (OPV) in an urban community in Guinea-Bissau in the early 1980s.
Methods
The child population had been followed with 3-monthly nutritional weighing sessions since 1978. From June 1981 DTP and OPV were offered from 3 months of age at these sessions. Due to the 3-monthly intervals between sessions, the children were allocated by birthday in a ‘natural experiment’ to receive vaccinations early or late between 3 and 5 months of age. We included children who were <6 months of age when vaccinations started and children born until the end of December 1983. We compared mortality between 3 and 5 months of age of DTP-vaccinated and not-yet-DTP-vaccinated children in Cox proportional hazard models.
Results
Among 3–5-month-old children, having received DTP (±OPV) was associated with a mortality hazard ratio (HR) of 5.00 (95% CI 1.53–16.3) compared with not-yet-DTP-vaccinated children. Differences in background factors did not explain the effect. The negative effect was particularly strong for children who had received DTP-only and no OPV (HR = 10.0 (2.61–38.6)). All-cause infant mortality after 3 months of age increased after the introduction of these vaccines (HR = 2.12 (1.07–4.19)).
Conclusion
DTP was associated with increased mortality; OPV may modify the effect of DTP.

Vaccine News – Study – INFANTS RECEIVING MERCURY-CONTAINING VACCINES DEVELOPED SPEECH DISORDERS, SLEEP DISORDERS, AND AUTISM, ACCORDING TO CDC SCIENTISTS

Dr. Andrew Moulden: Every Vaccine Produces Harm
by John P. Thomas
Health Impact News
Canadian physician Dr. Andrew Moulden provided clear scientific evidence to prove that every dose of vaccine given to a child or an adult produces harm. The truth that he uncovered was rejected by the conventional medical system and the pharmaceutical industry. Nevertheless, his warning and his message to America remains as a solid legacy of the man who stood up against big pharma and their program to vaccinate every person on the Earth.
Dr Moulden died unexpectedly in November of 2013 at age 49.
Because of the strong opposition from big pharma concerning Dr. Moulden’s research, I became concerned that the name of this brilliant researcher and his life’s work had nearly been deleted from the internet. His reputation was being disparaged, and his message of warning and hope was being distorted and buried without a tombstone.
I prepared a series of articles as a tribute to a great physician and as a memorial to a courageous individual who was not afraid to speak the truth about medical corruption and a flawed healthcare system that does more to harm health than it does to cure disease.
This is the first in a series of four articles about Dr. Moulden — the man, the physician, and the powerful advocate for ending all vaccine use. In future articles, I will summarize his detailed scientific evidence, which shows how vaccine damage occurs. I will explain the common mechanisms behind vaccine damage and how vaccines harm the health of everyone who receives them regardless of whether or not they notice any adverse reactions at the time they take the shots.
Dr. Moulden stated:
What we have done to each other [with vaccines] has produced the most profound damage to humankind by humankind in the history of humanity. And the reason why we got here is partly because of:
Our arrogance in thinking that we know everything. In physiology and medicine we do not know everything!
[Our greed] to advance our own self-interest to make money, to sell products and to advance corporate alliances. Commercialization has overtaken the fundamental human value of “do unto others as you would have others do unto you.” When society turns toward this human value, then we would all be working together for the greater good of each other. [However, other values have become more important] I don’t care whose feet I step on or how I get there as long as my American dream is realized. I don’t care who has to pay for it on the way of getting there. [1]
Dr. Moulden’s Credibility
Was Dr. Moulden a crackpot as some sources claim, or was he a brilliant physician and researcher? This series of articles will set the record straight, and summarize the contribution that his work has made to medical knowledge.
When I evaluate the credibility of people who are unknown to me, I begin by seeking answers to a few basic questions. For example: Is this person offering opinion, or can he or she back up the claims with valid science? Does he have educational credentials? Are there other physicians and scientists who support his or her beliefs and recommendations? Is this person controlled by the pharmaceutical industry, allopathic medical associations, or the US FDA (US Food and Drug Administration)? And finally, what do Quackwatch and their friends have to say about the person?
Dr. Moulden had a PhD in Clinical Psychology and Neuropsychology. He had a master’s degree in child development, and was also a medical doctor. [2] His work was respected by other researchers who don’t march to the drumbeat of the pharmaceutical companies. Dr. Moulden was a threat to the pharmaceutical industry, and their Quackwatch family of 21 related websites treated him as an enemy. [3, 4]

Vaccine Contraindications: Six People Who Should Not Be Vaccinated
The debate surrounding vaccinations is a fierce one, and personally, I don’t like to argue about it. I’m happy to make the right choices for my family while you make the right ones for yours. (I personally have suffered adverse reactions to vaccinations.) It’s ok to have different opinions, really it is. But there are a lot of folks out there who think everyone should be vaccinated, period, and those who choose not to vaccinate should be penalized or worse.
Listen. I get that people are scared and there’s a lot of fear-mongering in the media. But let’s be realistic here: vaccinations are a medical procedure. There are risks. Vaccinations are not right for everyone. There are at least six types of people in particular who should avoid vaccinations, and below, I’ll spell it out.
Vaccine Contraindications
Just like a particular surgery or prescription medication won’t work well for everyone, vaccinations are not a good choice for everyone.
Some people, in particular, are much more likely to have adverse reactions to vaccinations, including:

– Those with an autoimmune disease
– Children born to a mother with an autoimmune disease
– Anyone who is sick
– Pregnant women
– Those who have previously had a reaction to a vaccination

One size does not fit all
Clearly, vaccinations are not the right choice for everyone, and each family should decide what is right for them and their children. When parents are aware of vaccine contraindications, they can make informed and safer choices for their children.
Please share this post so that other parents can learn about vaccine contraindications and decide if vaccination is right for their children.

USA: Highest Vaccination Rate in the World Has the Worst Health
by PAUL FASSA
That “worst health” label includes a ranking of 34th in the world with infant mortality. In other words, the USA has the 34th worst infant survival with its highest rate of vaccinations. Some are directly from multiple vaccinations administered.
But the USA leads the world in infant vaccinations, those administered during the first year after their births – 26 vaccinations during that time.
The only vaccination I recall receiving during early childhood, circa 1948, was the smallpox vaccine, the one that left a circle of shallow pockmarks on the upper arm, a non-ink tattoo that proved you had received that vaccine. Months later there was the booster shot which gave me a vacation of several days away from my first grade teacher while sitting out the chicken pox.
During Naval training the mass vaccination high pressure hand held gun that replaced syringes and needles was tried on us with the polio shot. I wound up with a vacation in the base infirmary with an extended period of the flu. Between those two, there may have been a tetanus shot or two.
From the Healthy Home Economist:

-In1950, there were 3 childhood vaccines typically given when a child entered school.
-In 1983, there were 10 recommended vaccines by the age of 6 years old (24 doses, 7 injections, 4 oral doses for polio).
-In 2010, the CDC vax schedule totaled 68 doses with more than half given by the time a child was only a year and a half old.
-In 2016, the schedule has increased to 74 doses by age 17 with 53 injections and 3 oral doses of rotavirus.

The number of vaccines included in the current childhood vaccine schedule has quadrupled over the past 60 years, with several demanding multiple injections and boosters. During this exponential rise of CDC “recommended” schedules, the health of American children has plummeted.
Autoimmune diseases, learning disabilities, food allergies, chronic ailments, and childhood obesity have all risen. The overall health of this nation ranks very low compared to all other industrialized nations, dead last in most areas.
Vaccine false dogma is so heavy hardly anyone with authority, even in mainstream media, makes the connection between poor health with high vaccination rates. Instead, more, three added for 2016, are getting enforced by mandate or coerced by pediatricians who have the right to refuse medical care on kids who aren’t vaccinated.
Destroying Health with Vaccines is Good Business

50 Studies the AAP Avoided to Mention
There is a robust, worldwide body of published science from highly esteemed scientists questioning the safety of many different aspects of vaccines-how come we never hear from them? The majority of the most compelling science has been published since 2010. Below find 50 such studies to consider, sorted chronologically, and note that these studies only represent a portion of the published work implicating vaccinations in a wide variety of negative health outcomes.
The American Academy of Pediatrics made representations to President Trump in a letter dated 2/7/2017 that are utterly indefensible and inaccurate, as any rational review of the studies below quickly demonstrates. For example, the AAP wrote:
“Claims that vaccines are unsafe when administered according to expert recommendations have been disproven by a robust body of medical literature…we write to express our unequivocal support for the safety of vaccines.”
We contend that the AAP’s statements to the President are baseless, reckless, and easily refuted. The AAP’s letter alone supports the President’s desire to field a Vaccine Safety Commission and do all we can to make vaccines as safe as possible. Please click here for a list of all 50 studies detailed below.

2017
Temporal Association of Certain Neuropsychiatric Disorders Following Vaccination of Children and Adolescents A Pilot Case–Control Study
New Quality-Control Investigations on Vaccines Micro-and Nanocontamination
2016
Behavioral abnormalities in female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil
Autoimmune/Inflammatory Syndrome Induced by Adjuvants and Sjogren’s Syndrome
Combining Childhood Vaccines at One Visit Is Not Safe
Aluminum in Childhood Vaccines Is Unsafe
Aluminium in brain tissue in familial Alzheimer’s disease
2015
Evidence that Food Proteins in Vaccines Cause the Development of Food Allergies and Its Implications for Vaccine Policy
2014
Transcriptomic Analyses of Neurotoxic Effects in Mouse Brain After Intermittent Neonatal Administration of Thimerosal
A Dose-Response Relationship between Organic Mercury Exposure from Thimerosal-Containing Vaccines and Neurodevelopmental Disorders
A comparison of temporal trends in United States autism prevalence to trends in suspected environmental factors
2013
A Population-Based Cohort Study of Undervaccination in 8 Managed Care Organizations Across the United States
Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) 2013: Unveiling the pathogenic, clinical and diagnostic aspects
Aluminum in the central nervous system (CNS): toxicity in humans and animals, vaccine adjuvants, and autoimmunity
Autoimmune/inflammatory syndrome induced by adjuvants (Shoenfeld’s syndrome): clinical and immunological spectrum
A two-phase study evaluating the relationship between Thimerosal-containing vaccine administration and the risk for an autism spectrum disorder diagnosis in the United States
Human exposure to aluminium
Human Papilloma Virus Vaccine and Primary Ovarian Failure: Another Facet of the Autoimmune/Inflammatory Syndrome Induced by Adjuvants
2012
Risk of Febrile Seizures and Epilepsy After Vaccination With Diphtheria, Tetanus, Acellular Pertussis, Inactivated Poliovirus, and Haemophilus Influenzae Type b
Mechanisms of aluminum adjuvant toxicity and autoimmunity in pediatric populations
Neurologic adverse events following vaccination
The spectrum of ASIA: ‘Autoimmune (Auto-inflammatory) Syndrome induced by Adjuvants’
Relative trends in hospitalizations and mortality among infants by the number of vaccine doses and age, based on the Vaccine Adverse Event Reporting System (VAERS), 1990-2010
2011
Do aluminum vaccine adjuvants contribute to the rising prevalence of autism?
Maternal Thimerosal Exposure Results in Aberrant Cerebellar Oxidative Stress, Thyroid Hormone Metabolism, and Motor Behavior in Rat Pups; Sex- and Strain-Dependent Effects
2010
Interindividual variations in the efficacy and toxicity of vaccines
Sorting out the spinning of autism: heavy metals and the question of incidence
Influence of pediatric vaccines on amygdala growth and opioid ligand binding in rhesus macaque infants: A pilot study
The immunobiology of aluminium adjuvants: how do they really work?
Hepatitis B Vaccination of Male Neonates and Autism Diagnosis, NHIS 1997-2002
2009
Allergic Disease and Atopic Sensitization in Children in Relation to Measles Vaccination and Measles Infection
Long-term persistence of vaccine-derived aluminum hydroxide is associated with chronic cognitive dysfunction
Delayed acquisition of neonatal reflexes in newborn primates receiving a thimerosal-containing Hepatitis B vaccine: Influence of gestational age and birth weight
Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration
2008
Post-vaccination encephalomyelitis: Literature review and illustrative case
Thimerosal exposure in infants and neurodevelopmental disorders: An assessment of computerized medical records in the Vaccine Safety Datalink
Delay in diphtheria, pertussis, tetanus vaccination is associated with a reduced risk of childhood asthma?
Hepatitis B triple series vaccine and developmental disability in US children aged 1-9 years
2005
THE MERCURY USED AS A VACCINE PRESERVATIVE IS FAR MORE NEUROTOXIC THAN THE MERCURY FOUND IN FISH
Comparison of Blood and Brain Mercury Levels in Infant Monkeys Exposed to Methylmercury or Vaccines Containing Thimerosal
Thimerosal Neurotoxicity is Associated with Glutathione Depletion: Protection with Glutathione Precursors
2004
Activation of methionine synthase by insulin-like growth factor-1 and dopamine: a target for neurodevelopmental toxins and thimerosal
2002
UTAH STATE SCIENTISTS FIND AUTOIMMUNE REACTION TO MMR IN CHILDREN WITH AUTISM, INCLUDING AUTOIMMUNITY TO MYELIN BASIC PROTEIN, A BRAIN BUILDING-BLOCK
Abnormal Measles-Mumps-Rubella Antibodies and CNS Autoimmunity in Children with Autism
2001
Macrophagic myofasciitis lesions assess long-term persistence of vaccine derived aluminum hydroxide in muscle
2000
JAPANESE SCIENTISTS FIND VACCINE-STRAIN OF MEASLES IN THE GUTS OF CHILDREN WITH AUTISM
Detection and Sequencing of Measles Virus from Peripheral Mononuclear Cells from Patients with Inflammatory Bowel Disease and Autism
CDC SCIENTISTS ADMIT THAT 90% OF INFECTIOUS DISEASE MORTALITY DECREASE IN THE UNITED STATES HAPPENED BEFORE VACCINES WERE AVAILABLE
Annual Summary of Vital Statistics: Trends in the Health of Americans During the 20th Century
Iatrogenic exposure to mercury after hepatitis B vaccination in preterm infants
Effects of Diphtheria-Tetanus-Pertussis or Tetanus Vaccination on Allergies and Allergy-Related Respiratory Symptoms Among Children and Adolescents in the United States
1999
INFANTS RECEIVING MERCURY-CONTAINING VACCINES DEVELOPED SPEECH DISORDERS, SLEEP DISORDERS, AND AUTISM, ACCORDING TO CDC SCIENTISTS
Increased risk of developmental neurologic impairment after high exposure to thimerosal-containing vaccine in first month of life
INFECTIOUS DISEASE RATES DECLINED PRECIPITOUSLY IN THE UNITED STATES IN THE 20TH CENTURY BEFORE THE IMPLEMENTATION OF A NATIONAL VACCINE PROGRAM
Trends in Infectious Disease Mortality in the United States During the 20th Century
CDC SCIENTISTS FIND CHILDREN GIVEN THE MMR VACCINE SHED THE MEASLES VIRUS FOR AT LEAST 2 WEEKS AFTER GETTING THE VACCINE, MAKING THEM VECTORS TO SPREAD MEASLES
Detection of Measles Virus RNA in Urine Specimens from Vaccine Recipients

NaturalNews – Top doctors reveal that vaccines can trigger autoimmunity, turning our immune systems against us

Top doctors reveal that vaccines can trigger autoimmunity, turning our immune systems against us
(NaturalNews) Dr. Yehuda Shoenfeld is an Israeli clincian who has been extensively studying the human immune system for more than thirty years. Some say he is at the pinnacle of his profession, and that he is at the core of its foundation. He’s written 25 textbooks on the subject — some of which are key to the backbone of clincial practice. Dr. Shoenfeld has even been referred to as the “Godfather of Autoimmunology.” Autoimmunology is the study of the immune system when it is has turned against itself, resulting in a myriad of conditions including ulcertive colitis, multiple sclerosis and type 1 diabetes.
Lately, Dr. Shoenfeld has been shaking up the world of immunology with evidence that suggests that vaccines may indeed be playing a role in the onset of autoimmune disease. Specifically, some of the star ingredients found in vaccines — like aluminum, a toxic metal — are likely at the helm of the worldwide increase in autoimmune disorders. Evidence supporting this theory has been mounting over the last 15 years, but a noticeably stark increase in research has occured in the last five years. For example, recent study, authored by Dr. Shoenfeld and his colleagues, was published by the journal Pharmacological Research in 2015. In their report, the researchers identified four groups of people who will be most at risk of developing an autoimmune disease following vaccination.
The paper’s authors note that while vaccines may help to prevent illnesses that can cause autoimmunity, “On the other hand, many reports that describe post-vaccination autoimmunity strongly suggest that vaccines can indeed trigger autoimmunity.” The researchers state that “Almost all types of vaccines have been reported to be associated with the onset of ASIA [autoimmune/inflammatory syndrome induced by adjuvants].” The autoimmune diseases that may develop after vaccination include arthritis, lupus (systemic lupus erythematosus, SLE) diabetes mellitus, thrombocytopenia, vasculitis, dermatomyosiositis, Guillain-Barre syndrome and demyelinating disorders. Demyelinating disorders include conditions like multiple sclerosis. Demyelination refers to degradation of the myelin sheath — an insulating material that covers nerves — and results in impaired function of said nerves.
The term ASIA first appeared in the Journal of Autoimmunology a few years ago and is used as an umbrella term to describe a group of similar symptoms that appear after exposure to an adjuvant. Adjuvants are environmental agents, including common vaccine ingredients, that are known to spark the immune system into action. Using ASIA as a model, a massive amount of research has been conducted to begin answering questions surrounding environmental toxins, particularly the metal aluminum used in vaccines, and how they can create an immune system chain reaction in vulnerable individuals, as well as how they can possibly lead to autoimmune disease.
Autoimmune disease is the result of the body’s immune system turning against itself and the human body. When the immune system is functioning normally, it attacks foreign invaders of the body, such as a pathogenic bacteria. In the case of autoimmune disease, however, the immune system has begun attacking the body’s own cells somewhere within the body. In the case of type 1 diabetes, the immune system has targeted the Islets of Langerhans found in the pancreas. In rheumatoid arthritis, the immune system has begun attacking joint tissue. Similar events happen within other autoimmune diseases, but affecting different types of bodily tissues.
Several studies have indicated that the aluminium currently being used in vaccines is a great cause for concern, especially when it comes to autoimmune disease. A 2012 paper authored by researchers from the Neural Dynamics Research Group of the Department of Ophthalmology and Visual Sciences at the University of British Columbia, located in Canada, noted, “According to the US Food and Drug Administration, safety assessments for vaccines have often not included appropriate toxicity studies because vaccines have not been viewed as inherently toxic.”

Attacking Ourselves: Top Doctors Reveal Vaccines Turn Our Immune System Against Us
Posted on:
Tuesday, February 24th 2015 at 6:45 pm
Written By:
Celeste McGovern
This article is copyrighted by GreenMedInfo LLC, 2015
The research is hard to ignore, vaccines can trigger autoimmunity with a laundry list of diseases to follow. With harmful and toxic metals as some vaccine ingredients, who is susceptible and which individuals are more at risk?
No one would accuse Yehuda Shoenfeld of being a quack. The Israeli clinician has spent more than three decades studying the human immune system and is at the pinnacle of his profession. You might say he is more foundation than fringe in his specialty; he wrote the textbooks. The Mosaic of Autoimmunity, Autoantibodies, Diagnostic Criteria in Autoimmune Diseases, Infection and Autoimmunity, Cancer and Autoimmunity – the list is 25 titles long and some of them are cornerstones of clinical practice. Hardly surprising that Shoenfeld has been called the “Godfather of Autoimmunology” – the study of the immune system turned on itself in a wide array of diseases from type 1 diabetes to ulcerative colitis and multiple sclerosis.
But something strange is happening in the world of immunology lately and a small evidence of it is that the Godfather of Autoimmunology is pointing to vaccines – specifically, some of their ingredients including the toxic metal aluminum – as a significant contributor to the growing global epidemic of autoimmune diseases. The bigger evidence is a huge body of research that’s poured in in the past 15 years, and particularly in the past five years. Take for example, a recent article published in the journal Pharmacological Research in which Shoenfeld and colleagues issue unprecedented guidelines naming four categories of people who are most at risk for vaccine-induced autoimmunity.
“On one hand,” vaccines prevent infections which can trigger autoimmunity, say the paper’s authors, Alessandra Soriano, of the Department of Clinical Medicine and Rheumatology at the Campus Bio-Medico University in Rome, Gideon Nesher, of the Hebrew University Medical School in Jerusalem and Shoenfeld, founder and head of the Zabludowicz Center of Autoimmune Diseases in the Sheba Medical Center at Tel Hashomer. He is also editor of three medical journals and author of more than 1,500 research papers across the spectrum of medical journalism and founder of the International Congress on Autoimmunology. “On the other hand, many reports that describe post-vaccination autoimmunity strongly suggest that vaccines can indeed trigger autoimmunity. Defined autoimmune diseases that may occur following vaccinations include arthritis, lupus (systemic lupus erythematosus, SLE) diabetes mellitus, thrombocytopenia, vasculitis, dermatomyosiositis, Guillain-Barre syndrome and demyelinating disorders. Almost all types of vaccines have been reported to be associated with the onset of ASIA.”

Study – Mechanisms of aluminum adjuvant toxicity and autoimmunity in pediatric populations.
Abstract
Immune challenges during early development, including those vaccine-induced, can lead to permanent detrimental alterations of the brain and immune function. Experimental evidence also shows that simultaneous administration of as little as two to three immune adjuvants can overcome genetic resistance to autoimmunity. In some developed countries, by the time children are 4 to 6 years old, they will have received a total of 126 antigenic compounds along with high amounts of aluminum (Al) adjuvants through routine vaccinations. According to the US Food and Drug Administration, safety assessments for vaccines have often not included appropriate toxicity studies because vaccines have not been viewed as inherently toxic. Taken together, these observations raise plausible concerns about the overall safety of current childhood vaccination programs. When assessing adjuvant toxicity in children, several key points ought to be considered: (i) infants and children should not be viewed as “small adults” with regard to toxicological risk as their unique physiology makes them much more vulnerable to toxic insults; (ii) in adult humans Al vaccine adjuvants have been linked to a variety of serious autoimmune and inflammatory conditions (i.e., “ASIA”), yet children are regularly exposed to much higher amounts of Al from vaccines than adults; (iii) it is often assumed that peripheral immune responses do not affect brain function. However, it is now clearly established that there is a bidirectional neuro-immune cross-talk that plays crucial roles in immunoregulation as well as brain function. In turn, perturbations of the neuro-immune axis have been demonstrated in many autoimmune diseases encompassed in “ASIA” and are thought to be driven by a hyperactive immune response; and (iv) the same components of the neuro-immune axis that play key roles in brain development and immune function are heavily targeted by Al adjuvants. In summary, research evidence shows that increasing concerns about current vaccination practices may indeed be warranted. Because children may be most at risk of vaccine-induced complications, a rigorous evaluation of the vaccine-related adverse health impacts in the pediatric population is urgently needed.

Study – Predicting post-vaccination autoimmunity: who might be at risk?
Abstract
Vaccinations have been used as an essential tool in the fight against infectious diseases, and succeeded in improving public health. However, adverse effects, including autoimmune conditions may occur following vaccinations (autoimmune/inflammatory syndrome induced by adjuvants–ASIA syndrome). It has been postulated that autoimmunity could be triggered or enhanced by the vaccine immunogen contents, as well as by adjuvants, which are used to increase the immune reaction to the immunogen. Fortunately, vaccination-related ASIA is uncommon. Yet, by defining individuals at risk we may further limit the number of individuals developing post-vaccination ASIA. In this perspective we defined four groups of individuals who might be susceptible to develop vaccination-induced ASIA: patients with prior post-vaccination autoimmune phenomena, patients with a medical history of autoimmunity, patients with a history of allergic reactions, and individuals who are prone to develop autoimmunity (having a family history of autoimmune diseases; asymptomatic carriers of autoantibodies; carrying certain genetic profiles, etc.).

Study – Vaccines, adjuvants and autoimmunity.
Abstract
Vaccines and autoimmunity are linked fields. Vaccine efficacy is based on whether host immune response against an antigen can elicit a memory T-cell response over time. Although the described side effects thus far have been mostly transient and acute, vaccines are able to elicit the immune system towards an autoimmune reaction. The diagnosis of a definite autoimmune disease and the occurrence of fatal outcome post-vaccination have been less frequently reported. Since vaccines are given to previously healthy hosts, who may have never developed the disease had they not been immunized, adverse events should be carefully accessed and evaluated even if they represent a limited number of occurrences. In this review of the literature, there is evidence of vaccine-induced autoimmunity and adjuvant-induced autoimmunity in both experimental models as well as human patients. Adjuvants and infectious agents may exert their immune-enhancing effects through various functional activities, encompassed by the adjuvant effect. These mechanisms are shared by different conditions triggered by adjuvants leading to the autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome). In conclusion, there are several case reports of autoimmune diseases following vaccines, however, due to the limited number of cases, the different classifications of symptoms and the long latency period of the diseases, every attempt for an epidemiological study has so far failed to deliver a connection. Despite this, efforts to unveil the connection between the triggering of the immune system by adjuvants and the development of autoimmune conditions should be undertaken. Vaccinomics is a field that may bring to light novel customized, personalized treatment approaches in the future.

Study – On vaccine’s adjuvants and autoimmunity: Current evidence and future perspectives.
Abstract
Adjuvants are compounds incorporated into vaccines to enhance immunogenicity and the development of these molecules has become an expanding field of research in the last decades. Adding an adjuvant to a vaccine antigen leads to several advantages, including dose sparing and the induction of a more rapid, broader and strong immune response. Several of these molecules have been approved, including aluminium salts, oil-in-water emulsions (MF59, AS03 and AF03), virosomes and AS04. Adjuvants have recently been implicated in the new syndrome named “ASIA-Autoimmune/inflammatory Syndrome Induced by Adjuvants”, which describes an umbrella of clinical conditions including post-vaccination adverse reactions. Recent studies implicate a web of mechanisms in the development of vaccine adjuvant-induced autoimmune diseases, in particular, in those associated with aluminium-based compounds. Fewer and unsystematised data are instead available about other adjuvants, despite recent evidence indicating that vaccines with different adjuvants may also cause specific autoimmune adverse reactions possible towards different pathogenic mechanisms. This topic is of importance as the specific mechanism of action of each single adjuvant may have different effects on the course of different diseases. Herein, we review the current evidence about the mechanism of action of currently employed adjuvants and discuss the mechanisms by which such components may trigger autoimmunity.