Study: Acetaminophen Use for Fever in Children Associated with Autism Spectrum

Study: Acetaminophen Use for Fever in Children Associated with Autism Spectrum Disorder
Abstract
Autism Spectrum Disorder (ASD) is characterized by persistent deficits in social communication and restrictive behavior, interests, and activities. Our previous case-control study showed that use of acetaminophen at age 12–18 months is associated with increased likelihood for ASD (OR 8.37, 95% CI 2.08–33.7). In this study, we again show that acetaminophen use is associated with ASD (p = 0.013). Because these children are older than in our first study, the association is reversed; fewer children with ASD vs. non-ASD children use acetaminophen as a “first choice” compared to “never use” (OR 0.165, 95% CI 0.045, 0.599). We found significantly more children with ASD vs. non- ASD children change to the use of ibuprofen when acetaminophen is not effective at reducing fever (p = 0.033) and theorize this change in use is due to endocannabinoid system dysfunction. We also found that children with ASD vs. non-ASD children are significantly more likely to show an increase in sociability when they have a fever (p = 0.037) and theorize that this increase is due to anandamide activation of the endocannabinoid system in ASD children with low endocannabinoid tone from early acetaminophen use. In light of this we recommend that acetaminophen use be reviewed for safety in children.

Oral Contraceptives and Autism

Oral Contraceptives and Autism
The mechanisms by which oral contraceptives instigate neurodevelopmental changes is slowly emerging. It appears that in addition to preventing pregnancy, synthetic hormones like ethinylestradiol, used in most birth control formulations, initiate epigenetic alterations in the oocytes (eggs) causing persistent changes in expression of the estrogen receptor beta gene (ERβ). When those eggs become fertilized and conception ensues, the changes in the estrogen receptor gene impact the expression of autism and other neurodevelopmental disorders.
Ethinylestradiol is an Endocrine Disruptor
Ethinylestradiol is a known endocrine disruptor. Anything that disrupts endogenous hormones can be considered an endocrine disruptor. Evidence is emerging that ethinylestradiol may trigger what is called DNA methylation of the estrogen receptor gene. This then causes decreased messenger RNA resulting in impaired brain estrogen signaling in offspring [2]. Let’s think more deeply about this.
Methylation means that, by way of a chemical process, a gene is turned on (hypomethylation) or turned off (methylation) by an enzyme or protein. Researchers believe that methylation is one of a number of mechanisms by which environmental interactions influence genetic activity. In this case, ethinylestradiol silences or turns off some important processes that are associated with estrogen signaling, namely receptor activity.
Methylation and other epigenetic reactions influence health and disease processes across generations. This is called transgenerational transmission. So, I suspect that the deleterious effects of ethinylestradiol on the estrogen receptor gene are transgenerational. This is possible because the estrogen receptor gene may be an imprinted gene. Imprinting is a dynamic epigenetic phenomenon by which certain genes are expressed in a parent-of-origin manner. If the allele, an alternative form of the same gene, inherited from the father is imprinted, it is thereby silenced, and only the allele from the mother is expressed. If the allele from the mother is imprinted, then only the allele from the father is expressed.

Study: The link between oral contraceptive use and prevalence in autism spectrum disorder
Autism spectrum disorder (ASD) is a group of developmental disabilities that include full syndrome
autism, Asperger’s syndrome, and other pervasive developmental disorders. The identified prevalence of ASD has increased in a short time period across multiple studies causing some to conclude that it has reached epidemic proportions in the U.S.
Many possible explanations for the rise in numbers of individuals diagnosed with ASD have been offered and yet, causes and contributing factors for ASD are inadequately understood. Current evidence suggests that both genetics and environment play a part in causing ASD.
One possible risk factor for the increase in prevalence has been profoundly overlooked in the existing biomedical and epidemiologic literature. As the prevalence of ASD has risen in the last sixty years, so has the prevalence of the usage of the oral contraceptives and other modern hormonal delivery methods. In 1960 about one million American women were using oral contraceptives, today close to 11 million women in the U.S. use oral contraceptives. Eighty-two percent of sexually active women in the U.S. have used oral contraceptives at some point during their reproductive years. Thus, the growth in use of progesterone/estrogen-based contraceptives in the United State has reached near-ubiquitous levels among women in the child-bearing age range.
The suppression of ovulation produced by estrogen–progesterone is an indisputable abnormality. It is logical to consider the outcome of the ovum that would have been normally released from the ovary during ovulation. To date there is no comprehensive research into the potential neurodevelopmental effects of oral contraceptive use on progeny. The issue has been only sparsely considered in the biomedical literature. This article hypothesizes that the compounds, estrogen and progesterone, used in oral contraceptives modify the condition of the oocyte and give rise to a potent risk factor that helps explain the recent increase in the prevalence of ASD’s.
This hypothesis does not propose to delineate the cause of autism. Rather, it attempts to explain the recent dramatic increase in prevalence and point the way for further study that will lead to causal examination

Study: An epigenetic basis for autism spectrum disorder risk and oral contraceptive use
In the United States 1 in 68 children are diagnosed with autism spectrum disorder (ASD). Although the etiology is unknown, many scientists believe ASD is caused by a combination of genetic and environmental factors and/or epigenetic factors. The widespread use of oral contraceptives is one environmental risk factor that has been greatly overlooked in the biomedical literature. Oral contraceptives, synthetic hormones created to imitate natural human hormones and disrupt endogenous endocrine function to inhibit pregnancy, may be causing the harmful neurodevelopmental effects that result in the increased prevalence of ASD.
It is conceivable that the synthetic hormones repeatedly assault the oocyte causing persistent changes in expression of the estrogen receptor beta gene. Ethinylestradiol, a known endocrine
disruptor, may trigger DNA methylation of the estrogen receptor beta gene causing decreased mRNA resulting in impaired brain estrogen signaling in progeny. In addition, it is possible the deleterious effects are transgenerational as the estrogen receptor gene and many of its targets may be imprinted and the methylation marks protected from global demethylation and preserved through fertilization and beyond to progeny generations. This article will delineate the hypothesis that ethinylestradiol activates DNA methylation of the estrogen receptor beta gene causing decreased mRNA resulting in diminished brain estrogen signaling in offspring of mothers exposed to oral contraceptives. Considering the detrimental epigenetic and transgenerational effects proposed, it calls for further study.

Potential Link between Oral Contraceptives and Autism
Oral Contraceptives are Endocrine Disruptors
One of the compounds found in oral contraceptives is the synthetic estrogen called Ethinylestradiol (EE2). EE2 is a known endocrine disrupting compound (EDC) capable of causing harm to the endocrine system and to progeny. Studies show that EDCs have the potential to do harm by adversely affecting the sensitive hormonal pathways that regulate reproductive function in a variety of species including humans. The National Institute for Environmental Health Sciences (NIEHS) reports that EDCs may disturb the endocrine system and produce adverse developmental, reproductive, neurological, and immune effects in humans and wildlife. The NIEHS indicates that research also shows that the highest risk of endocrine disruption occurs during prenatal and early postnatal development. Humans might be exposed to EDCs through foods, beverages, pesticides, and cosmetics, but the case with EE2 is particularly striking because EE2 exposure in female humans occurs at a pharmacologically effective dose, administered every day, for extended periods of time.
Hormones and their signaling pathways are essential to normal functioning of all tissues and organs in invertebrate and vertebrate species. Normal communication of the endocrine system can be disrupted by exogenous substances like EDCs, which have the same attributes as endogenous hormones. EDCs possess the ability to be active at low concentrations and like endogenous hormones, they are able to bind to receptors at very low concentrations. Therefore, endocrine disruption can occur from low-dose exogenous hormone exposure or from hormonally active substances that interfere with receptors for other hormonally assisted processes. In addition, some EDCs are able to interact with multiple hormone receptors concurrently. They can work simultaneously to create additive or synergistic effects not observed with the individual compounds. EDCs can act on a number of physiological processes in a tissue specific manner. And, as with endogenous hormones, it is often not feasible to extrapolate low-dose effects from the high-dose effects of EDCs. Thus the mimicry of estradiol (E2) and the information that such compounds can cause harmful effects on reproduction and the endocrine system provide mechanistic evidence that EE2 found in oral contraceptives may adversely affect the oocyte or developing embryo.

Update: Oral Contraceptive Use and Autism
In the realm of environmental risk factors, the oral contraceptive hypothesis I first proposed is compelling. As a group of agents, there are explicit documented mechanisms through which oral contraceptives can impact the oocyte and/or the developing embryo. Additional reasons for considering the role of oral contraceptives and autism include:

The exposure concentration is directly administered and pharmacologically effective.
The exposure to the endocrine disruptor may be of larger magnitude than other environmental exposures that mostly occur through passive secondary means.
A temporal correlation exists between the increased prevalence of oral contraceptive use and the increased prevalence of autism spectrum disorders over the last fifty years.
The possibility exists that the effects of EE2 could intensify over generations due to transgenerational transmission of altered epigenetic programming.
Continued exposure across generations could possibly impart sensitivity to developing autism spectrum disorders.

Do We Really Understand Oral Contraceptives?
While researching my hypothesis linking oral contraceptive use to the development of autism in children, I wondered about why so many women are still using a drug that has dangerous side-effect and could cause neurodevelopmental disorders in offspring. The simple answer seems to be lack of accurate medical information. Not only do individual women lack critical information about the pill, but the support systems women depend on for advice and help with decision-making also seem to lack information about the pill.
All health choices are complex and influenced by multiple variables that all interact. There are multiple levels, underlying determinants of health behaviors, which are relevant for understanding why oral contraceptives are still the primary method of choice in the United States. The following influencing factors are not exhaustive, but do shed light on why pill use is so prevalent in the U.S. Simply put, we don’t know better.

Dr. Deisher testifies at the MN House about vaccine safety

Dr. Deisher testifies at the MN House about vaccine safety. She presents research demonstrating a link between the rise in the rates of autism and the use of aborted fetal cells in the production of vaccines. Dr. Deisher is the president and founder of SoundChoice, a non-profit that works to provide safe vaccination alternatives.

 

 

 

Calcium Chloride in Vaccines

Calcium Chloride in Vaccines: Limited Information Available
The U.S. Centers for Disease Control and Prevention (CDC) Vaccine Excipient and Media Summary lists two vaccines that contain calcium chloride:

  • Rotavirus (Rotarix) approved for use in infants six weeks to 24 weeks of age
  • Influenza (Afluria) approved for use in persons over the age of nine

Calcium Chloride: Materials Safety Record and Toxicity
According to the Materials and Safety Data Sheet (MSDS) on ScienceLab.com, calcium chloride is hazardous in case of skin contact (irritant), eye contact (irritant), ingestion and inhalation. The MSDS does not address the effects of calcium chloride through injection. Toxicological information is provided by the MSDS, which describes the biological effects of calcium chloride on humans as:
Mutagenic for mammalian somatic cells, mutagenic for bacteria and/or yeast and may cause damage to the following organs: heart, cardiovascular system. May affect genetic material based on animal data. May cause cancer (tumorigenic) based on animal data.11
The MSDS further provides these special remarks of its effects on humans:
Skin: May cause severe irritation and possible burns, especially if skin is wet. Contact with dry skin causes mild irritation. Contact of solid with moist/wet skin or skin contact with strong solutions may cause marked irritation or possible burns.
Eyes: May cause severe irritation, possible transient corneal injury, and possible eye burns.
Inhalation: May cause severe irritation of the upper respiratory tract with pain, inflammation and possible burns.
Ingestion: May cause severe gastrointestinal (digestive) tract irritation with nausea, vomiting and possible burns. May affect cardiovascular system (cardiac disturbances, slow heart beat), behavior (seizures), metabolism, blood, and brain, respiration (rapid respiration).
Chronic Potential Health Effects: Effects may be delayed.11
Calcium Chloride: Lack of Scientific Research on Human Health

Use of ‘control’ vaccines and mismatched groups expose malaria study as complete fraud

Mismatched group sizes suggest that children who receive malaria vaccine are actually more likely to contract malaria than control children
Then there is the issue of mismatched group sizes. According to the data, 57 of 2,830 children in the RTS,S group developed at least one episode of severe malaria following the vaccine, while only 56 of 1,466 children in the “control” group did. As you can see, the number of children in the RTS,S malaria vaccine group was nearly double the amount in the “control” group.

Study authors used these figures to suggest that RTS,S has an efficacy rate of 47.3 percent, and the mainstream media ran with it. But if the two group sizes had been the same, it appears as though children in the “control” group were actually better protected from malaria than children in the malaria vaccine group. By nearly doubling the size of the RTS,S group, study authors were able to arrive at an artificial efficacy rate that favored the malaria vaccine.

These are just a few of the many details that the mainstream media failed to carefully evaluate prior to jumping on the pro-malaria vaccine bandwagon, but they are details we here at NaturalNews simply could not ignore. The basic truth of the matter is that nothing has been proven by this study other than the fact that GSK and the Gates Foundation appear to have a clear agenda to get the RTS,S malaria vaccine approved, regardless of whether or not it actually safe and effective.

Read more at:

http://www.naturalnews.com/054047_malaria_vaccines_scientific_studies_control_group.html

Diphtheria and Tetanus DTaP Toxoids and Acellular Pertussis Vaccine Adsorbed

Adverse events reported during post-approval use of Tripedia vaccine include idiopathic thrombocytopenic purpura, SIDS, anaphylactic reaction, cellulitis, autism, convulsion/grand mal convulsion, encephalopathy, hypotonia, neuropathy, somnolence and apnea. Events were included in this list because of the seriousness or frequency of reporting. Because these events are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequencies or to establish a causal relationship to components of Tripedia vaccine

Click here for the document on the FDA website.

If they remove it, we’ve cached a copy at this link on Natural News.

A New Use for LEDs: Mind Control

A New Use for LEDs: Mind Control

By MICHAEL KANELLOS

Fred Maxik wants to make a light bulb that will help you sleep.

“Biological specific lights,” tuned so as not to interfere with an individual’s normal production of melatonin, the hormone secreted from the pineal gland linked to sleepiness, could begin to hit the market in about two years, according to Mr. Maxik, a founder of the Lighting Science Group, which specializes in LED bulbs.

With a biological bulb, you could read at night without experiencing the nagging irritability that can occur after using a computer or sitting close to a lamp near bedtime.

And other bulbs — or the same bulb programmed via a network— could help make consumers feel more refreshed in the morning by choreographing their wake-up ritual. “We could even do things like lights for sterilization, with photo catalysts” for bathrooms in perhaps five to six years, he added. While solid state lights and LED bulbs have been promoted as a tools for energy conservation, industry experts and executives suggest that efficiency will become a Trojan horse for a host of unexpected and arguably more valuable applications. Light-emitting diodes, after all, are semiconductors that can be programmed to emit light at precise wavelengths, colors and tones. Traditional light bulbs, the last vestige of the vacuum tube era, produce light with hot gases or wires.

Greater control over light would ideally lead to greater control over the surrounding environment, researchers suggest. “Light has these biological and behavior effects — why not build on it?” said George C. Brainard, a professor of neurology at the Jefferson Medical College at Thomas Jefferson University and one of the leading researchers in the field.

Dr. Brainard predicts that over the next decade or two, health benefits will come to be considered one of the primary attributes of bulbs along with energy consumption, aesthetics and brightness. He and Lighting Science are working with NASA on LED lights that are intended to allow astronauts to better adjust to phenomena like the 90-minute “days” experienced on the orbiting International Space Station.

Boeing included LEDs in the cabin of the new 787 Dreamliner that dim and increase in intensity to slightly adjust the circadian rhythms of passengers on transcontinental flights. The hope is that it will help passengers more easily adjust to jet lag.

Meanwhile, researchers at Japan’s Keio University and elsewhere have experimented with LED traffic lights and car taillights that emit photons in pulses like optical fibers. While humans can’t visually perceive the difference, the pulses serve up a data stream about traffic conditions or potential accidents.

“An LED is a light source, but it is an infinitely controllable source,” said Zach Gentry, an executive at enLighted, a company that combines LEDs with temperature, light and occupancy sensors to produce a device that monitors energy consumption and physical activity in office buildings. EnLighted just raised $14 million in capital.

The National Institute of Mental Health discovered the connection between light and health in 1980 in an experiment that showed bright white light could suppress melatonin production. A few years later at Harvard, scientists demonstrated that circadian rhythms could be disrupted.

Then in 2001, Dr. Brainard found that circadian rhythms could be disrupted with fairly low levels of blue light. He and others concluded that the eye must have undiscovered photoreceptors sensitive to blue light that perform nonvisual functions. It was a somewhat radical notion, but a year later, scientists at Brown University and Johns Hopkins physically isolated the receptor.

Light therapy is already used to treat seasonal affective disorder and premature infants. The Lighting Research Center at the Rensselaer Polytechnic Institute has noted associations between disruptions in the natural light-dark cycle and increased incidents of insomnia and breast cancer.

Traditional light sources can have the same physiological impact. LEDs, however, are easier to control. More important, the physiological effects can be triggered with comparatively low levels of blue light, which LEDs emit natively.

White light LEDs are actually blue LEDs covered by a yellow phosphor. Tinkering with the phosphors or combining blue and “white” LEDs in the same bulb could result in a somewhat more economical, compact “health” bulb.

While mood lighting for ordinary consumers remains a few years out, the public has already begun to experience some of the hidden benefits of LEDs. Many upscale retailers have installed LEDs to achieve special lighting effects or to make jewelry cases sparkle. Subway, the sandwich chain, is installing LED fixtures from Lunera Lighting in some outlets to enhance their appearance.

“You can create a color perspective that makes people look good,” said Don Peifer, one of the company’s co-founders. Before starting up Lunera, which specializes in LED fixtures that evenly “wash” offices and lobbies with light, Mr. Peifer worked as a lighting designer for photographers like Annie Leibovitz and Steven Klein.

Lunera has also installed fixtures in eBay’s data centers that eliminate vertical shadows in computer racks.

Redwood Systems, another Silicon Valley start-up, and enLighted are combining LEDs with temperature and occupancy sensors to help retailers determine whether consumers stop at certain aisles and whether check-out lines are growing shorter or longer.

Humans and artificial lighting have never been an ideal combination. Circadian disorders result from placing humans in unnatural situations. “Before the Industrial Revolution, people worked in fields,” Mr. Peifer said. “There was a really strong dichotomy between night and day.”

Maybe LEDs can restore some of the balance. “We don’t know what will happen in the future of lighting, and that is the exciting part of it,” Mr. Peifer said.

 

http://green.blogs.nytimes.com/2011/10/07/a-new-use-for-leds-mind-control/?_php=true&_type=blogs&_r=0