toxicity

Vaccine News – VAXXED TV – No more vaccinations for my family & Study – Aluminum in the central nervous system (CNS): toxicity in humans and animals, vaccine adjuvants, and autoimmunity

International journal of science – 05.Sep.2013

Study – Topoisomerases facilitate transcription of long genes linked to autism

Abstract
Topoisomerases are expressed throughout the developing and adult brain and are mutated in some individuals with autism spectrum disorder (ASD). However, how topoisomerases are mechanistically connected to ASD is unknown. Here we find that topotecan, a topoisomerase 1 (TOP1) inhibitor, dose-dependently reduces the expression of extremely long genes in mouse and human neurons, including nearly all genes that are longer than 200 kilobases. Expression of long genes is also reduced after knockdown of Top1 or Top2b in neurons, highlighting that both enzymes are required for full expression of long genes. By mapping RNA polymerase II density genome-wide in neurons, we found that this length-dependent effect on gene expression was due to impaired transcription elongation. Interestingly, many high-confidence ASD candidate genes are exceptionally long and were reduced in expression after TOP1 inhibition. Our findings suggest that chemicals and genetic mutations that impair topoisomerases could commonly contribute to ASD and other neurodevelopmental disorders.

Immunologic research – Jul.2013

Study – Aluminum in the central nervous system (CNS): toxicity in humans and animals, vaccine adjuvants, and autoimmunity

Authors and affiliations
C. A. Shaw – 1,2,3
L. Tomljenovic – 1
1.Neural Dynamics Research Group, Department of Ophthalmology and Visual SciencesUniversity of British Columbia (UBC)VancouverCanada
2.Program in Experimental MedicineUniversity of British Columbia (UBC)VancouverCanada
3.Program in NeuroscienceUniversity of British Columbia (UBC)VancouverCanada

Abstract
We have examined the neurotoxicity of aluminum in humans and animals under various conditions, following different routes of administration, and provide an overview of the various associated disease states. The literature demonstrates clearly negative impacts of aluminum on the nervous system across the age span. In adults, aluminum exposure can lead to apparently age-related neurological deficits resembling Alzheimer’s and has been linked to this disease and to the Guamanian variant, ALS–PDC. Similar outcomes have been found in animal models. In addition, injection of aluminum adjuvants in an attempt to model Gulf War syndrome and associated neurological deficits leads to an ALS phenotype in young male mice. In young children, a highly significant correlation exists between the number of pediatric aluminum-adjuvanted vaccines administered and the rate of autism spectrum disorders. Many of the features of aluminum-induced neurotoxicity may arise, in part, from autoimmune reactions, as part of the ASIA syndrome.

US National Library of Medicine
National Institutes of Health – Jun 2014

Study – Transcriptomic analyses of neurotoxic effects in mouse brain after intermittent neonatal administration of thimerosal.

Li X, Qu F, Xie W, Wang F, Liu H, Song S, Chen T, Zhang Y, Zhu S, Wang Y, Guo C, Tang TS.
Author information
State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.

Abstract
Thimerosal is a vaccine antimicrobial preservative which has long been suspected an iatrogenic factor possibly contributing to neurodevelopmental disorders including autism. The association between infant vaccine thimerosal exposure and autism remains an open question. Although thimerosal has been removed from mandatory childhood vaccines in the United States, thimerosal-preserved vaccines are still widely used outside of the United States especially in developing countries. Notably, thimerosal-containing vaccines are being given to the newborns within the first 12-24 h after birth in some countries. To examine the possible neurotoxic effects of early neonatal exposure to a higher level of thimerosal, FVB mice were subcutaneously injected with thimerosal-mercury at a dose which is 20× higher than that used for regular Chinese infant immunization during the first 4 months of life. Thimerosal-treated mice exhibited neural development delay, social interaction deficiency, and inclination of depression. Apparent neuropathological changes were also observed in adult mice neonatally treated with thimerosal. High-throughput RNA sequencing of autistic-behaved mice brains revealed the alternation of a number of canonical pathways involving neuronal development, neuronal synaptic function, and the dysregulation of endocrine system. Intriguingly, the elevation of anterior pituitary secreting hormones occurred exclusively in male but not in female thimerosal-treated mice, demonstrating for the first time the gender bias of thimerosal-mercury toxicity with regard to endocrine system. Our results indicate that higher dose of neonatal thimerosal-mercury (20× higher than that used in human) is capable of inducing long-lasting substantial dysregulation of neurodevelopment, synaptic function, and endocrine system, which could be the causal involvements of autistic-like behavior in mice.

VAXXED TV – Your Findings Are Only As Good As Your Data

Dental health connection

Government failure

MMR devastated my son

I refuse to vaccinate anyone

Vaxxed versus unvaxxed in my home

No more vaccinations for my family

Vaccines gave my son autism

Following Wayne!

DAD WANTED ME TO BE SURE

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ONE FOR ISRAEL Ministry – Jewish Johnathan Ben-David forgave his killer and you would not believe why!!!

How to accept Jesus Christ as your personal Saviour

Testimony by Phil Robertson from Duck Dynasty

1 Corinthians 15 Authorized (King James) Version (AKJV)
1 Moreover, brethren, I declare unto you the gospel which I preached unto you, which also ye have received, and wherein ye stand;
2 by which also ye are saved, if ye keep in memory what I preached unto you, unless ye have believed in vain.
3 For I delivered unto you first of all that which I also received, how that Christ died for our sins according to the scriptures;
4 and that he was buried, and that he rose again the third day according to the scriptures:

Hebrews 6 Authorized (King James) Version (AKJV)
1 Therefore leaving the principles of the doctrine of Christ, let us go on unto perfection; not laying again the foundation of repentance from dead works, and of faith toward God,
2 of the doctrine of baptisms, and of laying on of hands, and of resurrection of the dead, and of eternal judgment.
3 And this will we do, if God permit.
4 For it is impossible for those who were once enlightened, and have tasted of the heavenly gift, and were made partakers of the Holy Ghost,
5 and have tasted the good word of God, and the powers of the world to come,
6 if they shall fall away, to renew them again unto repentance; seeing they crucify to themselves the Son of God afresh, and put him to an open shame.
7 For the earth which drinketh in the rain that cometh oft upon it, and bringeth forth herbs meet for them by whom it is dressed, receiveth blessing from God:
8 but that which beareth thorns and briers is rejected, and is nigh unto cursing; whose end is to be burned.

Isaiah 53 – Old testament Prophecy about Jesus

1 Who hath believed our report? and to whom is the arm of the Lord revealed?
2 For he shall grow up before him as a tender plant,and as a root out of a dry ground:he hath no form nor comeliness;and when we shall see him,there is no beauty that we should desire him.
3 He is despised and rejected of men;a man of sorrows, and acquainted with grief:and we hid as it were our faces from him;he was despised, and we esteemed him not.
4 Surely he hath borne our griefs,and carried our sorrows:yet we did esteem him stricken,smitten of God, and afflicted.
5 But he was wounded for our transgressions,he was bruised for our iniquities:the chastisement of our peace was upon him;and with his stripes we are healed.
6 All we like sheep have gone astray;we have turned every one to his own way;and the Lord hath laid on him the iniquity of us all.
7 He was oppressed, and he was afflicted,yet he opened not his mouth:he is brought as a lamb to the slaughter,and as a sheep before her shearers is dumb,so he openeth not his mouth.
8 He was taken from prison and from judgment:and who shall declare his generation? for he was cut off out of the land of the living:for the transgression of my people was he stricken.
9 And he made his grave with the wicked,and with the rich in his death;because he had done no violence,neither was any deceit in his mouth.
10 Yet it pleased the Lord to bruise him;he hath put him to grief:when thou shalt make his soul an offering for sin,he shall see his seed, he shall prolong his days,and the pleasure of the Lord shall prosper in his hand.
11 He shall see of the travail of his soul, and shall be satisfied:by his knowledge shall my righteous servant justify many;for he shall bear their iniquities.
12 Therefore will I divide him a portion with the great,and he shall divide the spoil with the strong;because he hath poured out his soul unto death:and he was numbered with the transgressors;and he bare the sin of many,and made intercession for the transgressors.

Vaccine News – VAXXED TV – Vaccines injured my son & Study – Thiol-modulated mechanisms of the cytotoxicity of thimerosal and inhibition of DNA topoisomerase II alpha

US National Library of Medicine
National Institutes of Health – Feb 2012

Study – Mechanisms of aluminum adjuvant toxicity and autoimmunity in pediatric populations.

Tomljenovic L, Shaw CA.
Author information
Neural Dynamics Research Group, Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada. lucijat77@gmail.com

Abstract
Immune challenges during early development, including those vaccine-induced, can lead to permanent detrimental alterations of the brain and immune function. Experimental evidence also shows that simultaneous administration of as little as two to three immune adjuvants can overcome genetic resistance to autoimmunity. In some developed countries, by the time children are 4 to 6 years old, they will have received a total of 126 antigenic compounds along with high amounts of aluminum (Al) adjuvants through routine vaccinations. According to the US Food and Drug Administration, safety assessments for vaccines have often not included appropriate toxicity studies because vaccines have not been viewed as inherently toxic. Taken together, these observations raise plausible concerns about the overall safety of current childhood vaccination programs. When assessing adjuvant toxicity in children, several key points ought to be considered: (i) infants and children should not be viewed as “small adults” with regard to toxicological risk as their unique physiology makes them much more vulnerable to toxic insults; (ii) in adult humans Al vaccine adjuvants have been linked to a variety of serious autoimmune and inflammatory conditions (i.e., “ASIA”), yet children are regularly exposed to much higher amounts of Al from vaccines than adults; (iii) it is often assumed that peripheral immune responses do not affect brain function. However, it is now clearly established that there is a bidirectional neuro-immune cross-talk that plays crucial roles in immunoregulation as well as brain function. In turn, perturbations of the neuro-immune axis have been demonstrated in many autoimmune diseases encompassed in “ASIA” and are thought to be driven by a hyperactive immune response; and (iv) the same components of the neuro-immune axis that play key roles in brain development and immune function are heavily targeted by Al adjuvants. In summary, research evidence shows that increasing concerns about current vaccination practices may indeed be warranted. Because children may be most at risk of vaccine-induced complications, a rigorous evaluation of the vaccine-related adverse health impacts in the pediatric population is urgently needed.

The spectrum of ASIA: ‘Autoimmune (Auto-inflammatory) Syndrome induced by Adjuvants’

Sage journals – 1 Feb 2012

N Agmon-Levin – 1, GRV Hughes – 2, Y Shoenfeld1 – 3
1 – The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel
2 – Head, Lupus Research Unit, The Rayne Institute, St. Thomas’ Hospital, London, UK
3 – Sackler Faculty of Medicine, Incumbent of the Laura Schwarz-KipChair for Research of Autoimmune Diseases, Tel-Aviv University, Israel
Corresponding Author: Yehuda Shoenfeld, MD, FRCP, Zabludowicz Center for Autoimmune Diseases, Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel. Email: shoenfel@post.tau.ac.il

Another cornerstone of ASIA is the complex interaction between autoimmunity and adjuvanted vaccines. On the one hand vaccines are beneficial for the vast majority of subjects including those who suffer from autoimmune-rheumatic diseases as delineated in this issue by van Assen and Bijl.16 On the other hand in a small minority of individuals vaccine can trigger the appearance of autoantibodies as documented by Vista et al.17 and Perdan-Pirkmajer et al.18 Moreover, a link between immunization and defined autoimmune diseases has been reported elsewhere and herein.2 A plausible association between the flu vaccine and polymyalgia rheumatica is reported here by Soriano et al.19 from Italy, and Soldevilla et al.20 describe three patients diagnosed with SLE following immunization with the human papilloma vaccine from the Philippines. In addition, in a retrospective analysis Zafrir et al.21 details common denominators among 93 American patients diagnosed with immune-mediated conditions following inoculation with hepatitis B vaccine. In this cohort although different autoimmune diseases were diagnosed, many manifestation were common to all patients and 86% of them fulfilled the criteria for ASIA. Of note, these cohorts signify only one side of the ASIA spectrum as they cope with distinct immune-mediated diseases while ASIA also comprises enigmatic and non-defined medical conditions. Two such conditions, the macrophagic myofasciitic syndrome and the Gulf War syndrome, are thus reviewed in this special issue by Gherardi and Authier22 and Israeli.23

Study – Etiology of autism spectrum disorders: Genes, environment, or both?

C Shaw, S Sheth, D Li, L Tomljenovic

Authors affiliations
University of British Columbia, Vancouver, British Columbia, Canada

Abstract
Thus far, most of the research on both neurodevelopmental and neurodegenerative disorders has been focused on finding the presumed underlying genetic causes, while much less emphasis has been put on potential environmental factors. While some forms of autism are clearly genetic, the fact remains that heritability factors cannot adequately explain all reported cases nor their drastic increase over the last few decades. In particular, studies on twins have now shown that common environmental factors account for 55% of their risk for developing autism while genetic susceptibility explains only 37% of cases. Because the prenatal environment and early postnatal environment are shared between twins and because overt symptoms of autism emerge around the end of the first year of life, it is likely that at least some of the environmental factors contributing to the risk of autism exert their deleterious neurodevelopmental effect during this early period of life. Indeed, evidence has now emerged showing that autism may in part result from early-life immune insults induced by environmental xenobiotics. One of the most common xenobiotic with immuno-stimulating as well as neurotoxic properties to which infants under two years of age are routinely exposed worldwide is the aluminum (Al) vaccine adjuvant. In this review we discuss the mechanisms by which Al can induce adverse neurological and immunological effects and how these may provide important clues of Al’s putative role in autism. Because of the tight connection between the development of the immune and the central nervous system, the possibility that immune-overstimulation in early infancy via vaccinations may play a role in neurobehavioural disorders needs to be carefully considered.

Conclusion
There is now sufficient evidence from both human and animal studies showing that cumulative exposure to aluminium adjuvants is not as benign as previously assumed. Given that vaccines are the only medical intervention that we attempt to deliver to every living human on earth and that by far the largest target population for vaccination are healthy children, a better appreciation and understanding of vaccine adjuvant risks appears warranted.

US National Library of Medicine
National Institutes of Health – Feb 2008

Study – Thiol-modulated mechanisms of the cytotoxicity of thimerosal and inhibition of DNA topoisomerase II alpha.

Wu X1, Liang H, O’Hara KA, Yalowich JC, Hasinoff BB.
Author information
Faculty of Pharmacy, University of Manitoba, 50 Sifton Road, Winnipeg, Manitoba, R3T 2N2, Canada.

Abstract
Thimerosal is an organic mercury compound that is widely used as a preservative in vaccines and other solution formulations. The use of thimerosal has caused concern about its ability to cause neurological abnormalities due to mercury accumulation during a normal schedule of childhood vaccinations. While the chemistry and the biological effects of methylmercury have been well-studied, those of thimerosal have not. Thimerosal reacted rapidly with cysteine, GSH, human serum albumin, and single-stranded DNA to form ethylmercury adducts that were detectable by mass spectrometry. These results indicated that thimerosal would be quickly metabolized in vivo because of its reactions with protein and nonprotein thiols. Thimerosal also potently inhibited the decatenation activity of DNA topoisomerase II alpha, likely through reaction with critical free cysteine thiol groups. Thimerosal, however, did not act as a topoisomerase II poison and the lack of cross-resistance with a K562 cell line with a decreased level of topoisomerase II alpha (K/VP.5 cells) suggested that inhibition of topoisomerase II alpha was not a significant mechanism for the inhibition of cell growth. Depletion of intracellular GSH with buthionine sulfoximine treatment greatly increased the K562 cell growth inhibitory effects of thimerosal, which showed that intracellular glutathione had a major role in protecting cells from thimerosal. Pretreatment of thimerosal with glutathione did not, however, change its K562 cell growth inhibitory effects, a result consistent with the rapid exchange of the ethylmercury adduct among various thiol-containing cellular reactants. Thimerosal-induced single and double strand breaks in K562 cells were consistent with a rapid induction of apoptosis. In conclusion, these studies have elucidated some of the chemistry and biological activities of the interaction of thimerosal with topoisomerase II alpha and protein and nonprotein thiols and with DNA.

VAXXED TV – My daughter is unvaccinated and very healthy

Vaccines injured my son

Our doctor fired us

My grandson has autism from vaccines

My children are injured by vaccines

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Just saying Hi!

Vaccines killed my grandson

Linda Tells about her children and difficulties dealing with medical professionals
Linda speaks about her children’s reactions to vaccinations, the troubles with school officials and medical professionals.

Mother speaks about her daughter’s reaction to MR
Mother speaks at great length about her daughter’s progress through life as she develops illnesses as a result of 2 vaccine shots given at school

Vaxxed versus unvaxxed

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ONE FOR ISRAEL Ministry – Jewish Johnathan Ben-David forgave his killer and you would not believe why!!!

How to accept Jesus Christ as your personal Saviour

Testimony by Phil Robertson from Duck Dynasty

Isaiah 53 – Old testament Prophecy about Jesus

Vaccine News – VAXXED TV – I now realize the danger of vaccinations & Study – Infant mortality rates regressed against number of vaccine doses routinely given: Is there a biochemical or synergistic toxicity?

US National Library of Medicine
National Institutes of Health – Jan 2009

Study – Do childhood vaccines cause thrombocytopenia?
Laura J Sauvé, MD MPH and David Scheifele, MD
Vaccine Evaluation Centre, BC Children’s Hospital, Vancouver, British Columbia
Correspondence: Dr Laura Sauvé, Vaccine Evaluation Centre, Shaughnessy Site, Room L427, 4500 Oak Street, Vancouver, British Columbia

An increasing body of evidence has been gathered since the mid-1960s to support a link between vaccinations, particularly the measles-mumps-rubella (MMR) vaccine and idiopathic thrombocytopenic purpura (ITP). The incidence rate is estimated to be between one in 25,000 to one in 40,000 doses of MMR (1,2); this is much less frequent than after natural infection with measles (common), rubella (one in 3000 cases) and varicella. The purpose of the present commentary is to review vaccine-associated thrombocytopenia (VATP).
Vaccine-preventable diseases are becoming rare in Canada, with an average of 10 reported cases of measles per year between 2002 and 2006; although there was a large outbreak in Quebec in 2007, with 95 confirmed cases (3). With widespread vaccination and the near disappearance of vaccine-preventable diseases in Canada, there is less societal tolerance for adverse events following immunization (AEFI). One of the challenges in assessing AEFIs is distinguishing events that are causally linked with vaccination from those that are only temporally associated. Cases of thrombocytopenia in the first month after vaccination often have a history of recent viral infection or coadministration of medications that may also lead to thrombocytopenia, making the actual cause of VATP difficult to identify.
Since 1992, the Immunization Monitoring Program, ACTive (IMPACT), conducted by the Canadian Paediatric Society, has performed active surveillance for children who are hospitalized with AEFIs, including VATP. Trained nurse monitors at each of the 12 IMPACT centres review all admissions for children admitted for VATP (children with a platelet count of less than 100×109/L and no obvious other cause, such as cancer chemotherapy) within one month of documented receipt of any vaccine. Jadavji et al (4) reported on the first nine years of surveillance (with 61 cases) for VATP in 2003. One of the limitations in the IMPACT data is that detecting a case requires the treating physician to document administration of a vaccine in the previous month (the nurse monitors do not interview the parents). A recent American study (1) found that treating physicians had asked only two of 13 children with VATP about recent vaccination.
The IMPACT data on VATP are similar to reports from other countries, including the United Kingdom, France and the United States (1,2,5,6). In Canada, 103 cases of VATP have been documented by IMPACT since 1992 (7). The median age was 13 months, and 61% of those affected were boys. Petechial rash and bruising were the typical presenting signs. Most (73%) cases were treated with intravenous immunoglobulin. Most children did quite well, with rapid recovery; only six of 95 children with follow-up data still had abnormal platelet counts after three months. However, two children had severe bleeding-related complications, one had a gastrointestinal bleed requiring intensive care and one had post-traumatic intracranial bleeding leading to death.
Most cases of VATP are associated with MMR or measles vaccine, including 72% of the cases reported to IMPACT (25 of these 74 children had received one or more additional vaccines, including 10 children who also received the diphtheria, pertussis and tetanus vaccine, and 10 children who had received the varicella vaccine). Of the children who had MMR associated with thrombocytopenia in the IMPACT study, nine (12%) had a previous recorded dose of the vaccine without known thrombocytopenia. When all of the VATP cases were considered, 31% of the VATP episodes occurred after the second or third exposure to a vaccine.

US National Library of Medicine
National Institutes of Health – Sep 2011

Study – Infant mortality rates regressed against number of vaccine doses routinely given: Is there a biochemical or synergistic toxicity?

Abstract

The infant mortality rate (IMR) is one of the most important indicators of the socio-economic well-being and public health conditions of a country. The US childhood immunization schedule specifies 26 vaccine doses for infants aged less than 1 year—the most in the world—yet 33 nations have lower IMRs. Using linear regression, the immunization schedules of these 34 nations were examined and a correlation coefficient of r = 0.70 (p < 0.0001) was found between IMRs and the number of vaccine doses routinely given to infants. Nations were also grouped into five different vaccine dose ranges: 12–14, 15–17, 18–20, 21–23, and 24–26. The mean IMRs of all nations within each group were then calculated. Linear regression analysis of unweighted mean IMRs showed a high statistically significant correlation between increasing number of vaccine doses and increasing infant mortality rates, with r = 0.992 (p = 0.0009). Using the Tukey-Kramer test, statistically significant differences in mean IMRs were found between nations giving 12–14 vaccine doses and those giving 21–23, and 24–26 doses. A closer inspection of correlations between vaccine doses, biochemical or synergistic toxicity, and IMRs is essential.

Are flu vaccines risking senior citizens’ lives? Some say Yes.

A buried JAMA study from almost a decade ago which showed that there was no improvement in mortality rates among senior citizens with a flu vaccine, even after greatly increased vaccination rates. The study “got little attention,” she says, “because the science came down on the wrong side.” Whereas the researchers had set out to prove that the push for massive flu vaccination would save the world, the researchers were “astonished” to find that the data did not support their presupposition at all. The data actually shows that deaths increased, not decreased, among seniors following vaccination.
Johns Hopkins scientist, Peter Doshi, Ph.D., issued a report in the prestigious British Medical Journal, according to NewsLI, asserting that the CDC policy of routinely recommending the flu vaccine is being based on “low quality studies that do not substantiate claims.” He says there is no evidence that the vaccine reduces deaths among senior citizens. Interestingly, Doshi cites an Australian study which found significant risks for children as well, stating that “one in every 110 children under the age of five had convulsions following vaccinations in 2009 for H1N1 influenza.”
During the drug trials for the Fluzone flu vaccine, 23 seniors out of 3,833 died after receiving the shot, according to the drug’s package insert, reported by Health Impact News. Another 226 experienced “serious adverse effects.” The manufacturer denies any connection between the deaths and the flu vaccine.

JAMA internal medicine – 14 Feb 2005

Study – Impact of Influenza Vaccination on Seasonal Mortality in the US Elderly Population

Lone Simonsen, PhD; Thomas A. Reichert, MD, PhD; Cecile Viboud, PhD;

Abstract

Background Observational studies report that influenza vaccination reduces winter mortality risk from any cause by 50% among the elderly. Influenza vaccination coverage among elderly persons (≥65 years) in the United States increased from between 15% and 20% before 1980 to 65% in 2001. Unexpectedly, estimates of influenza-related mortality in this age group also increased during this period. We tried to reconcile these conflicting findings by adjusting excess mortality estimates for aging and increased circulation of influenza A(H3N2) viruses.

Methods We used a cyclical regression model to generate seasonal estimates of national influenza-related mortality (excess mortality) among the elderly in both pneumonia and influenza and all-cause deaths for the 33 seasons from 1968 to 2001. We stratified the data by 5-year age group and separated seasons dominated by A(H3N2) viruses from other seasons.

Results For people aged 65 to 74 years, excess mortality rates in A(H3N2)-dominated seasons fell between 1968 and the early 1980s but remained approximately constant thereafter. For persons 85 years or older, the mortality rate remained flat throughout. Excess mortality in A(H1N1) and B seasons did not change. All-cause excess mortality for persons 65 years or older never exceeded 10% of all winter deaths.

Conclusions We attribute the decline in influenza-related mortality among people aged 65 to 74 years in the decade after the 1968 pandemic to the acquisition of immunity to the emerging A(H3N2) virus. We could not correlate increasing vaccination coverage after 1980 with declining mortality rates in any age group. Because fewer than 10% of all winter deaths were attributable to influenza in any season, we conclude that observational studies substantially overestimate vaccination benefit.

VAXXED TV – Military vaccines made me sick

I Slept My Teenage Years AWAY!
Kelly recalls life before and after given vaccines during a swine flu epidemic.
Interview recorded on May 5th, 2017 in The United Kingdom

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Angela tells her story about her children and her foundation to help others in her area.
Interview recorded on May 5th, 2017 in The United Kingdom

TDap made my husband sick

Vaccinated versus unvaccinated

I now realize the danger of vaccinations

I was a scientist and will now never vaccinate my children

Vaccines gave my son autism

My 3 children are injured from vaccines

I am injured so I will never vaccinate my children

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How to accept Jesus Christ as your personal Saviour

Testimony by Phil Robertson from Duck Dynasty

Vaccine News – Study – The Blood-Brain Barrier Bottleneck in Brain Drug Development

Study – Systematic review and meta-analysis links autism and toxic metals and highlights the impact of country development status: Higher blood and erythrocyte levels for mercury and lead, and higher hair antimony, cadmium, lead, and mercury.

US National Library of Medicine
National Institutes of Health – 3 Oct 2017

Saghazadeh A – 1, Rezaei N – 2.
Author information
1 Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran; MetaCognition Interest Group (MCIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
2 Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Systematic Review and Meta-analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Boston, MA, USA. Electronic address: Rezaei_nima@tums.ac.ir.

Abstract
BACKGROUND:
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder that affects cognitive and higher cognitive functions. Increasing prevalence of ASD and high rates of related comorbidities has caused serious health loss and placed an onerous burden on the supporting families, caregivers, and health care services. Heavy metals are among environmental factors that may contribute to ASD. However, due to inconsistencies across studies, it is still hard to explain the association between ASD and toxic metals. Therefore the objective of this study was to investigate the difference in heavy metal measures between patients with ASD and control subjects.
METHODS:
We included observational studies that measured levels of toxic metals (antimony, arsenic, cadmium, lead, manganese, mercury, nickel, silver, and thallium) in different specimens (whole blood, plasma, serum, red cells, hair and urine) for patients with ASD and for controls. The main electronic medical database (PubMed and Scopus) were searched from inception through October 2016.
RESULTS:
52 studies were eligible to be included in the present systematic review, of which 48 studies were included in the meta-analyses. The hair concentrations of antimony (standardized mean difference (SMD)=0.24; 95% confidence interval (CI): 0.03 to 0.45) and lead (SMD=0.60; 95% confidence interval (CI): 0.17 to 1.03) in ASD patients were significantly higher than those of control subjects. ASD patients had higher erythrocyte levels of lead (SMD=1.55, CI: 0.2 to 2.89) and mercury (SMD=1.56, CI: 0.42 to 2.70). There were significantly higher blood lead levels in ASD patients (SMD=0.43, CI: 0.02 to 0.85). Sensitivity analyses showed that ASD patients in developed but not in developing countries have lower hair concentrations of cadmium (SMD=-0.29, CI: -0.46 to -0.12). Also, such analyses indicated that ASD patients in developing but not in developed lands have higher hair concentrations of lead (SMD=1.58, CI: 0.80 to 2.36) and mercury (SMD=0.77, CI: 0.31 to 1.23). These findings were confirmed by meta-regression analyses indicating that development status of countries significantly influences the overall effect size of mean difference for hair arsenic, cadmium, lead, and mercury between patients with ASD and controls.
CONCLUSION:
The findings help highlighting the role of toxic metals as environmental factors in the etiology of ASD, especially in developing lands. While there are environmental factors other than toxic metals that greatly contribute to the etiology of ASD in developed lands. It would be, thus, expected that classification of ASD includes etiological entities of ASD on the basis of implication of industrial pollutants (developed vs. developing ASD).

Study – Autism: A form of lead and mercury toxicity

Environmental Toxicology and Pharmacology
Volume 38, Issue 3, November 2014, Pages 1016–1024

Highlights
•Autism is a developmental disability characterized by severe, pervasive deficits in social interaction and communications.
•Lead and mercury two of the most common heavy metals in the environment.
•Lead and mercury can lead to autistic disorders.
•Many risk factors contribute to the high level of heavy metals in autistic children.
•Defect in the metabolism of the heavy metals in autistic children also contribute to the high level of these heavy metals in their body.
•Chelating agents can be used in the treatment of the autistic disorders.

Abstract
Aim
Autism is a developmental disability characterized by severe deficits in social interaction and communication. The definite cause of autism is still unknown. The aim of this study is to find out the relation between exposure to Lead and/or mercury as heavy metals and autistic symptoms, dealing with the heavy metals with chelating agents can improve the autististic symptoms.

Method
Blood and hair samples were obtained from 45 children from Upper Egypt with autism between the ages of 2 and 10 years and 45 children served as controls in the same age range, after taken an informed consent and fill a questionnaire to assess the risk factors. The samples were analyzed blindly for lead and mercury by using atomic absorption and ICP-MS. Data from the two groups were compared, then follow up of the autistic children after treatment with chelating agents were done.

Results
The results obtained showed significant difference among the two groups, there was high level of mercury and lead among those kids with autism. Significant decline in the blood level of lead and mercury with the use of DMSA as a chelating agent. In addition, there was decline in the autistic symptoms with the decrease in the lead and mercury level in blood.

Conclusion
Lead and mercury considered as one of the main causes of autism. Environmental exposure as well as defect in heavy metal metabolism is responsible for the high level of heavy metals. Detoxification by chelating agents had great role in improvement of those kids.

Study – The Blood-Brain Barrier: Bottleneck in Brain Drug Development

US National Library of Medicine
National Institutes of Health – Jan 2005

William M. Pardridge
Department of Medicine, UCLA, Los Angeles, California 90024
Address correspondence and reprint requests to William M. Pardridge, M.D., UCLA Warren Hall, 13-164, 900 Veteran Avenue, Los Angeles,

ABSTRACT
Summary: The blood-brain barrier (BBB) is formed by the brain capillary endothelium and excludes from the brain ∼100% of large-molecule neurotherapeutics and more than 98% of all small-molecule drugs. Despite the importance of the BBB to the neurotherapeutics mission, the BBB receives insufficient attention in either academic neuroscience or industry programs. The combination of so little effort in developing solutions to the BBB problem, and the minimal BBB transport of the majority of all potential CNS drugs, leads predictably to the present situation in neurotherapeutics, which is that there are few effective treatments for the majority of CNS disorders. This situation can be reversed by an accelerated effort to develop a knowledge base in the fundamental transport properties of the BBB, and the molecular and cellular biology of the brain capillary endothelium. This provides the platform for CNS drug delivery programs, which should be developed in parallel with traditional CNS drug discovery efforts in the molecular neurosciences.

VAXXED TV – Nick Johansen #vaxxed #PrayBig

Dr. Judy Mikovits, PhD Research Scientist at #TxMFA #TxMFA2017
Dr. Judy Mikovits, PhD research scientist, dives deep into the crude science of vaccination

Austin Bennett #vaxxed #PrayBig

Dawn Richardson

David Oldham

Barbara Loe Fisher #vaxxed #truth #science #praybig

Q&A vaccine syndrome

Global Vaccine Initiative Houston Protest #TxMFA #TxMFA2017
Jonathan Tommey and The Vaxxed Team hit the ground running at the Texas Medical Freedom Alliance world symposium in Housant, Texas.
They discusses vaccine safety concerns with our #TexasPeeps protesting on the ground and also interview medical doctor, Jim Meehan, M.D. with regard to his passion for exposing the deception endemic to the present vaccine paradigm.

Glaxo’s Vaccine Trials survivor speaks out
David tells his story and presents documentation of his history going through the Glaxo’s trials. His mother was told he had passed as an infant here they kept him as an orphan until 4 years old.
Interview recorded on May 5th, 2017 in The United Kingdom

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How to accept Jesus Christ as your personal Saviour

Testimony by Phil Robertson from Duck Dynasty

Vaccine News – Government Issues First Report in 2017 on Vaccine Injuries and Deaths: 275 Injured 4 Dead from Flu Shot

Study – Immunosuppressive and autoimmune effects of thimerosal in mice.

US National Library of Medicine
National Institutes of Health – Apr 2005

Havarinasab S, Häggqvist B, Björn E, Pollard KM, Hultman P.
Author information
Department of Molecular and Clinical Medicine, Molecular and Immunological Pathology (AIR), Linköping University, SE-581 85 Linköping, Sweden.

Abstract
The possible health effects of the organic mercury compound thimerosal (ethylmercurithiosalicylate), which is rapidly metabolized to ethylmercury (EtHg), have recently been much debated and the effect of this compound on the immune system is largely unknown. We therefore studied the effect of thimerosal by treating A.SW (H-2s) mice, susceptible to induction of autoimmunity by heavy metals, with 10 mg thimerosal/L drinking water (internal dose ca 590 microg Hg/kg body weight/day) for up to 30 days. The lymph node expression of IL-2 and IL-15 mRNA was increased after 2 days, and of IL-4 and IFN-gamma mRNA after 6 and 14 days. During the first 14 days treatment, the number of splenocytes, including T and B cells as well as Ig-secreting cells decreased. A strong immunostimulation superseded after 30 days treatment with increase in splenic weight, number of splenocytes including T and B cells and Ig-secreting cells, and Th2- as well as Th-1-dependent serum immunoglobulins. Antinucleolar antibodies (ANoA) targeting the 34-kDa nucleolar protein fibrillarin, and systemic immune-complex deposits developed. The H-2s strains SJL and B10.S also responded to thimerosal treatment with ANoA. The A.TL and B10.TL strain, sharing background genes with the A.SW and B10.S strain, respectively, but with a different H-2 haplotype (t1), did not develop ANoA, linking the susceptibility to H-2. Thimerosal-treated H-2s mice homozygous for the nu mutation (SJL-nu/nu), or lacking the T-cell co-stimulatory molecule CD28 (B10.S-CD28-/-), did not develop ANoA, which showed that the autoimmune response is T-cell dependent. Using H-2s strains with targeted mutations, we found that IFN-gamma and IL-6, but not IL-4, is important for induction of ANoA by thimerosal. The maximum added renal concentration of thimerosal (EtHg) and inorganic mercury occurred after 14 days treatment and was 81 microg Hg/g. EtHg made up 59% and inorganic mercury 41% of the renal mercury. In conclusion, the organic mercury compound thimerosal (EtHg) has initial immunosuppressive effects similar to those of MeHg. However, in contrast to MeHg, thimerosal treatment leads in genetically susceptible mice to a second phase with strong immunostimulation and autoimmunity, which is T-cell dependent, H-2 linked and may at least partly be due to the inorganic mercury derived from the metabolism of ethyl mercury.

Study – Elevated blood histamine caused by vaccinations and Vitamin C deficiency may mimic the shaken baby syndrome.

Clemetson CA. Med Hypotheses. 2004

Clemetson CA
Author information
Department of Obstetrics and Gynecology, Tulane University School of Medicine, New Orleans, LA, USA. megcc2000@yahoo.com

Abstract
The findings of subdural hematoma and retinal hemorrhages in infants, without any documented history of major trauma, do not always indicate child abuse. A combination of ascorbate depletion and the injection of foreign proteins can cause a very high blood histamine level, leading to capillary fragility and venular bleeding. This can be prevented by the administration of vitamin C.

Study – Asymptomatic transmission and the resurgence of Bordetella pertussis

Published: 24 June 2015

Benjamin M. AlthouseEmail author and Samuel V. Scarpino
Affiliated with Santa Fe Institute

Abstract

Background
The recent increase in whooping cough incidence (primarily caused by Bordetella pertussis) presents a challenge to both public health practitioners and scientists trying to understand the mechanisms behind its resurgence. Three main hypotheses have been proposed to explain the resurgence: 1) waning of protective immunity from vaccination or natural infection over time, 2) evolution of B. pertussis to escape protective immunity, and 3) low vaccine coverage. Recent studies have suggested a fourth mechanism: asymptomatic transmission from individuals vaccinated with the currently used acellular B. pertussis vaccines.

Methods
Using wavelet analyses of B. pertussis incidence in the United States (US) and United Kingdom (UK) and a phylodynamic analysis of 36 clinical B. pertussis isolates from the US, we find evidence in support of asymptomatic transmission of B. pertussis. Next, we examine the clinical, public health, and epidemiological consequences of asymptomatic B. pertussis transmission using a mathematical model.

Results
We find that: 1) the timing of changes in age-specific attack rates observed in the US and UK are consistent with asymptomatic transmission; 2) the phylodynamic analysis of the US sequences indicates more genetic diversity in the overall bacterial population than would be suggested by the observed number of infections, a pattern expected with asymptomatic transmission; 3) asymptomatic infections can bias assessments of vaccine efficacy based on observations of B. pertussis-free weeks; 4) asymptomatic transmission can account for the observed increase in B. pertussis incidence; and 5) vaccinating individuals in close contact with infants too young to receive the vaccine (“cocooning” unvaccinated children) may be ineffective.

Conclusions
Although a clear role for the previously suggested mechanisms still exists, asymptomatic transmission is the most parsimonious explanation for many of the observations surrounding the resurgence of B. pertussis in the US and UK. These results have important implications for B. pertussis vaccination policy and present a complicated scenario for achieving herd immunity and B. pertussis eradication.

Government Issues First Report in 2017 on Vaccine Injuries and Deaths: 275 Injured 4 Dead from Flu Shot

These quarterly meetings include a report from the Department of Justice (DOJ) on cases settled for vaccine injuries and deaths as mandated by the National Vaccine Injury Compensation Program (NVICP).
The NVICP was started as a result of a law passed in 1986 that gave pharmaceutical companies total legal immunity from being sued due to injuries and deaths resulting from vaccines.
Drug manufacturers in the vaccine market can now create as many new vaccines as they desire, with no risk of being sued if their product causes injury or death.
This has resulted in a huge increase of vaccines entering the market, and the U.S. government, through the Centers for Disease Control (CDC), is the largest purchaser of these vaccines, spending in excess of $4 billion taxpayer dollars each year to purchase these vaccines.
If you or a family member is injured or dies from vaccines, you must sue the federal government in this special vaccine court. Many cases are litigated for years before a settlement is reached.

James Chestnut, DC – Dubious Method Used By CDC & Big Pharma to “Prove” Flu Vaccine Efficacy
Is the CDC a defacto pharmaceutical company with an over $4 billion incentive to protect Merck and its other Big Pharma suppliers of vaccines? Is there proof of collusion and fraud at the highest levels of the CDC administration, and top-down influence on the allied health practitioners who administer the flu vaccine in blind faith to an unwitting public? What follows is an interview conducted by Toni Bark, MD of “Vaccines Revealed” with James Chestnut, DC an Evidence-Based Wellness and Prevention Lifestyle Clinician. Register for free for the entire 9-part docu-series “Vaccines Revealed” at their website by the same name.