International journal of science – 05.Sep.2013
Topoisomerases are expressed throughout the developing and adult brain and are mutated in some individuals with autism spectrum disorder (ASD). However, how topoisomerases are mechanistically connected to ASD is unknown. Here we find that topotecan, a topoisomerase 1 (TOP1) inhibitor, dose-dependently reduces the expression of extremely long genes in mouse and human neurons, including nearly all genes that are longer than 200 kilobases. Expression of long genes is also reduced after knockdown of Top1 or Top2b in neurons, highlighting that both enzymes are required for full expression of long genes. By mapping RNA polymerase II density genome-wide in neurons, we found that this length-dependent effect on gene expression was due to impaired transcription elongation. Interestingly, many high-confidence ASD candidate genes are exceptionally long and were reduced in expression after TOP1 inhibition. Our findings suggest that chemicals and genetic mutations that impair topoisomerases could commonly contribute to ASD and other neurodevelopmental disorders.
Immunologic research – Jul.2013
Authors and affiliations
C. A. Shaw – 1,2,3
L. Tomljenovic – 1
1.Neural Dynamics Research Group, Department of Ophthalmology and Visual SciencesUniversity of British Columbia (UBC)VancouverCanada
2.Program in Experimental MedicineUniversity of British Columbia (UBC)VancouverCanada
3.Program in NeuroscienceUniversity of British Columbia (UBC)VancouverCanada
We have examined the neurotoxicity of aluminum in humans and animals under various conditions, following different routes of administration, and provide an overview of the various associated disease states. The literature demonstrates clearly negative impacts of aluminum on the nervous system across the age span. In adults, aluminum exposure can lead to apparently age-related neurological deficits resembling Alzheimer’s and has been linked to this disease and to the Guamanian variant, ALS–PDC. Similar outcomes have been found in animal models. In addition, injection of aluminum adjuvants in an attempt to model Gulf War syndrome and associated neurological deficits leads to an ALS phenotype in young male mice. In young children, a highly significant correlation exists between the number of pediatric aluminum-adjuvanted vaccines administered and the rate of autism spectrum disorders. Many of the features of aluminum-induced neurotoxicity may arise, in part, from autoimmune reactions, as part of the ASIA syndrome.
US National Library of Medicine
National Institutes of Health – Jun 2014
Li X, Qu F, Xie W, Wang F, Liu H, Song S, Chen T, Zhang Y, Zhu S, Wang Y, Guo C, Tang TS.
State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Thimerosal is a vaccine antimicrobial preservative which has long been suspected an iatrogenic factor possibly contributing to neurodevelopmental disorders including autism. The association between infant vaccine thimerosal exposure and autism remains an open question. Although thimerosal has been removed from mandatory childhood vaccines in the United States, thimerosal-preserved vaccines are still widely used outside of the United States especially in developing countries. Notably, thimerosal-containing vaccines are being given to the newborns within the first 12-24 h after birth in some countries. To examine the possible neurotoxic effects of early neonatal exposure to a higher level of thimerosal, FVB mice were subcutaneously injected with thimerosal-mercury at a dose which is 20× higher than that used for regular Chinese infant immunization during the first 4 months of life. Thimerosal-treated mice exhibited neural development delay, social interaction deficiency, and inclination of depression. Apparent neuropathological changes were also observed in adult mice neonatally treated with thimerosal. High-throughput RNA sequencing of autistic-behaved mice brains revealed the alternation of a number of canonical pathways involving neuronal development, neuronal synaptic function, and the dysregulation of endocrine system. Intriguingly, the elevation of anterior pituitary secreting hormones occurred exclusively in male but not in female thimerosal-treated mice, demonstrating for the first time the gender bias of thimerosal-mercury toxicity with regard to endocrine system. Our results indicate that higher dose of neonatal thimerosal-mercury (20× higher than that used in human) is capable of inducing long-lasting substantial dysregulation of neurodevelopment, synaptic function, and endocrine system, which could be the causal involvements of autistic-like behavior in mice.
VAXXED TV – Your Findings Are Only As Good As Your Data
Dental health connection
MMR devastated my son
I refuse to vaccinate anyone
Vaxxed versus unvaxxed in my home
No more vaccinations for my family
Vaccines gave my son autism
DAD WANTED ME TO BE SURE
ONE FOR ISRAEL Ministry – Jewish Johnathan Ben-David forgave his killer and you would not believe why!!!
Testimony by Phil Robertson from Duck Dynasty
1 Corinthians 15 Authorized (King James) Version (AKJV)
1 Moreover, brethren, I declare unto you the gospel which I preached unto you, which also ye have received, and wherein ye stand;
2 by which also ye are saved, if ye keep in memory what I preached unto you, unless ye have believed in vain.
3 For I delivered unto you first of all that which I also received, how that Christ died for our sins according to the scriptures;
4 and that he was buried, and that he rose again the third day according to the scriptures:
Hebrews 6 Authorized (King James) Version (AKJV)
1 Therefore leaving the principles of the doctrine of Christ, let us go on unto perfection; not laying again the foundation of repentance from dead works, and of faith toward God,
2 of the doctrine of baptisms, and of laying on of hands, and of resurrection of the dead, and of eternal judgment.
3 And this will we do, if God permit.
4 For it is impossible for those who were once enlightened, and have tasted of the heavenly gift, and were made partakers of the Holy Ghost,
5 and have tasted the good word of God, and the powers of the world to come,
6 if they shall fall away, to renew them again unto repentance; seeing they crucify to themselves the Son of God afresh, and put him to an open shame.
7 For the earth which drinketh in the rain that cometh oft upon it, and bringeth forth herbs meet for them by whom it is dressed, receiveth blessing from God:
8 but that which beareth thorns and briers is rejected, and is nigh unto cursing; whose end is to be burned.
1 Who hath believed our report? and to whom is the arm of the Lord revealed?
2 For he shall grow up before him as a tender plant,and as a root out of a dry ground:he hath no form nor comeliness;and when we shall see him,there is no beauty that we should desire him.
3 He is despised and rejected of men;a man of sorrows, and acquainted with grief:and we hid as it were our faces from him;he was despised, and we esteemed him not.
4 Surely he hath borne our griefs,and carried our sorrows:yet we did esteem him stricken,smitten of God, and afflicted.
5 But he was wounded for our transgressions,he was bruised for our iniquities:the chastisement of our peace was upon him;and with his stripes we are healed.
6 All we like sheep have gone astray;we have turned every one to his own way;and the Lord hath laid on him the iniquity of us all.
7 He was oppressed, and he was afflicted,yet he opened not his mouth:he is brought as a lamb to the slaughter,and as a sheep before her shearers is dumb,so he openeth not his mouth.
8 He was taken from prison and from judgment:and who shall declare his generation? for he was cut off out of the land of the living:for the transgression of my people was he stricken.
9 And he made his grave with the wicked,and with the rich in his death;because he had done no violence,neither was any deceit in his mouth.
10 Yet it pleased the Lord to bruise him;he hath put him to grief:when thou shalt make his soul an offering for sin,he shall see his seed, he shall prolong his days,and the pleasure of the Lord shall prosper in his hand.
11 He shall see of the travail of his soul, and shall be satisfied:by his knowledge shall my righteous servant justify many;for he shall bear their iniquities.
12 Therefore will I divide him a portion with the great,and he shall divide the spoil with the strong;because he hath poured out his soul unto death:and he was numbered with the transgressors;and he bare the sin of many,and made intercession for the transgressors.
CDC admits 98 million Americans were given cancer virus via the polio shot
The CDC has admitted that between 1955–1963 over 98 million Americans received one or more doses of a polio shot which was contaminated with a cancer-causing virus called Simian vacuolating virus 40 (SV40). The CDC quickly took down the page, along with Google, but the site was luckily cached and saved to symbolize this grand admission.
To further confirm this unbelievable admission, Assistant Professor of Pathology at Loyola University in Chicago Dr. Michele Carbone has been able to independently verify the presence of the SV40 virus in tissue and bone samples from patients who died during that era. He found that 33% of the samples with osteosarcoma bone cancers, 40% of other bone cancers, and 60% of the mesothelioma’s lung cancers all contained this obscure virus. This leaves the postulation that upwards of 10–30 million actually contracted and were adversely affected by this virus, to be deadly accurate.
In this shocking interview, top Merck scientist Dr. Maurice Hilleman confesses (with laughter) that Merck vaccines (Polio) had been deliberately contaminated with SV40, a CANCER-CAUSING monkey virus from 1953 – 63. Learn all about the Vaccine-Cancer connection in the upcoming re-release of the Truth About Cancer documentary on May 16th: http://bit.ly/2qvyPzp
Did you see this radio show host ‘lose his mind’ over BillNye and #Vaccines? #HighWire
Vaccine Excipient & Media Summary
Excipients Included in U.S. Vaccines, by Vaccine
In addition to weakened or killed disease antigens (viruses or bacteria), vaccines contain very small amounts of other
ingredients – excipients or media.
Some excipients are added to a vaccine for a specific purpose. These include:
Preservatives, to prevent contamination. For example, thimerosal.
Adjuvants, to help stimulate a stronger immune response. For example, aluminum salts.
Stabilizers, to keep the vaccine potent during transportation and storage. For example, sugars or gelatin.
Others are residual trace amounts of materials that were used during the manufacturing process and removed. These include:
Cell culture materials, used to grow the vaccine antigens. For example, egg protein, various culture media.
Inactivating ingredients, used to kill viruses or inactivate toxins. For example, formaldehyde.
Antibiotics, used to prevent contamination by bacteria. For example, neomycin.
The following table lists all components, other than antigens, shown in the manufacturers’ package insert (PI) for each vaccine.
Each of these PIs, which can be found on the FDA’s website (see below) contains a description of that vaccine’s manufacturing
process, including the amount and purpose of each substance. In most PIs, this information is found in Section 11: “Description.”
All information was extracted from manufacturers’ package inserts, current as of January 6, 2017.
If in doubt about whether a PI has been updated since then, check the FDA’s website at:
THE ONLY AMMO THAT YOU WILL NEED TO OPEN THE MINDS OF EVEN THE IGNORANT!
VACCINE INSERTS pdf’s: http://www.immunize.org/fda/
Food and Drug Administration FDA Product Approval: Vaccine index
Flu Cases Show Huge Drop Thanks To…Less Flu Shots?
By Paul Webber – May 2, 2017
I was stunned to read an article from BlackburnNews.com, titled, Big Drop In Reported Flu Cases. I wasn’t particularly stunned to read that flu cases in the region were down, I was more stunned to read a writer’s blasphemous inability to achieve logic. I haven’t seen a swing and miss this bad since Pedro Cerrano swung and missed for the first hour of the movie, Major League. So I’m here to help the cause.
The opening sentence really tells us a lot (not all, but a lot) of what we need to know. Lots of residents aren’t getting a flu shot, lots or residents aren’t getting the flu. Valid? Not totally, but that’s a decent start. We now find out that there is a 94% decrease in confirmed flu cases from the prior year. What do we also know? I remind you, less than half of residents got a flu shot. So what conclusion is drawn by health officials? That flu shots are helping stave off the flu.
My head hurts. I need to take a breath. That’s a fallacy. This writer is employed and paid to write things. My head is exploding.
2-Month Old Infant Suffered Apnea and Died Following 8 Vaccines
Monday, August 01, 2016
(NaturalNews) Another family is mourning the loss of their two-month old baby following routine vaccinations. Cash Dewayne Thomas was having apnea episodes following the vitamin K injection and hepatitis B vaccine given to him at birth. When his mother sought help from numerous doctors, they ignored her concerns and would not put Cash on a breathing monitor.
At his two-month well-baby checkup, Cash’s pediatrician assured his mother the vaccines were safe and signed off for the nurse to vaccinate Cash with eight more vaccine doses, even though Cash’s breathing problems had not been addressed. He died 16 days later, which is one of the critical days infants pass away or suffer breathing issues after vaccination.
After burying their son, Cash’s parents, Whitney Hill and Jesse Dewayne Thomas, regretted that they listened to the doctor over their own instincts. They entrusted the doctors with their infant son and know the vaccines led to his breathing problems and ultimately his death.
Cash’s mother and father want to send a strong message to parents who support vaccines and hope their son’s story will help save others from suffering a loss like they have.
“Life ruined by a single vaccine” — All This Father Wanted Was To See His Newborn, Instead This Happened…
This is the story of Ben Hammond, his family, and a tragedy that has become all too familiar and all too often ignored by both mainstream and local media. Controversy has erupted on both sides of the vaccine movement, and it’s far from over.
Father of Five, Paralyzed by the DTaP Vaccination
Ben and Tanya’s fifth child, James, was born eight weeks premature in September 2012. The doctors at the hospital made the father get a 3-in-1 vaccination (DTaP: whooping cough, diphtheria, and tetanus) before he could see his baby.
He was up to date on vaccinations, but the hospital told him he needed the whooping cough booster.
Instead of protecting him, the vaccine almost killed him; it left him paralyzed, unable to work, and struggling with serious lifelong health issues, the family says.
“Horrendous, absolutely horrendous. Watching your husband go from the big, Aussie man that he was to a complete quad. I’m now no longer a wife; I’m now his carer,” Tanya said in an interview with 9 News Perth (Australia). 
Vaccine failure is well established: Malignant mumps in MMR vaccinated children
Mon, 24 Nov 2014 19:05 UTC
A new study finds highly malignant mumps infections in those successfully vaccinated against the virus…
A provocative new study titled, “Epidemic of complicated mumps in previously vaccinated young adults in the South-West of France,” reveals that the MMR vaccine, despite generating high rates of presumably protective IgG antibodies against mumps, does not always translate into real-world immunity against infection as we have repeatedly been told. To the contrary, the study details cases where, despite the detection of high levels of antibodies against the mumps virus, patients contracted a malignant form of mumps that only rarely follows from natural, community acquired infection.
Vaccine Failure Is Well Established In the Scientific Literature
While counter-intuitive to those who uncritically accept the official marketing copy of the vaccine industry and their cheerleaders within government and the mainstream media, the research community and general public is beginning to appreciate how prevalent and well-documented vaccine failure really is, especially in the case of measles, hepatitis B, chickenpox,pertussis (whooping cough), HIV, polio, HPV, and influenza vaccines that do not work as advertised.
Study 2014 – Epidemic of complicated mumps in previously vaccinated young adults in the South-West of France
Five cases of meningitis, 1 of orchitis, and 1 of unilateral hearing impairment were identified. Each of the 7 patients had been previously vaccinated with MMR, 4 had received 2 doses of this vaccine. Blood tests revealed high rates of IgG antibodies, usually considered as sufficient for immunological protection, and every patient had at least 1 positive RT-PCR test for mumps.
Outbreaks of complicated mumps may still occur despite a broad coverage of MMR vaccination. The clinical presentation suggested mumps but the final diagnosis could only be confirmed by genomic detection of the virus. Unusual viral strains with increased neurovirulence, insufficient population coverage associated with immunity decrease over time may explain outbreaks of complicated mumps. A full vaccine scheme of contact people or a third injection of vaccine for previously vaccinated people who are at risk of developing mumps are required to prevent further spreading of the disease during the outbreak.